DK155793C - Analogifremgangsmaade til fremstilling af 3-substituerede pyrrolidiner eller piperidiner samt 3-substituerede pyrrolidiner eller piperidiner til brug som udgangsmateriale ved fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af 3-substituerede pyrrolidiner eller piperidiner samt 3-substituerede pyrrolidiner eller piperidiner til brug som udgangsmateriale ved fremgangsmaaden

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Publication number
DK155793C
DK155793C DK342881A DK342881A DK155793C DK 155793 C DK155793 C DK 155793C DK 342881 A DK342881 A DK 342881A DK 342881 A DK342881 A DK 342881A DK 155793 C DK155793 C DK 155793C
Authority
DK
Denmark
Prior art keywords
carbon atoms
piperidines
group
substituted pyrrolidines
preparation
Prior art date
Application number
DK342881A
Other languages
Danish (da)
English (en)
Other versions
DK342881A (da
DK155793B (da
Inventor
Folke Lars-Erik Arvidsson
Per Arvid Emil Carlsson
Uli Alf Hacksell
John Stephan Mikael Hjort
Per Lennart Lindberg
John Lars Gunnar Nilsson
Domingo Sanchez
Nils Uno Eimer Svensson
Haakan Vilhelm Wikstroem
Original Assignee
Per Arvid Emil Carlsson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Per Arvid Emil Carlsson filed Critical Per Arvid Emil Carlsson
Publication of DK342881A publication Critical patent/DK342881A/da
Publication of DK155793B publication Critical patent/DK155793B/da
Application granted granted Critical
Publication of DK155793C publication Critical patent/DK155793C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK342881A 1979-12-05 1981-07-31 Analogifremgangsmaade til fremstilling af 3-substituerede pyrrolidiner eller piperidiner samt 3-substituerede pyrrolidiner eller piperidiner til brug som udgangsmateriale ved fremgangsmaaden DK155793C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE7910026 1979-12-05
SE7910026 1979-12-05
PCT/SE1980/000319 WO1981001552A1 (en) 1979-12-05 1980-12-05 New phenyl-azacycloalkanes
SE8000319 1980-12-05

Publications (3)

Publication Number Publication Date
DK342881A DK342881A (da) 1981-07-31
DK155793B DK155793B (da) 1989-05-16
DK155793C true DK155793C (da) 1989-10-02

Family

ID=20339477

Family Applications (1)

Application Number Title Priority Date Filing Date
DK342881A DK155793C (da) 1979-12-05 1981-07-31 Analogifremgangsmaade til fremstilling af 3-substituerede pyrrolidiner eller piperidiner samt 3-substituerede pyrrolidiner eller piperidiner til brug som udgangsmateriale ved fremgangsmaaden

Country Status (17)

Country Link
US (1) US4426386A (sv)
EP (2) EP0030526B1 (sv)
JP (1) JPS6135175B2 (sv)
AT (1) ATE42281T1 (sv)
AU (1) AU542153B2 (sv)
CA (1) CA1147339A (sv)
DD (1) DD155065A5 (sv)
DE (1) DE3070247D1 (sv)
DK (1) DK155793C (sv)
ES (3) ES8205768A1 (sv)
FI (1) FI67371C (sv)
GR (1) GR72841B (sv)
HU (1) HU185422B (sv)
IE (1) IE50674B1 (sv)
PT (1) PT72172B (sv)
SE (1) SE8107742L (sv)
WO (1) WO1981001552A1 (sv)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE446335B (sv) * 1982-03-30 1986-09-01 Astra Laekemedel Ab Ren enantiomer av en metasubstituerad 3-fenyl-1-propylpiperidin
US4937346A (en) * 1979-12-05 1990-06-26 Per Arvid Emil Carlsson Phenyl-azacykloalkanes
SE8305362D0 (sv) * 1983-09-30 1983-09-30 Astra Laekemedel Ab Novel substituted phenylazacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds
EP0077607A1 (en) * 1981-09-17 1983-04-27 Beecham Group Plc N-substituted 3-aryl piperidines and derivatives thereof
US4719219A (en) * 1982-03-30 1988-01-12 Per A. E. Carlsson Phenyl-azacycloalkanes and use thereof in treatment of central nervous system disorders
DE3377575D1 (en) * 1982-10-01 1988-09-08 Hoffmann La Roche Separation of racemic 1-propyl-3-aryl piperidines
US4593037A (en) * 1984-07-26 1986-06-03 Pfizer Inc. 1,3-disubstituted piperidine compounds as neuroleptic agents
JPH0657695B2 (ja) * 1985-07-12 1994-08-03 エーザイ株式会社 ４−シアノピペリジン誘導体
US4826869A (en) * 1988-02-19 1989-05-02 Syntex (U.S.A.) Inc. N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines
DE3930282A1 (de) * 1989-09-11 1991-03-21 Boehringer Ingelheim Kg Verwendung von dopamin-autorezeptor-agonisten bei der behandlung von drogenabhaengigkeit
GB9113031D0 (en) * 1991-06-17 1991-08-07 Smithkline Beecham Plc Compounds
SE9802546D0 (sv) * 1998-07-15 1998-07-15 Ross Nicholas Waters Medicinal product and method for treatment and prevention of dyskinesia
JP2002540149A (ja) * 1999-03-31 2002-11-26 ザ プロクター アンド ギャンブル カンパニー ウイルス感染治療のためのカルバミン酸エステル誘導体の使用法
US7346938B2 (en) * 2002-08-02 2008-03-25 Roy W. Mattson, Jr. Retrofit suction sanitation safety cover
EP1707558A1 (en) * 2005-03-21 2006-10-04 Ferrer Internacional, S.A. Benzoic acid ester compounds, compositions, uses and methods related thereto

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2892842A (en) 1959-06-30 Their preparation
DE1144279B (de) * 1957-09-26 1963-02-28 Robins Co Inc A H Verfahren zur Herstellung von 3-Aryl-3-hydroxypyrrolidinen und deren Salzen
FR1248129A (fr) * 1959-02-12 1960-12-09 Mead Johnson & Co Procédé de préparation des 1-acyl- et 1-carbalkoxy-3 pyrrolidinols
US2975193A (en) * 1959-06-18 1961-03-14 Parke Davis & Co Organic amine compounds and method of obtaining the same
NO116115B (sv) * 1962-06-01 1969-02-03 Parke Davis & Co
DK104980C (da) * 1962-06-20 1966-08-01 Parke Davis & Company A Corp O Fremgangsmåde til fremstilling af optisk aktive eller racemiske 1-methylpyrrolidinderivater eller syreadditionssalte deraf.
DK104736C (da) * 1962-06-20 1966-06-27 Parke Davis & Company A Corp O Fremgangsmåde til fremstilling af optisk aktive eller racemiske pyrrolidin-derivater eller syreadditionssalte deraf.
DK105337C (da) * 1962-06-20 1966-09-19 Parke Davis & Company A Corp O Fremgangsmåde til fremstilling af optisk aktive eller racemiske pyrrolidinforbindelser eller syreadditionssalte deraf.
DE1470155A1 (de) * 1963-04-11 1969-06-04 Parke Davis & Co Neue Pyrrolidinverbindungen,ihre Saeureadditionssalze,sowie Verfahren zu deren Herstellung
GB1012008A (en) * 1963-08-01 1965-12-01 Parke Davis & Co Process for the production of pyrrolidine compounds
GB1198973A (en) 1969-02-07 1970-07-15 Parke Davis & Co Pyrrolidine Compounds with an Unsaturated Substituent and Methods for their Production
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
CH526536A (de) 1970-02-05 1972-08-15 Sandoz Ag Verfahren zur Herstellung neuer 3-Phenylpyrrolidinderivate
GB1283452A (en) * 1970-07-24 1972-07-26 Parke Davis & Co Substituted 1,3-dialkylpyrrolidines and processes for their production
US3970656A (en) * 1974-06-11 1976-07-20 Government Of The United States 1-Alkyl-4-m-hydroxyphenyl-4-propionyl piperidines
FR2310761A1 (fr) 1975-05-16 1976-12-10 Roussel Uclaf Nouveaux derives de la phenyl-piperidine et leurs sels, procede de preparation et application a titre de medicaments
FR2310762A1 (fr) 1975-05-16 1976-12-10 Roussel Uclaf Nouveaux derives n-substitues de la phenyl piperidine et leurs sels, procede de preparation et application a titre de medicaments
DE2701705A1 (de) * 1976-01-28 1977-08-04 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
FR2340734A1 (fr) * 1976-02-13 1977-09-09 Roussel Uclaf Nouveaux derives de la m-trifluoromethylphenyl piperidine et leurs sels, procede de preparation et application a titre de medicaments
FR2380261A2 (fr) * 1977-02-11 1978-09-08 Roussel Uclaf Nouveaux derives de la m-trifluoromethylphenylpiperidine et leurs sels, procede de preparation et application a titre de medicaments

Also Published As

Publication number Publication date
SE8107742L (sv) 1981-12-23
EP0030526A1 (en) 1981-06-17
ATE42281T1 (de) 1989-05-15
AU6642681A (en) 1981-06-19
EP0084920A2 (en) 1983-08-03
ES508030A0 (es) 1982-10-01
IE50674B1 (en) 1986-06-11
ES8300703A1 (es) 1982-11-01
HU185422B (en) 1985-02-28
WO1981001552A1 (en) 1981-06-11
ES508029A0 (es) 1982-11-01
PT72172B (en) 1982-07-05
JPS56501679A (sv) 1981-11-19
IE802545L (en) 1981-06-05
EP0084920B1 (en) 1989-04-19
CA1147339A (en) 1983-05-31
DD155065A5 (de) 1982-05-12
ES497489A0 (es) 1982-08-01
EP0084920A3 (en) 1985-05-22
ES8300092A1 (es) 1982-10-01
PT72172A (en) 1981-01-01
DK342881A (da) 1981-07-31
ES8205768A1 (es) 1982-08-01
EP0030526B1 (en) 1985-02-27
JPS6135175B2 (sv) 1986-08-12
AU542153B2 (en) 1985-02-07
FI67371C (fi) 1985-03-11
DK155793B (da) 1989-05-16
GR72841B (sv) 1983-12-07
US4426386A (en) 1984-01-17
DE3070247D1 (en) 1985-04-04
FI814080L (fi) 1981-12-18
FI67371B (fi) 1984-11-30

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