US2987445A
(en)
*
|
1958-10-10 |
1961-06-06 |
Rohm & Haas |
Drug composition
|
US3087860A
(en)
*
|
1958-12-19 |
1963-04-30 |
Abbott Lab |
Method of prolonging release of drug from a precompressed solid carrier
|
US3336200A
(en)
*
|
1963-05-28 |
1967-08-15 |
Warner Lambert Pharmaceutical |
Tablet structure
|
IT1066857B
(it)
*
|
1965-12-15 |
1985-03-12 |
Acraf |
Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
|
US3652589A
(en)
*
|
1967-07-27 |
1972-03-28 |
Gruenenthal Chemie |
1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
|
GB1368574A
(en)
|
1971-02-12 |
1974-10-02 |
Ives Lab Inc |
Divisible tablet
|
US4131675A
(en)
|
1978-02-09 |
1978-12-26 |
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. |
Use of combinations of L-DOPA with trazodone and L-DOPA with etoperidone in Parkinsonism
|
US4968509A
(en)
|
1987-07-27 |
1990-11-06 |
Mcneilab, Inc. |
Oral sustained release acetaminophen formulation and process
|
US5004613A
(en)
*
|
1987-07-27 |
1991-04-02 |
Mcneil-Ppc, Inc. |
Oral sustained release pharmaceutical formulation and process
|
US4820522A
(en)
*
|
1987-07-27 |
1989-04-11 |
Mcneilab, Inc. |
Oral sustained release acetaminophen formulation and process
|
IT1233412B
(it)
*
|
1987-12-02 |
1992-03-30 |
Acraf |
Uso del trazodone
|
US4938968A
(en)
*
|
1988-07-26 |
1990-07-03 |
Norjec Development Associates, Inc. |
Controlled release indomethacin
|
US5133974A
(en)
*
|
1989-05-05 |
1992-07-28 |
Kv Pharmaceutical Company |
Extended release pharmaceutical formulations
|
US5603956A
(en)
*
|
1990-11-27 |
1997-02-18 |
Labopharm Inc. |
Cross-linked enzymatically controlled drug release
|
CA2041774C
(en)
|
1990-11-27 |
1994-04-19 |
Mircea A. Mateescu |
Use of cross-linked amylose as a matrix for the slow release of biologically active compounds
|
JP3381190B2
(ja)
|
1991-09-06 |
2003-02-24 |
マクニーラブ・インコーポレーテツド |
トラマドール物質およびアセトアミノフェンを含んでなる組成物並びにそれの使用
|
US5407686A
(en)
*
|
1991-11-27 |
1995-04-18 |
Sidmak Laboratories, Inc. |
Sustained release composition for oral administration of active ingredient
|
US5286493A
(en)
*
|
1992-01-27 |
1994-02-15 |
Euroceltique, S.A. |
Stabilized controlled release formulations having acrylic polymer coating
|
GB2284760B
(en)
|
1993-11-23 |
1998-06-24 |
Euro Celtique Sa |
A method of preparing pharmaceutical compositions by melt pelletisation
|
US5681585A
(en)
|
1991-12-24 |
1997-10-28 |
Euro-Celtique, S.A. |
Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
US5958459A
(en)
*
|
1991-12-24 |
1999-09-28 |
Purdue Pharma L.P. |
Opioid formulations having extended controlled released
|
US5273760A
(en)
|
1991-12-24 |
1993-12-28 |
Euroceltigue, S.A. |
Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
|
US5968551A
(en)
|
1991-12-24 |
1999-10-19 |
Purdue Pharma L.P. |
Orally administrable opioid formulations having extended duration of effect
|
US5478577A
(en)
*
|
1993-11-23 |
1995-12-26 |
Euroceltique, S.A. |
Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
|
FR2688422A1
(fr)
|
1992-03-11 |
1993-09-17 |
Coletica |
Microcapsules a parois en polysaccharides contenant des fonctions alcools primaires, et compositions en contenant.
