WO2004058392A3 - Intramolekular triplettsensibilisierte o-nitrophenylethyl-photoschutzgruppen - Google Patents

Intramolekular triplettsensibilisierte o-nitrophenylethyl-photoschutzgruppen Download PDF

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Publication number
WO2004058392A3
WO2004058392A3 PCT/EP2003/014823 EP0314823W WO2004058392A3 WO 2004058392 A3 WO2004058392 A3 WO 2004058392A3 EP 0314823 W EP0314823 W EP 0314823W WO 2004058392 A3 WO2004058392 A3 WO 2004058392A3
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WO
WIPO (PCT)
Prior art keywords
nitrophenylethyl
sensitized
intramolecular
groups
triplet
Prior art date
Application number
PCT/EP2003/014823
Other languages
English (en)
French (fr)
Other versions
WO2004058392A2 (de
Inventor
Ramon Gueimil
Matthias Scheffler
Sven Stahl
Original Assignee
Febit Ag
Ramon Gueimil
Matthias Scheffler
Sven Stahl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10260591A external-priority patent/DE10260591A1/de
Priority claimed from DE10260592A external-priority patent/DE10260592A1/de
Application filed by Febit Ag, Ramon Gueimil, Matthias Scheffler, Sven Stahl filed Critical Febit Ag
Priority to AU2003298235A priority Critical patent/AU2003298235A1/en
Publication of WO2004058392A2 publication Critical patent/WO2004058392A2/de
Publication of WO2004058392A3 publication Critical patent/WO2004058392A3/de

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Structural Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft neue photoaktivierbare Schutzgruppen, deren Quantenausbeute durch Bereitstellung eines intramolekularen Sensibilisators signifikant erhöht werden, und deren Verwendung bei der Synthese von Biopolymeren.
PCT/EP2003/014823 2002-12-23 2003-12-23 Intramolekular triplettsensibilisierte o-nitrophenylethyl-photoschutzgruppen WO2004058392A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003298235A AU2003298235A1 (en) 2002-12-23 2003-12-23 Intramolecular triplet-sensitized o-nitrophenylethyl photoprotective groups

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10260592.0 2002-12-23
DE10260591A DE10260591A1 (de) 2002-12-23 2002-12-23 Photoaktivierbare zweistufige Schutzgruppen für die Synthese von Biopolymeren
DE10260592A DE10260592A1 (de) 2002-12-23 2002-12-23 Intramolekular triplettsensibilisierte o-Nitrophenylethyl-Photoschutzgruppen
DE10260591.2 2002-12-23

Publications (2)

Publication Number Publication Date
WO2004058392A2 WO2004058392A2 (de) 2004-07-15
WO2004058392A3 true WO2004058392A3 (de) 2004-08-26

Family

ID=32683475

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2003/014822 WO2004058391A2 (de) 2002-12-23 2003-12-23 Photoaktivierbare zweistufige schutzgruppen für die synthese von biopolymeren
PCT/EP2003/014823 WO2004058392A2 (de) 2002-12-23 2003-12-23 Intramolekular triplettsensibilisierte o-nitrophenylethyl-photoschutzgruppen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/014822 WO2004058391A2 (de) 2002-12-23 2003-12-23 Photoaktivierbare zweistufige schutzgruppen für die synthese von biopolymeren

Country Status (4)

Country Link
US (1) US7737089B2 (de)
EP (1) EP1585830A2 (de)
AU (2) AU2003290117A1 (de)
WO (2) WO2004058391A2 (de)

