DK1520175T3 - Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer - Google Patents

Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer

Info

Publication number
DK1520175T3
DK1520175T3 DK03737795T DK03737795T DK1520175T3 DK 1520175 T3 DK1520175 T3 DK 1520175T3 DK 03737795 T DK03737795 T DK 03737795T DK 03737795 T DK03737795 T DK 03737795T DK 1520175 T3 DK1520175 T3 DK 1520175T3
Authority
DK
Denmark
Prior art keywords
neoplasms
agents
oncolytic viruses
phenotype determination
phenotype
Prior art date
Application number
DK03737795T
Other languages
Danish (da)
English (en)
Inventor
Bradley G Thompson
Matthew C Coffey
Original Assignee
Oncolytics Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncolytics Biotech Inc filed Critical Oncolytics Biotech Inc
Application granted granted Critical
Publication of DK1520175T3 publication Critical patent/DK1520175T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/14Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK03737795T 2002-06-28 2003-06-25 Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer DK1520175T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39203102P 2002-06-28 2002-06-28
US44318803P 2003-01-29 2003-01-29
PCT/CA2003/000951 WO2004003562A2 (fr) 2002-06-28 2003-06-25 Virus oncolytiques en tant qu'agents de phenotypage destines a des neoplasmes

Publications (1)

Publication Number Publication Date
DK1520175T3 true DK1520175T3 (da) 2008-02-11

Family

ID=30003222

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03737795T DK1520175T3 (da) 2002-06-28 2003-06-25 Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer
DK07021569.4T DK1890151T3 (da) 2002-06-28 2003-06-25 Onkolytiske vira som midler til fænotypebestemmelse for neoplasmer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK07021569.4T DK1890151T3 (da) 2002-06-28 2003-06-25 Onkolytiske vira som midler til fænotypebestemmelse for neoplasmer

Country Status (20)

