ATE19516T1 - 3-(p-alkylsulfonylphenyl)-und 3-(palkylsulfinylphenyl)oxazolidinonderivate als antibakterielle wirkstoffe. - Google Patents
3-(p-alkylsulfonylphenyl)-und 3-(palkylsulfinylphenyl)oxazolidinonderivate als antibakterielle wirkstoffe.Info
- Publication number
- ATE19516T1 ATE19516T1 AT81108603T AT81108603T ATE19516T1 AT E19516 T1 ATE19516 T1 AT E19516T1 AT 81108603 T AT81108603 T AT 81108603T AT 81108603 T AT81108603 T AT 81108603T AT E19516 T1 ATE19516 T1 AT E19516T1
- Authority
- AT
- Austria
- Prior art keywords
- alkylsulfonylphenyl
- palkylsulfinylphenyl
- antibacterial agents
- oxazolidinone derivatives
- oxazolidinone
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/199,698 US4340606A (en) | 1980-10-23 | 1980-10-23 | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
EP81108603A EP0050827B1 (de) | 1980-10-23 | 1981-10-21 | 3-(p-Alkylsulfonylphenyl)-und 3-(p-Alkylsulfinylphenyl)oxazolidinonderivate als antibakterielle Wirkstoffe |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE19516T1 true ATE19516T1 (de) | 1986-05-15 |
Family
ID=22738648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT81108603T ATE19516T1 (de) | 1980-10-23 | 1981-10-21 | 3-(p-alkylsulfonylphenyl)-und 3-(palkylsulfinylphenyl)oxazolidinonderivate als antibakterielle wirkstoffe. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4340606A (de) |
EP (1) | EP0050827B1 (de) |
JP (1) | JPS5799576A (de) |
AT (1) | ATE19516T1 (de) |
CA (1) | CA1167449A (de) |
DE (1) | DE3174516D1 (de) |
DK (1) | DK150603C (de) |
IE (1) | IE52127B1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8401951A1 (es) * | 1981-12-04 | 1984-01-16 | Du Pont | Un procedimiento para la preparacion de derivados de bencenosulfonamidas. |
US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
ES533097A0 (es) * | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
JPS60241893A (ja) * | 1984-05-15 | 1985-11-30 | Kanegafuchi Chem Ind Co Ltd | 光学活性(s)―オキサゾリジノン誘導体の製造方法 |
CA1260948A (en) | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
CA1323370C (en) * | 1986-09-12 | 1993-10-19 | Davis H. Crater | Fluorochemical oxazolidinones |
US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4985429A (en) * | 1987-10-09 | 1991-01-15 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US5039690A (en) * | 1987-10-09 | 1991-08-13 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
US4965268A (en) * | 1987-10-09 | 1990-10-23 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US5036093A (en) * | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
US5036092A (en) * | 1987-10-09 | 1991-07-30 | Du Pont Merck Pharmaceutical | Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents |
US5032605A (en) * | 1987-10-09 | 1991-07-16 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4942183A (en) * | 1987-10-16 | 1990-07-17 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
US4977173A (en) * | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
DE4119611A1 (de) * | 1991-06-14 | 1992-12-17 | Bayer Ag | Mittel zur bekaempfung von schaedlingen auf basis substituierter oxazolidinone, neue substituierte oxazolidinone, deren herstellung und verwendung |
WO1993009103A1 (en) * | 1991-11-01 | 1993-05-13 | The Upjohn Company | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
JP3558088B2 (ja) * | 1992-12-08 | 2004-08-25 | ファルマシア・アンド・アップジョン・カンパニー | トロポン−置換のフェニルオキサゾリジノン抗菌剤 |
US5883093A (en) * | 1995-09-12 | 1999-03-16 | Pharmacia & Upjohn Company | Phenyloxazolidinone antimicrobials |
US6107519A (en) * | 1997-11-07 | 2000-08-22 | Pharmacia & Upjohn Company | Process to produce oxazolidinones |
