CY1108401T1 - Παραγωγα πυρρολοϊμιδαζολης, η παρασκευη τους, φαρμακευτικες συνθεσεις που τα περιεχουν και η χρηση τους ως νοοτροπικων παραγοντων - Google Patents

Παραγωγα πυρρολοϊμιδαζολης, η παρασκευη τους, φαρμακευτικες συνθεσεις που τα περιεχουν και η χρηση τους ως νοοτροπικων παραγοντων

Info

Publication number
CY1108401T1
CY1108401T1 CY20081101113T CY081101113T CY1108401T1 CY 1108401 T1 CY1108401 T1 CY 1108401T1 CY 20081101113 T CY20081101113 T CY 20081101113T CY 081101113 T CY081101113 T CY 081101113T CY 1108401 T1 CY1108401 T1 CY 1108401T1
Authority
CY
Cyprus
Prior art keywords
preparation
nootropic
pharmaceutical compositions
compositions containing
pyrroloimidazolo
Prior art date
Application number
CY20081101113T
Other languages
English (en)
Inventor
Carlo Farina
Stefania Gagliardi
Carlo Parini
Marisa Martinelli
Carla Ghelardini
Original Assignee
Neurotune Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurotune Ag filed Critical Neurotune Ag
Publication of CY1108401T1 publication Critical patent/CY1108401T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)

Abstract

Περιγράφονται νέες δικυκλικές αρυλιμιδαζολόνες με νοοτροπική δράση (δηλαδή δράση προστασίας και εγκεφαλικής διέγερσης), αναλγητική και αντιυπεραλγητική δράση. Περιγράφονται επίσης μέθοδος παρασκευής τους και φαρμακευτικές συνθέσεις που τις περιέχουν, χρήσιμες για την αγωγή νοητικών ανεπαρκειών και διαφόρων τύπων πόνων.
CY20081101113T 2003-03-24 2008-10-08 Παραγωγα πυρρολοϊμιδαζολης, η παρασκευη τους, φαρμακευτικες συνθεσεις που τα περιεχουν και η χρηση τους ως νοοτροπικων παραγοντων CY1108401T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000573A ITMI20030573A1 (it) 2003-03-24 2003-03-24 Composti ad azione nootropica, loro preparazione,
EP04741432A EP1608655B8 (en) 2003-03-24 2004-03-22 Pyrroloimidazole derivatives, their preparation, pharmaceutical compositions containing them, and their use as nootropic agents

Publications (1)

Publication Number Publication Date
CY1108401T1 true CY1108401T1 (el) 2014-02-12

Family

ID=33042696

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101113T CY1108401T1 (el) 2003-03-24 2008-10-08 Παραγωγα πυρρολοϊμιδαζολης, η παρασκευη τους, φαρμακευτικες συνθεσεις που τα περιεχουν και η χρηση τους ως νοοτροπικων παραγοντων

Country Status (24)

