DK1597238T3 - HIV-replicationshæmmende pyrimidiner og triaziner - Google Patents

HIV-replicationshæmmende pyrimidiner og triaziner

Info

Publication number
DK1597238T3
DK1597238T3 DK04737252T DK04737252T DK1597238T3 DK 1597238 T3 DK1597238 T3 DK 1597238T3 DK 04737252 T DK04737252 T DK 04737252T DK 04737252 T DK04737252 T DK 04737252T DK 1597238 T3 DK1597238 T3 DK 1597238T3
Authority
DK
Denmark
Prior art keywords
triazines
hiv replication
replication inhibiting
inhibiting pyrimidines
pyrimidines
Prior art date
Application number
DK04737252T
Other languages
Danish (da)
English (en)
Inventor
Jerome Emile George Guillemont
Elisabeth Therese Jea Pasquier
Jan Heeres
Kurt Hertogs
Eva Bettens
Paulus Joannes Lewi
Jonge Marc Rene De
Lucien Maria Henricus Koymans
Frederik Frans Desire Daeyaert
Hendrik Maarten Vinkers
Paul Adriaan Jan Janssen
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of DK1597238T3 publication Critical patent/DK1597238T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK04737252T 2003-02-20 2004-02-20 HIV-replicationshæmmende pyrimidiner og triaziner DK1597238T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03100411 2003-02-20
US47501203P 2003-06-02 2003-06-02
PCT/EP2004/050177 WO2004074262A1 (en) 2003-02-20 2004-02-20 Hiv replication inhibiting pyrimidines and triazines

Publications (1)

Publication Number Publication Date
DK1597238T3 true DK1597238T3 (da) 2007-09-10

Family

ID=32910137

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04737252T DK1597238T3 (da) 2003-02-20 2004-02-20 HIV-replicationshæmmende pyrimidiner og triaziner

Country Status (27)

Country Link
US (2) US7585870B2 (pt)
EP (2) EP1603887B1 (pt)
JP (2) JP4586014B2 (pt)
KR (2) KR20050094896A (pt)
CN (2) CN1751031B (pt)
AP (1) AP2005003373A0 (pt)
AR (2) AR044500A1 (pt)
AT (2) ATE506353T1 (pt)
AU (2) AU2004213187B2 (pt)
BR (2) BRPI0407741B8 (pt)
CA (2) CA2516699C (pt)
CL (2) CL2004000303A1 (pt)
CY (1) CY1106788T1 (pt)
DE (2) DE602004006383T2 (pt)
DK (1) DK1597238T3 (pt)
EA (2) EA011256B1 (pt)
ES (1) ES2287734T3 (pt)
HR (2) HRP20050821A2 (pt)
IL (2) IL169596A (pt)
MX (2) MXPA05008866A (pt)
MY (1) MY138308A (pt)
NO (2) NO20054311L (pt)
NZ (2) NZ541601A (pt)
PL (2) PL227295B1 (pt)
PT (1) PT1597238E (pt)
TW (2) TW200510339A (pt)
WO (2) WO2004074262A1 (pt)

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NZ545270A (en) 2003-07-30 2010-04-30 Rigel Pharmaceuticals Inc 2,4-Pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
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AR074209A1 (es) 2008-11-24 2010-12-29 Boehringer Ingelheim Int Derivados de pirimidina utiles para el tratamiento del cancer
KR101295937B1 (ko) 2009-03-11 2013-08-14 화이자 인코포레이티드 글루코카이네이즈 억제제로서 사용되는 벤조푸라닐 유도체
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
US9249124B2 (en) 2011-03-30 2016-02-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Aurora kinase inhibitors and methods of making and using thereof
JP5999177B2 (ja) 2011-05-04 2016-09-28 アリアド・ファーマシューティカルズ・インコーポレイテッド Egfr発動性がんの細胞増殖阻害用化合物
GB201119358D0 (en) 2011-11-10 2011-12-21 Lewi Paulus J Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
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Also Published As

Publication number Publication date
JP2006518357A (ja) 2006-08-10
CA2516589A1 (en) 2004-09-02
EA200501327A1 (ru) 2006-02-24
CY1106788T1 (el) 2012-05-23
CN1751031A (zh) 2006-03-22
DE602004032321D1 (de) 2011-06-01
EA200501326A1 (ru) 2006-02-24
EP1597238A1 (en) 2005-11-23
HRP20050821A2 (en) 2006-11-30
AR044500A1 (es) 2005-09-14
DE602004006383T2 (de) 2008-01-10
IL169647A (en) 2013-05-30
US20060142571A1 (en) 2006-06-29
TW200510339A (en) 2005-03-16
AU2004213187A1 (en) 2004-09-02
CA2516589C (en) 2012-04-17
AP2005003373A0 (en) 2005-09-30
AU2004213186B2 (en) 2009-10-01
CN100572364C (zh) 2009-12-23
EA011256B1 (ru) 2009-02-27
BRPI0407741B8 (pt) 2021-05-25
CA2516699C (en) 2011-07-12
US20060194804A1 (en) 2006-08-31
NO20054312D0 (no) 2005-09-19
EP1603887A1 (en) 2005-12-14
PL378136A1 (pl) 2006-03-06
JP4586013B2 (ja) 2010-11-24
PT1597238E (pt) 2007-08-08
AU2004213186A1 (en) 2004-09-02
CN1751030A (zh) 2006-03-22
NO20054311L (no) 2005-10-27
MXPA05008867A (es) 2005-10-05
MXPA05008866A (es) 2005-10-05
NO20054311D0 (no) 2005-09-19
WO2004074262A1 (en) 2004-09-02
ES2287734T3 (es) 2007-12-16
PL226954B1 (pl) 2017-10-31
EP1603887B1 (en) 2011-04-20
CL2004000306A1 (es) 2005-04-08
NO20054312L (no) 2005-11-16
KR20050094896A (ko) 2005-09-28
WO2004074261A1 (en) 2004-09-02
NZ541601A (en) 2007-09-28
ATE506353T1 (de) 2011-05-15
ATE361915T1 (de) 2007-06-15
CA2516699A1 (en) 2004-09-02
CL2004000303A1 (es) 2005-04-08
IL169596A (en) 2017-02-28
HRP20050820A2 (en) 2006-11-30
EP1597238B1 (en) 2007-05-09
KR20050099994A (ko) 2005-10-17
BRPI0407741A (pt) 2006-02-14
MY138308A (en) 2009-05-29
US7585870B2 (en) 2009-09-08
JP4586014B2 (ja) 2010-11-24
EA010423B1 (ru) 2008-08-29
PL227295B1 (pl) 2017-11-30
BRPI0407741B1 (pt) 2018-05-29
AR044499A1 (es) 2005-09-14
NZ542428A (en) 2007-11-30
JP2006518356A (ja) 2006-08-10
AU2004213187B2 (en) 2009-11-05
IL169596A0 (en) 2007-07-04
DE602004006383D1 (de) 2007-06-21
IL169647A0 (en) 2007-07-04
BRPI0407732A (pt) 2006-02-14
TW200500346A (en) 2005-01-01
CN1751031B (zh) 2010-07-21
US7442705B2 (en) 2008-10-28
PL378064A1 (pl) 2006-02-20

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