Country Link
US (3) US7306902B2 (fr)
EP (2) EP1890151B1 (fr)
JP (1) JP2005531306A (fr)
CN (1) CN1666105B (fr)
AR (1) AR039768A1 (fr)
AT (2) ATE555388T1 (fr)
AU (2) AU2003245760B2 (fr)
BR (1) BR0311983A (fr)
CA (1) CA2487824C (fr)
DE (1) DE60317331T2 (fr)
DK (2) DK1520175T3 (fr)
ES (2) ES2292981T3 (fr)
HK (2) HK1069877A1 (fr)
IL (2) IL165498A0 (fr)
MX (1) MXPA04012414A (fr)
NZ (1) NZ537116A (fr)
PT (1) PT1890151E (fr)
SI (1) SI1890151T1 (fr)
TW (3) TWI327167B (fr)
WO (1) WO2004003562A2 (fr)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ425699A0 (en) 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
US8491884B2 (en) 2000-05-03 2013-07-23 Oncolytics Biotech Inc. Virus clearance of neoplastic cells from mixed cellular compositions
US7306902B2 (en) * 2002-06-28 2007-12-11 Oncolyties Biotech Inc. Oncolytic viruses as phenotyping agents for neoplasms
US20040115170A1 (en) * 2001-11-30 2004-06-17 Brown Earl Garnet Oncolytic virus
AU2003249059A1 (en) 2002-07-24 2004-02-09 Arizona Board Of Regents Use of vaccinia virus deleted for the e3l gene as a vaccine vector
AU2002953436A0 (en) 2002-12-18 2003-01-09 The University Of Newcastle Research Associates Limited A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
WO2005007824A2 (fr) * 2003-07-08 2005-01-27 Arizona Board Of Regents Mutants du virus vaccine tenant lieu d'agents oncolytiques
WO2005111200A1 (fr) * 2004-05-17 2005-11-24 Universite De Montreal Souches de reovirus et procedes d'utilisation de celles-ci
WO2007099401A2 (fr) 2005-08-01 2007-09-07 University Technologies International, Inc. Reovirus attenue
US10668119B2 (en) 2005-08-01 2020-06-02 Virocure, Inc. Attenuated reovirus
ATE516370T1 (de) * 2005-12-22 2011-07-15 Sloan Kettering Inst Cancer Verfahren zur erfassung von krebszellen unter verwendung eines virus
AU2007215328A1 (en) * 2006-02-13 2007-08-23 Oncolytics Biotech Inc. Use of local immune suppression to enhance oncolytic viral therapy
US10369171B2 (en) 2007-03-13 2019-08-06 Virocure, Inc. Attenuated reoviruses for selection of cell populations
WO2008144067A1 (fr) * 2007-05-21 2008-11-27 Board Of Regents, University Of Texas System Procédés et compositions pour le traitement du cancer en utilisant l'activité oncolytique vrs
KR101585702B1 (ko) * 2008-05-22 2016-01-15 제일약품주식회사 종양파괴 바이러스 요법에 대한 과다증식성 세포의 종양 억제인자-기초된 민감성
JP2011520994A (ja) * 2008-05-27 2011-07-21 オンコリティクス バイオテク,インコーポレーテッド 腫瘍崩解性レオウイルス療法中の炎症性サイトカイン産生の排除
TW200951143A (en) * 2008-05-27 2009-12-16 Oncolytics Biotech Inc Modulating interstitial pressure and oncolytic viral delivery and distribution
US8481297B2 (en) * 2009-01-08 2013-07-09 Yale University Compositions and methods of use of an oncolytic vesicular stomatitis virus
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
US9428565B2 (en) 2011-01-31 2016-08-30 The General Hospital Corporation Treatment and bioluminescent visualization using multimodal TRAIL molecules
WO2013052915A2 (fr) 2011-10-05 2013-04-11 Genelux Corporation Procédé de détection de la réplication ou colonisation d'un produit thérapeutique biologique
WO2013138522A2 (fr) 2012-03-16 2013-09-19 Genelux Corporation Méthodes d'évaluation de l'efficacité et de la surveillance d'un traitement viral oncolytique
WO2013158265A1 (fr) 2012-04-20 2013-10-24 Genelux Corporation Méthodes d'imagerie pour virothérapie oncolytique
EP3473708B1 (fr) 2012-07-24 2021-01-27 The General Hospital Corporation Traitement par virus oncolytique de tumeurs résistantes
US9605074B2 (en) 2012-08-30 2017-03-28 The General Hospital Corporation Multifunctional nanobodies for treating cancer
US20140140959A1 (en) 2012-10-05 2014-05-22 Aladar A. Szalay Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes
US20160303174A1 (en) * 2013-12-11 2016-10-20 The General Hospital Corporation Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors
WO2015103438A2 (fr) 2014-01-02 2015-07-09 Genelux Corporation Traitement d'appoint par un virus oncolytique avec des agents qui augmentent l'infectivité du virus
