DK1562611T3 - Heterocykliske siliciumforbindelser og deres anvendelse til behandling af sygdomme eller tilstande associeret med GnRH (gonadotropinfrigivende hormon) - Google Patents
Heterocykliske siliciumforbindelser og deres anvendelse til behandling af sygdomme eller tilstande associeret med GnRH (gonadotropinfrigivende hormon)Info
- Publication number
- DK1562611T3 DK1562611T3 DK03775585T DK03775585T DK1562611T3 DK 1562611 T3 DK1562611 T3 DK 1562611T3 DK 03775585 T DK03775585 T DK 03775585T DK 03775585 T DK03775585 T DK 03775585T DK 1562611 T3 DK1562611 T3 DK 1562611T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- treatment
- sup
- gnrh
- releasing hormone
- Prior art date
Links
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title abstract 4
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title abstract 4
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 4
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- -1 Heterocyclic silicon compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 201000010260 leiomyoma Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 229910052710 silicon Inorganic materials 0.000 abstract 2
- 239000010703 silicon Substances 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000021267 infertility disease Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0227131A GB0227131D0 (en) | 2002-11-20 | 2002-11-20 | Compounds and their use |
| GB0310472A GB0310472D0 (en) | 2003-05-07 | 2003-05-07 | Compounds and their use |
| GB0317283A GB0317283D0 (en) | 2003-07-23 | 2003-07-23 | Compounds and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1562611T3 true DK1562611T3 (da) | 2006-12-04 |
Family
ID=32329550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03775585T DK1562611T3 (da) | 2002-11-20 | 2003-11-19 | Heterocykliske siliciumforbindelser og deres anvendelse til behandling af sygdomme eller tilstande associeret med GnRH (gonadotropinfrigivende hormon) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060052344A1 (es) |
| EP (1) | EP1562611B1 (es) |
| JP (1) | JP2006510725A (es) |
| AT (1) | ATE334687T1 (es) |
| AU (1) | AU2003283607A1 (es) |
| CA (1) | CA2507532A1 (es) |
| DE (1) | DE60307313T2 (es) |
| DK (1) | DK1562611T3 (es) |
| ES (1) | ES2270129T3 (es) |
| WO (1) | WO2004045625A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06000371A (es) * | 2003-07-09 | 2006-03-28 | Paradigm Therapeutics Ltd | Compuestos de organosilicio y su uso. |
| US20090291915A1 (en) * | 2004-12-17 | 2009-11-26 | Graham Andrew Showell | Silicon Compounds and Their Use |
| US20080261918A1 (en) * | 2004-12-17 | 2008-10-23 | Graham Andrew Showell | Silicon Compounds and Their Use |
| DE102008062878A1 (de) * | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| CN101921286B (zh) * | 2009-06-15 | 2013-06-05 | 海门瑞一医药科技有限公司 | 一种三甲基硅乙炔的合成工艺 |
| CN102391298A (zh) * | 2011-12-27 | 2012-03-28 | 上海立科药物化学有限公司 | 双三甲基硅基乙炔的合成方法 |
| US10717035B2 (en) | 2017-02-13 | 2020-07-21 | Praxair Technology, Inc. | Tunable adsorbents |
| WO2020252787A1 (zh) * | 2019-06-21 | 2020-12-24 | 辽宁凯莱英医药化学有限公司 | 三甲基硅基乙炔的连续化合成系统及连续化合成方法 |
| CN114805542A (zh) * | 2022-04-29 | 2022-07-29 | 江苏尤里卡生物科技有限公司 | 一种基于尿液中促性腺激素的纯化方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2237966T3 (es) * | 1998-08-20 | 2005-08-01 | Agouron Pharmaceuticals, Inc. | Agentes de gnrh no peptidicos, metodos y compuestos intermedios para su preparacion. |
| AU2003202115A1 (en) * | 2002-02-12 | 2003-09-04 | Pfizer Inc. | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh) |
| BR0312123A (pt) * | 2002-06-13 | 2005-03-29 | Pfizer | Agentes de gnrh não peptìdicos, composições farmacêuticas e métodos para o seu uso |
-
2003
- 2003-11-19 EP EP03775585A patent/EP1562611B1/en not_active Expired - Lifetime
- 2003-11-19 US US10/531,333 patent/US20060052344A1/en not_active Abandoned
- 2003-11-19 ES ES03775585T patent/ES2270129T3/es not_active Expired - Lifetime
- 2003-11-19 AU AU2003283607A patent/AU2003283607A1/en not_active Abandoned
- 2003-11-19 DE DE60307313T patent/DE60307313T2/de not_active Expired - Fee Related
- 2003-11-19 WO PCT/GB2003/005015 patent/WO2004045625A1/en active IP Right Grant
- 2003-11-19 CA CA002507532A patent/CA2507532A1/en not_active Abandoned
- 2003-11-19 AT AT03775585T patent/ATE334687T1/de not_active IP Right Cessation
- 2003-11-19 JP JP2004570306A patent/JP2006510725A/ja active Pending
- 2003-11-19 DK DK03775585T patent/DK1562611T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE334687T1 (de) | 2006-08-15 |
| DE60307313D1 (de) | 2006-09-14 |
| EP1562611B1 (en) | 2006-08-02 |
| US20060052344A1 (en) | 2006-03-09 |
| CA2507532A1 (en) | 2004-06-03 |
| AU2003283607A1 (en) | 2004-06-15 |
| DE60307313T2 (de) | 2006-12-14 |
| WO2004045625A1 (en) | 2004-06-03 |
| JP2006510725A (ja) | 2006-03-30 |
| EP1562611A1 (en) | 2005-08-17 |
| ES2270129T3 (es) | 2007-04-01 |
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