DE60237089D1 - Kompetitiver bindungstest zur identifikation von hcv-polymeraseinhibitoren - Google Patents

Kompetitiver bindungstest zur identifikation von hcv-polymeraseinhibitoren

Info

Publication number
DE60237089D1
DE60237089D1 DE60237089T DE60237089T DE60237089D1 DE 60237089 D1 DE60237089 D1 DE 60237089D1 DE 60237089 T DE60237089 T DE 60237089T DE 60237089 T DE60237089 T DE 60237089T DE 60237089 D1 DE60237089 D1 DE 60237089D1
Authority
DE
Germany
Prior art keywords
sup
sub
alkyl
hcv polymerase
het
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60237089T
Other languages
English (en)
Inventor
George Kukolj
Pierre L Beaulieu
Ginette Mckercher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Boehringer Ingelheim Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd
Application granted granted Critical
Publication of DE60237089D1 publication Critical patent/DE60237089D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/18Togaviridae; Flaviviridae
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/91245Nucleotidyltransferases (2.7.7)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
DE60237089T 2001-08-07 2002-08-05 Kompetitiver bindungstest zur identifikation von hcv-polymeraseinhibitoren Expired - Lifetime DE60237089D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31027201P 2001-08-07 2001-08-07
PCT/CA2002/001214 WO2003014377A2 (en) 2001-08-07 2002-08-05 Competitive binding assay for identifying inhibitors of hcv polymerase

Publications (1)

Publication Number Publication Date
DE60237089D1 true DE60237089D1 (de) 2010-09-02

Family

ID=23201740

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60237089T Expired - Lifetime DE60237089D1 (de) 2001-08-07 2002-08-05 Kompetitiver bindungstest zur identifikation von hcv-polymeraseinhibitoren

Country Status (13)

Country Link
US (1) US7294457B2 (de)
EP (1) EP1417493B1 (de)
JP (1) JP4646514B2 (de)
AT (1) ATE475095T1 (de)
CA (1) CA2450142C (de)
DE (1) DE60237089D1 (de)
DK (1) DK1417493T3 (de)
ES (1) ES2347954T3 (de)
HU (1) HUP0400670A3 (de)
IL (1) IL159981A0 (de)
MX (1) MXPA04001127A (de)
NZ (2) NZ554933A (de)
WO (1) WO2003014377A2 (de)

Families Citing this family (34)

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Publication number Priority date Publication date Assignee Title
EP2335700A1 (de) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7592352B2 (en) 2003-05-06 2009-09-22 Smithkline Beecham Corporation Substituted thieno and furo-pyridines
RU2355687C2 (ru) 2003-08-01 2009-05-20 Дженелэбс Текнолоджиз, Инк Бициклические производные имидазола в качестве средства против вирусов семейства flaviviridae
US8129841B2 (en) 2006-12-14 2012-03-06 Stats Chippac, Ltd. Solder joint flip chip interconnection
US8216930B2 (en) 2006-12-14 2012-07-10 Stats Chippac, Ltd. Solder joint flip chip interconnection having relief structure
USRE47600E1 (en) 2003-11-10 2019-09-10 STATS ChipPAC Pte. Ltd. Semiconductor device and method of forming electrical interconnect with stress relief void
TWI378516B (en) 2003-11-10 2012-12-01 Chippac Inc Bump-on-lead flip chip interconnection
US8026128B2 (en) 2004-11-10 2011-09-27 Stats Chippac, Ltd. Semiconductor device and method of self-confinement of conductive bump material during reflow without solder mask
US8574959B2 (en) 2003-11-10 2013-11-05 Stats Chippac, Ltd. Semiconductor device and method of forming bump-on-lead interconnection
US9029196B2 (en) 2003-11-10 2015-05-12 Stats Chippac, Ltd. Semiconductor device and method of self-confinement of conductive bump material during reflow without solder mask
JPWO2005049622A1 (ja) * 2003-11-19 2007-06-07 日本たばこ産業株式会社 5−5員縮合複素環化合物及びそのhcvポリメラーゼ阻害剤としての用途
DK1706403T3 (da) * 2003-12-22 2012-04-23 Leuven K U Res & Dev Imidazo[4,5-c]pyridinforbindelser og fremgangsmåder til antiviral behandling
RS52931B (en) * 2004-02-20 2014-02-28 Boehringer Ingelheim International Gmbh VIRAL POLYMERASE INHIBITORS
SI1719773T1 (sl) * 2004-02-24 2009-08-31 Japan Tobacco Inc Kondenzirane heterotetraciklične spojine in njihova uporaba kot inhibitorji polimeraze HCV
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
WO2006019831A1 (en) * 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
NZ556624A (en) * 2004-12-21 2010-06-25 Gilead Sciences Inc 5-((3-(2,4-trifluoromethyphenyl)isoxazol-5-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine and method of antiviral treatment
EP1866318B1 (de) 2005-03-02 2011-06-22 Fibrogen, Inc. Thienopyridinverbindungen und verfahren zu ihrer verwendung
US8841779B2 (en) 2005-03-25 2014-09-23 Stats Chippac, Ltd. Semiconductor device and method of forming high routing density BOL BONL and BONP interconnect sites on substrate
KR20070107154A (ko) 2005-03-25 2007-11-06 스태츠 칩팩, 엘티디. 기판상에 좁은 상호접속 사이트를 갖는 플립 칩 상호접속체
JP5015154B2 (ja) * 2005-08-12 2012-08-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
CN101374815B (zh) 2006-01-27 2013-07-17 菲布罗根有限公司 使低氧诱导因子(hif)稳定的氰基异喹啉化合物
CN103497184A (zh) * 2006-04-04 2014-01-08 菲布罗根有限公司 作为hif调节剂的吡咯并吡啶和噻唑并吡啶化合物
KR101143596B1 (ko) * 2006-07-07 2012-05-11 길리애드 사이언시즈, 인코포레이티드 신규의 피리다진 화합물 및 이의 용도
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
AU2009314155B2 (en) 2008-11-14 2015-10-08 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
PL2897939T3 (pl) 2012-09-21 2017-08-31 Sanofi Pochodne amidu kwasu benzoimidazolo-karboksylowego do leczenia chorób metabolicznych i sercowo-naczyniowych
DK2951159T3 (en) 2013-01-24 2018-11-19 Fibrogen Inc CRYSTALLIC FORMS OF {[1-CYANO-5- (4-CHLORPHENOXY) -4-HYDROXY-ISOQUINOLIN-3-CARBONYL] -AMINO} ACETIC ACID
EA201891620A1 (ru) 2016-02-05 2019-02-28 Денали Терапьютикс Инк. Ингибиторы взаимодействующей с рецептором протеинкиназы 1
HRP20220636T1 (hr) 2016-12-09 2022-07-22 Denali Therapeutics Inc. Spojevi korisni kao inhibitori ripk1
TW202334089A (zh) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Pparg反向激動劑及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002520051A (ja) * 1998-07-20 2002-07-09 リボザイム・ファーマシューティカルズ・インコーポレーテッド 抗ウイルス剤としての核酸分子の使用
JP2001069995A (ja) * 1999-07-02 2001-03-21 Japan Tobacco Inc 結晶構造解析に適したhcvポリメラーゼ及びその利用方法
US6770666B2 (en) * 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
AU763356C (en) 1999-12-27 2004-08-26 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
WO2002070739A2 (en) 2001-03-08 2002-09-12 Boehringer Ingelheim (Canada) Ltd Assay for identifying inhibitors of the rna dependent rna polymerase (ns5b) of hcv
CA2448737C (en) 2001-07-20 2010-06-01 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (de) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur

Also Published As

Publication number Publication date
CA2450142A1 (en) 2003-02-20
NZ554933A (en) 2009-01-31
EP1417493A2 (de) 2004-05-12
US20030108862A1 (en) 2003-06-12
ATE475095T1 (de) 2010-08-15
MXPA04001127A (es) 2004-07-08
DK1417493T3 (da) 2010-10-04
NZ531488A (en) 2008-06-30
WO2003014377A3 (en) 2003-12-18
HUP0400670A3 (en) 2006-06-28
WO2003014377A2 (en) 2003-02-20
EP1417493B1 (de) 2010-07-21
CA2450142C (en) 2009-12-22
US7294457B2 (en) 2007-11-13
JP4646514B2 (ja) 2011-03-09
HUP0400670A2 (en) 2006-03-28
JP2005500055A (ja) 2005-01-06
IL159981A0 (en) 2004-06-20
ES2347954T3 (es) 2010-11-26

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