DK144986D0 - Fremgangsmaade til detektering af en nukleinsyresekvens og middel til udoevelse af fremgangsmaaden samt fremgangsmaader til kloning af vektormed en specifik nukleinsyresekvens henholdsvis til syntetisering afet nukleinsyrefragment - Google Patents

Fremgangsmaade til detektering af en nukleinsyresekvens og middel til udoevelse af fremgangsmaaden samt fremgangsmaader til kloning af vektormed en specifik nukleinsyresekvens henholdsvis til syntetisering afet nukleinsyrefragment

Info

Publication number
DK144986D0
DK144986D0 DK144986A DK144986A DK144986D0 DK 144986 D0 DK144986 D0 DK 144986D0 DK 144986 A DK144986 A DK 144986A DK 144986 A DK144986 A DK 144986A DK 144986 D0 DK144986 D0 DK 144986D0
Authority
DK
Denmark
Prior art keywords
nucleic acid
acid sequence
sentence
synthetic
detecting
Prior art date
Application number
DK144986A
Other languages
English (en)
Other versions
DK144986A (da
DK171161B1 (da
Inventor
Kary B Mullis
Norman Arnheim
Randall K Saiki
Henry A Ehrlich
Glenn T Horn
Stephen J Scharf
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27418965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK144986(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/791,308 external-priority patent/US4683202A/en
Priority claimed from US06/828,144 external-priority patent/US4683195A/en
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of DK144986D0 publication Critical patent/DK144986D0/da
Publication of DK144986A publication Critical patent/DK144986A/da
Application granted granted Critical
Publication of DK171161B1 publication Critical patent/DK171161B1/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795Porphyrin- or corrin-ring-containing peptides
    • C07K14/805Haemoglobins; Myoglobins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00495Means for heating or cooling the reaction vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Detergent Compositions (AREA)
  • Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK144986A 1985-03-28 1986-03-26 Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve DK171161B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US71697585A 1985-03-28 1985-03-28
US71697585 1985-03-28
US06/791,308 US4683202A (en) 1985-03-28 1985-10-25 Process for amplifying nucleic acid sequences
US79130885 1985-10-25
US82814486 1986-02-07
US06/828,144 US4683195A (en) 1986-01-30 1986-02-07 Process for amplifying, detecting, and/or-cloning nucleic acid sequences

Publications (3)

Publication Number Publication Date
DK144986D0 true DK144986D0 (da) 1986-03-26
DK144986A DK144986A (da) 1986-09-29
DK171161B1 DK171161B1 (da) 1996-07-08

Family

ID=27418965

Family Applications (3)

Application Number Title Priority Date Filing Date
DK144986A DK171161B1 (da) 1985-03-28 1986-03-26 Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
DK026595A DK171871B1 (da) 1985-03-28 1995-03-17 Fremgangsmåder til kloning af vektor med en specifik nukleinsyresekvens, der er indeholdt i en nukleinsyre, og til syntetisering af et nukleinsyrefragment ud fra et eksisterende nukleinsyrefragment
DK13296A DK175469B1 (da) 1985-03-28 1996-02-09 Fremgangsmåde til multiplikation og påvisning af nukleinsyresekvenser

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK026595A DK171871B1 (da) 1985-03-28 1995-03-17 Fremgangsmåder til kloning af vektor med en specifik nukleinsyresekvens, der er indeholdt i en nukleinsyre, og til syntetisering af et nukleinsyrefragment ud fra et eksisterende nukleinsyrefragment
DK13296A DK175469B1 (da) 1985-03-28 1996-02-09 Fremgangsmåde til multiplikation og påvisning af nukleinsyresekvenser

Country Status (12)

