ES2061204T3 - Nuevos derivados de la amino-piperidina, de la amino-pirrolidina y de la amino-perhidroacepina, procedimientos de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de la amino-piperidina, de la amino-pirrolidina y de la amino-perhidroacepina, procedimientos de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2061204T3
ES2061204T3 ES91401274T ES91401274T ES2061204T3 ES 2061204 T3 ES2061204 T3 ES 2061204T3 ES 91401274 T ES91401274 T ES 91401274T ES 91401274 T ES91401274 T ES 91401274T ES 2061204 T3 ES2061204 T3 ES 2061204T3
Authority
ES
Spain
Prior art keywords
radical
amino
perhydroacepine
pirrolidine
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91401274T
Other languages
English (en)
Inventor
Jean-Louis Peglion
Francis Colpaert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2061204T3 publication Critical patent/ES2061204T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE FORMULA (I): EN LA QUE: -M REPRESENTA 0, 1, 2, 3 O 4, -N Y P REPRESENTAN 0, 1 O 2, -W REPRESENTA UN ATOMO DE OXIGENO, UN RADICAL -NH-, O ES UN SIMPLE ENLACE, -R REPRESENTA UN RADICAL 1, 2-DIHIDRO 2-OXO 1-FENIL 1, 8-NAFTIRIDIN-3-ILO, UN RADICAL BENZOCICLOBUTEN-1-ILO, UN RADICAL INDANILO, UN RADICAL 2, 3 -DIHIDRO BENZOFURAN-2-ILO O UN RADICAL 4-OXO 4H-CROMEN-2-ILO, -R SUB 1 REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO DE 1 A 6 ATOMOS DE CARBONO O UN RADICAL ARILO, Y -R SUB 2 REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO, UN RADICAL ALCENO, UN RADICAL CICLOALQUILO, UN RADICAL BENCILO O UN RADICAL FENILO, UN RADICAL ARALQUILO, UN RADICAL ALCOXIALQUILO O UN RADICAL ALQUILO POLIHALOGENADO; SUS ISOMEROS OPTICOS Y SUS SALES DE ADICION CON UN ACIDO ORGANICO O MINERAL FARMACEUTICO ACEPTABLE. MEDICAMENTOS
ES91401274T 1990-05-18 1991-05-17 Nuevos derivados de la amino-piperidina, de la amino-pirrolidina y de la amino-perhidroacepina, procedimientos de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2061204T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9006220A FR2662162B1 (fr) 1990-05-18 1990-05-18 Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2061204T3 true ES2061204T3 (es) 1994-12-01

Family

ID=9396741

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91401274T Expired - Lifetime ES2061204T3 (es) 1990-05-18 1991-05-17 Nuevos derivados de la amino-piperidina, de la amino-pirrolidina y de la amino-perhidroacepina, procedimientos de preparacion y composiciones farmaceuticas que los contienen.

Country Status (15)