Country Link
US (3) US7544705B2 (el)
EP (1) EP1608655B8 (el)
JP (1) JP4920408B2 (el)
CN (1) CN100522963C (el)
AT (1) ATE401327T1 (el)
AU (1) AU2004224087B2 (el)
BR (1) BRPI0408601A (el)
CA (1) CA2520008C (el)
CY (1) CY1108401T1 (el)
DE (1) DE602004015089D1 (el)
DK (1) DK1608655T3 (el)
EA (1) EA009558B1 (el)
ES (1) ES2309534T3 (el)
HK (1) HK1083837A1 (el)
HR (1) HRP20050833A2 (el)
IT (1) ITMI20030573A1 (el)
NO (1) NO20054898L (el)
NZ (1) NZ543154A (el)
PL (2) PL378939A1 (el)
PT (1) PT1608655E (el)
RS (1) RS20050725A (el)
SI (1) SI1608655T1 (el)
WO (1) WO2004085438A2 (el)
ZA (1) ZA200508578B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) * 2006-11-15 2008-05-28 Nikem Research S.R.L. Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
ITMI20070770A1 (it) * 2007-04-16 2008-10-17 Brane Discovery S R L Impiego di dimiracetam nel trattamento del dolore cronico
AU2012201853B2 (en) * 2007-04-16 2013-06-27 Neurotune Ag Use of dimiracetam in the treatment of chronic pain
JP5917148B2 (ja) 2008-10-16 2016-05-11 ザ ジョーンズ ホプキンズ ユニバーシティＴｈｅ Ｊｏｈｎｓ Ｈｏｐｋｉｎｓ Ｕｎｉｖｅｒｓｉｔｙ 認知機能を改善するための方法および組成物
US9125898B2 (en) 2008-11-14 2015-09-08 Neurotune Ag Acetam derivatives for pain relief
EP2533645B1 (en) * 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
PL2598504T3 (pl) * 2010-07-26 2014-10-31 Neurotune Ag Sposób otrzymywania dimiracetamu
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
US10925834B2 (en) 2015-05-22 2021-02-23 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
JOP20190251A1 (ar) 2017-05-31 2019-10-21 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
CN113164767A (zh) 2018-12-04 2021-07-23 美蒂斯制药公司 包含非外消旋比例的(r)-2-(2-氧代-1-吡咯烷基)丁酰胺和(s)-2-(2-氧代-1-吡咯烷基)丁酰胺的协同组合物
CN113195494A (zh) 2018-12-04 2021-07-30 美蒂斯制药公司 包含非外消旋比例的R-2-(取代的磺酰基)-六氢-吡咯并[1,2-a]吡嗪-6(2H)-酮和S-2-(取代的磺酰基)-六氢-吡咯并[1,2-a]吡嗪-6(2H)-酮的协同组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582838A (en) * 1984-08-24 1986-04-15 Warner-Lambert Company Derivatives of dihydro-1H-pyrrolo[1,2-c]imidazol-3,5-dione as cognition activators
IT1233860B (it) * 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
US5200406A (en) * 1988-02-08 1993-04-06 I.S.F. Societa Per Azioni Pharmaceutically useful 2,5-dioxo-1H-octahydroimidazo[1,2-A]azepines
JP3400466B2 (ja) * 1991-10-28 2003-04-28 日本水産株式会社 高純度エイコサペンタエン酸またはそのエステルの製造方法
GB9123641D0 (en) * 1991-11-07 1992-01-02 Isf Spa Process
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) * 2006-11-15 2008-05-28 Nikem Research S.R.L. Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents

Also Published As

Publication number Publication date
HRP20050833A2 (en) 2006-02-28
NO20054898L (no) 2005-10-24
DE602004015089D1 (de) 2008-08-28
PL1608655T3 (pl) 2009-03-31
DK1608655T3 (da) 2008-11-03
JP4920408B2 (ja) 2012-04-18
US7544705B2 (en) 2009-06-09
EA200501501A1 (ru) 2006-04-28
RS20050725A (en) 2007-11-15
EP1608655A2 (en) 2005-12-28
ZA200508578B (en) 2007-04-25
WO2004085438A3 (en) 2004-11-25
NZ543154A (en) 2008-03-28
US20090163565A1 (en) 2009-06-25
CA2520008C (en) 2011-08-23
CN100522963C (zh) 2009-08-05
BRPI0408601A (pt) 2006-03-07
EA009558B1 (ru) 2008-02-28
ES2309534T3 (es) 2008-12-16
US7732473B2 (en) 2010-06-08
WO2004085438A2 (en) 2004-10-07
AU2004224087B2 (en) 2010-04-01
CA2520008A1 (en) 2004-10-07
SI1608655T1 (sl) 2008-12-31
JP2006523198A (ja) 2006-10-12
US20070027137A1 (en) 2007-02-01
EP1608655B1 (en) 2008-07-16
CN1756757A (zh) 2006-04-05
HK1083837A1 (en) 2006-07-14
ATE401327T1 (de) 2008-08-15
ITMI20030573A1 (it) 2004-09-25
PT1608655E (pt) 2008-10-07
EP1608655B8 (en) 2008-10-15
US20100173945A1 (en) 2010-07-08
PL378939A1 (pl) 2006-06-12
AU2004224087A1 (en) 2004-10-07

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