Country Link
EP (1) EP0200362B1 (da)
JP (1) JP2546576B2 (da)
AT (3) ATE206168T1 (da)
AU (1) AU591104B2 (da)
CA (2) CA1340121E (da)
DE (5) DE200362T1 (da)
DK (3) DK171161B1 (da)
ES (3) ES8706823A1 (da)
HK (1) HK84994A (da)
IE (1) IE61304B1 (da)
IL (1) IL78284A (da)
SG (1) SG111293G (da)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1278755C (en) * 1985-03-15 1991-01-08 William J. Knowles Labelling of oligonucleotides
US4808520A (en) * 1985-03-15 1989-02-28 Molecular Diagnostics, Inc. Labelling of oligonucleotides
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4746604A (en) * 1985-05-24 1988-05-24 Enzo Biochem, Inc. Specific binding assays utilizing a viable cell as a label
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
CA1284931C (en) * 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5604099A (en) * 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5356774A (en) * 1986-04-16 1994-10-18 The Trustees Of Columbia University In The City Of New York Replicative RNA-based amplification/detection systems
AU632857C (en) * 1986-08-22 2003-10-09 F. Hoffmann-La Roche Ag Purified thermostable enzyme
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US5079351A (en) * 1986-11-26 1992-01-07 Cetus Corporation Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization
EP0272098A3 (en) * 1986-12-15 1990-06-06 City Of Hope National Medical Center Method for amplification and detection of rna sequences
US5783412A (en) * 1987-02-26 1998-07-21 Biosearch International Pty. Ltd. Method of detection of carcinogenic human papillomavirus
AU622104B2 (en) * 1987-03-11 1992-04-02 Sangtec Molecular Diagnostics Ab Method of assaying of nucleic acids, a reagent combination and kit therefore
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1317535C (en) * 1987-06-30 1993-05-11 Nanibhushan Dattagupta Assay of sequences using amplified genes
US5273879A (en) * 1987-07-23 1993-12-28 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
AU618965B2 (en) * 1987-07-31 1992-01-16 Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
CA1340843C (en) * 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
FR2629458B2 (fr) * 1987-07-31 1991-08-09 Ire Celltarg Sa Nouvelles sondes d'acides nucleiques specifiques de differents types de virus de papillome humain
US6090591A (en) * 1987-07-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
DE3726934A1 (de) * 1987-08-13 1989-02-23 Merck Patent Gmbh Verfahren zum nachweis von nukleinsaeure-sequenzen
US5268267A (en) * 1987-08-21 1993-12-07 The General Hospital Corporation Method for diagnosing small cell carcinoma
JP2634208B2 (ja) * 1987-11-13 1997-07-23 パイオニア・ハイ―ブレツド・インターナシヨナル・インコーポレイテツド 制限断片長多型性分析方法及びその装置
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
FI79342C (fi) * 1987-12-23 1989-12-11 Orion Yhtymae Oy Apparat, del av en apparat och foerfarande foer maongfaldigande av nukleinsyror.
CA1325761C (en) * 1987-12-25 1994-01-04 Takanori Oka Method of detecting an intended nucleic acid in a sample
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
EP0406280A1 (en) * 1988-03-25 1991-01-09 Akzo Nobel N.V. Method for amplifying and detecting nucleic acid in a test liquid
US8148065B1 (en) * 1988-04-06 2012-04-03 City Of Hope Ligation amplification of nucleic acid sequences
IT1224253B (it) * 1988-04-08 1990-09-26 Sclavo Spa Oligonucleotidi sintetici utili per la determinazione di chlamydia trachomatis in un campione biologico
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
GB8818020D0 (en) * 1988-07-28 1988-09-01 Ici Plc Method for amplification of nucleotide sequences
AU629845B2 (en) * 1988-08-30 1992-10-15 Abbott Laboratories Detection and amplification of target nucleic acid sequences
US5091310A (en) * 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
US5766847A (en) * 1988-10-11 1998-06-16 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Process for analyzing length polymorphisms in DNA regions
DE3834636A1 (de) * 1988-10-11 1990-04-19 Max Planck Gesellschaft Verfahren zur analyse von laengenpolymorphismen in dna-bereichen
DE3930312A1 (de) * 1988-10-24 1990-04-26 Max Planck Gesellschaft Verfahren zur direkten sequenzierung von nukleinsaeureketten
US5077192A (en) * 1988-10-25 1991-12-31 The General Hospital Corporation Method of detecting antigenic, nucleic acid-containing macromolecular entities
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
