DK149886C - Analogifremgangsmaade til fremstilling af 5-methylisoxazol-4-carboxylsyre-(4-trifluormethyl)-anilid - Google Patents
Analogifremgangsmaade til fremstilling af 5-methylisoxazol-4-carboxylsyre-(4-trifluormethyl)-anilidInfo
- Publication number
- DK149886C DK149886C DK534279A DK534279A DK149886C DK 149886 C DK149886 C DK 149886C DK 534279 A DK534279 A DK 534279A DK 534279 A DK534279 A DK 534279A DK 149886 C DK149886 C DK 149886C
- Authority
- DK
- Denmark
- Prior art keywords
- methylisoxazole
- anilide
- analogy
- trifluoromethyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Lubricants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2854439 | 1978-12-16 | ||
| DE19782854439 DE2854439A1 (de) | 1978-12-16 | 1978-12-16 | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK534279A DK534279A (da) | 1980-06-17 |
| DK149886B DK149886B (da) | 1986-10-20 |
| DK149886C true DK149886C (da) | 1987-04-21 |
Family
ID=6057414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK534279A DK149886C (da) | 1978-12-16 | 1979-12-14 | Analogifremgangsmaade til fremstilling af 5-methylisoxazol-4-carboxylsyre-(4-trifluormethyl)-anilid |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US4284786A (no) |
| EP (1) | EP0013376B1 (no) |
| JP (1) | JPS5583767A (no) |
| AR (2) | AR222680A1 (no) |
| AT (1) | ATE1067T1 (no) |
| AU (1) | AU529341B2 (no) |
| BG (1) | BG60764B2 (no) |
| CA (1) | CA1129867A (no) |
| DE (2) | DE2854439A1 (no) |
| DK (1) | DK149886C (no) |
| EG (1) | EG13926A (no) |
| ES (2) | ES486750A1 (no) |
| FI (1) | FI64154C (no) |
| GR (1) | GR72731B (no) |
| HU (1) | HU178015B (no) |
| IE (1) | IE49126B1 (no) |
| IL (1) | IL58951A (no) |
| LU (1) | LU90466I2 (no) |
| MX (2) | MX6174E (no) |
| NL (1) | NL990037I1 (no) |
| NO (1) | NO148925C (no) |
| NZ (1) | NZ192400A (no) |
| PH (1) | PH16627A (no) |
| PT (1) | PT70596A (no) |
| ZA (1) | ZA796793B (no) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3247454A1 (de) * | 1982-12-22 | 1984-06-28 | Laboratorios Bago S.A., Buenos Aires | Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2538806B1 (fr) * | 1982-12-30 | 1986-02-21 | Bago Sa Labor | Composes phenyl-3 methyl isoxazole-5 carboxy-4 anilides substitues, actifs therapeutiquement contre l'inflammation et la douleur |
| DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
| US5268382A (en) * | 1985-09-27 | 1993-12-07 | Hoechst Aktiengesellschaft | Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus |
| US4935434A (en) * | 1988-01-26 | 1990-06-19 | Bristol-Myers Company | Antiarthritic isoxazole-4-carboxamides |
| FR2662692B1 (fr) * | 1990-05-30 | 1995-04-28 | Novapharme | Derives heterocycliques doues d'activite anticonvulsivante, procede de preparation et composition pharmaceutique. |
| US5258397A (en) * | 1988-11-30 | 1993-11-02 | Novapharme | 3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions |
| DD297328A5 (de) * | 1989-08-18 | 1992-01-09 | �������@���������k���Kk�� | 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen |
| US5583150A (en) * | 1989-08-18 | 1996-12-10 | Alcon Laboratories, Inc. | 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases |
| US5001124A (en) * | 1990-02-02 | 1991-03-19 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| US5108999A (en) * | 1990-02-02 | 1992-04-28 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| US5494911A (en) * | 1990-05-18 | 1996-02-27 | Hoechst Aktiengesellschaft | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use |
| US6133301A (en) * | 1991-08-22 | 2000-10-17 | Aventis Pharma Deutschland Gmbh | Pharmaceuticals for the treatment of rejection reactions in organ transplantations |
| DE4127737A1 (de) * | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
| DE59407413D1 (de) * | 1993-01-08 | 1999-01-21 | Hoechst Ag | Verwendung von Leflunomid zur Hemmung von Interleukin 1 beta |
