FR2288729A1 - Procede de preparation d'acide 5-(2, 4-difluorophenyl) salicylique - Google Patents

Procede de preparation d'acide 5-(2, 4-difluorophenyl) salicylique

Info

Publication number
FR2288729A1
FR2288729A1 FR7522332A FR7522332A FR2288729A1 FR 2288729 A1 FR2288729 A1 FR 2288729A1 FR 7522332 A FR7522332 A FR 7522332A FR 7522332 A FR7522332 A FR 7522332A FR 2288729 A1 FR2288729 A1 FR 2288729A1
Authority
FR
France
Prior art keywords
difluorophenyl
preparation
salicylic acid
salicylic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7522332A
Other languages
English (en)
Other versions
FR2288729B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/571,165 external-priority patent/US3992459A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2288729A1 publication Critical patent/FR2288729A1/fr
Application granted granted Critical
Publication of FR2288729B1 publication Critical patent/FR2288729B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR7522332A 1974-07-22 1975-07-17 Procede de preparation d'acide 5-(2, 4-difluorophenyl) salicylique Granted FR2288729A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49062074A 1974-07-22 1974-07-22
US56720175A 1975-04-16 1975-04-16
US05/571,165 US3992459A (en) 1975-05-01 1975-05-01 Preparation of biphenyl compounds

Publications (2)

Publication Number Publication Date
FR2288729A1 true FR2288729A1 (fr) 1976-05-21
FR2288729B1 FR2288729B1 (fr) 1977-12-09

Family

ID=27413871

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7522332A Granted FR2288729A1 (fr) 1974-07-22 1975-07-17 Procede de preparation d'acide 5-(2, 4-difluorophenyl) salicylique

Country Status (11)

Country Link
JP (1) JPS5134135A (fr)
CH (1) CH615146A5 (fr)
DE (1) DE2532559C3 (fr)
DK (1) DK145643C (fr)
FR (1) FR2288729A1 (fr)
GB (2) GB1496231A (fr)
IE (1) IE41582B1 (fr)
LU (1) LU73032A1 (fr)
NL (1) NL188689C (fr)
NO (1) NO143874C (fr)
SE (1) SE428560B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216340A (en) * 1979-05-02 1980-08-05 Merck & Co., Inc. Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives
IT1133963B (it) * 1980-10-21 1986-07-24 D & D Srl Derivati piridossinici ad attivita' terapeutica,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4482502A (en) * 1983-04-25 1984-11-13 Ethyl Corporation Preparation of biaryl compounds
JPH0582493U (ja) * 1992-04-06 1993-11-09 株式会社エースプレミアム 走行玩具

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE703499A (fr) * 1966-09-08 1968-03-05

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
GB1359987A (en) * 1970-10-12 1974-07-17 Boots Co Ltd 2-substituted biphenylyl propionic acids
JPS4916419A (fr) * 1972-05-31 1974-02-13

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE703499A (fr) * 1966-09-08 1968-03-05

Also Published As

Publication number Publication date
GB1496231A (en) 1977-12-30
NO752482L (fr) 1976-01-23
JPS5134135A (en) 1976-03-23
DK310075A (da) 1976-01-23
NL7508127A (nl) 1976-01-26
NO143874C (no) 1981-04-29
NL188689C (nl) 1992-09-01
JPS569496B2 (fr) 1981-03-02
FR2288729B1 (fr) 1977-12-09
DE2532559A1 (de) 1976-02-05
SE428560B (sv) 1983-07-11
DK145643B (da) 1983-01-10
DE2532559B2 (de) 1979-02-15
DE2532559C3 (de) 1979-10-04
CH615146A5 (en) 1980-01-15
NO143874B (no) 1981-01-19
IE41582L (en) 1976-01-22
LU73032A1 (fr) 1976-07-01
NL188689B (nl) 1992-04-01
SE7507764L (sv) 1976-01-23
IE41582B1 (en) 1980-02-13
DK145643C (da) 1983-07-11
GB1496232A (en) 1977-12-30

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