ATE102256T1 (de) * 1988-11-21 1994-03-15 Dynal As Sonden aus nukleinsaeuren.
AU4829690A (en) 1988-12-16 1990-07-10 Siska Diagnostics, Inc. Self-sustained, sequence replication system
GB8902689D0 (en) * 1989-02-07 1989-03-30 Ici Plc Assay method
WO1990009456A1 (de) * 1989-02-16 1990-08-23 Viktor Balazs Malignitätstest (krebs-test) mit verwendung von der polymerasekettenreaktion
WO1990010064A1 (en) * 1989-03-03 1990-09-07 Genentech, Inc. Improved methods for in vitro dna amplification and genomic cloning and mapping
FR2645878B1 (fr) * 1989-04-17 1994-02-25 Institut Nal Sante Recherc Medic Sequences nucleotidiques d'actinomycetales, applications a la synthese ou a la detection d'acides nucleiques, produits d'expression de ces sequences et application en tant que compositions immunogenes
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6969586B1 (en) 1989-05-16 2005-11-29 Scripps Research Institute Method for tapping the immunological repertoire
US6291159B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6680192B1 (en) 1989-05-16 2004-01-20 Scripps Research Institute Method for producing polymers having a preselected activity
US6291160B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6291161B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US5504007A (en) * 1989-05-19 1996-04-02 Becton, Dickinson And Company Rapid thermal cycle apparatus
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5035996A (en) 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
ATE466111T1 (de) 1989-06-02 2010-05-15 Pasteur Institut Nukleotidsequenzen des genoms von retroviren des typs hiv-1, hiv-2 und siv und deren anwendungen, insbesondere zur amplifikation von genomen dieser retroviren und für die in-vitro-diagnostik von durch diese viren ausgelösten infektionen
ES2091225T3 (es) * 1989-07-11 1996-11-01 Gen Probe Inc Metodos para la amplificacion de las secuencias de acidos nucleicos.
FR2651007B1 (fr) * 1989-08-18 1992-09-04 Pasteur Institut Fragments d'acides nucleiques et reactifs de diagnostic derives du genome de hhv6/sie et procede de diagnostic des infections a hhv6
US5213961A (en) * 1989-08-31 1993-05-25 Brigham And Women's Hospital Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction
GB8920097D0 (en) * 1989-09-06 1989-10-18 Ici Plc Amplification processes
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
CA2024978A1 (en) * 1989-09-22 1991-03-23 Annie L. Wu Nucleic acid detection method using unequal primer concentrations in polymerase chain reaction
GB8926269D0 (en) * 1989-11-21 1990-01-10 Dynal As Plasmid
EP0502037A1 (en) * 1989-11-24 1992-09-09 Isis Innovation Limited Prenatal genetic determination
US5436163A (en) * 1989-12-01 1995-07-25 The Blood Center Of Southeastern Wisconsin Polymorphism of human platelet membrane glycoprotein IIb and diagnostic applications thereof
JP3096722B2 (ja) * 1990-01-17 2000-10-10 日本ケミカルリサーチ株式会社 ポリメラーゼ・チェーン・リアクション用プライマーの作製法およびそれを用いるdnaの増幅法
DE4001154A1 (de) * 1990-01-17 1991-07-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von modifizierten nukleinsaeuren
GB9002625D0 (en) * 1990-02-06 1990-04-04 Univ Singapore Human leukocyte antigen typing
WO1991015599A1 (en) * 1990-04-05 1991-10-17 Amrad Corporation Limited A method for detecting dna
WO1991017262A1 (en) * 1990-04-30 1991-11-14 The University Of British Columbia Method of establishing identity
ES2092527T3 (es) 1990-06-08 1996-12-01 Behringwerke Ag Metodo para la determinacion cuantitativa de secuencias de adn.
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
EP0487218B1 (en) * 1990-10-31 1997-12-29 Tosoh Corporation Method for detecting or quantifying target nucleic acid
WO1992007957A1 (en) * 1990-10-31 1992-05-14 Cimino George D Methods and compositions for minimizing inhibition of nucleic acid amplification
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
JP3183510B2 (ja) 1990-12-31 2001-07-09 プロメガ・コーポレイシヨン Rnaレプリカーゼのdna依存性rnaポリメラーゼ活性を用いる核酸増幅
AU8997991A (en) * 1991-01-31 1992-08-06 Becton Dickinson & Company Exonuclease mediated strand displacement amplification
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
ATE163308T1 (de) * 1991-08-28 1998-03-15 Boehringer Mannheim Gmbh Primer für matrizenabhängige enzymatische nukleinsäuresynthesen
DE4129653A1 (de) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh Verfahren zum nachweis aehnlicher nukleinsaeuren
