DK148874C - Fremgangsmaade til fjernelse eller koncentrering af hepatitisvirus fra blandinger af biologiske materialer - Google Patents

Fremgangsmaade til fjernelse eller koncentrering af hepatitisvirus fra blandinger af biologiske materialer

Info

Publication number
DK148874C
DK148874C DK308476A DK308476A DK148874C DK 148874 C DK148874 C DK 148874C DK 308476 A DK308476 A DK 308476A DK 308476 A DK308476 A DK 308476A DK 148874 C DK148874 C DK 148874C
Authority
DK
Denmark
Prior art keywords
mixtures
removal
procedure
concentration
biological materials
Prior art date
Application number
DK308476A
Other languages
English (en)
Other versions
DK308476A (da
DK148874B (da
Inventor
Lars-Olov Andersson
Haakan Gunnar Borg
Gudrun Monica Einarsson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE7507854A external-priority patent/SE417613B/xx
Priority claimed from SE7605632A external-priority patent/SE421076B/xx
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of DK308476A publication Critical patent/DK308476A/da
Publication of DK148874B publication Critical patent/DK148874B/da
Application granted granted Critical
Publication of DK148874C publication Critical patent/DK148874C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/82—Hepatitis associated antigens and antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
DK308476A 1975-07-09 1976-07-08 Fremgangsmaade til fjernelse eller koncentrering af hepatitisvirus fra blandinger af biologiske materialer DK148874C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE7507854 1975-07-09
SE7507854A SE417613B (sv) 1975-07-09 1975-07-09 Forfarande for separation eller koncentrering av hepatitvirus ur blandningar av biologiskt material
SE7605632 1976-05-18
SE7605632A SE421076B (sv) 1976-05-18 1976-05-18 Forfarande for separation eller koncentrering av hepatitvirus ur blandningar av biologiskt material

Publications (3)

Publication Number Publication Date
DK308476A DK308476A (da) 1977-01-10
DK148874B DK148874B (da) 1985-11-04
DK148874C true DK148874C (da) 1986-04-14

Family

ID=26656635

Family Applications (1)

Application Number Title Priority Date Filing Date
DK308476A DK148874C (da) 1975-07-09 1976-07-08 Fremgangsmaade til fjernelse eller koncentrering af hepatitisvirus fra blandinger af biologiske materialer

Country Status (20)