CN1167701C (zh) * | 1996-04-11 | 2004-09-22 | 法玛西雅厄普约翰美国公司 | 制备噁唑烷酮胺的方法 |
US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
EP1049682A1 (de) | 1998-01-23 | 2000-11-08 | Versicor, Inc. | Oxazolidinone kombinatorische bibliotheken, verfahren zu ihrer herstellung und zusammensetzungen |
US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
AU4224699A (en) | 1999-01-27 | 2000-08-18 | Pharmacia & Upjohn Company | Assays for modulators of elongation factor p activity |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
DE60118241T2 (de) * | 2000-10-17 | 2006-12-28 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Verfahren zur herstellung von oxazolidinonverbindungen |
CA2464109A1 (en) * | 2001-10-18 | 2003-12-24 | Michigan State University | Process for the preparation of oxazolidinones and method of use thereof |
WO2005035530A1 (en) | 2003-10-16 | 2005-04-21 | Symed Labs Limited | A novel crystalline form of linezolid |
KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
PL1737850T3 (pl) | 2004-04-19 | 2008-02-29 | Symed Labs Ltd | Nowy sposób wytwarzania linezolidu i związków pokrewnych |
EP1768967B1 (de) * | 2004-07-20 | 2009-04-22 | Symed Labs Limited | Neue zwischenprodukte für linezolid und verwandte verbindungen |
TWI389897B (zh) | 2005-02-22 | 2013-03-21 | Chugai Pharmaceutical Co Ltd | 1- (2H) -isoquinolinone derivatives |
EP2757104B1 (de) | 2008-10-10 | 2019-08-14 | Merck Sharp & Dohme Corp. | In der synthese von oxazolidinonen verwendete verbindungen |
EP2393808B1 (de) | 2009-02-03 | 2019-05-08 | Merck Sharp & Dohme Corp. | Kristalline form von r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-on-dihydrogenphosphat |
US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
SI2595968T1 (sl) | 2011-02-24 | 2016-01-29 | Lee Pharma Limited | Novi postopek za pripravo linezolida in njegovih novih intermediatov |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3546241A (en) * | 1968-05-21 | 1970-12-08 | Dow Chemical Co | N-(alkylsulfinyl) ethyl-pyrrolidinones and oxazolidinones |
FR2356422A1 (fr) * | 1976-03-01 | 1978-01-27 | Delalande Sa | Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique |
FR2380780A2 (fr) | 1977-02-22 | 1978-09-15 | Delalande Sa | Application en therapeutique des hydroxymethyl-5 oxazolidinones-2, notamment comme antidepresseurs |
LU80081A1 (fr) | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
US4128654A (en) * | 1978-02-10 | 1978-12-05 | E. I. Du Pont De Nemours And Company | 5-Halomethyl-3-phenyl-2-oxazolidinones |
US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
-
1980
- 1980-10-23 US US06/199,698 patent/US4340606A/en not_active Expired - Lifetime
-
1981
- 1981-10-21 DE DE8181108603T patent/DE3174516D1/de not_active Expired
- 1981-10-21 EP EP81108603A patent/EP0050827B1/de not_active Expired
- 1981-10-21 AT AT81108603T patent/ATE19516T1/de not_active IP Right Cessation
- 1981-10-22 JP JP56167999A patent/JPS5799576A/ja active Granted
- 1981-10-22 IE IE2478/81A patent/IE52127B1/en unknown
- 1981-10-22 DK DK467281A patent/DK150603C/da not_active IP Right Cessation
- 1981-10-22 CA CA000388496A patent/CA1167449A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3174516D1 (en) | 1986-06-05 |
DK467281A (da) | 1982-04-24 |
JPH0216303B2 (de) | 1990-04-16 |
EP0050827B1 (de) | 1986-04-30 |
CA1167449A (en) | 1984-05-15 |
DK150603B (da) | 1987-04-13 |
US4340606A (en) | 1982-07-20 |
IE812478L (en) | 1982-04-23 |
IE52127B1 (en) | 1987-06-24 |
JPS5799576A (en) | 1982-06-21 |
DK150603C (da) | 1987-09-28 |
EP0050827A1 (de) | 1982-05-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |