DK1417493T3 - Kompetitiv bindingsassay til identifikation af inhibitorer af HCV-polymerase - Google Patents

Kompetitiv bindingsassay til identifikation af inhibitorer af HCV-polymerase

Info

Publication number
DK1417493T3
DK1417493T3 DK02753998.0T DK02753998T DK1417493T3 DK 1417493 T3 DK1417493 T3 DK 1417493T3 DK 02753998 T DK02753998 T DK 02753998T DK 1417493 T3 DK1417493 T3 DK 1417493T3
Authority
DK
Denmark
Prior art keywords
sup
sub
alkyl
hcv polymerase
het
Prior art date
Application number
DK02753998.0T
Other languages
English (en)
Inventor
Pierre L Beaulieu
Ginette Mckercher
George Kukolj
Original Assignee
Boehringer Ingelheim Ca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Ca Ltd
Application granted granted Critical
Publication of DK1417493T3 publication Critical patent/DK1417493T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/18Togaviridae; Flaviviridae
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/91245Nucleotidyltransferases (2.7.7)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DK02753998.0T 2001-08-07 2002-08-05 Kompetitiv bindingsassay til identifikation af inhibitorer af HCV-polymerase DK1417493T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31027201P 2001-08-07 2001-08-07
PCT/CA2002/001214 WO2003014377A2 (en) 2001-08-07 2002-08-05 Competitive binding assay for identifying inhibitors of hcv polymerase

Publications (1)

Publication Number Publication Date
DK1417493T3 true DK1417493T3 (da) 2010-10-04

Family

ID=23201740

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02753998.0T DK1417493T3 (da) 2001-08-07 2002-08-05 Kompetitiv bindingsassay til identifikation af inhibitorer af HCV-polymerase

Country Status (13)

Country Link
US (1) US7294457B2 (da)
EP (1) EP1417493B1 (da)
JP (1) JP4646514B2 (da)
AT (1) ATE475095T1 (da)
CA (1) CA2450142C (da)
DE (1) DE60237089D1 (da)
DK (1) DK1417493T3 (da)
ES (1) ES2347954T3 (da)
HU (1) HUP0400670A3 (da)
IL (1) IL159981A0 (da)
MX (1) MXPA04001127A (da)
NZ (2) NZ531488A (da)
WO (1) WO2003014377A2 (da)