Country Link
US (1) US4168300A (da)
JP (1) JPS5210416A (da)
AT (1) AT355215B (da)
AU (1) AU510068B2 (da)
CA (1) CA1076956A (da)
CH (1) CH630115A5 (da)
CS (1) CS223818B2 (da)
DE (1) DE2630753A1 (da)
DK (1) DK148874C (da)
ES (1) ES449670A1 (da)
FI (1) FI55868C (da)
FR (1) FR2317309A1 (da)
GB (1) GB1531558A (da)
IE (1) IE43952B1 (da)
IL (1) IL49752A (da)
IT (1) IT1062511B (da)
NL (1) NL7607647A (da)
NO (1) NO148339C (da)
NZ (1) NZ181384A (da)
PL (1) PL105363B1 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE420977B (sv) * 1976-03-18 1981-11-16 Kabi Ab Forfarande for rening och isolering av hepatitvirus for vaccinframstellning
SE452336B (sv) * 1978-06-16 1987-11-23 Boehringer Mannheim Gmbh Forfarande for pavisning av sjukdomsalstrande mikroorganismer vilka adsorberats extrakorporalt pa en selektivt bindande adsorbent
US4282315A (en) * 1979-09-13 1981-08-04 Corning Glass Works Preparation of enriched whole virus radioligand
US4478914B1 (en) * 1980-01-24 1997-06-17 Roger W Giese Process for applying multiple layers of a protein and a ligand extender to a surface and to the multiple layer system
US4282287A (en) * 1980-01-24 1981-08-04 Giese Roger W Biochemical avidin-biotin multiple-layer system
USRE31712E (en) * 1980-01-24 1984-10-23 Biochemical avidin-biotin multiple-layer system
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4411795A (en) * 1980-03-10 1983-10-25 Baxter Travenol Laboratories, Inc. Particle adsorption
US4381239A (en) * 1981-02-10 1983-04-26 Tanabe Seiyaku Co., Ltd. Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith
US4488969A (en) * 1982-02-09 1984-12-18 Amf Incorporated Fibrous media containing millimicron-sized particulates
US4511473A (en) * 1982-02-09 1985-04-16 Amf Incorporated Fibrous media containing millimicron-sized particulates
US4596660A (en) * 1982-07-23 1986-06-24 Amf Inc. Fibrous media containing millimicron-sized particulates
US4434093A (en) 1982-07-26 1984-02-28 Ortho Diagnostic Systems Inc. Methods for preparation of HBs Ag free gamma globulins
JPS5961887U (ja) * 1982-10-15 1984-04-23 三菱化学株式会社 コ−クス自動選別装置
US4515714A (en) * 1983-03-09 1985-05-07 Juridicial Foundation, The Chemo-Semo-Sero-Therapeutic Research Institute Method for purification of hepatitis B virus surface antigen
US4627915A (en) * 1983-04-06 1986-12-09 Asahi Kasei Kogyo Kabushiki Kaisha Absorbent of autoantibody and immune complexes, adsorbing device and blood purifying apparatus comprising the same
WO1984004696A1 (en) * 1983-05-31 1984-12-06 Baxter Travenol Lab Particle adsorption
US4820805A (en) * 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4764369A (en) * 1983-07-14 1988-08-16 New York Blood Center Inc. Undenatured virus-free biologically active protein derivatives
US4563303A (en) * 1984-04-14 1986-01-07 Judicial Foundation The Chemosero-Therapeutic Research Institute Method for purification of filamentous hemagglutinin
JPS6147185A (ja) * 1984-08-09 1986-03-07 Chemo Sero Therapeut Res Inst 日本脳炎ウイルスの精製方法
JPS6147186A (ja) * 1984-08-09 1986-03-07 Chemo Sero Therapeut Res Inst インフルエンザウイルスの精製方法
JPS6147187A (ja) * 1984-08-10 1986-03-07 Chemo Sero Therapeut Res Inst 狂犬病ウイルスの精製方法
JPS61103895A (ja) * 1984-10-26 1986-05-22 Green Cross Corp:The ＨＢｓＡｇの精製方法
CA1244349A (en) * 1985-06-26 1988-11-08 Jen-Chang Hsia Purification of hemoglobin and modified hemoglobin by affinity chromatography
ES2033938T3 (es) * 1987-01-21 1993-04-01 Abbott Laboratories Un ensayo de neutralizacion para confirmar la presencia de un ligando en una muestra biologica.
US4869826A (en) * 1987-09-01 1989-09-26 Process Biotechnology, Inc. Cellular adsorbents for removal of viral contaminants from blood and complex protein solutions
JP2729484B2 (ja) * 1988-04-28 1998-03-18 株式会社ミドリ十字 アンチトロンビン−▲ｉｉｉ▼の精製方法
JP2852307B2 (ja) * 1989-02-09 1999-02-03 吉富製薬株式会社 ウイルスの除去された蛋白質製剤の製造法
US5274081A (en) * 1989-09-20 1993-12-28 Immuno A.G. Complex suitable for carrying out a method of purifying pre-S hepatitis B surface antigen
US5576175A (en) * 1989-09-20 1996-11-19 Immuno Aktiengesellschaft Complex suitable for carrying out a method of purifying pre-S hepatitis B surface antigen
US5221483A (en) * 1990-06-29 1993-06-22 Coulter Corporation Process and apparatus for removal of DNA, viruses and endotoxins
US5076933A (en) * 1990-06-29 1991-12-31 Coulter Corporation Process and apparatus for removal of dna and viruses
DK1386660T3 (da) * 1996-08-30 2009-12-21 Upfront Chromatography As Isolering af immunoglobuliner
WO2009132330A2 (en) * 2008-04-25 2009-10-29 Biotrove, Inc. Separation cartridges and methods for fabrication and use thereof
CN106138851A (zh) * 2016-09-08 2016-11-23 四川聚豪生物科技有限公司 一种可有效治疗乙肝的汤剂药物及其制备方法
CN109896976B (zh) * 2019-02-27 2022-07-12 宁波大学 一种十六代酰肼羧酸钠引发剂及其制备与使用方法
CN109867737B (zh) * 2019-02-27 2022-03-18 宁波大学 一种双子型酰肼阴离子引发剂及其制备与使用方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3425962A (en) * 1966-12-28 1969-02-04 Bristol Myers Co Salt of a diethylaminoethyl cross-linked dextran anion exchanger
US3636191A (en) * 1969-10-08 1972-01-18 Cancer Res Inst Vaccine against viral hepatitis and process
GB1392181A (en) * 1971-04-16 1975-04-30 Rech Et Dapplications Soc Gen Fixation of nitrogenous materials
US3852157A (en) * 1971-05-14 1974-12-03 Syva Corp Compounds for enzyme amplification assay
SE361320B (da) * 1972-03-14 1973-10-29 Exploaterings Ab Tbf
JPS5533442B2 (da) * 1972-09-14 1980-08-30
ZA74350B (en) * 1973-01-30 1974-11-27 Baxter Laboratories Inc Fractionation of blood
SE413986B (sv) * 1973-03-23 1980-07-07 Exploaterings Ab Tbf Sett att separera amfipatiska emnen innehallande bade hydrofila och hydrofoba grupper samt gelprodukt for genomforande av separationen
US3951937A (en) * 1973-12-20 1976-04-20 The Community Blood Council Of Greater New York, Inc. Large scale purification of hepatitis type B antigen using polyethylene glycol
US3994870A (en) * 1974-01-31 1976-11-30 The Community Blood Council Of Greater New York, Inc. Purification of hepatitis B surface antigen
CS171963B1 (da) * 1974-02-01 1976-11-29
US4000098A (en) * 1974-08-16 1976-12-28 Palo Alto Medical Research Foundation Separation of proteins by hydrophobic adsorption
US3992517A (en) * 1975-02-19 1976-11-16 Pfizer Inc. Detection of hepatitis B surface antigen by latex agglutination
US3976767A (en) * 1975-04-14 1976-08-24 The New York Blood Center Purification of hepatitis B surface antigen by chromatography on agarose containing aminoalkyl residues

