DK146856C - Analogifremgangsmaade til fremstilling af 17alfa-(3-hydroxypropyl)-17beta-hydroxy-4-gonen-3-oner - Google Patents

Analogifremgangsmaade til fremstilling af 17alfa-(3-hydroxypropyl)-17beta-hydroxy-4-gonen-3-oner

Info

Publication number
DK146856C
DK146856C DK96177A DK96177A DK146856C DK 146856 C DK146856 C DK 146856C DK 96177 A DK96177 A DK 96177A DK 96177 A DK96177 A DK 96177A DK 146856 C DK146856 C DK 146856C
Authority
DK
Denmark
Prior art keywords
17alfa
gonen
oner
17beta
hydroxypropyl
Prior art date
Application number
DK96177A
Other languages
Danish (da)
English (en)
Other versions
DK146856B (da
DK96177A (da
Inventor
Rainer Philippson
Bernhard Krieger
Jorge Casals-Stenzel
Ulrich Kerb
Wolfgang Losert
Klaus Prezewowsky
Rudolf Wiechert
Dieter Bittler
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19762609695 external-priority patent/DE2609695A1/de
Priority claimed from DE19762609694 external-priority patent/DE2609694C3/de
Priority claimed from DE19762627187 external-priority patent/DE2627187A1/de
Priority claimed from DE19762627186 external-priority patent/DE2627186A1/de
Priority claimed from DE19762644427 external-priority patent/DE2644427A1/de
Priority claimed from DE19762646043 external-priority patent/DE2646043C2/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK96177A publication Critical patent/DK96177A/da
Priority to DK403382A priority Critical patent/DK403382A/da
Publication of DK146856B publication Critical patent/DK146856B/da
Application granted granted Critical
Publication of DK146856C publication Critical patent/DK146856C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96177A 1976-03-05 1977-03-04 Analogifremgangsmaade til fremstilling af 17alfa-(3-hydroxypropyl)-17beta-hydroxy-4-gonen-3-oner DK146856C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK403382A DK403382A (da) 1976-03-05 1982-09-09 Fremgangsmaade til fremstilling af 4-androsten-3-oner

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
DE19762609695 DE2609695A1 (de) 1976-03-05 1976-03-05 7-substituierte 4-androsten-3-one und verfahren zu ihrer herstellung
DE2609695 1976-03-05
DE2609694 1976-03-05
DE19762609694 DE2609694C3 (de) 1976-03-05 1976-03-05 17 a-(3-Hydroxpropyl)-17 ß- hydroxy-7 a-thioalkanoyl-4-androsten- 3-one und Verfahren zu deren Herstellung
DE2627187 1976-06-16
DE19762627187 DE2627187A1 (de) 1976-06-16 1976-06-16 7-substituierte 4-androsten-3-one und verfahren zu ihrer herstellung ii
DE19762627186 DE2627186A1 (de) 1976-03-05 1976-06-16 7-substituierte 4-androsten-3-one und verfahren zu ihrer herstellung iii
DE2627186 1976-06-16
DE2644427 1976-09-30
DE19762644427 DE2644427A1 (de) 1976-09-30 1976-09-30 17 beta-hydroxy-17 alpha-(3-acyloxypropyl)-4.6-androstadien-3-one und deren salze
DE2646043 1976-10-08
DE19762646043 DE2646043C2 (de) 1976-10-08 1976-10-08 7α-Acetylthio-6α-methyl-4-androsten-3-one, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Publications (3)

Publication Number Publication Date
DK96177A DK96177A (da) 1977-09-06
DK146856B DK146856B (da) 1984-01-23
DK146856C true DK146856C (da) 1984-07-02

Family

ID=27544260

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96177A DK146856C (da) 1976-03-05 1977-03-04 Analogifremgangsmaade til fremstilling af 17alfa-(3-hydroxypropyl)-17beta-hydroxy-4-gonen-3-oner

Country Status (15)

