DK1495055T3 - Produktion af funktionelle antistoffer i filamentøse svampe - Google Patents
Produktion af funktionelle antistoffer i filamentøse svampeInfo
- Publication number
- DK1495055T3 DK1495055T3 DK03719861.1T DK03719861T DK1495055T3 DK 1495055 T3 DK1495055 T3 DK 1495055T3 DK 03719861 T DK03719861 T DK 03719861T DK 1495055 T3 DK1495055 T3 DK 1495055T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- filamentous fungi
- functional antibodies
- antibodies
- functional
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37388902P | 2002-04-18 | 2002-04-18 | |
| US41154002P | 2002-09-18 | 2002-09-18 | |
| US41153702P | 2002-09-18 | 2002-09-18 | |
| US45213403P | 2003-03-04 | 2003-03-04 | |
| PCT/US2003/012246 WO2003089614A2 (en) | 2002-04-18 | 2003-04-17 | Production of functional antibodies in filamentous fungi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1495055T3 true DK1495055T3 (da) | 2013-11-11 |
Family
ID=29255585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03719861.1T DK1495055T3 (da) | 2002-04-18 | 2003-04-17 | Produktion af funktionelle antistoffer i filamentøse svampe |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20040018573A1 (https=) |
| EP (1) | EP1495055B1 (https=) |
| JP (1) | JP2006512891A (https=) |
| AU (1) | AU2003222664A1 (https=) |
| DK (1) | DK1495055T3 (https=) |
| WO (1) | WO2003089614A2 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006512891A (ja) * | 2002-04-18 | 2006-04-20 | ジェネンコー・インターナショナル・インク | 糸状菌における機能性抗体の生産 |
| EP1578774B1 (en) * | 2002-09-18 | 2013-11-06 | Danisco US Inc. | Purification of immunoglobulins |
| US7208585B2 (en) * | 2002-09-18 | 2007-04-24 | Genencor International, Inc. | Protein purification |
| AU2004261980A1 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody CDR polypeptide sequences with restricted diversity |
| DK1689777T3 (da) * | 2003-11-05 | 2007-06-11 | Ares Trading Sa | Fremgangsmåde til oprensning af il18-bindende protein |
| JP2007535913A (ja) * | 2004-01-21 | 2007-12-13 | ノボザイムス アクティーゼルスカブ | ヘテロカリオン菌類又は菌類宿主細胞におけるモノクローナル抗体の生成 |
| EP1941025B1 (en) * | 2005-10-17 | 2011-06-29 | Novozymes A/S | Use of fungal mutants for expression of antibodies |
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| US20080026376A1 (en) | 2006-07-11 | 2008-01-31 | Huaming Wang | KEX2 cleavage regions of recombinant fusion proteins |
| US8198046B2 (en) | 2006-07-11 | 2012-06-12 | Danisco Us Inc. | KEX2 cleavage regions of recombinant fusion proteins |
| CN101516906B (zh) | 2006-07-21 | 2013-11-06 | 诺维信股份有限公司 | 提高具有生物学活性之多肽的分泌的方法 |
| US20100062491A1 (en) * | 2007-01-05 | 2010-03-11 | Novozymes A/S | Overexpression of the Chaperone BIP in a Heterokaryon |
| EP2129685B1 (en) * | 2007-03-21 | 2013-11-20 | Danisco US Inc. | Over expression of foldases and chaperones improves protein production |
| JP5769142B2 (ja) * | 2007-09-04 | 2015-08-26 | 独立行政法人酒類総合研究所 | ピヒア属酵母において異種タンパク質を高分泌させる方法 |
| KR101680906B1 (ko) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| WO2009082209A1 (en) * | 2007-12-21 | 2009-07-02 | Fujifilm Manufacturing Europe B.V. | Improvement of the secretion yield of a protein of interest by in vivo proteolytic processing of a multimeric precursor |
| SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
| TW201006485A (en) | 2008-06-03 | 2010-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CN102149825B (zh) | 2008-07-08 | 2015-07-22 | Abbvie公司 | 前列腺素e2双重可变结构域免疫球蛋白及其用途 |
| JP2010183885A (ja) * | 2009-02-13 | 2010-08-26 | Kobe Univ | タンパク質の製造方法およびそれに用いる発現ベクター |
| US20120059155A1 (en) * | 2009-05-07 | 2012-03-08 | Novozymes Biopharma Dk A/S | Method of Controlling O-Linked Glycosylation of Antibodies |
| DK2427486T3 (en) | 2009-05-07 | 2015-05-26 | Novozymes Biopharma Dk As | A process for purifying albumin |
| WO2010141468A1 (en) * | 2009-06-01 | 2010-12-09 | Way Jeffrey C | Methods and molecules for yield improvement involving metabolic engineering |