Also Published As

Publication number Publication date
NO148339C (no) 1983-09-21
IT1062511B (it) 1984-10-20
DE2630753A1 (de) 1977-01-20
NZ181384A (en) 1978-12-18
NL7607647A (nl) 1977-01-11
IE43952L (en) 1977-01-09
ES449670A1 (es) 1978-02-01
FR2317309A1 (fr) 1977-02-04
PL105363B1 (pl) 1979-10-31
IE43952B1 (en) 1981-07-15
IL49752A (en) 1979-07-25
CA1076956A (en) 1980-05-06
PL191019A1 (pl) 1978-04-24
US4168300A (en) 1979-09-18
NO762392L (da) 1977-01-11
CH630115A5 (de) 1982-05-28
ATA500576A (de) 1979-07-15
DK308476A (da) 1977-01-10
FI55868C (fi) 1979-10-10
CS223818B2 (en) 1983-11-25
AT355215B (de) 1980-02-25
JPS641444B2 (da) 1989-01-11
DK148874B (da) 1985-11-04
IL49752A0 (en) 1976-08-31
GB1531558A (en) 1978-11-08
JPS5210416A (en) 1977-01-26
FR2317309B1 (da) 1979-06-01
NO148339B (no) 1983-06-13
FI55868B (fi) 1979-06-29
AU1568476A (en) 1978-01-12
DE2630753C2 (da) 1989-01-19
FI761997A (da) 1977-01-10
AU510068B2 (en) 1980-06-05

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