|
US5292534A
(en)
*
|
1992-03-25 |
1994-03-08 |
Valentine Enterprises, Inc. |
Sustained release composition and method utilizing xanthan gum and an active ingredient
|
HU221591B
(hu)
|
1992-07-24 |
2002-11-28 |
Labopharm Inc. |
Keresztkötéses polihidroxil-származék enzimatikusan szabályozott hatóanyag-kibocsátáshoz
|
SE9202250D0
(sv)
*
|
1992-07-29 |
1992-07-29 |
Gacell Lab Ab |
Controlled release morphine preparation
|
IL103096A
(en)
*
|
1992-09-08 |
1996-12-05 |
Chemagis Ltd |
Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.
|
FR2698560B1
(fr)
*
|
1992-11-30 |
1995-02-03 |
Virbac Laboratoires |
Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications.
|
US5616343A
(en)
*
|
1993-03-25 |
1997-04-01 |
Labopharm, Inc. |
Cross-linked amylose as a binder/disintegrant in tablets
|
NZ260408A
(en)
*
|
1993-05-10 |
1996-05-28 |
Euro Celtique Sa |
Controlled release preparation comprising tramadol
|
DE4315525B4
(de)
|
1993-05-10 |
2010-04-15 |
Euro-Celtique S.A. |
Pharmazeutische Zusammensetzung
|
IL109944A
(en)
|
1993-07-01 |
1998-12-06 |
Euro Celtique Sa |
Continuous release dosage form containing morphine and a method of preparing such sustained release unit dosage forms
|
IL110014A
(en)
|
1993-07-01 |
1999-11-30 |
Euro Celtique Sa |
Solid controlled-release oral dosage forms of opioid analgesics
|
US5879705A
(en)
|
1993-07-27 |
1999-03-09 |
Euro-Celtique S.A. |
Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
|
ES2113673T3
(es)
*
|
1993-08-24 |
1998-05-01 |
Akzo Nobel Nv |
Lentes oftalmicas.
|
DE4329794C2
(de)
*
|
1993-09-03 |
1997-09-18 |
Gruenenthal Gmbh |
Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung
|
US6210714B1
(en)
*
|
1993-11-23 |
2001-04-03 |
Euro-Celtique S.A. |
Immediate release tablet cores of acetaminophen having sustained-release coating
|
EP0654263B1
(en)
|
1993-11-23 |
2002-01-23 |
Euro-Celtique S.A. |
Method for preparing a sustained release composition
|
US5891471A
(en)
*
|
1993-11-23 |
1999-04-06 |
Euro-Celtique, S.A. |
Pharmaceutical multiparticulates
|
KR100354702B1
(ko)
|
1993-11-23 |
2002-12-28 |
유로-셀티크 소시에떼 아노뉨 |
약학조성물의제조방법및서방형조성물
|
US5843480A
(en)
|
1994-03-14 |
1998-12-01 |
Euro-Celtique, S.A. |
Controlled release diamorphine formulation
|
US5560331A
(en)
|
1994-05-10 |
1996-10-01 |
Yamaha Hatsudoki Kabushiki Kaisha |
Cylinder head for engine
|
GB2290965A
(en)
*
|
1994-07-11 |
1996-01-17 |
Therapicon Srl |
Multiple layer capsules for drugs
|
US6586006B2
(en)
*
|
1994-08-04 |
2003-07-01 |
Elan Drug Delivery Limited |
Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
|
US5965161A
(en)
*
|
1994-11-04 |
1999-10-12 |
Euro-Celtique, S.A. |
Extruded multi-particulates
|
EP0807433A4
(en)
|
1994-12-27 |
2005-12-28 |
Akzo Nobel Nv |
PREPARING WITH DELAYED RELEASE
|
US5981592A
(en)
|
1995-03-13 |
1999-11-09 |
Loma Linda University Medical Center |
Method and composition for treating cystic fibrosis
|
US6214331B1
(en)
*
|
1995-06-06 |
2001-04-10 |
C. R. Bard, Inc. |
Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
|
DE19530575A1
(de)
|
1995-08-19 |
1997-02-20 |
Gruenenthal Gmbh |
Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz
|
GB9519363D0
(en)
*
|
1995-09-22 |
1995-11-22 |
Euro Celtique Sa |
Pharmaceutical formulation
|
IL116281A
(en)
*
|
1995-12-07 |
1999-06-20 |
Chemagis Ltd |
Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
|
IT1282650B1
(it)
*
|
1996-02-19 |
1998-03-31 |
Jagotec Ag |
Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
|
US5773031A
(en)
*
|
1996-02-27 |
1998-06-30 |
L. Perrigo Company |
Acetaminophen sustained-release formulation
|
CA2173818A1
(fr)
*
|
1996-04-10 |
1997-10-11 |
Francois Chouinard |
Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose
|
IL119121A
(en)
*
|
1996-08-22 |
2000-11-21 |
Chemagis Ltd |
Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride
|
DE19640062B4
(de)
*
|
1996-09-28 |
2006-04-27 |
Lts Lohmann Therapie-Systeme Ag |
Orale Zubereitung, enthaltend in einer in wässrigem Medium quellbaren Matrix wenigstens einen pharmazeutischen Wirkstoff
|
ES2565163T3
(es)
|
1996-10-28 |
2016-03-31 |
General Mills, Inc. |
Imbibición y encapsulación de partículas de liberación controlada y producto encapsulado
|
US5879707A
(en)
*
|
1996-10-30 |
1999-03-09 |
Universite De Montreal |
Substituted amylose as a matrix for sustained drug release
|
DK0971690T4
(en)
*
|
1996-12-18 |
2015-07-13 |
Bimeda Res & Dev Ltd |
Anti-infective intramammary veterinary composition.
|
US5807575A
(en)
|
1997-02-14 |
1998-09-15 |
Rougier Inc. |
Manufacture of cross-linked amylose useful as a excipient for control release of active compounds
|
DE19710008A1
(de)
|
1997-03-12 |
1998-09-17 |
Basf Ag |
Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung
|
BE1011045A3
(fr)
*
|
1997-03-14 |
1999-04-06 |
Ucb Sa |
Compositions pharmaceutiques pour la liberation controlee de substances actives.
|
CA2270975C
(en)
|
1997-07-02 |
2003-04-01 |
Euro-Celtique, S.A. |
Stabilized sustained release tramadol formulations
|
FR2772615B1
(fr)
*
|
1997-12-23 |
2002-06-14 |
Lipha |
Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
|
US5877351A
(en)
*
|
1997-12-24 |
1999-03-02 |
Wyckoff Chemical Company, Inc. |
Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts
|
US6110973A
(en)
*
|
1998-01-29 |
2000-08-29 |
Sepracor |
Methods for treating obesity and weight gain using optically pure (-)-bupropion
|
US6284273B1
(en)
*
|
1998-02-24 |
2001-09-04 |
Vincent Lenaerts |
Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds
|
US6245357B1
(en)
*
|
1998-03-06 |
2001-06-12 |
Alza Corporation |
Extended release dosage form
|
EP2338482A3
(en)
|
1998-04-14 |
2011-12-21 |
The General Hospital Corporation |
Methods for treating neuropsychiatric disorders
|
US6156342A
(en)
|
1998-05-26 |
2000-12-05 |
Andex Pharmaceuticals, Inc. |
Controlled release oral dosage form
|
US6143325A
(en)
|
1998-06-05 |
2000-11-07 |
Bristol-Myers Squibb Company |
Nefazodone dosage form
|
CA2337966A1
(en)
|
1998-07-10 |
2000-01-20 |
U.S. Medical Research Institute Of Infectious Diseases |
Vaccine against staphylococcus intoxication
|
US6806294B2
(en)
|
1998-10-15 |
2004-10-19 |
Euro-Celtique S.A. |
Opioid analgesic
|
US6245387B1
(en)
*
|
1998-11-03 |
2001-06-12 |
Diamon-Fusion International, Inc. |
Capped silicone film and method of manufacture thereof
|
US6129205A
(en)
|
1998-12-09 |
2000-10-10 |
Ashworth Bros. Inc. |
Variable loop count conveyor belt
|
PE20001396A1
(es)
*
|
1999-01-18 |
2000-12-23 |
Gruenenthal Chemie |
Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista
|
DE19901686A1
(de)
|
1999-01-18 |
2000-07-20 |
Gruenenthal Gmbh |
Retardierte Tramadolzubereitungen mit einem lagerstabilen Freisetzungsprofil und Verfahren zu deren Herstellung
|
DE19901683B4
(de)
|
1999-01-18 |
2005-07-21 |
Grünenthal GmbH |
Analgetikum mit kontrollierter Wirkstofffreisetzung
|
DE19901687B4
(de)
|
1999-01-18 |
2006-06-01 |
Grünenthal GmbH |
Opioide Analgetika mit kontrollierter Wirkstofffreisetzung
|
ES2197600T3
(es)
|
1999-01-29 |
2004-01-01 |
Disphar International B.V. |
Composiciones farmaceuticas.
