DK145643C - Fremgangsmaade til fremstilling af 5-(2,4-difluorphenyl)salicylsyre - Google Patents

Fremgangsmaade til fremstilling af 5-(2,4-difluorphenyl)salicylsyre

Info

Publication number
DK145643C
DK145643C DK310075A DK310075A DK145643C DK 145643 C DK145643 C DK 145643C DK 310075 A DK310075 A DK 310075A DK 310075 A DK310075 A DK 310075A DK 145643 C DK145643 C DK 145643C
Authority
DK
Denmark
Prior art keywords
difluorphenyl
preparing
salicylic acid
salicylic
acid
Prior art date
Application number
DK310075A
Other languages
Danish (da)
English (en)
Other versions
DK310075A (da
DK145643B (da
Inventor
Howard Jones
Robert William Houser
Torleif Utne
Ronald Bradford Jobson
Alfred Vincent Lovell
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/571,165 external-priority patent/US3992459A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK310075A publication Critical patent/DK310075A/da
Publication of DK145643B publication Critical patent/DK145643B/da
Application granted granted Critical
Publication of DK145643C publication Critical patent/DK145643C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK310075A 1974-07-22 1975-07-09 Fremgangsmaade til fremstilling af 5-(2,4-difluorphenyl)salicylsyre DK145643C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US49062074A 1974-07-22 1974-07-22
US49062074 1974-07-22
US56720175A 1975-04-16 1975-04-16
US56720175 1975-04-16
US05/571,165 US3992459A (en) 1975-05-01 1975-05-01 Preparation of biphenyl compounds
US57116575 1975-05-01

Publications (3)

Publication Number Publication Date
DK310075A DK310075A (da) 1976-01-23
DK145643B DK145643B (da) 1983-01-10
DK145643C true DK145643C (da) 1983-07-11

Family

ID=27413871

Family Applications (1)

Application Number Title Priority Date Filing Date
DK310075A DK145643C (da) 1974-07-22 1975-07-09 Fremgangsmaade til fremstilling af 5-(2,4-difluorphenyl)salicylsyre

Country Status (11)

Country Link
JP (1) JPS5134135A (de)
CH (1) CH615146A5 (de)
DE (1) DE2532559C3 (de)
DK (1) DK145643C (de)
FR (1) FR2288729A1 (de)
GB (2) GB1496231A (de)
IE (1) IE41582B1 (de)
LU (1) LU73032A1 (de)
NL (1) NL188689C (de)
NO (1) NO143874C (de)
SE (1) SE428560B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216340A (en) * 1979-05-02 1980-08-05 Merck & Co., Inc. Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives
IT1133963B (it) * 1980-10-21 1986-07-24 D & D Srl Derivati piridossinici ad attivita' terapeutica,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4482502A (en) * 1983-04-25 1984-11-13 Ethyl Corporation Preparation of biaryl compounds
JPH0582493U (ja) * 1992-04-06 1993-11-09 株式会社エースプレミアム 走行玩具

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO120372B (de) * 1966-09-08 1970-10-12 Merck & Co Ltd
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
GB1359987A (en) * 1970-10-12 1974-07-17 Boots Co Ltd 2-substituted biphenylyl propionic acids
JPS4916419A (de) * 1972-05-31 1974-02-13

Also Published As

Publication number Publication date
GB1496231A (en) 1977-12-30
NO752482L (de) 1976-01-23
JPS5134135A (en) 1976-03-23
DK310075A (da) 1976-01-23
NL7508127A (nl) 1976-01-26
NO143874C (no) 1981-04-29
NL188689C (nl) 1992-09-01
JPS569496B2 (de) 1981-03-02
FR2288729B1 (de) 1977-12-09
DE2532559A1 (de) 1976-02-05
SE428560B (sv) 1983-07-11
DK145643B (da) 1983-01-10
DE2532559B2 (de) 1979-02-15
FR2288729A1 (fr) 1976-05-21
DE2532559C3 (de) 1979-10-04
CH615146A5 (en) 1980-01-15
NO143874B (no) 1981-01-19
IE41582L (en) 1976-01-22
LU73032A1 (de) 1976-07-01
NL188689B (nl) 1992-04-01
SE7507764L (sv) 1976-01-23
IE41582B1 (en) 1980-02-13
GB1496232A (en) 1977-12-30

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Legal Events

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PUP Patent expired