| WO2011028811A2 (en) | 2009-09-01 | 2011-03-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| BR112012008833A2 (pt) | 2009-10-15 | 2015-09-08 | Abbott Lab | imunoglobulinas de dominio variavel duplo e usos das mesmas |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| JP2013539364A (ja) | 2010-08-26 | 2013-10-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリンおよびその使用 |
| EP3604339B1 (en) | 2011-01-14 | 2021-03-10 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
| TW201333035A (zh) | 2011-12-30 | 2013-08-16 | Abbvie Inc | 針對il-13及/或il-17之雙特異性結合蛋白 |
| RU2645252C2 (ru) | 2012-01-05 | 2018-02-19 | Глюкос Финланд Ой | Клетка нитчатых грибов с дефицитом протеаз и способы ее применения |
| KR101505157B1 (ko) * | 2012-05-08 | 2015-03-24 | 주식회사 종근당 | 항―ErbB2 항체 변이체 |
| EP2852610B1 (en) | 2012-05-23 | 2018-07-11 | Glykos Finland Oy | Production of fucosylated glycoproteins |
| TW202037609A (zh) | 2012-11-01 | 2020-10-16 | 美商艾伯維有限公司 | 抗-vegf/dll4雙重可變區域免疫球蛋白及其用途 |
| US20140273094A1 (en) * | 2013-03-15 | 2014-09-18 | Bristol-Myers Squibb Company | Methods of enhancing protein quality and quantity by yeast fed-batch fermentation |
| WO2014144280A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17 |
| SG11201600115SA (en) | 2013-07-10 | 2016-02-26 | Novartis Ag | Multiple proteases deficient filamentous fungal cells and methods of use thereof |
| SG11201700446XA (en) | 2014-07-21 | 2017-02-27 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| KR101515535B1 (ko) | 2015-01-28 | 2015-05-06 | 주식회사 종근당 | 항―ErbB2 항체 변이체 |
| JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| AU2016381992B2 (en) | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
| SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
| CN107674900B (zh) * | 2017-06-12 | 2021-05-14 | 诺利如一(安阳)生物科技有限公司 | 一种采用串联膜浓缩大豆肽的工艺方法 |
| EP3696274A4 (en) | 2017-10-10 | 2021-07-28 | Ajinomoto Co., Inc. | PROTEIN MANUFACTURING PROCESS |
| CN112119090B (zh) | 2018-03-15 | 2023-01-13 | 中外制药株式会社 | 对寨卡病毒具有交叉反应性的抗登革热病毒抗体及使用方法 |
| US20220169706A1 (en) | 2019-03-28 | 2022-06-02 | Danisco Us Inc | Engineered antibodies |
| US20230203191A1 (en) | 2020-03-30 | 2023-06-29 | Danisco Us Inc | Engineered antibodies |
| EP4166647A4 (en) | 2020-06-11 | 2025-01-01 | Ajinomoto Co., Inc. | Method for producing protein |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| EP4554619A1 (en) | 2022-07-15 | 2025-05-21 | Danisco US Inc. | Methods for producing monoclonal antibodies |
| TW202413407A (zh) | 2022-08-15 | 2024-04-01 | 國立大學法人東京大學 | 使用絲狀真菌之免疫球蛋白或多聚體免疫球蛋白之製造方法 |
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| DE3009104C2 (de) * | 1980-03-10 | 1990-10-04 | Odenwald-Chemie GmbH, 6901 Schönau | Verwendung eines Epoxydharzes zur Herstellung von feuerhemmenden Schichten oder Überzügen und Verfahren zur Herstellung derselben |
| CA1338400C (en) | 1983-08-31 | 1996-06-18 | David H. Gelfand | Recombinant fungal cellulases |
| DE3650202T3 (de) | 1985-08-29 | 2004-06-03 | Genencor International, Inc., South San Francisco | Expression von heterologen Polypeptiden in filamentösen Pilzen, Verfahren zu deren Herstellung und Vektoren zu deren Herstellung. |
| US20020061560A1 (en) * | 1985-08-29 | 2002-05-23 | Genencor, Inc. | DNA sequences, vectors, and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi |
| US5364770A (en) * | 1985-08-29 | 1994-11-15 | Genencor International Inc. | Heterologous polypeptides expressed in aspergillus |
| US5679543A (en) * | 1985-08-29 | 1997-10-21 | Genencor International, Inc. | DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5610034A (en) * | 1987-04-29 | 1997-03-11 | Alko Group Ltd. | Immunoglobulin production by trichoderma |
| US5218093A (en) * | 1989-03-01 | 1993-06-08 | Allelix Biopharmaceuticals, Inc. | EGF variants and pharmaceutical use thereof |
| GB9215540D0 (en) * | 1992-07-22 | 1992-09-02 | Celltech Ltd | Protein expression system |
| ES2162863T3 (es) * | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| US5683899A (en) * | 1994-02-03 | 1997-11-04 | University Of Hawaii | Methods and compositions for combinatorial-based discovery of new multimeric molecules |
| US5643745A (en) * | 1994-02-03 | 1997-07-01 | University Of Hawaii | Heterologous dimeric proteins produced in heterokaryons |
