DK1492766T3 - Forbedret CC-1065-analogsyntese - Google Patents

Forbedret CC-1065-analogsyntese

Info

Publication number
DK1492766T3
DK1492766T3 DK03714042T DK03714042T DK1492766T3 DK 1492766 T3 DK1492766 T3 DK 1492766T3 DK 03714042 T DK03714042 T DK 03714042T DK 03714042 T DK03714042 T DK 03714042T DK 1492766 T3 DK1492766 T3 DK 1492766T3
Authority
DK
Denmark
Prior art keywords
enhanced
synthesis
cbi
analog synthesis
improved
Prior art date
Application number
DK03714042T
Other languages
English (en)
Inventor
Ravi V J Chari
Robert Yongxin Zhao
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Application granted granted Critical
Publication of DK1492766T3 publication Critical patent/DK1492766T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Transmission Systems Not Characterized By The Medium Used For Transmission (AREA)
  • Level Indicators Using A Float (AREA)
  • Silicon Polymers (AREA)
DK03714042T 2002-04-05 2003-03-19 Forbedret CC-1065-analogsyntese DK1492766T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/116,052 US6534660B1 (en) 2002-04-05 2002-04-05 CC-1065 analog synthesis
PCT/US2003/007276 WO2003087055A1 (en) 2002-04-05 2003-03-19 Improved cc-1065 analog synthesis

Publications (1)

Publication Number Publication Date
DK1492766T3 true DK1492766T3 (da) 2007-09-10

Family

ID=22364940

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03714042T DK1492766T3 (da) 2002-04-05 2003-03-19 Forbedret CC-1065-analogsyntese

Country Status (13)