| DK0607774T3 (da) * | 1993-01-08 | 1999-08-16 | Hoechst Ag | Anvendelse af leflunomid til inhibering af interleukin 1 alfa |
| ES2124801T3 (es) * | 1993-01-08 | 1999-02-16 | Hoechst Ag | Empleo de leflunomida para la inhibicion del factor de necrosis de tumores alfa. |
| ES2125356T3 (es) * | 1993-01-08 | 1999-03-01 | Hoechst Ag | Empleo de leflunomida para la inhibicion de interleuquina 8. |
| TW314467B (no) * | 1993-03-31 | 1997-09-01 | Hoechst Ag | |
| DE4323636A1 (de) * | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
| LT3589B (en) | 1993-11-30 | 1995-12-27 | Hoechst Ag | Using of known combination for treatment of rejection reaction by transplantation of organs |
| US5610173A (en) * | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US6335356B1 (en) | 1994-01-07 | 2002-01-01 | Sugen, Inc. | Method of treating a patient by parenteral administration of a lipophilic compound |
| US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
| US5624946A (en) * | 1994-07-05 | 1997-04-29 | Williams; James | Use of leflunomide to control and reverse chronic allograft rejection |
| CA2202904C (en) * | 1994-10-17 | 2006-12-19 | Yukio Amano | Pharmaceutical composition for prophylaxis and treatment of type i allergic diseases |
| US5721277A (en) * | 1995-04-21 | 1998-02-24 | Sugen, Inc. | Compounds and methods for inhibiting hyper-proliferative cell growth |
| US6331555B1 (en) | 1995-06-01 | 2001-12-18 | University Of California | Treatment of platelet derived growth factor related disorders such as cancers |
| DE19539638A1 (de) * | 1995-10-25 | 1997-04-30 | Hoechst Ag | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
| DE19702988A1 (de) * | 1997-01-28 | 1998-07-30 | Hoechst Ag | Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika |
| US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
| ES2150808T3 (es) * | 1997-08-08 | 2000-12-01 | Aventis Pharma Gmbh | Forma cristalina de (4-trifluorometil)-anilida de acido 5-metilisoxazol-4-carboxilico. |
| US7691890B2 (en) | 1998-03-11 | 2010-04-06 | James W. Williams | Anti-viral uses of leflunomide products |
| US20050255071A1 (en) * | 1998-12-10 | 2005-11-17 | Aventis Pharma Deutschland Gmbh | Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors |
| DE19908527C2 (de) | 1999-02-26 | 2001-08-30 | Aventis Pharma Gmbh | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
| US6566395B1 (en) | 1999-05-25 | 2003-05-20 | Biomedicines, Inc. | Methods of treating proliferative disorders |
| DE19960443C2 (de) * | 1999-12-15 | 2002-05-08 | Aventis Pharma Gmbh | Verfahren zur Auffindung von Nukleotidsyntheseinhibitoren mit weniger Nebenwirkungen |
| CN1411373A (zh) * | 1999-12-16 | 2003-04-16 | 特瓦制药工业有限公司 | 制备来氟米特的新方法和新晶形的来氟米特 |
| EP1473035A1 (en) * | 2000-02-15 | 2004-11-03 | Teva Pharmaceutical Industries Ltd. | Leflunomide of high purity |
| HUP0301865A3 (en) * | 2000-02-15 | 2005-12-28 | Teva Pharma | A method for synthesizing leflunomide |
| AU2001284891A1 (en) * | 2000-08-14 | 2002-02-25 | Teva Pharmaceutical Industries Ltd. | Micronized leflunomide |
| CA2443285C (en) | 2001-04-05 | 2007-08-21 | Aventis Pharmaceuticals Inc. | Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| US20030139606A1 (en) * | 2001-11-09 | 2003-07-24 | Ray Anup Kumar | Process for preparing 5-methylisoxazole-4-carboxylic- (4'-trifluoromethyl)-anilide |
| US20050158371A1 (en) * | 2002-02-12 | 2005-07-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel external agent |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US20060024376A1 (en) * | 2004-07-30 | 2006-02-02 | The University Of Chicago | Methods and compositions for reducing toxicity associated with leflunomide treatment |
| EP1920772A4 (en) * | 2005-08-31 | 2010-11-17 | Kowa Co | PROPHYLACTIC AND / OR THERAPEUTIC METHOD FOR COMBATING RHEUMATOID ARTHRITIS |