DE4132133A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen herstellung von ribonukleinsaeuren
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
US5612199A (en) * 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
ES2112302T3 (es) 1991-10-11 1998-04-01 Behringwerke Ag Metodo para producir un polinucleotido para uso en amplificacion con un unico cebador y oligonucleotidos que contienen fosforotioato como cebadores para la amplificacion de acidos nucleicos.
US5270184A (en) * 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
FI915731A0 (fi) * 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
DE4212555A1 (de) * 1992-04-15 1993-10-21 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Nukleinsäuren
CA2135073C (en) * 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
WO1994003637A1 (en) * 1992-07-31 1994-02-17 Syntex (Usa) Inc. Method for introducing defined sequences at the 3' end of polynucleotides
DE4236708A1 (de) * 1992-10-30 1994-05-05 Bayer Ag Spezifische Gensonden und Verfahren zur Diagnostik von Candida albicans
DE4302459A1 (de) * 1993-01-29 1994-08-04 Bayer Ag Sulfocumarinhaltige Nukleotide und deren Verwendung in Nachweisverfahren für Nukleinsäuren
US6294323B1 (en) 1993-04-14 2001-09-25 Behringwerke Ag Self initiating single primer amplification of nucleic acids
US5491086A (en) * 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
CA2168245A1 (en) 1993-07-29 1995-02-09 C. Anthony Hunt Polynucleotide decoys that inhibit mhc-ii expression and uses thereof
WO1995025180A1 (en) * 1994-03-16 1995-09-21 Gen-Probe Incorporated Isothermal strand displacement nucleic acid amplification
DE4420732A1 (de) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
DE4421901A1 (de) * 1994-06-23 1996-01-04 Bayer Ag Ein DNA-Schnelltest zum Nachweis von chinolonresistenten Staphylococcus aureus Erregern in klinischem Probenmaterial
EP0752474A1 (en) 1995-07-07 1997-01-08 Boehringer Mannheim Gmbh Nucleic acid coding for CMP-N-acetyl-neuraminic acid hydroxylase and its use for the production of modified glycoproteins
EP0834571A1 (en) 1996-10-03 1998-04-08 Roche Diagnostics GmbH Thermostable nucleic acid polymerase from Thermococcus gorgonarius
JP3689333B2 (ja) 1997-08-08 2005-08-31 アクゾ・ノベル・エヌ・ベー Hiv−1の全てのサブタイプを増幅及び検出するためにプライマー及びプローブとして使用できる核酸配列
JPH11146799A (ja) * 1997-09-10 1999-06-02 Snow Brand Milk Prod Co Ltd 新規プライマー及びその利用
US6103468A (en) * 1997-10-07 2000-08-15 Labatt Brewing Company Limited Rapid two-stage polymerase chain reaction method for detection of lactic acid bacteria in beer
EP1062512A4 (en) 1998-03-10 2001-12-12 Univ California METHODS AND TOOLS USED TO IDENTIFY COMPOUNDS THAT MODULATE ATHEROSCLEROSIS BY ALTERATION OF THE LDL-PROTEOGLYCANE BINDING
AU773765B2 (en) 1998-10-01 2004-06-03 Variagenics, Inc. Methods for treating or identifying a subject at risk for a neurological disease by determining the presence of variant GPIIIA and/or variant GPIIB allele
DE19848665A1 (de) * 1998-10-22 2000-04-27 Bayer Ag Ein automatisierbarer Schnelltest zum direkten Nachweis der APC Resistenz Mutation mit spezifischen Primern und Probes
US20020146728A1 (en) 1998-12-03 2002-10-10 Tanja Ligensa IGF-1 receptor interacting proteins
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
DE19916929A1 (de) 1999-04-15 2000-10-19 Bayer Ag Ein automatisierbarer Schnelltest zum Nachweis von Krebserkrankungen auf der Basis von Telomerase(hTC) mRNA mit spezifischen Primern und Sonden
US20020025519A1 (en) 1999-06-17 2002-02-28 David J. Wright Methods and oligonucleotides for detecting nucleic acid sequence variations
EP1099757B1 (en) 1999-11-11 2010-02-24 F. Hoffmann-La Roche Ag Process for the determination of CTp11 and for determining whether a tumor sample has metatastic potential
AU2001260309A1 (en) 2000-05-19 2001-12-03 F.Hoffmann-La Roche Ag A process for determining the tumoricidal potential of a sample by the use of a nucleic acid which is downregulated in human tumor cells
JP3489053B2 (ja) 2000-08-28 2004-01-19 日本航空電子工業株式会社 ケーブルコネクタ
US6866999B2 (en) 2000-10-10 2005-03-15 Richard Glenn Wunderink Method for identifying increased risk of death from community acquired pneumonia
AU2001297872B2 (en) 2000-11-17 2006-11-09 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
US9394332B2 (en) 2002-08-29 2016-07-19 Epigenomics Ag Method for bisulfite treatment
US20050026168A1 (en) 2002-12-13 2005-02-03 Genesis Group Inc. Method for the detection of risk factors associated with myocardial infarction