|
US6248363B1
(en)
*
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
DE19940740A1
(de)
*
|
1999-08-31 |
2001-03-01 |
Gruenenthal Gmbh |
Pharmazeutische Salze
|
DE19940944B4
(de)
*
|
1999-08-31 |
2006-10-12 |
Grünenthal GmbH |
Retardierte, orale, pharmazeutische Darreichungsformen
|
CN1202815C
(zh)
|
1999-08-31 |
2005-05-25 |
格吕伦塔尔有限公司 |
含有曲马朵糖精盐的持续释放给药剂型
|
DE19947747A1
(de)
|
1999-10-05 |
2001-04-12 |
Gruenenthal Gmbh |
Verwendung von (+)-Tramadol, O-Demethyltramadol bzw. (+)-O-Demethyltramadol zur Therapie der Harninkontinenz
|
PE20010623A1
(es)
|
1999-10-05 |
2001-07-07 |
Gruenenthal Chemie |
Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
|
US6339105B1
(en)
*
|
1999-10-12 |
2002-01-15 |
Ortho-Mcneil Pharmaceutical, Inc. |
Analgesic regimen
|
US6211229B1
(en)
*
|
2000-02-17 |
2001-04-03 |
Neil B. Kavey |
Treatment of transient and short term insomnia
|
US6645537B2
(en)
|
2000-02-18 |
2003-11-11 |
Keurig, Incorporated |
Beverage filter cartridge
|
US6326404B1
(en)
|
2000-02-21 |
2001-12-04 |
Gruenenthal Gmbh |
Use of O-desmethyl-N-mono-desmethyl-tramadol
|
DE10014588A1
(de)
|
2000-03-27 |
2001-10-04 |
Basf Ag |
Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
|
GB0007419D0
(en)
*
|
2000-03-27 |
2000-05-17 |
Smithkline Beecham Gmbh |
Composition
|
DE10015479A1
(de)
|
2000-03-29 |
2001-10-11 |
Basf Ag |
Feste orale Darreichungsformen mit retardierter Wirkstofffreisetzung und hoher mechanischer Stabilität
|
GB0009522D0
(en)
|
2000-04-19 |
2000-06-07 |
Smithkline Beecham Plc |
Composition
|
US6955821B2
(en)
|
2000-04-28 |
2005-10-18 |
Adams Laboratories, Inc. |
Sustained release formulations of guaifenesin and additional drug ingredients
|
JP2001353519A
(ja)
*
|
2000-06-14 |
2001-12-25 |
Suncall Corp |
二重構造クラッドパイプ及びその製造方法
|
DE10029201A1
(de)
*
|
2000-06-19 |
2001-12-20 |
Basf Ag |
Verfahren zur Herstellung fester oraler Darreichungsformen mit retardierender Wirkstoffreisetzung
|
US6607748B1
(en)
*
|
2000-06-29 |
2003-08-19 |
Vincent Lenaerts |
Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
|
EP1190712B1
(en)
|
2000-09-22 |
2004-09-01 |
SMB Technology |
Oral once daily tramadol beads composition
|
KR100960200B1
(ko)
*
|
2000-10-30 |
2010-05-27 |
유로-셀티크 소시에떼 아노뉨 |
서방성 하이드로코돈 제형
|
US20020106408A1
(en)
*
|
2000-12-01 |
2002-08-08 |
Johnatan Bacon |
Prolamin-based sustained-release compositions and delayed-onset compositions
|
IL151150A0
(en)
*
|
2001-01-31 |
2003-04-10 |
Roehm Gmbh |
Multiparticulate drug form comprising at least two differently coated pellet forms
|
US20020165246A1
(en)
|
2001-03-05 |
2002-11-07 |
Andrew Holman |
Administration of sleep restorative agents
|
US6806293B1
(en)
|
2001-03-12 |
2004-10-19 |
Darley Pharmaceuticals Ltd |
Use of pheromone compounds having MAP kinase modulating activity
