HK1083837A1 - Pyrroloimidazole derivatives, their preperation, pharmaceutical compositions containing them, and their use as nootropic agents - Google Patents

Pyrroloimidazole derivatives, their preperation, pharmaceutical compositions containing them, and their use as nootropic agents

Info

Publication number
HK1083837A1
HK1083837A1 HK06103951A HK06103951A HK1083837A1 HK 1083837 A1 HK1083837 A1 HK 1083837A1 HK 06103951 A HK06103951 A HK 06103951A HK 06103951 A HK06103951 A HK 06103951A HK 1083837 A1 HK1083837 A1 HK 1083837A1
Authority
HK
Hong Kong
Prior art keywords
pharmaceutical compositions
preperation
compositions containing
nootropic agents
action
Prior art date
Application number
HK06103951A
Other languages
English (en)
Inventor
Carlo Farina
Stefania Gagliardi
Carlo Parini
Marisa Martinelli
Carla Ghelardini
Original Assignee
Nikem Research Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikem Research Srl filed Critical Nikem Research Srl
Publication of HK1083837A1 publication Critical patent/HK1083837A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK06103951A 2003-03-24 2006-03-30 Pyrroloimidazole derivatives, their preperation, pharmaceutical compositions containing them, and their use as nootropic agents HK1083837A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000573A ITMI20030573A1 (it) 2003-03-24 2003-03-24 Composti ad azione nootropica, loro preparazione,
PCT/EP2004/050339 WO2004085438A2 (en) 2003-03-24 2004-03-22 Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents

Publications (1)

Publication Number Publication Date
HK1083837A1 true HK1083837A1 (en) 2006-07-14

Family

ID=33042696

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06103951A HK1083837A1 (en) 2003-03-24 2006-03-30 Pyrroloimidazole derivatives, their preperation, pharmaceutical compositions containing them, and their use as nootropic agents

Country Status (24)

Country Link
US (3) US7544705B2 (el)
EP (1) EP1608655B8 (el)
JP (1) JP4920408B2 (el)
CN (1) CN100522963C (el)
AT (1) ATE401327T1 (el)
AU (1) AU2004224087B2 (el)
BR (1) BRPI0408601A (el)
CA (1) CA2520008C (el)
CY (1) CY1108401T1 (el)
DE (1) DE602004015089D1 (el)
DK (1) DK1608655T3 (el)
EA (1) EA009558B1 (el)
ES (1) ES2309534T3 (el)
HK (1) HK1083837A1 (el)
HR (1) HRP20050833A2 (el)
IT (1) ITMI20030573A1 (el)
NO (1) NO20054898L (el)
NZ (1) NZ543154A (el)
PL (2) PL378939A1 (el)
PT (1) PT1608655E (el)
RS (1) RS20050725A (el)
SI (1) SI1608655T1 (el)
WO (1) WO2004085438A2 (el)
ZA (1) ZA200508578B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) * 2006-11-15 2008-05-28 Nikem Research S.R.L. Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
ITMI20070770A1 (it) * 2007-04-16 2008-10-17 Brane Discovery S R L Impiego di dimiracetam nel trattamento del dolore cronico
AU2012201853B2 (en) * 2007-04-16 2013-06-27 Neurotune Ag Use of dimiracetam in the treatment of chronic pain
CN102227217A (zh) * 2008-10-16 2011-10-26 约翰斯.霍普金斯大学 改善认知功能的方法和组合物
US9125898B2 (en) 2008-11-14 2015-09-08 Neurotune Ag Acetam derivatives for pain relief
EA037187B1 (ru) * 2010-02-09 2021-02-17 Дзе Джонс Хопкинс Юниверсити Способ и композиция для лечения когнитивного расстройства
EP2598504B1 (en) * 2010-07-26 2014-04-16 Neurotune AG Process for the preparation of dimiracetam
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144801A1 (en) 2013-03-15 2014-09-18 Agenebio Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US10925834B2 (en) 2015-05-22 2021-02-23 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
JOP20190251A1 (ar) 2017-05-31 2019-10-21 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
MX2021006248A (es) 2018-12-04 2021-08-11 Metys Pharmaceuticals AG Composiciones sinergicas que comprenden r-2-(sulfonil sustituido)-hexahidro-pirrolo[1,2-a]pirazin-6(2h)-onas y s-2-(sulfonil sustituido)-hexahidro-pirrolo[1,2-a]pirazin-6(2h)-on as en una proporcion no racemica.
JOP20210082A1 (ar) 2018-12-04 2023-01-30 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد و(s)-2-(2-أوكسو بيروليدين-1-يل)بيوتان أميد بنسبة غير راسيمية

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582838A (en) * 1984-08-24 1986-04-15 Warner-Lambert Company Derivatives of dihydro-1H-pyrrolo[1,2-c]imidazol-3,5-dione as cognition activators
IT1233860B (it) * 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
US5200406A (en) * 1988-02-08 1993-04-06 I.S.F. Societa Per Azioni Pharmaceutically useful 2,5-dioxo-1H-octahydroimidazo[1,2-A]azepines
JP3400466B2 (ja) * 1991-10-28 2003-04-28 日本水産株式会社 高純度エイコサペンタエン酸またはそのエステルの製造方法
GB9123641D0 (en) 1991-11-07 1992-01-02 Isf Spa Process
ITMI20030573A1 (it) * 2003-03-24 2004-09-25 Nikem Research Srl Composti ad azione nootropica, loro preparazione,
EP1925304A1 (en) * 2006-11-15 2008-05-28 Nikem Research S.R.L. Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents

Also Published As

Publication number Publication date
EP1608655B1 (en) 2008-07-16
JP4920408B2 (ja) 2012-04-18
SI1608655T1 (sl) 2008-12-31
PT1608655E (pt) 2008-10-07
CN1756757A (zh) 2006-04-05
RS20050725A (en) 2007-11-15
CA2520008C (en) 2011-08-23
DK1608655T3 (da) 2008-11-03
EA009558B1 (ru) 2008-02-28
WO2004085438A3 (en) 2004-11-25
US7544705B2 (en) 2009-06-09
US20100173945A1 (en) 2010-07-08
NO20054898L (no) 2005-10-24
WO2004085438A2 (en) 2004-10-07
EP1608655B8 (en) 2008-10-15
JP2006523198A (ja) 2006-10-12
AU2004224087B2 (en) 2010-04-01
CY1108401T1 (el) 2014-02-12
AU2004224087A1 (en) 2004-10-07
US20090163565A1 (en) 2009-06-25
PL1608655T3 (pl) 2009-03-31
CA2520008A1 (en) 2004-10-07
EP1608655A2 (en) 2005-12-28
US7732473B2 (en) 2010-06-08
ZA200508578B (en) 2007-04-25
CN100522963C (zh) 2009-08-05
ATE401327T1 (de) 2008-08-15
PL378939A1 (pl) 2006-06-12
ITMI20030573A1 (it) 2004-09-25
DE602004015089D1 (de) 2008-08-28
US20070027137A1 (en) 2007-02-01
EA200501501A1 (ru) 2006-04-28
ES2309534T3 (es) 2008-12-16
HRP20050833A2 (en) 2006-02-28
NZ543154A (en) 2008-03-28
BRPI0408601A (pt) 2006-03-07

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120322