DK141753B - Analogifremgangsmåde til fremstilling af azaspirodecan- og -undecandionderivater eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af azaspirodecan- og -undecandionderivater eller syreadditionssalte deraf. Download PDF

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Publication number
DK141753B
DK141753B DK589670AA DK589670A DK141753B DK 141753 B DK141753 B DK 141753B DK 589670A A DK589670A A DK 589670AA DK 589670 A DK589670 A DK 589670A DK 141753 B DK141753 B DK 141753B
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formula
cha
compounds
compound
carbon atoms
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DK589670AA
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Danish (da)
English (en)
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DK141753C (xx
Inventor
Yao Hua Wu
James Warren Rayburn
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Bristol Myers Co
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Publication of DK141753B publication Critical patent/DK141753B/da
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Publication of DK141753C publication Critical patent/DK141753C/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK589670AA 1969-11-24 1970-11-20 Analogifremgangsmåde til fremstilling af azaspirodecan- og -undecandionderivater eller syreadditionssalte deraf. DK141753B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87960469 1969-11-24
US00879604A US3717634A (en) 1969-11-24 1969-11-24 N-(heteroarcyclic)piperazinylalkyl-azaspiroalkanediones

Publications (2)

Publication Number Publication Date
DK141753B true DK141753B (da) 1980-06-09
DK141753C DK141753C (xx) 1980-11-24

Family

ID=25374483

Family Applications (1)

Application Number Title Priority Date Filing Date
DK589670AA DK141753B (da) 1969-11-24 1970-11-20 Analogifremgangsmåde til fremstilling af azaspirodecan- og -undecandionderivater eller syreadditionssalte deraf.

Country Status (14)

