DK150603C - Analogifremgangsmaade til fremstilling af 3-(4-sulfonylphenyl)-oxazolidinonderivater eller farmaceutisk acceptable syre- eller basesalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 3-(4-sulfonylphenyl)-oxazolidinonderivater eller farmaceutisk acceptable syre- eller basesalte deraf

Info

Publication number
DK150603C
DK150603C DK467281A DK467281A DK150603C DK 150603 C DK150603 C DK 150603C DK 467281 A DK467281 A DK 467281A DK 467281 A DK467281 A DK 467281A DK 150603 C DK150603 C DK 150603C
Authority
DK
Denmark
Prior art keywords
derivatives
sulphonylphenyl
oxazolidino
analogue
preparation
Prior art date
Application number
DK467281A
Other languages
English (en)
Other versions
DK467281A (da
DK150603B (da
Inventor
Robert Benson Fugitt
Raymond Wilson Luckenbaugh
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK467281A publication Critical patent/DK467281A/da
Publication of DK150603B publication Critical patent/DK150603B/da
Application granted granted Critical
Publication of DK150603C publication Critical patent/DK150603C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK467281A 1980-10-23 1981-10-22 Analogifremgangsmaade til fremstilling af 3-(4-sulfonylphenyl)-oxazolidinonderivater eller farmaceutisk acceptable syre- eller basesalte deraf DK150603C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19969880 1980-10-23
US06/199,698 US4340606A (en) 1980-10-23 1980-10-23 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents

Publications (3)

Publication Number Publication Date
DK467281A DK467281A (da) 1982-04-24
DK150603B DK150603B (da) 1987-04-13
DK150603C true DK150603C (da) 1987-09-28

Family

ID=22738648

Family Applications (1)

Application Number Title Priority Date Filing Date
DK467281A DK150603C (da) 1980-10-23 1981-10-22 Analogifremgangsmaade til fremstilling af 3-(4-sulfonylphenyl)-oxazolidinonderivater eller farmaceutisk acceptable syre- eller basesalte deraf

Country Status (8)

Country Link
US (1) US4340606A (da)
EP (1) EP0050827B1 (da)
JP (1) JPS5799576A (da)
AT (1) ATE19516T1 (da)
CA (1) CA1167449A (da)
DE (1) DE3174516D1 (da)
DK (1) DK150603C (da)
IE (1) IE52127B1 (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560666B2 (en) * 1981-12-04 1987-04-16 E.I. Du Pont De Nemours And Company P(2-oxo oxazolidinyl)benzene sulphonamides
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
JPS60241893A (ja) * 1984-05-15 1985-11-30 Kanegafuchi Chem Ind Co Ltd 光学活性（ｓ）―オキサゾリジノン誘導体の製造方法
CA1260948A (en) 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
CA1323370C (en) * 1986-09-12 1993-10-19 Davis H. Crater Fluorochemical oxazolidinones
US5036092A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
US4985429A (en) * 1987-10-09 1991-01-15 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US5039690A (en) * 1987-10-09 1991-08-13 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US5032605A (en) * 1987-10-09 1991-07-16 Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
US4942183A (en) * 1987-10-16 1990-07-17 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5182403A (en) * 1988-09-15 1993-01-26 The Upjohn Company Substituted 3(5'indazolyl) oxazolidin-2-ones
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
DE4119611A1 (de) * 1991-06-14 1992-12-17 Bayer Ag Mittel zur bekaempfung von schaedlingen auf basis substituierter oxazolidinone, neue substituierte oxazolidinone, deren herstellung und verwendung
EP0610265B1 (en) * 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
DE69316240T2 (de) * 1992-12-08 1998-05-20 Upjohn Co Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
SG85683A1 (en) * 1996-04-11 2002-01-15 Upjohn Co Process to prepare oxazolidinones
NZ504372A (en) 1997-11-07 2002-12-20 Upjohn Co Process to produce N-[3-fluoro-4(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinones
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
CA2318969A1 (en) 1998-01-23 1999-07-29 Mikhail F. Gordeev Oxazolidinone combinatorial libraries, compositions and methods of preparation
AU4224699A (en) 1999-01-27 2000-08-18 Pharmacia & Upjohn Company Assays for modulators of elongation factor p activity
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
ATE321024T1 (de) * 2000-10-17 2006-04-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von oxazolidinonverbindungen
CA2464109A1 (en) * 2001-10-18 2003-12-24 Michigan State University Process for the preparation of oxazolidinones and method of use thereof
ES2803516T3 (es) 2003-10-16 2021-01-27 Symed Labs Ltd Una forma cristalina de linezolid
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
ES2294494T3 (es) 2004-04-19 2008-04-01 Symed Labs Limited Un nuevo procedimiento para la preparacion de linezolid y compuestos relacionados.
EP1768967B1 (en) 2004-07-20 2009-04-22 Symed Labs Limited Novel intermediates for linezolid and related compounds
TWI389897B (zh) 2005-02-22 2013-03-21 Chugai Pharmaceutical Co Ltd 1- (2H) -isoquinolinone derivatives
RU2659792C1 (ru) 2008-10-10 2018-07-04 Мерк Шарп Энд Домэ Корп. Оксазолидиноны и способ их очистки
MX384300B (es) 2009-02-03 2025-03-14 Merck Sharp & Dohme Llc Forma cristalina del fosfato de dihidrogeno r) -3- (4- (2- (2-metiltetrazol-5-il) piridin-5-il) -3-fluorofenil) -5-hidroximetil oxazolidin-2-ona.
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
EP2595968B1 (en) 2011-02-24 2015-09-09 Lee Pharma Limited Novel process for preparation of linezolid and its novel intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3546241A (en) * 1968-05-21 1970-12-08 Dow Chemical Co N-(alkylsulfinyl) ethyl-pyrrolidinones and oxazolidinones
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
FR2380780A2 (fr) 1977-02-22 1978-09-15 Delalande Sa Application en therapeutique des hydroxymethyl-5 oxazolidinones-2, notamment comme antidepresseurs
LU80081A1 (fr) 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) * 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones

Also Published As

Publication number Publication date
IE52127B1 (en) 1987-06-24
DK467281A (da) 1982-04-24
EP0050827A1 (en) 1982-05-05
DE3174516D1 (en) 1986-06-05
US4340606A (en) 1982-07-20
JPH0216303B2 (da) 1990-04-16
IE812478L (en) 1982-04-23
JPS5799576A (en) 1982-06-21
DK150603B (da) 1987-04-13
CA1167449A (en) 1984-05-15
ATE19516T1 (de) 1986-05-15
EP0050827B1 (en) 1986-04-30

Similar Documents

Publication Publication Date Title
DK467281A (da) 3-(p-alkylsulfonylphenyl)-oxazolidinonderivater eller salte deraf deres fremstilling og anvendelse
DK151884C (da) Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK518683A (da) Fremgangsmaade til fremstilling af 4aeepi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller farmaceutisk acceptable syreadditionssalte deraf og mellemprodukter ved fremgangsmaaden
DK148711C (da) Analogifremgangsmaade til fremstilling af 1-(3-mercapto-2-methylpropanoyl)-prolyl-aminosyre-derivater, optiske isomere deraf eller farmaceutisk acceptable salte deraf
DK304682A (da) Vandholdigt topisk praeparat og fremgangsmaade til formindskelse af vandtab fra saadanne praeparater
DK153397C (da) Analogifremgangsmaade til fremstilling af 1,3,4-trisubstituerede 4-arylpiperidiner eller farmaceutisk acceptable syreadditionssalte deraf
FI823860L (fi) 3-(1-substituerade-4-piperidyl)-1,2-bensisoxazoler, en process foer framstaellning daerav, en farmaceutisk komposition innehaollande dessa och deras anvaendning som laekemedel
DK148795C (da) Anologifremgangsmaade til fremstilling af 3-(2-morpholino-ethyl-amino)-5-phenyl-pyridazin eller farmaceutisk acceptable syreadditionssalte deraf
DK84181A (da) Derivater af 3,4,5-trihydroxypiperidin,fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler samt til dyreernaering
DK146592C (da) Analogifremgangsmaade til fremstilling af n-substituerede benzensulfonamider eller syreadditionssalte deraf
DK154950C (da) Analogifremgangsmaade til fremstilling af 1-(benzazolylalkyl)-piperidinderivater eller de farmaceutisk acceptable syreadditionssalte deraf
DK151017C (da) Analogifremgangsmaade til fremstilling af substituerede n-(4-indolyl-piperidino-alkyl)-benzimidazoloner eller fysiologisk acceptable syreadditionssalte deraf
DK141097C (da) Analogifremgangsmaade til fremstilling af n-(1-(omega-phenylalkyl)-piperidyl-4)-n-(alfa-pyridyl)-carboxylsyreamider eller fysiologisk acceptable salte heraf
DK163181C (da) Analogifremgangsmaade til fremstilling af n,n'-di(arylalkylen)alkylendiaminer eller farmaceutisk acceptable salte deraf
DK157013C (da) Analogifremgangsmaade til fremstilling af fluorholdige 1,4-dihydropyridiner eller farmaceutisk acceptable syreadditionssalte deraf
ATE1241T1 (de) Verfahren zur herstellung von 4,5-perfluor-1,3-dioxolanen.
AU6319480A (en) 2-hydroxyalkyl-3,4,5-trihydroxypiperidines
DK150597C (da) Analogifremgangsmaade til fremstilling af 3,4-bis-substituerede 1,2,5-oxadiazol-2-oxider eller farmakologisk acceptable syreadditionssalte deraf
DK144033C (da) Analogifremgangsmaade til fremstilling af l-3-(3,4-dihydroxy-phenyl)-2-methyl-alanin-peptider eller farmakologisk acceptable salte deraf
DK149888C (da) Analogifremgangsmaade til fremstilling af 1-(1,3,4-oxadiazolyl-2-phenoxy)-3-(4-phenylpiperazinyl)-propan-2-oler eller fysiologisk acceptable syreadditionssalte heraf
DK160875C (da) Analogifremgangsmaade til fremstilling af 3,7-diazabicyklooe3.3.1aa-nonanforbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK152211C (da) Analogifremgangsmaade til fremstilling af n-phenyl-n-(4-piperidinyl)-amider eller farmaceutisk acceptable syreadditionssalte deraf.
DK205682A (da) Ringformige sulfenamider,fremgangsmaade til fremstilling derafderes anvendelse i laegemidler samt deres fremstilling
DK151254C (da) Analogifremgangsmaade til fremstilling af 2-hydroxymethyl-pyrazin-derivater eller farmaceutisk acceptable salte deraf
DK151021C (da) Analogifremgangsmaade til fremstilling af 17,18-dehydro-apovincaminol-3',4',5'-trimethoxybenzoat eller farmaceutisk acceptable syreadditionssalte deraf

Legal Events

Date Code Title Description
PBP Patent lapsed