Country Link
US (1) US4118488A (xx)
JP (1) JPS52111552A (xx)
AT (2) AT365611B (xx)
BE (1) BE852089A (xx)
CA (1) CA1078826A (xx)
CH (1) CH631462A5 (xx)
DD (1) DD128659A5 (xx)
DK (1) DK146856C (xx)
FR (1) FR2342990A1 (xx)
GB (1) GB1579298A (xx)
IE (1) IE44711B1 (xx)
IL (1) IL51586A (xx)
LU (1) LU76883A1 (xx)
NL (1) NL7702369A (xx)
SE (1) SE420732B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53116361A (en) * 1977-03-17 1978-10-11 Mitsubishi Chem Ind Ltd Preparation of 7 acylthioo44enee33oxosteroid
ES469510A1 (es) * 1977-05-16 1978-12-01 Schering Ag Procedimiento para la preparacion de 17beta hidroxi-4-an- drosten-3-onas.
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3130644A1 (de) * 1981-07-29 1983-02-17 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue androstan-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten
DE3461090D1 (en) * 1983-02-18 1986-12-04 Schering Ag 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
US4552871A (en) * 1983-04-13 1985-11-12 Ciba Geigy Corporation Steroids of the 20-spiroxane series, processes for the manufacture thereof, pharmaceutical preparations containing such compounds and the use of the latter
EP0973791B1 (en) * 1995-12-11 2007-06-20 G.D. Searle LLC. Process for the preparation of an epoxy compound
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
BR9714510A (pt) 1996-12-11 2000-11-28 Searle & Co Processo e preparo de esteróides de 9,11-époxi e intermediários úteis dos mesmos
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
KR20100131018A (ko) * 2002-03-22 2010-12-14 파마시아 앤드 업존 캄파니 엘엘씨 에플레레논의 제조를 위한 신규 중간체
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137690A (en) * 1963-09-26 1964-06-16 Searle & Co 17beta-hydroxy-3-oxoandrost-4-en-17alpha-ylpropionaldehyde lactol and delta1, delta6, delta1, 6, 19-nor and 7alpha-acetylthio congeners
DE1250818B (de) * 1963-10-01 1967-09-28 G. D. Searle & Co., Chicago, 111. (V. St. A.) Verfahren zur Herstellung von 3-Oxozl4.Asteroiden
US3798213A (en) * 1971-01-25 1974-03-19 Merck & Co Inc 7 alpha-methyl-20-spiroxane-3-ones and process
US3753979A (en) * 1971-12-06 1973-08-21 Merck & Co Inc Substituted 1,2alpha-methylene-6,7alpha-halomethylene-20-spirox-4-en-3-ones or 3-ols and acyl esters thereof
DE2251476A1 (de) * 1972-10-20 1974-05-02 Hoechst Ag Verfahren zur herstellung von beta(3-keto-7 alpha-thioacyl-17 beta-hydroxy4-androsten-17 alpha -yl)-propionsaeuregamma -lactonen
CH609357A5 (xx) * 1973-05-25 1979-02-28 Schering Ag

Also Published As

Publication number Publication date
ATA180980A (de) 1982-07-15
GB1579298A (en) 1980-11-19
AT365611B (de) 1982-02-10
DK146856B (da) 1984-01-23
SE7702455L (sv) 1977-09-06
JPS52111552A (en) 1977-09-19
BE852089A (fr) 1977-09-05
US4118488A (en) 1978-10-03
DK96177A (da) 1977-09-06
DD128659A5 (de) 1977-11-30
SE420732B (sv) 1981-10-26
CH631462A5 (de) 1982-08-13
IL51586A0 (en) 1977-05-31
IE44711L (en) 1977-09-05
IE44711B1 (en) 1982-03-10
ATA141377A (de) 1981-06-15
NL7702369A (nl) 1977-09-07
AT370110B (de) 1983-03-10
LU76883A1 (xx) 1977-07-11
FR2342990B1 (xx) 1979-03-09
FR2342990A1 (fr) 1977-09-30
CA1078826A (en) 1980-06-03
IL51586A (en) 1981-10-30

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