TW200510437A - Phosphinane compound with immunomodulating activity - Google Patents

Phosphinane compound with immunomodulating activity

Info

Publication number
TW200510437A
TW200510437A TW093124155A TW93124155A TW200510437A TW 200510437 A TW200510437 A TW 200510437A TW 093124155 A TW093124155 A TW 093124155A TW 93124155 A TW93124155 A TW 93124155A TW 200510437 A TW200510437 A TW 200510437A
Authority
TW
Taiwan
Prior art keywords
compound
phosphinane
immunomodulating activity
activity
immunomodulating
Prior art date
Application number
TW093124155A
Other languages
Chinese (zh)
Inventor
Masao Chino
Kunitomo Adachi
Yoshihito Tanaka
Kunio Sugahara
Hirofumi Matsuyuki
Ayumi Tomatsu
Masatoshi Kiuchi
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Publication of TW200510437A publication Critical patent/TW200510437A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657109—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms esters of oxyacids of phosphorus in which one or more exocyclic oxygen atoms have been replaced by (a) sulfur atom(s)
    • C07F9/657118—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms esters of oxyacids of phosphorus in which one or more exocyclic oxygen atoms have been replaced by (a) sulfur atom(s) non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention is directed to a phosphinane compound having a unique immunomodulating activity, a process for a preparation thereof, a pharmaceutical composition containing the same, and a method of preventing or treating disorders or diseases mediated by T lymphocytes by administering the compound to a subject in need of treatment.
TW093124155A 2003-08-12 2004-08-12 Phosphinane compound with immunomodulating activity TW200510437A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49454303P 2003-08-12 2003-08-12

Publications (1)

Publication Number Publication Date
TW200510437A true TW200510437A (en) 2005-03-16

Family

ID=34135347

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093124155A TW200510437A (en) 2003-08-12 2004-08-12 Phosphinane compound with immunomodulating activity

Country Status (2)

Country Link
TW (1) TW200510437A (en)
WO (1) WO2005014603A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0513110A (en) 2004-07-16 2008-04-29 Kyorin Seiyaku Kk medicament comprising diaryl sulfide compound or diaryl ether compound having a 2-amine-1,3-propanediol structure having a peripherally circulating lymphocyte reducing activity, in combination with an immunosuppressive agent and / or an antiinflammatory agent and expression method for the prevention of side effect
MX2007004319A (en) 2004-10-12 2007-06-15 Kyorin Seiyaku Kk Process for producing 2-amino-2-[2-[4-(3-benzyloxy ??phenylthio)-2-chlorophenyl] ethyl]-1,3-propanediol hydrochloride or hydrate thereof and intermediate for the same.
AU2006300485B2 (en) 2005-10-07 2011-08-25 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent for liver disease containing 2-amino-1,3-propanediol derivative as active ingredient and therapeutic method for liver disease
TWI389683B (en) 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
JP5140593B2 (en) 2006-08-08 2013-02-06 杏林製薬株式会社 Amino alcohol derivatives and immunosuppressants containing them as active ingredients
KR101339976B1 (en) 2006-08-08 2013-12-10 교린 세이야꾸 가부시키 가이샤 Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient
JP5452237B2 (en) 2008-02-07 2014-03-26 杏林製薬株式会社 Therapeutic or prophylactic agent for inflammatory bowel disease comprising an amino alcohol derivative as an active ingredient
CA2840031A1 (en) 2011-08-19 2013-02-28 Westfaelische Wilhelms-Universitaet Muenster New ligands for targeting of s1p receptors for in vivo imaging and treatment of diseases
WO2017099822A1 (en) * 2015-12-08 2017-06-15 Retrophin, Inc. Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders
GB201715786D0 (en) 2017-09-29 2017-11-15 Univ College Cardiff Consultants Ltd Compounds
US11696904B2 (en) * 2020-01-10 2023-07-11 The Regents Of The University Of California Prodrug for therapeutic applications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8533101A (en) * 2000-08-31 2002-03-13 Merck & Co Inc Phosphate derivatives as immunoregulatory agents

Also Published As

Publication number Publication date
WO2005014603A1 (en) 2005-02-17

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