Country Link
US (3) US6534660B1 (da)
EP (1) EP1492766B1 (da)
JP (1) JP4578105B2 (da)
AT (1) ATE361278T1 (da)
AU (1) AU2003218060B2 (da)
CA (1) CA2456453C (da)
DE (1) DE60313595T2 (da)
DK (1) DK1492766T3 (da)
ES (1) ES2286418T3 (da)
HK (1) HK1068138A1 (da)
NZ (1) NZ530854A (da)
PT (1) PT1492766E (da)
WO (1) WO2003087055A1 (da)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
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US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
ES2503719T3 (es) 2005-02-11 2014-10-07 Immunogen, Inc. Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
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US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
SI1928503T1 (sl) * 2005-08-24 2012-11-30 Immunogen Inc Postopek za pripravo konjugatov majtansinoid protitelo
AU2006294554B2 (en) * 2005-09-26 2013-03-21 E. R. Squibb & Sons, L.L.C. Antibody-drug conjugates and methods of use
NZ566395A (en) * 2005-09-26 2012-03-30 Medarex Inc Human monoclonal antibodies to CD70
JP5116686B2 (ja) 2005-10-26 2013-01-09 メダレックス インコーポレイテッド Ｃｃ−１０６５類似体の調製方法及び調製用化合物
CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
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EP2044122B1 (en) * 2006-07-18 2018-03-28 Sanofi Antagonist antibody against epha2 for the treatment of cancer
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
JP2010513306A (ja) * 2006-12-14 2010-04-30 メダレックス インコーポレーティッド Ｃｄ７０に結合するヒト抗体およびその使用
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
CN104013956B (zh) * 2007-01-25 2018-12-18 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
EP2121667B1 (en) 2007-02-21 2016-06-08 E. R. Squibb & Sons, L.L.C. Chemical linkers with single amino acids and conjugates thereof
JP5618549B2 (ja) * 2007-03-15 2014-11-05 ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤
ES2609915T3 (es) 2007-08-14 2017-04-25 Ludwig Institute For Cancer Research Ltd. Anticuerpo monoclonal 175 direccionado al receptor de EGF y derivados y usos del mismo
KR20100097753A (ko) * 2007-12-26 2010-09-03 바이오테스트 아게 Ｃｄ138 표적성 면역접합체 및 이의 용도
US9011864B2 (en) * 2007-12-26 2015-04-21 Biotest Ag Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
MX341344B (es) 2007-12-26 2016-08-16 Biotest Ag Agentes dirigidos a cd138 y sus usos.
JP2011508738A (ja) * 2007-12-26 2011-03-17 バイオテスト・アクチエンゲゼルシヤフト Ｃｄ１３８発現腫瘍細胞のターゲティングを向上させる方法及び剤
US8236319B2 (en) 2008-04-30 2012-08-07 Immunogen, Inc. Cross-linkers and their uses
CN104984360A (zh) 2009-06-03 2015-10-21 伊缪诺金公司 轭合方法
US20110076232A1 (en) 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
AR078470A1 (es) 2009-10-02 2011-11-09 Sanofi Aventis Anticuerpos que se unen especificamente al receptor epha2
IN2012DN02780A (da) 2009-10-06 2015-09-18 Immunogen Inc
MY171008A (en) 2011-03-29 2019-09-23 Immunogen Inc Preparation of maytansinoid antibody conjugates by a one-step process
KR102272828B1 (ko) 2011-03-29 2021-07-05 이뮤노젠 아이엔씨 일-단계 방법에 의한 메이탄시노이드 항체 접합체의 제조
WO2012171020A1 (en) 2011-06-10 2012-12-13 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
BR112014013694A2 (pt) 2011-12-08 2017-06-13 Biotest Ag método para tratar uma doença, e, kit
AU2013326881B2 (en) 2012-10-04 2018-08-02 Immunogen, Inc. Use of a PVDF membrane to purify cell-binding agent cytotoxic agent conjugates
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US10226535B2 (en) 2012-12-10 2019-03-12 Mersana Therapeutics, Inc. Auristatin compounds and conjugates thereof
JP6334553B2 (ja) 2012-12-10 2018-05-30 メルサナ セラピューティクス，インコーポレイティド タンパク質−高分子−薬剤コンジュゲート
WO2014093640A1 (en) 2012-12-12 2014-06-19 Mersana Therapeutics,Inc. Hydroxy-polmer-drug-protein conjugates
KR102087850B1 (ko) 2013-10-11 2020-03-12 메르사나 테라퓨틱스, 인코포레이티드 단백질-고분자-약물 접합체
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ES2960619T3 (es) 2014-02-28 2024-03-05 Hangzhou Dac Biotech Co Ltd Enlazadores cargados y sus usos para la conjugación
CN104860867B (zh) * 2015-04-23 2017-06-13 浙江大学 2,3‑二取代‑1H‑苯并[f]吲哚‑4,9‑二酮化合物及其制备法
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US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
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WO2017194568A1 (en) 2016-05-11 2017-11-16 Sanofi Treatment regimen using anti-muc1 maytansinoid immunoconjugate antibody for the treatment of tumors
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Also Published As

Publication number Publication date
US20030195365A1 (en) 2003-10-16
JP4578105B2 (ja) 2010-11-10
ATE361278T1 (de) 2007-05-15
EP1492766B1 (en) 2007-05-02
DE60313595D1 (de) 2007-06-14
WO2003087055A1 (en) 2003-10-23
EP1492766A4 (en) 2005-12-14
ES2286418T3 (es) 2007-12-01
US6534660B1 (en) 2003-03-18
HK1068138A1 (en) 2005-04-22
DE60313595T2 (de) 2008-01-10
US6586618B1 (en) 2003-07-01
CA2456453C (en) 2010-08-17
NZ530854A (en) 2005-11-25
AU2003218060A1 (en) 2003-10-27
PT1492766E (pt) 2007-07-26
JP2005522506A (ja) 2005-07-28
EP1492766A1 (en) 2005-01-05
US7329760B2 (en) 2008-02-12
AU2003218060B2 (en) 2008-06-26
CA2456453A1 (en) 2003-10-23

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