WO2004067545A1 (en) 2003-01-29 2004-08-12 Roche Diagnostics Gmbh Improved method for bisulfite treatment
US7501240B2 (en) 2003-12-02 2009-03-10 Roche Molecular Systems, Inc. Method for bisulfite treatment
EP1632578A1 (en) 2004-09-03 2006-03-08 Roche Diagnostics GmbH DNA decontamination method
EP1666150B1 (en) 2004-11-20 2015-01-07 Roche Diagnostics GmbH Nucleic acid preparation
DE602006014106D1 (de) 2005-03-14 2010-06-17 Link Genomics Inc Verfahren zur diagnose von prostatakrebs
EP1882036B1 (en) 2005-05-17 2012-02-15 Ozgene Pty Ltd Sequential cloning system
EP1748081A1 (en) 2005-07-28 2007-01-31 Roche Diagnostics GmbH Analytical method and device
ATE472100T1 (de) 2005-09-06 2010-07-15 Hoffmann La Roche Vorrichtung mit komprimierbarer matrix und homogenem strömungsprofil
EP1798542A1 (en) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytical method and instrument
EP1798650A1 (en) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytical method and instrument
US7981606B2 (en) 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
EP1991694B1 (en) 2006-02-13 2016-04-13 Fluidigm Canada Inc. Element-tagged oligonucleotide gene expression analysis
EP1962084A1 (en) 2007-02-21 2008-08-27 Roche Diagnostics GmbH Apparatus for emitting and detecting beams of light
CN101932927B (zh) 2007-12-06 2012-07-04 新加坡科技研究局 用于进行和监测化学反应的集成装置及其操作方法
JP5049404B2 (ja) 2008-03-31 2012-10-17 エージェンシー フォー サイエンス, テクノロジー アンド リサーチ 相互接続マルチチャンバデバイスを使用する流体処理および移送の方法
EP2127751B1 (en) 2008-05-19 2012-05-16 Roche Diagnostics GmbH Improved cooler / heater arrangement with solid film lubricant
BR122013014156A2 (pt) 2008-11-11 2015-07-14 Danisco Us Inc Composição de limpeza compreendendo variantes de subtilisina, bem como processo de limpeza
BR122013014157A2 (pt) 2008-11-11 2018-11-13 Danisco Us Inc. composições de limpeza compreendendo variantes de subtilisina de bacillus, bem como processo de limpeza
EP2371951A4 (en) 2008-11-27 2012-07-18 Riken NOVEL MUTS PROTEIN AND METHOD OF USING SAME FOR DETERMINING MUTATIONS
US8852912B2 (en) 2009-04-01 2014-10-07 Danisco Us Inc. Compositions and methods comprising alpha-amylase variants with altered properties
WO2011072099A2 (en) 2009-12-09 2011-06-16 Danisco Us Inc. Compositions and methods comprising protease variants
BR112012028466B1 (pt) 2010-05-06 2020-03-17 The Procter & Gamble Company Composição de produtos com variantes de protease e método para tratar e/ou limpar uma superfície
CA2834865C (en) 2011-05-05 2021-03-09 Danisco Us Inc. Compositions and methods comprising serine protease variants
US20140287477A1 (en) 2011-10-28 2014-09-25 Danisco Us Inc. Variant Maltohexaose-Forming Alpha-Amylase Variants
US20140342431A1 (en) 2011-12-22 2014-11-20 Danisco Us Inc. Variant Alpha-Amylases and Methods of Use, Thereof
ES2909509T3 (es) 2012-06-08 2022-05-06 Danisco Us Inc Variante de alfa-amilasas con mayor actividad en polímeros de almidón
ES2865080T3 (es) 2012-10-12 2021-10-14 Danisco Us Inc Composiciones y métodos que comprenden una variante de enzima lipolítica
EP2971123B1 (en) 2013-03-15 2021-05-05 Labrador Diagnostics LLC Nucleic acid amplification
EP3587592A1 (en) 2013-03-15 2020-01-01 Theranos IP Company, LLC Nucleic acid amplification
EP3042208A4 (en) 2013-09-06 2017-04-19 Theranos, Inc. Systems and methods for detecting infectious diseases
EP2889382A1 (en) 2013-12-30 2015-07-01 Centrum Badan DNA Sp. z o.o. Oligonucleotides, use thereof, methods and a kit for detection of DNA Borrelia burgdorferi, Bartonella henselae, Babesia divergens, Anaplasma phagocytophilum
EP3957996A1 (en) * 2015-10-05 2022-02-23 The University of North Carolina at Chapel Hill Fluidic devices, kits, and solid supports for decoding methods for multiplexing assays
JP7181522B2 (ja) * 2018-09-18 2022-12-01 国立研究開発法人農業・食品産業技術総合研究機構 プライマーセット、及びそれを用いた標的ヌクレオチド配列の増幅方法
CN114729346A (zh) 2019-09-13 2022-07-08 丹尼斯科美国公司 热稳定的葡萄糖异构酶变体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4351901A (en) * 1980-03-24 1982-09-28 Cetus Corporation Method for single nucleotide alteration
EP0138242A1 (en) * 1983-09-07 1985-04-24 Duphar International Research B.V Method of preparing DNA complementary to the genome of coronaviruses
AU577334B2 (en) * 1983-10-11 1988-09-22 International Genetic Engineering, Inc. Synthetic thaumatin genes
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin

Also Published As

Publication number Publication date
ES557287A0 (es) 1987-10-16
ES557288A0 (es) 1987-10-16
DE3650762D1 (de) 2001-10-31
DE3687537D1 (de) 1993-03-04
EP0200362A3 (en) 1987-02-25
CA1340121E (en) 1998-11-10
ES553468A0 (es) 1987-06-16
DE200362T1 (de) 1992-04-09
SG111293G (en) 1994-02-25
ES8800357A1 (es) 1987-10-16
JP2546576B2 (ja) 1996-10-23
ES8800356A1 (es) 1987-10-16
IE61304B1 (en) 1994-10-19
EP0200362B1 (en) 1993-01-20
AU591104B2 (en) 1989-11-30
DE3650763D1 (de) 2001-10-31
DE3650762T2 (de) 2002-07-04
IL78284A0 (en) 1986-07-31
IE860843L (en) 1986-09-28
IL78284A (en) 1991-09-16
DK175469B1 (da) 2004-11-01
CA1291429C (en) 1991-10-29
HK84994A (en) 1994-08-26
EP0200362A2 (en) 1986-11-05
DK171871B1 (da) 1997-07-21
ES8706823A1 (es) 1987-06-16
ATE206168T1 (de) 2001-10-15
AU5532386A (en) 1986-10-02
DK144986A (da) 1986-09-29
ATE206169T1 (de) 2001-10-15
DK26595A (da) 1995-03-17
DK13296A (da) 1996-02-09
DE3687537T2 (de) 1993-05-13
DK171161B1 (da) 1996-07-08
JPH067166A (ja) 1994-01-18
ATE84822T1 (de) 1993-02-15
DE502589T1 (de) 1993-09-23

Similar Documents

Publication Publication Date Title
DK144986D0 (da) Fremgangsmaade til detektering af en nukleinsyresekvens og middel til udoevelse af fremgangsmaaden samt fremgangsmaader til kloning af vektormed en specifik nukleinsyresekvens henholdsvis til syntetisering afet nukleinsyrefragment
NO895090D0 (no) Fremgangsmaate og system for deteksjonsdiagnostisering.
PT92602A (pt) Processo de preparacao de um adn de cadeia dupla, de deteccao de sequencias de acido nucleico alvo e de amplificacao de uma sequencia de acido nucleico alvo
FI972992A0 (fi) In vitro -foerfarande foer producering av sekvenseringstemplat
DE3850093T2 (de) Verfahren zur Amplifizierung von Nukleinsäuren.
Sorge et al. ExoMeth sequencing of DNA: eliminating the need for subcloning and oligonucleotide primers.
ATE231922T1 (de) Modifizierung von oligonukleotid-primer-sequenzen zum manipilieren der zugabe von nicht-template- nukleotiden

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired
PUP Patent expired