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EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2004100947A2 (en) 2003-05-06 2004-11-25 Smithkline Beecham Corporation Novel chemical compounds
US7511145B2 (en) 2003-08-01 2009-03-31 Genelabs Technologies, Inc. Bicyclic heteroaryl derivatives
KR101237172B1 (ko) 2003-11-10 2013-02-25 스태츠 칩팩, 엘티디. 범프-온-리드 플립 칩 인터커넥션
US8129841B2 (en) 2006-12-14 2012-03-06 Stats Chippac, Ltd. Solder joint flip chip interconnection
US9029196B2 (en) 2003-11-10 2015-05-12 Stats Chippac, Ltd. Semiconductor device and method of self-confinement of conductive bump material during reflow without solder mask
USRE47600E1 (en) 2003-11-10 2019-09-10 STATS ChipPAC Pte. Ltd. Semiconductor device and method of forming electrical interconnect with stress relief void
US8026128B2 (en) 2004-11-10 2011-09-27 Stats Chippac, Ltd. Semiconductor device and method of self-confinement of conductive bump material during reflow without solder mask
US8216930B2 (en) 2006-12-14 2012-07-10 Stats Chippac, Ltd. Solder joint flip chip interconnection having relief structure
US8574959B2 (en) 2003-11-10 2013-11-05 Stats Chippac, Ltd. Semiconductor device and method of forming bump-on-lead interconnection
EP1688420A4 (en) * 2003-11-19 2008-10-22 Japan Tobacco Inc 5-5 LOW-CONDENSED HETEROCYCLIC COMPOUND AND THEIR USE AS HCV POLYMERASE INHIBITOR
US20050222198A1 (en) 2003-12-22 2005-10-06 K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
DK1718608T3 (da) * 2004-02-20 2013-10-14 Boehringer Ingelheim Int Virale polymeraseinhibitorer
EP2206715A1 (en) * 2004-02-24 2010-07-14 Japan Tobacco, Inc. Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
MX2007000481A (es) * 2004-07-14 2007-03-29 Ptc Therapeutics Inc Metodos para tratar hepatitis c.
ES2324794T3 (es) * 2004-12-21 2009-08-14 Gilead Sciences Inc Imidazo(4,5-c)pyridine componente y metodo de tratamiento antiviral.
JP4792048B2 (ja) 2005-03-02 2011-10-12 ファイブロゲン インコーポレイティッド チエノピリジン化合物およびその使用方法
US8841779B2 (en) 2005-03-25 2014-09-23 Stats Chippac, Ltd. Semiconductor device and method of forming high routing density BOL BONL and BONP interconnect sites on substrate
JP2008535225A (ja) 2005-03-25 2008-08-28 スタッツ チップパック リミテッド 基板上に狭い配線部分を有するフリップチップ配線
CA2618682C (en) * 2005-08-12 2011-06-21 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
ZA200806752B (en) * 2006-01-27 2009-10-28 Fibrogen Inc Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (HIF)
AU2007234408B2 (en) * 2006-04-04 2011-05-19 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as HIF modulators
PT2038275E (pt) * 2006-07-07 2010-04-08 Puerstinger Gerhard Novo composto de piridazina e sua utilização
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
US8927591B2 (en) 2008-11-14 2015-01-06 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
MX2015003653A (es) 2012-09-21 2015-09-25 Sanofi Sa Derivados de amida del acido benzoimidazol-carboxilico como moduladores del receptor apj.
ES2694297T3 (es) 2013-01-24 2018-12-19 Fibrogen, Inc. Formas cristalinas de ácido {[1-ciano-5-(4-clorofenoxi)-4-hidroxi-isoquinolina-3-carbonilo]-amino}-acético
WO2017136727A2 (en) 2016-02-05 2017-08-10 Denali Therapeutics Inc. Compounds, compositions and methods
HRP20220636T1 (hr) 2016-12-09 2022-07-22 Denali Therapeutics Inc. Spojevi korisni kao inhibitori ripk1
TW202334089A (zh) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Pparg反向激動劑及其用途
TW202334164A (zh) 2022-01-12 2023-09-01 美商戴納立製藥公司 (S)-5-苄基-N-(5-甲基-4-側氧基-2,3,4,5-四氫吡啶並[3,2-b][1,4]氧氮呯-3-基)-4H-1,2,4-三唑-3-甲醯胺的晶型

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2334161A1 (en) * 1998-07-20 2000-01-27 Ribozyme Pharmaceuticals, Inc. Use of nucleic acid molecules as antiviral agents
JP2001069995A (ja) * 1999-07-02 2001-03-21 Japan Tobacco Inc 結晶構造解析に適したhcvポリメラーゼ及びその利用方法
US6770666B2 (en) * 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
CN1167680C (zh) 1999-12-27 2004-09-22 日本烟草产业株式会社 稠环化合物及其药物用途
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
NZ528644A (en) 2001-03-08 2005-05-27 Boehringer Ingelheim Ca Ltd A method for identifying a potential inhibitor of the binding between a HCV NS5B RNA-dependent RNA polymerase and an appropriate primer-template
JP4558314B2 (ja) 2001-07-20 2010-10-06 ベーリンガー インゲルハイム (カナダ) リミテッド ウイルスポリメラーゼインヒビター
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure

Also Published As

Publication number Publication date
JP4646514B2 (ja) 2011-03-09
US7294457B2 (en) 2007-11-13
DE60237089D1 (de) 2010-09-02
CA2450142C (en) 2009-12-22
NZ531488A (en) 2008-06-30
JP2005500055A (ja) 2005-01-06
EP1417493A2 (en) 2004-05-12
US20030108862A1 (en) 2003-06-12
MXPA04001127A (es) 2004-07-08
ES2347954T3 (es) 2010-11-26
WO2003014377A2 (en) 2003-02-20
CA2450142A1 (en) 2003-02-20
HUP0400670A3 (en) 2006-06-28
HUP0400670A2 (en) 2006-03-28
EP1417493B1 (en) 2010-07-21
WO2003014377A3 (en) 2003-12-18
ATE475095T1 (de) 2010-08-15
NZ554933A (en) 2009-01-31
IL159981A0 (en) 2004-06-20

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