Country Link
US (2) US3717634A (xx)
BE (1) BE759371A (xx)
CH (2) CH552607A (xx)
CY (1) CY886A (xx)
DE (1) DE2057845A1 (xx)
DK (1) DK141753B (xx)
ES (1) ES530335A0 (xx)
FR (1) FR2073406B1 (xx)
GB (1) GB1332194A (xx)
HK (1) HK6177A (xx)
KE (1) KE2691A (xx)
MY (1) MY7700151A (xx)
NL (1) NL7017031A (xx)
ZA (1) ZA707826B (xx)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4123538A (en) * 1977-08-30 1978-10-31 Mcneil Laboratories, Incorporated (2-Amino-2-oxoethoxy)acetic acid compounds, compositions and methods
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4261990A (en) * 1979-03-09 1981-04-14 Ciba-Geigy Corporation N-alkyleneiminoalkyl-dicarboximides as antiallergics and antiasthmatics
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
US4351939A (en) * 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
US4417049A (en) * 1980-10-16 1983-11-22 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
CA1172255A (en) * 1980-12-11 1984-08-07 Robert R. Covington Buspirone process
US4320131A (en) * 1981-03-16 1982-03-16 Mead Johnson & Company N-[(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)alkylene]azaspiroalkanediones and N-[(4-hydroxy-4-phenylpiperidin-1-yl)alkylene]azaspiroalkanediones
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
US4456756A (en) * 1981-08-03 1984-06-26 Mead Johnson & Company Spirothiazolidinyl piperazine derivatives
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4361565A (en) * 1981-12-28 1982-11-30 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
US4409223A (en) * 1982-08-06 1983-10-11 Riblet Leslie A Anxiolytic method
US4620006A (en) * 1982-08-11 1986-10-28 Eastman Kodak Company Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines
US4620002A (en) * 1982-08-11 1986-10-28 Eastman Kodak Company 2-pyrimidyl alkanesulfonates
US4515947A (en) * 1982-08-11 1985-05-07 Eastman Kodak Company Cyanoalkylpiperazines and methods for their preparation and use
JPS5976059A (ja) * 1982-10-21 1984-04-28 Sumitomo Chem Co Ltd 環状イミド誘導体及びその酸付加塩
US4438119A (en) 1982-12-23 1984-03-20 Mead Johnson & Company Method for alleviation of extrapyramidal motor disorders
FR2540499B1 (fr) * 1983-02-07 1986-09-26 Bristol Myers Co Derive de 5-fluoro-pyrimidine-2-yl piperazine antipsychotique
US4581357A (en) * 1983-02-07 1986-04-08 Mead Johnson & Company Antipsychotic 5-fluoro-pyrimidin-2-yl piperazine compound
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
CA1250291A (en) * 1984-07-23 1989-02-21 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)-piperazinyl derivatives of 1-pyrrolidin-2-ones
US4612312A (en) * 1984-07-30 1986-09-16 Merrell Dow Pharmaceuticals Inc. Glutarimide antianxiety and antihypertensive agents
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
US4677104A (en) * 1985-05-06 1987-06-30 Bristol-Myers Company Antipsychotic fused-ring pyridinylpiperazine derivatives
HUT43600A (en) * 1985-06-22 1987-11-30 Sandoz Ag Process for production of new thiazole derivatives and medical compound containing those
NZ216720A (en) * 1985-07-08 1990-09-26 Bristol Myers Co Diazinylpiperidine derivatives and pharmaceutical compositions
US4826843A (en) * 1985-07-08 1989-05-02 Bristol-Myers Cerebral function enhancing diazinylpiperidine derivatives
US4812567A (en) * 1985-10-16 1989-03-14 American Home Products Corporation Polycyclic spiroimides with psychotropic activity
US4634703A (en) * 1985-10-25 1987-01-06 Bristol-Myers Company Method for alleviation of panic disorders
US4640921A (en) * 1986-02-04 1987-02-03 Bristol-Myers Treatment of sexual dysfunction with buspirone
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
ZA871449B (en) * 1986-03-05 1987-08-20 Merrell Dow Pharmaceutical Inc. Aromatic omega-alkylimino-tetrahydro-6h-1,3-thiazin-6-one derivatives
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
US4687772A (en) * 1986-10-07 1987-08-18 Bristol-Myers Company Method for improvement of short term memory
PL152958B1 (en) * 1987-02-25 1991-02-28 Egyt Gyogyszervegyeszeti Gyar Method for manufacturing piperazine derivatives
US4777173A (en) * 1987-03-25 1988-10-11 Bristol-Myers Company Method for treatment of alcohol abuse
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides
US4748240A (en) * 1987-04-03 1988-05-31 American Home Products Corporation Psychotropic bicyclic imides
US4732983A (en) * 1987-04-03 1988-03-22 American Home Products Corporation Pyschotropic polycyclic imides
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
SE8704097D0 (sv) * 1987-10-22 1987-10-22 Astra Ab Oral formulation of buspirone and salts thereof
HU208690B (en) * 1987-10-26 1993-12-28 Pfizer Process for producing 1-hjeterocyclic sulfonyl-3-(pyrimidinyl piperazinyl)-propane derivatives and pharmaceutical compositions comprising same
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
US5116970A (en) * 1988-02-18 1992-05-26 New James S Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US5242911A (en) * 1988-06-17 1993-09-07 Pfizer Inc. Bridged bicyclic imides as anxiolytics and antidepressants
US4859671A (en) * 1988-07-08 1989-08-22 American Home Products Corporation 2-substituted 1,2-benzisothiazol-3(2H)-one 1,1-dioxide useful as an anxiolytic agent
US5468749A (en) * 1988-08-30 1995-11-21 Gawin; Frank H. Method for treatment of substance addiction
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
WO1990006303A1 (en) * 1988-12-02 1990-06-14 Pfizer Inc. Arylpiperidine derivatives
US4873331A (en) * 1988-12-09 1989-10-10 American Home Products Corporation Noradamantyl-carboxylic acid piperazinoalkyl esters
US4882432A (en) * 1989-01-09 1989-11-21 American Home Products Corporation Polycyclic-carbamic acid piperazinoalkyl esters and amides
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
US5340812A (en) * 1989-04-22 1994-08-23 John Wyeth & Brother, Limited Piperazine derivatives
HU212301B (en) * 1989-04-28 1996-05-28 Alkaloida Vegyeszeti Gyar Process for producing buspirone
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
FR2654934B1 (fr) * 1989-11-29 1994-09-30 Midy Spa Utilisation de derive [4-(2-pyrimidinyl)-1-piperazinyl] butyliques pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale.
US6432956B1 (en) 1990-02-12 2002-08-13 William C. Dement Method for treatment of sleep apneas
ES2019228A6 (es) * 1990-02-13 1991-06-01 Espanola Prod Quimicos Procedimiento de obtencion de nuevos derivados de azaspiro (4.5) decano-7, 9-diona.
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5098904A (en) * 1990-06-27 1992-03-24 Bristol-Myers Squibb Company Cerebral function enhancing pyrimidinyl derivatives
DE69116302T2 (de) * 1990-10-23 1996-05-30 Akzo Nobel Nv 4-[4- oder 6-(Trifluormethyl-2-pyridinyl)]-1-piperazinyl-alkyl substituierte Laktame
SU1825501A3 (ru) * 1990-10-29 1995-12-10 И.В. Комиссаров Dl-3-[(4-[4- (2-пиридил)-1- пиперазинил]бутил)] -1,8,8-триметил -3-азабицикло[3,2,1] октан-2,4-диона дигидрохлорид, проявляющий противотревожную, нейролептическую и противорвотную активность
US5633009A (en) * 1990-11-28 1997-05-27 Sano Corporation Transdermal administration of azapirones
US5431922A (en) * 1991-03-05 1995-07-11 Bristol-Myers Squibb Company Method for administration of buspirone
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
US5137894A (en) * 1991-12-05 1992-08-11 New James S 4-(4-Piperidinyl-thieno[3,2-c]pyridine derivatives of n-alkylglutarimides
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
ATE241359T1 (de) * 1993-03-26 2003-06-15 Beth Israel Hospital Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5338738A (en) * 1993-04-19 1994-08-16 Bristol-Myers Squibb Company Cerebral function enhancers: acyclic amide derivatives of pyrimidinylpiperidines
HU217129B (hu) * 1993-07-16 1999-11-29 EGIS Gyógyszergyár Rt. Eljárás nagy tisztaságú buspiron gyógyászati hatóanyag előállítására
US5391570A (en) * 1993-10-14 1995-02-21 Bristol-Myers Squibb Aminomethyl-benzodioxane and benzopyran serotonergic agents
KR950014099A (ko) * 1993-11-10 1995-06-15 장기하 N-(2-피리미딜)피페라지닐 부틸아미드의 제조방법
US5538985A (en) * 1994-01-27 1996-07-23 Mitsui Toatsu Chemicals, Inc. Pyrrolidinone derivatives
US5521313A (en) * 1994-05-05 1996-05-28 Bristol-Myers Squibb Company Process for preparing certain azapirones
WO1996006846A1 (es) * 1994-09-01 1996-03-07 Universidad Complutense De Madrid Nuevos derivados de arilpiperazinas
ES2095811B1 (es) * 1995-07-28 1997-08-01 Univ Madrid Complutense Nuevos derivados de arilpiperazinas.
