DK146205C - Analogifremgangsmaade til fremstilling af 8alfa-ergolin-i-derivater - Google Patents

Analogifremgangsmaade til fremstilling af 8alfa-ergolin-i-derivater

Info

Publication number
DK146205C
DK146205C DK562376A DK562376A DK146205C DK 146205 C DK146205 C DK 146205C DK 562376 A DK562376 A DK 562376A DK 562376 A DK562376 A DK 562376A DK 146205 C DK146205 C DK 146205C
Authority
DK
Denmark
Prior art keywords
8alfa
ergolin
derivatives
preparation
analogy procedure
Prior art date
Application number
DK562376A
Other languages
Danish (da)
English (en)
Other versions
DK146205B (da
DK562376A (da
Inventor
Peter Stuetz
Theodor Fehr
Paul Stadler
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1668075A external-priority patent/CH620441A5/de
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK562376A publication Critical patent/DK562376A/da
Publication of DK146205B publication Critical patent/DK146205B/da
Application granted granted Critical
Publication of DK146205C publication Critical patent/DK146205C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06Lysergic acid amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK562376A 1975-12-23 1976-12-14 Analogifremgangsmaade til fremstilling af 8alfa-ergolin-i-derivater DK146205C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1668075A CH620441A5 (en) 1975-12-23 1975-12-23 Process for the preparation of novel ergoline compounds
CH1668075 1975-12-23
CH618876 1976-05-18
CH618876 1976-05-18

Publications (3)

Publication Number Publication Date
DK562376A DK562376A (da) 1977-06-24
DK146205B DK146205B (da) 1983-07-25
DK146205C true DK146205C (da) 1983-12-27

Family

ID=25699142

Family Applications (2)

Application Number Title Priority Date Filing Date
DK562376A DK146205C (da) 1975-12-23 1976-12-14 Analogifremgangsmaade til fremstilling af 8alfa-ergolin-i-derivater
DK554179A DK554179A (da) 1975-12-23 1979-12-21 Fremgangsmaade til fremstilling af ergolinderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK554179A DK554179A (da) 1975-12-23 1979-12-21 Fremgangsmaade til fremstilling af ergolinderivater

Country Status (20)

Country Link
US (1) US4348391A (de)
JP (1) JPS5278900A (de)
AU (1) AU514288B2 (de)
CA (1) CA1092100A (de)
DE (1) DE2656344A1 (de)
DK (2) DK146205C (de)
ES (1) ES454442A1 (de)
FI (1) FI763587A (de)
FR (1) FR2336135A1 (de)
GB (1) GB1567484A (de)
HK (1) HK3483A (de)
IE (1) IE44242B1 (de)
IL (1) IL51133A (de)
MY (1) MY8400060A (de)
NL (1) NL7614018A (de)
NZ (1) NZ182934A (de)
PH (1) PH14035A (de)
PT (1) PT66006B (de)
SE (1) SE432253B (de)
SG (1) SG63382G (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3127845A1 (de) * 1980-07-25 1982-04-22 Sandoz-Patent-GmbH, 7850 Lörrach Ergolinderivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammensetzungen und ihre anwendung bei der therapeutischen behandlung
BE889713A (fr) * 1980-07-25 1982-01-25 Sandoz Sa Nouveaux derives de l'ergoline, leur preparation et leur application comme medicaments
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
GB2112382B (en) * 1981-11-06 1985-03-06 Erba Farmitalia Ergoline derivatives
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
HU196399B (en) * 1983-02-16 1988-11-28 Sandoz Ag Process for producing ergoline derivatives and pharmaceutical compositions comprising such compounds
CH652719A5 (en) * 1983-02-16 1985-11-29 Sandoz Ag Ergoline derivatives, their preparation and use
CH664568A5 (de) * 1984-01-12 1988-03-15 Sandoz Ag 8-alpha-acylaminoergoline.
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
GB8615471D0 (en) * 1986-06-25 1986-07-30 Erba Farmitalia T-butyl ergoline derivatives
US4798834A (en) * 1987-08-31 1989-01-17 Eli Lilly And Company Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement
AT392945B (de) * 1988-06-27 1991-07-10 Gerhard Mader Ges M B H Ing Lager- und transportbehaelter fuer schuettgueter und lose materialien
IT1232692B (it) * 1989-08-04 1992-03-04 Poli Ind Chimica Spa Derivati ergolinici con attivita' dopaminergica
WO2000054776A1 (en) * 1999-03-17 2000-09-21 Eugen Eigenmann Use of prolactin inhibitors for the treatment of fertility problems in animal species

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3185695A (en) * 1965-05-25 Dbwethyl-ergoline ii derivatives
US3245996A (en) * 1966-04-12 Cyanoethyl lysergol
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US3232943A (en) * 1966-02-01 Cyanoethyl ergolene and ergoline derivatives
US3270020A (en) * 1966-08-30 Dihydro ergocornine
US2533698A (en) * 1950-12-12 Urethanes containing the lysergic
CH415658A (de) * 1962-06-18 1966-06-30 Sandoz Ag Verfahren zur Herstellung von neuen Urethanen
BE712054A (de) * 1967-03-16 1968-07-15
US3920664A (en) * 1972-07-21 1975-11-18 Lilly Co Eli D-2-halo-6-alkyl-8-substituted ergolines and related compounds
US3880856A (en) * 1973-06-29 1975-04-29 Lilly Co Eli Ergoline dimers
CS171480B1 (de) * 1974-03-19 1976-10-29
CH605936A5 (en) * 1974-07-19 1978-10-13 Sandoz Ag 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs
GB1517971A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 8alpha-substituted ergoline i derivatives
US3904757A (en) * 1974-08-08 1975-09-09 Lilly Co Eli Treatment of parkinsonism
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes

Also Published As

Publication number Publication date
FI763587A (de) 1977-06-24
AU2079376A (en) 1978-06-29
GB1567484A (en) 1980-05-14
IL51133A0 (en) 1977-02-28
HK3483A (en) 1983-01-20
JPS5278900A (en) 1977-07-02
CA1092100A (en) 1980-12-23
FR2336135A1 (fr) 1977-07-22
DK146205B (da) 1983-07-25
MY8400060A (en) 1984-12-31
PH14035A (en) 1980-12-12
PT66006B (fr) 1978-07-06
SE7614085L (sv) 1977-06-24
SG63382G (en) 1983-09-09
DE2656344A1 (de) 1977-07-07
FR2336135B1 (de) 1980-03-07
PT66006A (fr) 1977-01-01
JPS6133031B2 (de) 1986-07-31
DE2656344C2 (de) 1990-11-08
US4348391A (en) 1982-09-07
IL51133A (en) 1981-11-30
AU514288B2 (en) 1981-02-05
NZ182934A (en) 1978-12-18
SE432253B (sv) 1984-03-26
ES454442A1 (es) 1978-03-01
DK554179A (da) 1979-12-21
IE44242B1 (en) 1981-09-23
NL7614018A (nl) 1977-06-27
DK562376A (da) 1977-06-24

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