DK1448181T3 - Farmaceutisk præparat som omfatter en kombination af metformin og en 4-oxobutansyre og anvendelse deraf til behandling af diabetes - Google Patents

Farmaceutisk præparat som omfatter en kombination af metformin og en 4-oxobutansyre og anvendelse deraf til behandling af diabetes

Info

Publication number
DK1448181T3
DK1448181T3 DK02787576T DK02787576T DK1448181T3 DK 1448181 T3 DK1448181 T3 DK 1448181T3 DK 02787576 T DK02787576 T DK 02787576T DK 02787576 T DK02787576 T DK 02787576T DK 1448181 T3 DK1448181 T3 DK 1448181T3
Authority
DK
Denmark
Prior art keywords
alkyl
aryl
metformin
diabetes
pharmaceutical composition
Prior art date
Application number
DK02787576T
Other languages
English (en)
Inventor
Dominique Marais
Gerard Moinet
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1448181T3 publication Critical patent/DK1448181T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK02787576T 2001-11-28 2002-11-06 Farmaceutisk præparat som omfatter en kombination af metformin og en 4-oxobutansyre og anvendelse deraf til behandling af diabetes DK1448181T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0115398A FR2832633B1 (fr) 2001-11-28 2001-11-28 Composition pharmaceutique comprenant une association metformine et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete

Publications (1)

Publication Number Publication Date
DK1448181T3 true DK1448181T3 (da) 2006-09-04

Family

ID=8869889

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02787576T DK1448181T3 (da) 2001-11-28 2002-11-06 Farmaceutisk præparat som omfatter en kombination af metformin og en 4-oxobutansyre og anvendelse deraf til behandling af diabetes

Country Status (22)

Country Link
US (1) US20050020609A1 (da)
EP (1) EP1448181B1 (da)
JP (1) JP2005515984A (da)
KR (1) KR20040058266A (da)
CN (1) CN1592615A (da)
AT (1) ATE327746T1 (da)
AU (1) AU2002351848A1 (da)
BR (1) BR0214487A (da)
CA (1) CA2468280A1 (da)
CY (1) CY1105165T1 (da)
DE (1) DE60211938T2 (da)
DK (1) DK1448181T3 (da)
ES (1) ES2266605T3 (da)
FR (1) FR2832633B1 (da)
HU (1) HUP0402241A2 (da)
MX (1) MXPA04005033A (da)
PL (1) PL369894A1 (da)
PT (1) PT1448181E (da)
RU (1) RU2004119817A (da)
TW (1) TW200300341A (da)
WO (1) WO2003045368A1 (da)
ZA (1) ZA200405021B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117855A1 (ja) * 2004-06-04 2005-12-15 Kowa Company., Ltd. 糖尿病の予防または治療のための薬剤
EP1792580A1 (en) 2005-09-27 2007-06-06 Ziterion GmbH Two-part dental implants made of biocompatible ceramics
EP1967157A1 (en) 2007-03-05 2008-09-10 Ziterion GmbH Hybrid two-part dental implant
EP2106767A1 (en) 2008-03-31 2009-10-07 Ziterion GmbH Two-part dental implant
GB201004058D0 (en) * 2010-03-11 2010-04-28 Consiglio Nazionale Ricerche Diagnostic assay for obesity and related disorders
WO2020064857A1 (en) * 2018-09-28 2020-04-02 Société des Produits Nestlé S.A. Compounds that enhance the action of metformin
CN114349665B (zh) * 2021-11-30 2023-06-09 潍坊博创国际生物医药研究院 二甲双胍焦谷氨酸晶体及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863915A (en) * 1996-05-15 1999-01-26 Bayer Corporation Substituted 4-arylbutyric acid derivatives as matrix metalloprotease
FR2752422B1 (fr) * 1996-08-16 1998-11-06 Lipha Composition pharmaceutique contenant des acides 4-oxo-butanoiques
US6011049A (en) * 1997-02-19 2000-01-04 Warner-Lambert Company Combinations for diabetes
GB9922710D0 (en) * 1999-09-24 1999-11-24 Bayer Ag Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatatives for the treatment of multiple sclerosis
US6296874B1 (en) * 2000-05-01 2001-10-02 Aeropharm Technology Incorporated Core formulation comprising troglitazone and abiguanide

Also Published As

Publication number Publication date
BR0214487A (pt) 2004-10-19
HUP0402241A2 (hu) 2005-02-28
RU2004119817A (ru) 2005-04-20
DE60211938T2 (de) 2007-05-24
EP1448181A1 (en) 2004-08-25
CA2468280A1 (en) 2003-06-05
MXPA04005033A (es) 2004-08-11
KR20040058266A (ko) 2004-07-03
EP1448181B1 (en) 2006-05-31
PL369894A1 (en) 2005-05-02
CN1592615A (zh) 2005-03-09
FR2832633A1 (fr) 2003-05-30
JP2005515984A (ja) 2005-06-02
ATE327746T1 (de) 2006-06-15
CY1105165T1 (el) 2010-03-03
AU2002351848A1 (en) 2003-06-10
DE60211938D1 (de) 2006-07-06
ZA200405021B (en) 2005-05-30
PT1448181E (pt) 2006-10-31
ES2266605T3 (es) 2007-03-01
WO2003045368A1 (en) 2003-06-05
US20050020609A1 (en) 2005-01-27
FR2832633B1 (fr) 2004-09-24
TW200300341A (en) 2003-06-01

Similar Documents

Publication Publication Date Title
DK1263722T3 (da) Farmaceutiske sammensætninger, som indeholder azetidinderivat, nye azetidinderivater og fremstilling deraf
AR036045A1 (es) Amidas de acidos antranilicos con cadena lateral de heteroarilsulfonilo, su empleo para la preparacion de un medicamento, asi como composiciones farmaceuticas que las contienen
RU2006138019A (ru) Улучшенный способ отбеливания зубов
DE602005007339D1 (de) Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivolol
AR042658A1 (es) Derivados de 1,5-diaril-pirrol-3-carboxamida y su uso como moduladores de receptores canabinoides
NO20030619L (no) Prolinderivater og anvendelse derav som legemidler
WO2003024955A3 (en) Small molecule inhibitors of caspases
RS24604A (en) Herbicides containing substituted thien- 3-yl-sulfonylamino (thio)carbonyl- triazolin(thi)one
ATE355075T1 (de) Behandlung der glykogenspeicherkrankheit typ ii
DK1448181T3 (da) Farmaceutisk præparat som omfatter en kombination af metformin og en 4-oxobutansyre og anvendelse deraf til behandling af diabetes
EP1314719A4 (en) BENZOIC ACID DERIVATIVES AND MEDICAMENTS HAVING THE SAME AS ACTIVE INGREDIENT
ATE364586T1 (de) Steigerung der wirksamkeit von wirkstoffen durch micellare zubereitung mit retinolderivaten
SE0002476D0 (sv) New compounds
DK2316454T3 (da) Doseringsform indeholdende pantoprazol som aktiv bestanddel
EA200701805A1 (ru) Состав аэрозоля для дозирующих ингаляторов под давлением
DE502004005055D1 (de) Oxaliplatinlösungskonzentrate
FR2848851B1 (fr) Procede d'obtention d'un principe actif presentant des capacites apaisantes, principe actif et compositions obtenues
EA200300272A1 (ru) Новые производные хиназолина, способ их получения и фармацевтические композиции, содержащие их
DE60230629D1 (de) Verwendung von 2,5-dihydroxybenzolsulfonsäure-derivaten bei der herstellung eines medikaments zur verstärkung der wirkung anderer arzneimittel zur behandlung der erektilen dysfunktion
DE50111407D1 (de) Mittel enthaltend n-chlortaurin sowie dessen verwendung zur behandlung von schleimhautpolypen
BRPI0406840A (pt) Derivados de acil-fenil-uréia substituìdos por carbonilamino, processos para a sua preparação e sua aplicação
NO20050834L (no) Ny indolinforbindelse og medisinsk anvendelse derav
ATE366234T1 (de) Neue substanz mit antitumorwirkung/entzündungshemmender wirkung
SE0501490L (sv) En sammansättning för behanding av ytor och användning därav
RU2003114406A (ru) Витаминная композиция