Country Link
US (1) US5189045A (es)
EP (1) EP0457686B1 (es)
JP (1) JPH0794429B2 (es)
AT (1) ATE109466T1 (es)
AU (1) AU631990B2 (es)
CA (1) CA2042875A1 (es)
DE (1) DE69103206T2 (es)
DK (1) DK0457686T3 (es)
ES (1) ES2061204T3 (es)
FR (1) FR2662162B1 (es)
IE (1) IE65592B1 (es)
NZ (1) NZ238181A (es)
OA (1) OA09354A (es)
PT (1) PT97710B (es)
ZA (1) ZA913772B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272157A (en) * 1990-03-07 1993-12-21 Synthelabo Derivatives of 4-(aminomethyl) piperidine, their preparation and their therapeutic application
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2681325B1 (fr) * 1991-09-16 1993-12-17 Fabre Medicament Pierre Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
FR2694005B1 (fr) * 1992-07-21 1994-08-26 Adir Nouvelles aminoalkylchromones, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
KR100238346B1 (ko) * 1993-04-07 2000-03-02 오쓰까 아끼히꼬 피페리딘 유도체를 유효성분으로 하는 말초혈관확장제
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
AU1867095A (en) * 1994-01-10 1995-08-01 Technion Research & Development Foundation Ltd. 1-aminoindan derivatives and compositions thereof
US5914349A (en) 1994-01-10 1999-06-22 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US5827875A (en) * 1996-05-10 1998-10-27 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5885983A (en) * 1996-05-10 1999-03-23 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
CA2275425C (en) 1996-12-18 2009-08-04 Michael Chorev Aminoindan derivatives
FR2775687B1 (fr) * 1998-03-04 2000-04-14 Adir Nouveaux composes du benzocyclobutane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL143226A0 (en) * 1998-11-20 2002-04-21 Hoffmann La Roche Pyrrolidine derivatives-ccr-3 receptor antagonists
US6737547B1 (en) 1998-12-31 2004-05-18 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using N-acyl-1H-aminoindenes
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CN1224624C (zh) * 1999-12-08 2005-10-26 格勒兰制药株式会社 1,8－二氮杂萘－2(1h)－酮衍生物
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
EP1689742B1 (en) * 2003-11-24 2010-03-17 Pfizer, Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
WO2005058885A2 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Piperidine derivatives and their use as glycine transporter inhibitors
MY142362A (en) 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
JP2009518433A (ja) * 2005-12-09 2009-05-07 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム 神経保護用の低用量ラドスチギルの使用
US20100234427A1 (en) * 2006-02-17 2010-09-16 Dan Peters 1-phenethylpiperidine derivatives and their use as opioid receptor ligands
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
US8188113B2 (en) * 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US20100298380A1 (en) * 2007-08-02 2010-11-25 Neurosearch A/S N-aryl-n-piperidin-4-ylmethyl-amide derivatives and thier use as monoamine neurotransmitter re-uptake inhibitors
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
MX2022001863A (es) 2019-08-12 2022-05-30 Deciphera Pharmaceuticals Llc Metodos para tratar los tumores del estroma gastrointestinal.
IL293864A (en) 2019-12-30 2022-08-01 Deciphera Pharmaceuticals Llc Preparations of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3- phenylurea
LT4084778T (lt) 2019-12-30 2024-01-25 Deciphera Pharmaceuticals, Llc Amorfinės kinazės inhibitoriaus vaistinės formos ir jų panaudojimo būdai
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2628973A (en) * 1951-02-24 1953-02-17 Searle & Co Aryloxyacetates of basically substituted arylakanols and derivatives thereof
DE1294957B (de) * 1966-07-02 1969-05-14 Boehringer & Soehne Gmbh Verfahren zur Herstellung von Hydrindensulfonylharnstoffen und -sulfonylsemicarbaziden
US3910931A (en) * 1970-09-03 1975-10-07 Wyeth John & Brother Ltd 1-(Naphthylalkyl- or indenylalkyl)-piperidines
PH17019A (en) * 1980-03-01 1984-05-11 Wyeth John & Brother Ltd 4-piperidyl-or dehydropiperidyl-urea derivatives and method of use
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
US4791112A (en) * 1987-02-02 1988-12-13 The Boc Group, Inc. N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds

Also Published As

Publication number Publication date
EP0457686A1 (fr) 1991-11-21
EP0457686B1 (fr) 1994-08-03
ATE109466T1 (de) 1994-08-15
PT97710B (pt) 1998-08-31
JPH0794429B2 (ja) 1995-10-11
US5189045A (en) 1993-02-23
PT97710A (pt) 1992-02-28
IE911683A1 (en) 1991-11-20
CA2042875A1 (fr) 1991-11-19
JPH06340620A (ja) 1994-12-13
DE69103206D1 (de) 1994-09-08
ZA913772B (en) 1992-02-26
DE69103206T2 (de) 1995-03-09
FR2662162A1 (fr) 1991-11-22
DK0457686T3 (da) 1994-12-12
AU7710591A (en) 1991-11-21
NZ238181A (en) 1993-02-25
FR2662162B1 (fr) 1995-01-20
AU631990B2 (en) 1992-12-10
OA09354A (fr) 1992-09-15
IE65592B1 (en) 1995-11-01

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