EA201700181A1 (ru) 2014-10-14 2017-09-29 Галозим, Инк. Композиции аденозиндеаминазы-2 (ада-2), их варианты и способы использования
EP3261669B1 (fr) 2015-02-25 2022-08-03 Memorial Sloan Kettering Cancer Center Utilisation de virus de la vaccine ankara modifié (mva) non réplicatif inactivé en tant que mono-immunothérapie ou en association avec des agents de blocage de point de contrôle pour des tumeurs solides
US10548930B2 (en) 2015-04-17 2020-02-04 Memorial Sloan Kettering Cancer Center Use of MVA or MVAΔE3L as immunotherapeutic agents against solid tumors
CN109152827B (zh) 2016-02-25 2023-07-21 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
SG11201807051VA (en) 2016-02-25 2018-09-27 Memorial Sloan Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy
WO2017181152A2 (fr) 2016-04-15 2017-10-19 Alpine Immune Sciences, Inc. Protéines immunomodulatrices à variants de cd80 et leurs utilisations
SG11201808457PA (en) 2016-04-15 2018-10-30 Alpine Immune Sciences Inc Icos ligand variant immunomodulatory proteins and uses thereof
WO2017205674A1 (fr) 2016-05-25 2017-11-30 Arizona Board Of Regents On Behalf Of Arizona State University Mutants de virus oncolytiques de la vaccine et leur utilisation pour le traitement du cancer
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
EP3491013A1 (fr) 2016-07-28 2019-06-05 Alpine Immune Sciences, Inc. Protéines immunomodulatrices à variants de cd155 et leurs utilisations
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
CN109982708B (zh) * 2016-09-27 2023-05-23 萨特治疗学有限公司 优化的溶瘤病毒及其用途
EP3872180A1 (fr) 2016-10-20 2021-09-01 Alpine Immune Sciences, Inc. Protéines immunomodulatrices sécrétables de type variant et thérapie cellulaire utilisant des cellules obtenues par génie génétique
US11920156B2 (en) 2017-02-09 2024-03-05 Indapta Therapeutics, Inc. Engineered natural killer (NK) cells and compositions and methods thereof
AU2018235838B2 (en) 2017-03-16 2023-12-14 Alpine Immune Sciences, Inc. CD80 variant immunomodulatory proteins and uses thereof
KR20240039221A (ko) 2017-03-16 2024-03-26 알파인 이뮨 사이언시즈, 인코포레이티드 Pd-l1 리간드 변이체 면역조절 단백질 및 그의 용도
AU2018235835A1 (en) 2017-03-16 2019-09-05 Alpine Immune Sciences, Inc. PD-L2 variant immunomodulatory proteins and uses thereof
US11242509B2 (en) 2017-05-12 2022-02-08 Memorial Sloan Kettering Cancer Center Vaccinia virus mutants useful for cancer immunotherapy
US20200283500A1 (en) 2017-10-18 2020-09-10 Alpine Immune Sciences, Inc. Variant icos ligand immunomodulatory proteins and related compositions and methods
KR102662837B1 (ko) 2018-06-04 2024-05-03 카리디 바이오테라퓨틱스, 인크. 바이러스 치료법의 강화를 위한 세포-기반 비히클
US11505782B2 (en) 2018-06-04 2022-11-22 Calidi Biotherapeutics, Inc. Cell-based vehicles for potentiation of viral therapy
US20210363219A1 (en) 2018-06-15 2021-11-25 Alpine Immune Sciences, Inc. Pd-1 variant immunomodulatory proteins and uses thereof
EP3844276A2 (fr) 2018-08-28 2021-07-07 Actym Therapeutics, Inc. Souches bactériennes immunostimulatrices modifiées et utilisations associées
EP3876951A1 (fr) 2018-11-06 2021-09-15 Calidi Biotherapeutics, Inc. Systèmes améliorés pour thérapie virale oncolytique à médiation cellulaire
US20220008466A1 (en) 2018-11-21 2022-01-13 Indapta Therapeutics, Inc Methods for expansion of natural killer (nk) cell subset and related compositions and methods
KR20210135987A (ko) 2018-11-30 2021-11-16 알파인 이뮨 사이언시즈, 인코포레이티드 Cd86 변이체 면역조절 단백질 및 그의 용도
CA3176660A1 (fr) 2019-02-27 2020-09-03 Actym Therapeutics, Inc. Bacteries immunostimulatrices modifiees en vue de coloniser des tumeurs, des cellules immunitaires residant dans une tumeur et le microenvironnement tumoral
JP2023523429A (ja) 2020-04-22 2023-06-05 インダプタ セラピューティクス インコーポレイテッド ナチュラルキラー(nk)細胞組成物およびそれを生成させるための方法
WO2022147480A1 (fr) 2020-12-30 2022-07-07 Ansun Biopharma, Inc. Virus oncolytique codant pour la sialidase et agent de ciblage de cellule immunitaire multispécifique