ES2082727B1 (es) * 1994-09-01 1996-10-16 Univ Madrid Complutense Nuevos derivados de arilpiperazinas.
US5602128A (en) * 1994-12-02 1997-02-11 American Home Products Corporation N-heterocycloalkyl carboxamides as serotonergic agents
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
AU5101798A (en) * 1996-12-04 1998-06-29 Bristol-Myers Squibb Company Method for oral administration of buspirone
US5922341A (en) * 1997-10-28 1999-07-13 Vivus, Incorporated Local administration of pharmacologically active agents to treat premature ejaculation
US6037360A (en) * 1997-10-28 2000-03-14 Vivus, Incorporated Administration of 5-HT3 receptor antagonists to treat premature ejaculation
US6228864B1 (en) 1997-10-28 2001-05-08 Vivus, Inc. Administration of 5-HT receptor agonists and antagonists, to treat premature ejaculation
US6376494B1 (en) * 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US6312717B1 (en) 1998-07-07 2001-11-06 Bristol-Myers Squibb Company Method for treatment of anxiety and depression
AU4683499A (en) * 1998-07-30 2000-02-21 Bristol-Myers Squibb Company Improved method for treatment of sleep-related respiratory disorders
US6313114B1 (en) 1999-01-07 2001-11-06 American Home Products Corp 3,4-Dihydro-2H-benzo[1,4]oxazinyl-methyl)-[3-(1H-indol-3yl)-alkyl]- amines
US6306859B1 (en) 1999-03-02 2001-10-23 American Home Products Corporation N-substituted imide derivatives with serotonergic activity
US6566361B2 (en) 1999-06-30 2003-05-20 Laboratories, Upsa Azapirone pain treatment
US20050137206A1 (en) * 1999-08-05 2005-06-23 Yevich Joseph P. Method for treatment of anxiety and depression
US6150365A (en) * 1999-08-05 2000-11-21 Bristol-Myers Squibb Company Anxiety method
US20030069251A1 (en) * 1999-08-05 2003-04-10 Yevich Joseph P. Antianxiety composition
JP2003517468A (ja) 1999-11-12 2003-05-27 ワイス セロトニン5−ht1a活性を有する分枝アダマンチルおよびノルアダマチルアリール−およびアラルキルピペラジン
US6831084B1 (en) 1999-11-12 2004-12-14 Wyeth Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
ATE374192T1 (de) * 2000-11-29 2007-10-15 Lilly Co Eli 1-(2-m-methansulfonamidophenylethyl)-4-(m- trifluoromethylphenyl)piperazine und ihre akzeptablen pharmazeutischen salze und solvate und ihre verwendung zur behandlung von inkontinenz
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
US7067518B2 (en) * 2002-09-05 2006-06-27 Wyeth Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
US20080217501A1 (en) * 2007-02-14 2008-09-11 Chad Jensen Power a-frame
TW200904437A (en) 2007-02-14 2009-02-01 Janssen Pharmaceutica Nv 2-aminopyrimidine modulators of the histamine H4 receptor
US20090023744A1 (en) * 2007-06-18 2009-01-22 The General Hospital Corporation Combination therapy for depression
JP5439377B2 (ja) * 2007-09-14 2014-03-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンh4受容体のチエノ−及びフロ−ピリミジン調節物質
PE20110061A1 (es) 2008-06-12 2011-01-31 Janssen Pharmaceutica Nv Derivados de diamino-piridina, pirimidina y piridazina como moduladores del receptor h4 de histamina
BRPI1003506B1 (pt) 2010-09-24 2019-12-03 Ache Int Bvi Ltd composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a
HUE031661T2 (en) 2010-10-15 2017-07-28 Contera Pharma Aps Combinations of serotonin receptor agonists for the treatment of movement disorders
NZ700474A (en) 2012-04-18 2016-10-28 Contera Pharma Aps Orally available pharmaceutical formulation suitable for improved management of movement disorders
CN109689036A (zh) 2016-07-11 2019-04-26 康特拉医药公司 用于治疗早晨运动不能的脉冲药物输送系统

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL143925C (xx) * 1965-03-09
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation

Also Published As

Publication number Publication date
CH552607A (de) 1974-08-15
MY7700151A (en) 1977-12-31
NL7017031A (xx) 1971-05-26
BE759371A (fr) 1971-05-24
KE2691A (en) 1977-03-04
US3907801A (en) 1975-09-23
FR2073406B1 (xx) 1974-10-11
US3717634A (en) 1973-02-20
FR2073406A1 (xx) 1971-10-01
GB1332194A (en) 1973-10-03
ES8505251A3 (es) 1985-05-16
DK141753C (xx) 1980-11-24
CH552608A (de) 1974-08-15
CY886A (en) 1977-03-18
ZA707826B (en) 1971-07-28
DE2057845A1 (de) 1971-06-09
ES530335A0 (es) 1985-05-16
HK6177A (en) 1977-02-04

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