TW200510437A - Phosphinane compound with immunomodulating activity - Google Patents
Phosphinane compound with immunomodulating activityInfo
- Publication number
- TW200510437A TW200510437A TW093124155A TW93124155A TW200510437A TW 200510437 A TW200510437 A TW 200510437A TW 093124155 A TW093124155 A TW 093124155A TW 93124155 A TW93124155 A TW 93124155A TW 200510437 A TW200510437 A TW 200510437A
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- phosphinane
- immunomodulating activity
- activity
- immunomodulating
- Prior art date
Links
- -1 Phosphinane compound Chemical class 0.000 title abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657109—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms esters of oxyacids of phosphorus in which one or more exocyclic oxygen atoms have been replaced by (a) sulfur atom(s)
- C07F9/657118—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms esters of oxyacids of phosphorus in which one or more exocyclic oxygen atoms have been replaced by (a) sulfur atom(s) non-condensed with carbocyclic rings or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention is directed to a phosphinane compound having a unique immunomodulating activity, a process for a preparation thereof, a pharmaceutical composition containing the same, and a method of preventing or treating disorders or diseases mediated by T lymphocytes by administering the compound to a subject in need of treatment.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49454303P | 2003-08-12 | 2003-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200510437A true TW200510437A (en) | 2005-03-16 |
Family
ID=34135347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW093124155A TW200510437A (en) | 2003-08-12 | 2004-08-12 | Phosphinane compound with immunomodulating activity |
Country Status (2)
Country | Link |
---|---|
TW (1) | TW200510437A (en) |
WO (1) | WO2005014603A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0513110A (en) | 2004-07-16 | 2008-04-29 | Kyorin Seiyaku Kk | medicament comprising diaryl sulfide compound or diaryl ether compound having a 2-amine-1,3-propanediol structure having a peripherally circulating lymphocyte reducing activity, in combination with an immunosuppressive agent and / or an antiinflammatory agent and expression method for the prevention of side effect |
MX2007004319A (en) | 2004-10-12 | 2007-06-15 | Kyorin Seiyaku Kk | Process for producing 2-amino-2-[2-[4-(3-benzyloxy ??phenylthio)-2-chlorophenyl] ethyl]-1,3-propanediol hydrochloride or hydrate thereof and intermediate for the same. |
AU2006300485B2 (en) | 2005-10-07 | 2011-08-25 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for liver disease containing 2-amino-1,3-propanediol derivative as active ingredient and therapeutic method for liver disease |
TWI389683B (en) | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
JP5140593B2 (en) | 2006-08-08 | 2013-02-06 | 杏林製薬株式会社 | Amino alcohol derivatives and immunosuppressants containing them as active ingredients |
KR101339976B1 (en) | 2006-08-08 | 2013-12-10 | 교린 세이야꾸 가부시키 가이샤 | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient |
JP5452237B2 (en) | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | Therapeutic or prophylactic agent for inflammatory bowel disease comprising an amino alcohol derivative as an active ingredient |
CA2840031A1 (en) | 2011-08-19 | 2013-02-28 | Westfaelische Wilhelms-Universitaet Muenster | New ligands for targeting of s1p receptors for in vivo imaging and treatment of diseases |
WO2017099822A1 (en) * | 2015-12-08 | 2017-06-15 | Retrophin, Inc. | Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders |
GB201715786D0 (en) | 2017-09-29 | 2017-11-15 | Univ College Cardiff Consultants Ltd | Compounds |
US11696904B2 (en) * | 2020-01-10 | 2023-07-11 | The Regents Of The University Of California | Prodrug for therapeutic applications |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8533101A (en) * | 2000-08-31 | 2002-03-13 | Merck & Co Inc | Phosphate derivatives as immunoregulatory agents |
-
2004
- 2004-08-12 WO PCT/JP2004/011867 patent/WO2005014603A1/en active Application Filing
- 2004-08-12 TW TW093124155A patent/TW200510437A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2005014603A1 (en) | 2005-02-17 |
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