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) * 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US5670330A (en) * 1992-09-29 1997-09-23 Mcgill University Anti-tumor agent assay using PKR
AU682854B2 (en) 1993-02-16 1997-10-23 Onyx Pharmaceuticals Cytopathic viruses for therapy and prophylaxis of neoplasia
US5801029A (en) 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
DK1314431T3 (da) 1993-04-30 2008-11-10 Wellstat Biologics Corp Oprensede sammensætninger af Newcastle disease virus
CA2178902A1 (fr) 1993-12-14 1995-06-22 Drew Pardoll Liberation controlee de substances pharmaceutiquement actives pour l'immunotherapie
WO1995032300A1 (fr) 1994-05-23 1995-11-30 University Of Medicine & Dentistry Of New Jersey Destruction biologique selective des cellules tumorales
US5585096A (en) 1994-06-23 1996-12-17 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
US5840502A (en) 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US6777177B1 (en) * 1997-10-10 2004-08-17 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression
US6136307A (en) * 1997-08-13 2000-10-24 Oncolytics Biotech Inc. Reovirus for the treatment of cellular proliferative disorders
CA2508238C (fr) 1997-08-13 2008-01-15 Oncolytics Biotech Inc. Reovirus pour le traitement des neoplasies
US6110461A (en) 1997-08-13 2000-08-29 Oncolytics Biotech Inc. Reovirus for the treatment of neoplasia
US7780962B2 (en) * 1997-10-09 2010-08-24 Wellstat Biologics Corporation Treatment of neoplasms with RNA viruses
NZ518945A (en) 1997-10-09 2007-03-30 Wellstat Biologics Corp Treatment of neoplasms with viruses
US6475481B2 (en) 1997-11-18 2002-11-05 Canji Inc Purging of stem cell products
EP1061806A4 (fr) 1998-03-12 2001-09-12 Univ Pennsylvania Cellules productrices pour virus aptes a la replication utilisees dans le traitement de la malignite
ATE318176T1 (de) 1998-08-31 2006-03-15 Julian L Ambrus Verfahren zur entfernung von hiv und anderen viren aus blut
EP1390046A4 (fr) 1999-04-15 2005-04-20 Wellstat Biologics Corp Traitement de neoplasmes avec des virus
DE19934788B4 (de) * 1999-07-27 2004-05-27 T-Mobile Deutschland Gmbh Verfahren zur automatischen Anpassung von Daten an die Fähigkeiten einer Nutzer-Software
NZ517573A (en) 1999-09-17 2004-02-27 Pro Virus Inc Sequences of the oncolytic virus strain vesicular stromatitis virus (VSV)
AU782020B2 (en) 1999-11-12 2005-06-30 Oncolytics Biotech, Inc. Viruses for the treatment of cellular proliferative disorders
AUPQ425699A0 (en) 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
AR028039A1 (es) 2000-05-03 2003-04-23 Oncolytics Biotech Inc Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas
US7306902B2 (en) * 2002-06-28 2007-12-11 Oncolyties Biotech Inc. Oncolytic viruses as phenotyping agents for neoplasms
AR028040A1 (es) * 2000-05-03 2003-04-23 Oncolytics Biotech Inc Remocion de virus de celulas neoplasticas a partir de composiciones celulares mixtas
US20020037543A1 (en) * 2000-06-26 2002-03-28 Atkins Harold L. Purging of cells using viruses
WO2002004596A2 (fr) 2000-07-07 2002-01-17 President And Fellows Of Harvard College Diagnostic et traitement de cellules cancereuses a l'aide de virus mutants
MXPA03004029A (es) 2000-11-09 2004-02-12 Oncolytics Biotech Inc Metodos para tratamiento de trastornos proliferativos celulares.
US20030138405A1 (en) * 2001-04-17 2003-07-24 Juan Fueyo Conditionally replicative adenovirus to target the Rb and Rb-related pathways