| US6300114B1 (en) * | 1994-07-29 | 2001-10-09 | Rohm Enzyme Finland Oy | Sequences of xylanase and xylanase expression vectors |
| CN1231588C (zh) * | 1996-01-19 | 2005-12-14 | 诺沃奇梅兹生物技术有限公司 | 丝状真菌的形态突变体 |
| US6140113A (en) * | 1996-03-28 | 2000-10-31 | The Johns Hopkins University | Polynucleotides encoding molecular complexes which modify immune responses |
| US6265204B1 (en) * | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
| GB9703406D0 (en) * | 1997-02-19 | 1997-04-09 | Chiron Spa | Expression of heterologous proteins |
| US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| US6232112B1 (en) * | 1997-11-24 | 2001-05-15 | Flinders Technologies Pty Ltd Of Flinders University | Reagents and methods for diversification of DNA |
| ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| HUP0100813A3 (en) * | 1998-02-25 | 2003-08-28 | Lexigen Pharmaceuticals Corp L | Enhancing the circulating half-life of antibody-based fusion proteins |
| AU1219000A (en) | 1998-10-22 | 2000-05-08 | Regents Of The University Of California, The | Functionally assembled antigen-specific intact recombinant antibody and a methodfor production thereof |
| US6767701B1 (en) * | 1998-10-26 | 2004-07-27 | Novozymes A/S | Methods of constructing and screening a DNA library of interest in filamentous fungal cells |
| WO2000025574A1 (en) * | 1998-10-30 | 2000-05-11 | Thomas Jefferson University | Production of biomedical peptides and proteins in plants using plant virus vectors |
| US7083945B1 (en) * | 2000-10-27 | 2006-08-01 | The Board Of Regents Of The University Of Texas System | Isolation of binding proteins with high affinity to ligands |
| US7094571B2 (en) * | 2000-10-27 | 2006-08-22 | The Board Of Regents Of The University Of Texas System | Combinatorial protein library screening by periplasmic expression |
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| AU2001297872B2 (en) * | 2000-11-17 | 2006-11-09 | University Of Rochester | In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells |
| BRPI0209933B8 (pt) * | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| JP2006512891A (ja) * | 2002-04-18 | 2006-04-20 | ジェネンコー・インターナショナル・インク | 糸状菌における機能性抗体の生産 |
| US7611866B2 (en) * | 2002-07-15 | 2009-11-03 | Board Of Regents, The University Of Texas System | Selection of bacterial inner-membrane anchor polypeptides |
| TWI335821B (en) * | 2002-12-16 | 2011-01-11 | Genentech Inc | Immunoglobulin variants and uses thereof |
| EP1588166A4 (en) * | 2003-01-09 | 2007-06-27 | Macrogenics Inc | VECTOR SYSTEM WITH DOUBLE EXPRESSION FOR EXPRESSING ANTIBODIES IN BACTERIAL AND MAMMAL CELLS |
| US20060024782A1 (en) * | 2004-01-21 | 2006-02-02 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon filamentous fungus or in a filamentous fungal host cell |
| CA2560074A1 (en) * | 2004-03-18 | 2005-11-03 | Board Of Regents, The University Of Texas System | Combinatorial protein library screening by periplasmic expression |
| DK2102239T3 (da) * | 2006-11-30 | 2012-05-29 | Res Dev Foundation | Forbedrede immunoglobulin-biblioteker |
| EP2155789B1 (en) * | 2007-05-01 | 2013-07-24 | Research Development Foundation | Immunoglobulin fc libraries |
-
2003
- 2003-04-17 JP JP2003586327A patent/JP2006512891A/ja active Pending
- 2003-04-17 DK DK03719861.1T patent/DK1495055T3/da active
- 2003-04-17 US US10/418,836 patent/US20040018573A1/en not_active Abandoned
- 2003-04-17 AU AU2003222664A patent/AU2003222664A1/en not_active Abandoned
- 2003-04-17 WO PCT/US2003/012246 patent/WO2003089614A2/en not_active Ceased
- 2003-04-17 EP EP03719861.1A patent/EP1495055B1/en not_active Revoked
-
2004
- 2004-12-09 US US11/007,886 patent/US7977067B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006512891A (ja) | 2006-04-20 |
| US7977067B2 (en) | 2011-07-12 |
| EP1495055B1 (en) | 2013-08-14 |
| WO2003089614A3 (en) | 2004-02-26 |
| EP1495055A4 (en) | 2007-08-01 |
| AU2003222664A8 (en) | 2003-11-03 |
| US20040018573A1 (en) | 2004-01-29 |
| US20050158825A1 (en) | 2005-07-21 |
| WO2003089614A2 (en) | 2003-10-30 |
| EP1495055A2 (en) | 2005-01-12 |
| AU2003222664A1 (en) | 2003-11-03 |
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