|
US7858118B2
(en)
*
|
2001-04-11 |
2010-12-28 |
Galephar Pharmaceutical Research, Inc. |
Extended release composition containing Tramadol
|
US6659373B1
(en)
|
2001-05-30 |
2003-12-09 |
L. R. Nelson |
One touch actuated valve
|
US6968551B2
(en)
|
2001-06-11 |
2005-11-22 |
John Hediger |
System and user interface for generation and processing of software application installation instructions
|
US6818504B2
(en)
*
|
2001-08-10 |
2004-11-16 |
Hynix Semiconductor America, Inc. |
Processes and structures for self-aligned contact non-volatile memory with peripheral transistors easily modifiable for various technologies and applications
|
US20030092724A1
(en)
*
|
2001-09-18 |
2003-05-15 |
Huaihung Kao |
Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic
|
WO2003037296A2
(en)
|
2001-10-29 |
2003-05-08 |
Labopharm Inc. |
Methods and dosage forms for improving the bioavailability of therapeutic agents
|
US6863901B2
(en)
*
|
2001-11-30 |
2005-03-08 |
Collegium Pharmaceutical, Inc. |
Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration
|
KR100540035B1
(ko)
|
2002-02-01 |
2005-12-29 |
주식회사 태평양 |
다단계 경구 약물 방출 제어 시스템
|
ATE460933T1
(de)
|
2002-05-24 |
2010-04-15 |
Carl-Fr Coester |
Pharmazeutische wirkstoffkombination sowie deren verwendung
|
AU2003271024A1
(en)
*
|
2002-09-21 |
2004-04-08 |
Jin Wang |
Sustained release compound of acetamidophenol and tramadol
|
US8487002B2
(en)
|
2002-10-25 |
2013-07-16 |
Paladin Labs Inc. |
Controlled-release compositions
|
TWI319713B
(en)
*
|
2002-10-25 |
2010-01-21 |
|
Sustained-release tramadol formulations with 24-hour efficacy
|
DE60322091D1
(de)
|
2002-10-25 |
2008-08-21 |
Labopharm Inc |
Zubereitungen mit kontrollierter freisetzung
|
AR045972A1
(es)
|
2002-10-25 |
2005-11-23 |
Labopharm Inc |
Formulaciones de tramadol de liberacion sostenida con eficacia de 24 horas
|
US6669929B1
(en)
*
|
2002-12-30 |
2003-12-30 |
Colgate Palmolive Company |
Dentifrice containing functional film flakes
|
US7413749B2
(en)
*
|
2003-03-11 |
2008-08-19 |
Purdue Pharma L.P. |
Titration dosing regimen for controlled release tramadol
|
US20060172006A1
(en)
*
|
2003-10-10 |
2006-08-03 |
Vincent Lenaerts |
Sustained-release tramadol formulations with 24-hour clinical efficacy
|
CN1926728A
(zh)
*
|
2004-01-07 |
2007-03-07 |
光谱物理学公司 |
工业用直接二极管泵浦超快速放大器系统
|
CA2587406A1
(en)
*
|
2004-11-16 |
2006-05-26 |
Limerick Neurosciences, Inc. |
Methods and compositions for treating pain
|
PL2402005T3
(pl)
*
|
2005-08-24 |
2021-11-22 |
Endo Pharmaceuticals Inc. |
Formulacje nalbufiny o przedłużonym uwalnianiu
|
CA2616204C
(en)
*
|
2005-09-09 |
2015-12-01 |
Labopharm Inc. |
Sustained drug release composition
|
US20070237816A1
(en)
|
2006-04-06 |
2007-10-11 |
David Finkelstein |
Acetaminophen formulation for joint pain relief
|