Also Published As

Publication number Publication date
HK1069877A1 (en) 2005-06-03
PT1890151E (pt) 2012-05-25
US7306902B2 (en) 2007-12-11
MXPA04012414A (es) 2005-04-19
TW201005097A (en) 2010-02-01
CA2487824A1 (fr) 2004-01-08
SI1890151T1 (sl) 2012-08-31
BR0311983A (pt) 2005-04-26
US20100105122A1 (en) 2010-04-29
EP1520175A2 (fr) 2005-04-06
TW200940709A (en) 2009-10-01
ES2292981T3 (es) 2008-03-16
HK1112509A1 (en) 2008-09-05
AU2003245760A1 (en) 2004-01-19
WO2004003562A2 (fr) 2004-01-08
TWI334444B (en) 2010-12-11
EP1520175B1 (fr) 2007-11-07
CN1666105A (zh) 2005-09-07
AU2003245760B2 (en) 2008-07-03
ES2385845T3 (es) 2012-08-01
EP1890151A1 (fr) 2008-02-20
IL220139A (en) 2013-03-24
WO2004003562A3 (fr) 2004-05-06
IL165498A0 (en) 2006-01-15
TWI402345B (zh) 2013-07-21
DK1890151T3 (da) 2012-06-18
CA2487824C (fr) 2013-08-20
CN1666105B (zh) 2015-11-25
DE60317331T2 (de) 2008-08-21
AR039768A1 (es) 2005-03-09
NZ537116A (en) 2008-04-30
AU2008207579B2 (en) 2011-10-20
AU2008207579A1 (en) 2008-09-18
TW200401032A (en) 2004-01-16
US20040029112A1 (en) 2004-02-12
US20080014577A1 (en) 2008-01-17
ATE555388T1 (de) 2012-05-15
TWI327167B (en) 2010-07-11
JP2005531306A (ja) 2005-10-20
US8222036B2 (en) 2012-07-17
EP1890151B1 (fr) 2012-04-25
DE60317331D1 (de) 2007-12-20
IL220139A0 (en) 2012-07-31
ATE377754T1 (de) 2007-11-15

Similar Documents

Publication Publication Date Title
DK1520175T3 (da) Oncolytiske vira som midler til fænotypebestemmelse af neoplasmer
DK1423391T3 (da) Pyrrolopyrimidiner som midler til inhibering af cysteinproteaser
DK1730110T3 (da) Svovlforbindelser som inhibitorer af hepatitis C-virus NS3-serinprotease
NO20043642L (no) Heterocykiske tripeptider som hepatitt C inhibitorer
IS8476A (is) Lifrarbólgu C-veirutálmar
DK3395339T3 (da) Hurtigt opløsende formulering af cinacalcet-hcl
DK1562589T3 (da) Diaminotriazoler der er nyttige som inhibitorer af proteinkinaser
DK1402075T3 (da) Udvikling af egnede mutationer til svækkelse af dengue-vira samt kimære dengue-vira
DK1492785T3 (da) 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
IS2761B (is) Ný amínóbensófenónefnasambönd
NO20023283D0 (no) Flammestopper
DK1802579T3 (da) Derivater af 3-arylaminopyridin
DK1504126T3 (da) Fremgangsmåde til regulering af genekspression
DK2060570T3 (da) Som modulatorer af dopamin-d3-receptorer anvendelige azabicyclo(3.1.0)hexanderivater
DK1542977T3 (da) 2,5-dioxoimidazolidin-4-ylacetamider og analoger som inhibitorer af metalloproteinase MMP12
DK1948176T3 (da) Diarylurinstoffer til behandling af pulmonær hypertension
DK1997512T3 (da) Fremgangsmåder til behandling af TWEAK-relaterede tilstande
DE602004025775D1 (de) Innengekühltes strömungsleitendes Komponent
DK1401828T3 (da) N-Formylhydroxylaminforbindelser som inhibitorer af PDF
DK1660090T3 (da) Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
ATE398450T1 (de) Derivate von aryl-chinazolin/aryl-2amino-phenyl- methanon zurförderung der freisetzung von parathormon
DK1773787T3 (da) Fremgangsmåde til fremstilling af 3-phenyl(thio)uraciler og -dithiouraciler
DE602004012448D1 (de) Morpholinylhaltige benzimidazole als inhibitoren der replikation von respiratory syncytial virus
DK1438289T3 (da) Indolderivater som cox II-inhibitorer
DK1516540T3 (da) Anvendelse af vitamin D-forbindelser