| EP2125895B1 (en) | 2007-02-02 | 2015-04-08 | Vegenics Pty Ltd | Vegf receptor antagonists for treating organ transplant alloimmunity and arteriosclerosis |
| CN101817797B (zh) * | 2009-02-26 | 2013-04-10 | 江苏亚邦爱普森药业有限公司 | 高纯度3-甲基-n-[4-(三氟甲基)苯基]-4-异噁唑甲酰胺的合成方法 |
| US9138309B2 (en) | 2010-02-05 | 2015-09-22 | Allergan, Inc. | Porous materials, methods of making and uses |
| US9205577B2 (en) * | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
| US11202853B2 (en) * | 2010-05-11 | 2021-12-21 | Allergan, Inc. | Porogen compositions, methods of making and uses |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| CA3094324A1 (en) | 2018-03-26 | 2019-10-03 | Clear Creek Bio, Inc. | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
| MX2022010962A (es) | 2020-03-06 | 2022-10-07 | Actelion Pharmaceuticals Ltd | Metodos para ralentizar la perdida de volumen cerebral. |
| US20210300873A1 (en) | 2020-03-20 | 2021-09-30 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
| EP4415699A1 (en) | 2021-10-11 | 2024-08-21 | Laboratoires Juvise Pharmaceuticals | Methods of treating multiple sclerosis |
| US20240261268A1 (en) | 2022-02-11 | 2024-08-08 | Vanda Pharmaceuticals Inc. | Methods of slowing an increase in brain ventricular volume |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087534A (en) * | 1974-05-22 | 1978-05-02 | David Ovadia | N-haloalkylmio urazole pesticides |
| DE2524959C2 (de) * | 1975-06-05 | 1983-02-10 | Hoechst Ag, 6000 Frankfurt | 5-Methyl-isoxazol-4-carbonsäureanilide, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel |
| ES448386A1 (es) * | 1975-06-05 | 1978-04-16 | Hoechst Ag | Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico. |
| DE2654797A1 (de) * | 1976-12-03 | 1978-06-08 | Hoechst Ag | Verfahren zur herstellung von isoxazolderivaten |
-
1978
- 1978-12-16 DE DE19782854439 patent/DE2854439A1/de not_active Withdrawn
-
1979
- 1979-12-11 ES ES486750A patent/ES486750A1/es not_active Expired
- 1979-12-11 ES ES486758A patent/ES486758A1/es not_active Expired
- 1979-12-12 EG EG748/79A patent/EG13926A/xx active
- 1979-12-13 MX MX798546U patent/MX6174E/es unknown
- 1979-12-13 AT AT79105142T patent/ATE1067T1/de active
- 1979-12-13 FI FI793899A patent/FI64154C/fi not_active IP Right Cessation
- 1979-12-13 US US06/103,551 patent/US4284786A/en not_active Expired - Lifetime
- 1979-12-13 DE DE7979105142T patent/DE2962929D1/de not_active Expired
- 1979-12-13 EP EP79105142A patent/EP0013376B1/de not_active Expired
- 1979-12-14 PT PT70596A patent/PT70596A/pt active IP Right Revival
- 1979-12-14 NZ NZ192400A patent/NZ192400A/xx unknown
- 1979-12-14 ZA ZA00796793A patent/ZA796793B/xx unknown
- 1979-12-14 PH PH23418A patent/PH16627A/en unknown
- 1979-12-14 HU HU79HO2201A patent/HU178015B/hu unknown
- 1979-12-14 GR GR60761A patent/GR72731B/el unknown
- 1979-12-14 CA CA342,109A patent/CA1129867A/en not_active Expired
- 1979-12-14 AU AU53853/79A patent/AU529341B2/en not_active Expired
- 1979-12-14 JP JP16170079A patent/JPS5583767A/ja active Granted
- 1979-12-14 NO NO794094A patent/NO148925C/no unknown
- 1979-12-14 IE IE2426/79A patent/IE49126B1/en active Protection Beyond IP Right Term
- 1979-12-14 DK DK534279A patent/DK149886C/da active
- 1979-12-14 AR AR279310A patent/AR222680A1/es active
- 1979-12-14 IL IL58951A patent/IL58951A/xx unknown
-
1981
- 1981-03-03 US US06/239,986 patent/US4351841A/en not_active Expired - Lifetime
- 1981-05-19 AR AR285378A patent/AR226894A1/es active
-
1984
- 1984-03-12 MX MX8403A patent/MX8403A/es unknown
-
1994
- 1994-02-23 BG BG098534A patent/BG60764B2/bg unknown
-
1999
- 1999-10-27 LU LU90466C patent/LU90466I2/fr unknown
- 1999-10-29 NL NL990037C patent/NL990037I1/nl unknown
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