DK1546134T3 - Piperazinsubstituerede arylbenzodiazepiner - Google Patents

Piperazinsubstituerede arylbenzodiazepiner

Info

Publication number
DK1546134T3
DK1546134T3 DK03784411T DK03784411T DK1546134T3 DK 1546134 T3 DK1546134 T3 DK 1546134T3 DK 03784411 T DK03784411 T DK 03784411T DK 03784411 T DK03784411 T DK 03784411T DK 1546134 T3 DK1546134 T3 DK 1546134T3
Authority
DK
Denmark
Prior art keywords
sup
sub
alkyl
optionally substituted
hydrogen
Prior art date
Application number
DK03784411T
Other languages
Danish (da)
English (en)
Inventor
Thomas Daniel Aicher
Zhaogen Chen
Huerou Yvan Le
Fionna Mitchell Martin
Marta Maria Pineiro-Nunez
Vincent Patrick Rocco
Kevin Michael Ruley
John Mehnert Schaus
Patrick Gianpietro Spinazze
David Edward Tupper
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1546134T3 publication Critical patent/DK1546134T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK03784411T 2002-08-05 2003-07-28 Piperazinsubstituerede arylbenzodiazepiner DK1546134T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40129702P 2002-08-05 2002-08-05
PCT/IB2003/003583 WO2004014895A1 (en) 2002-08-05 2003-07-28 Piperazine substituted aryl benzodiazepines

Publications (1)

Publication Number Publication Date
DK1546134T3 true DK1546134T3 (da) 2007-09-10

Family

ID=31715704

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03784411T DK1546134T3 (da) 2002-08-05 2003-07-28 Piperazinsubstituerede arylbenzodiazepiner

Country Status (10)

Country Link
US (1) US7384934B2 (pt)
EP (1) EP1546134B1 (pt)
AT (1) ATE361289T1 (pt)
AU (1) AU2003264915A1 (pt)
CY (1) CY1110382T1 (pt)
DE (1) DE60313634T2 (pt)
DK (1) DK1546134T3 (pt)
ES (1) ES2285227T3 (pt)
PT (1) PT1546134E (pt)
WO (1) WO2004014895A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE327744T1 (de) 2001-03-20 2006-06-15 Sanol Arznei Schwarz Gmbh Neue verwendung von peptidverbindungen bei der behandlung von nicht-neuropathischem entzündungsschmerz
EP1243263B1 (en) 2001-03-21 2002-11-27 Schwarz Pharma Ag Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain
WO2005026177A1 (en) * 2003-09-09 2005-03-24 Eli Lilly And Company Substituted piperazines of azepines, oxazepines, and thiazepines
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
DE602005021970D1 (de) 2004-08-27 2010-08-05 Ucb Pharma Gmbh Verwendung von peptidverbindungen zur behandlung von schmerzen durch knochenkrebs, chemotherapie- und nucleosid-bedingten schmerzen
EP1642889A1 (en) 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
MY147756A (en) 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
ES2645529T3 (es) 2006-06-15 2017-12-05 Ucb Pharma Gmbh Composición farmacéutica con efecto sinérgico anticonvulsionante
CN103214473A (zh) 2007-03-15 2013-07-24 ARYx医疗有限公司 二苯并[b,f][1,4]氧杂氮杂*化合物
AU2009208909A1 (en) * 2008-01-31 2009-08-06 Fermion Oy A process for the preparation of quetiapine
PL395468A1 (pl) * 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego
ES2666000T3 (es) 2012-08-21 2018-04-30 Janssen Pharmaceutica, N.V. Anticuerpos para aripiprazol y uso de los mismos
ES2691092T3 (es) 2012-08-21 2018-11-23 Janssen Pharmaceutica Nv Anticuerpos contra la risperidona y uso de los mismos
US9304126B2 (en) 2012-08-21 2016-04-05 Janssen Pharmaceutica Nv Haptens of quetiapine
AU2013305901B2 (en) 2012-08-21 2017-10-26 Saladax Biomedical Inc. Antibodies to olanzapine and use thereof
CN104822660A (zh) 2012-08-21 2015-08-05 詹森药业有限公司 阿立哌唑半抗原及其在免疫测定中的应用
CN110054693A (zh) 2012-08-21 2019-07-26 詹森药业有限公司 喹硫平半抗原的抗体及其用途
EP3492473A1 (en) * 2012-08-21 2019-06-05 Janssen Pharmaceutica NV Haptens of olanzipine
CA2882595C (en) 2012-08-21 2019-06-04 Ortho-Clinical Diagnostics, Inc. Antibodies to olanzapine haptens and use thereof
US9394354B2 (en) 2012-08-21 2016-07-19 Janssen Pharmaceutica Nv Haptens of paliperidone
US9410972B2 (en) 2012-08-21 2016-08-09 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
AU2013305938B2 (en) 2012-08-21 2017-08-17 Saladax Biomedical Inc. Antibodies to paliperidone haptens and use thereof
EP2888285B1 (en) 2012-08-21 2024-04-17 Janssen Pharmaceutica NV Antibodies to aripiprazole haptens and use thereof
CA2882560C (en) 2012-08-21 2020-10-27 Ortho-Clinical Diagnostics, Inc. Haptens of risperidone and paliperidone for use in immunoassays
EP2888284B1 (en) 2012-08-21 2022-07-06 Janssen Pharmaceutica NV Antibodies to risperidone haptens and use thereof
CN104736561B (zh) 2012-08-21 2018-06-12 詹森药业有限公司 帕潘立酮的抗体及其用途
WO2014062428A1 (en) 2012-10-15 2014-04-24 Albemarle Corporation Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
RU2610169C2 (ru) 2014-09-11 2017-02-08 Общество С Ограниченной Ответственностью "Валентек" ПРОИЗВОДНЫЕ 7-ФТОРО-8-ХЛОРО-5Н-ДИБЕНЗО[b, е][1, 4]ДИАЗЕПИНА И ИХ ПРИМЕНЕНИЕ
CN104530077A (zh) * 2014-12-29 2015-04-22 杭州师范大学 一种奥氮平中间体的合成方法
GB201510010D0 (en) 2015-06-09 2015-07-22 King S College London PDD and BPD compounds
GB201514928D0 (en) 2015-08-21 2015-10-07 King S College London PDD compounds
US20180339985A1 (en) 2015-08-21 2018-11-29 Femtogenix Limited Pdd compounds
WO2017106501A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to risperidone and use thereof
WO2017106508A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
CN110452183B (zh) * 2019-09-04 2023-03-14 中国科学院上海有机化学研究所 一种手性杂环化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
US5602121A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. Alkyl-substituted compounds having dopamine receptor affinity
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
JP3156933B2 (ja) * 1997-09-02 2001-04-16 ウェルファイド株式会社 縮合チオフェン化合物およびその医薬用途
EP1492794B1 (en) 2002-03-28 2007-12-12 Eli Lilly And Company Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders

Also Published As

Publication number Publication date
US7384934B2 (en) 2008-06-10
DE60313634T2 (de) 2008-01-31
US20060084643A1 (en) 2006-04-20
EP1546134A1 (en) 2005-06-29
ATE361289T1 (de) 2007-05-15
AU2003264915A1 (en) 2004-02-25
PT1546134E (pt) 2007-08-10
CY1110382T1 (el) 2015-04-29
WO2004014895A1 (en) 2004-02-19
EP1546134B1 (en) 2007-05-02
ES2285227T3 (es) 2007-11-16
DE60313634D1 (de) 2007-06-14

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