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WO2004058391A2 (de) * 2002-12-23 2004-07-15 Febit Biotech Gmbh Photoaktivierbare zweistufige schutzgruppen für die synthese von biopolymeren
DE102005027667A1 (de) * 2005-06-15 2006-12-28 Febit Biotech Gmbh Verfahren zur Qualitätskontrolle funktionalisierter Oberflächen
CN105637097A (zh) 2013-08-05 2016-06-01 特韦斯特生物科学公司 从头合成的基因文库
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
CA2975855A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
US10844373B2 (en) 2015-09-18 2020-11-24 Twist Bioscience Corporation Oligonucleic acid variant libraries and synthesis thereof
CN108698012A (zh) 2015-09-22 2018-10-23 特韦斯特生物科学公司 用于核酸合成的柔性基底
CN115920796A (zh) 2015-12-01 2023-04-07 特韦斯特生物科学公司 功能化表面及其制备
EP3500672A4 (de) 2016-08-22 2020-05-20 Twist Bioscience Corporation De-novo-synthetisierte nukleinsäure-bibliotheken
KR102217487B1 (ko) 2016-09-21 2021-02-23 트위스트 바이오사이언스 코포레이션 핵산 기반 데이터 저장
KR102514213B1 (ko) 2016-12-16 2023-03-27 트위스트 바이오사이언스 코포레이션 면역 시냅스의 변이체 라이브러리 및 그의 합성
SG11201907713WA (en) 2017-02-22 2019-09-27 Twist Bioscience Corp Nucleic acid based data storage
WO2018170169A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
SG11201912057RA (en) 2017-06-12 2020-01-30 Twist Bioscience Corp Methods for seamless nucleic acid assembly
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2019051501A1 (en) 2017-09-11 2019-03-14 Twist Bioscience Corporation PROTEINS BINDING TO GPCR AND METHODS OF SYNTHESIS
JP7066840B2 (ja) 2017-10-20 2022-05-13 ツイスト バイオサイエンス コーポレーション ポリヌクレオチド合成のための加熱されたナノウェル
EP3735459A4 (de) 2018-01-04 2021-10-06 Twist Bioscience Corporation Digitale informationsspeicherung auf dna-basis
KR20210013128A (ko) 2018-05-18 2021-02-03 트위스트 바이오사이언스 코포레이션 핵산 하이브리드화를 위한 폴리뉴클레오타이드, 시약 및 방법
CA3131691A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
CN113766930A (zh) 2019-02-26 2021-12-07 特韦斯特生物科学公司 Glp1受体的变异核酸文库
US11332738B2 (en) 2019-06-21 2022-05-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4444996A1 (de) * 1994-12-16 1996-06-20 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen
DE19620170A1 (de) * 1996-05-20 1997-11-27 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen
WO2000061594A2 (de) * 1999-04-08 2000-10-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Nucleosid-derivate mit photolabilen schutzgruppen
WO2002020150A2 (en) * 2000-09-11 2002-03-14 Affymetrix, Inc. Photocleavable protecting groups
WO2002062815A1 (de) * 2001-02-05 2002-08-15 Febit Ag Hybrid-schutzgruppe
WO2002062747A1 (de) * 2001-02-05 2002-08-15 Febit Ag Fotolabile schutzgruppen für die synthese von biopolymeren

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066259A1 (en) * 1999-05-05 2000-11-09 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
DE10122357A1 (de) * 2001-05-09 2002-11-14 Febit Ferrarius Biotech Gmbh Hybridverfahren zur Herstellung von Trägern für die Analytbestimmung
WO2003004510A1 (de) * 2001-07-03 2003-01-16 Febit Ag Zweistufige schutzgruppen für die synthese von biopolymeren
WO2004058391A2 (de) * 2002-12-23 2004-07-15 Febit Biotech Gmbh Photoaktivierbare zweistufige schutzgruppen für die synthese von biopolymeren

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4444996A1 (de) * 1994-12-16 1996-06-20 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen
DE19620170A1 (de) * 1996-05-20 1997-11-27 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen
WO2000061594A2 (de) * 1999-04-08 2000-10-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Nucleosid-derivate mit photolabilen schutzgruppen
WO2002020150A2 (en) * 2000-09-11 2002-03-14 Affymetrix, Inc. Photocleavable protecting groups
WO2002062815A1 (de) * 2001-02-05 2002-08-15 Febit Ag Hybrid-schutzgruppe
WO2002062747A1 (de) * 2001-02-05 2002-08-15 Febit Ag Fotolabile schutzgruppen für die synthese von biopolymeren

Also Published As

Publication number Publication date
WO2004058392A2 (de) 2004-07-15
US7737089B2 (en) 2010-06-15
WO2004058391A3 (de) 2004-08-26
AU2003298235A1 (en) 2004-07-22
EP1585830A2 (de) 2005-10-19
AU2003298235A8 (en) 2004-07-22
AU2003290117A1 (en) 2004-07-22
WO2004058391A2 (de) 2004-07-15
US20060111564A1 (en) 2006-05-25
AU2003290117A8 (en) 2004-07-22

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