DK141700B - Analogifremgangsmåde til fremstilling af cinchonin- eller cinchonidinderivater. - Google Patents

Analogifremgangsmåde til fremstilling af cinchonin- eller cinchonidinderivater. Download PDF

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Publication number
DK141700B
DK141700B DK637674AA DK637674A DK141700B DK 141700 B DK141700 B DK 141700B DK 637674A A DK637674A A DK 637674AA DK 637674 A DK637674 A DK 637674A DK 141700 B DK141700 B DK 141700B
Authority
DK
Denmark
Prior art keywords
trifluoromethyl
bis
chloro
mixture
ethyl
Prior art date
Application number
DK637674AA
Other languages
Danish (da)
English (en)
Other versions
DK637674A (de
DK141700C (de
Inventor
Milan Radoje Uskokovic
Guenter Grethe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK637674A publication Critical patent/DK637674A/da
Publication of DK141700B publication Critical patent/DK141700B/da
Application granted granted Critical
Publication of DK141700C publication Critical patent/DK141700C/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK637674AA 1973-12-07 1974-12-06 Analogifremgangsmåde til fremstilling af cinchonin- eller cinchonidinderivater. DK141700B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42264573A 1973-12-07 1973-12-07
US42264573 1973-12-07

Publications (3)

Publication Number Publication Date
DK637674A DK637674A (de) 1975-07-28
DK141700B true DK141700B (da) 1980-05-27
DK141700C DK141700C (de) 1980-12-08

Family

ID=23675777

Family Applications (1)

Application Number Title Priority Date Filing Date
DK637674AA DK141700B (da) 1973-12-07 1974-12-06 Analogifremgangsmåde til fremstilling af cinchonin- eller cinchonidinderivater.

Country Status (17)

Country Link
JP (1) JPS5088076A (de)
AT (2) AT339310B (de)
BE (1) BE823023A (de)
BR (1) BR7410249A (de)
CA (1) CA1039283A (de)
CH (1) CH605916A5 (de)
DE (1) DE2458146A1 (de)
DK (1) DK141700B (de)
FR (1) FR2292476A1 (de)
GB (1) GB1441519A (de)
IL (1) IL46181A (de)
KE (1) KE2718A (de)
MY (1) MY7700239A (de)
NL (1) NL7415931A (de)
PH (1) PH10837A (de)
SE (1) SE415100B (de)
ZA (1) ZA747664B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2381044A1 (fr) * 1977-02-17 1978-09-15 Hoffmann La Roche Procede pour la preparation de mefloquine
HU191508B (en) * 1982-12-02 1987-02-27 Alkaloida Vegyeszeti Gyar,Hu Process for preparing new chloromethyl-quinoline derivatives
HU188235B (en) * 1982-12-11 1986-03-28 Alkaloida Vegyeszeti Gyar,Hu Process for producing fluoro-methyl-quinoline derivatives
AU9740998A (en) * 1997-09-08 1999-03-29 F. Hoffmann-La Roche Ag Piperidine derivatives against malaria
JP2002360830A (ja) * 2001-06-04 2002-12-17 Heiwa Corp 球貯蔵入賞装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1217427A (en) * 1967-12-21 1970-12-31 America Home Products Corp Cinchona alkaloid derivatives
CH590274A5 (de) * 1970-03-16 1977-07-29 Hoffmann La Roche
CH565792A5 (de) * 1971-01-07 1975-08-29 Hoffmann La Roche

Also Published As

Publication number Publication date
BR7410249A (pt) 1976-06-29
KE2718A (en) 1977-07-15
AT339310B (de) 1977-10-10
AU7559274A (en) 1976-05-27
DK637674A (de) 1975-07-28
AT353792B (de) 1979-12-10
DE2458146A1 (de) 1975-06-12
NL7415931A (nl) 1975-06-10
BE823023A (fr) 1975-06-06
CA1039283A (en) 1978-09-26
ATA24577A (de) 1979-05-15
MY7700239A (en) 1977-12-31
SE7415160L (de) 1975-06-09
ATA977974A (de) 1977-02-15
PH10837A (en) 1977-09-09
GB1441519A (en) 1976-07-07
FR2292476A1 (fr) 1976-06-25
IL46181A (en) 1978-03-10
CH605916A5 (de) 1978-10-13
ZA747664B (en) 1976-01-28
FR2292476B1 (de) 1979-05-18
DK141700C (de) 1980-12-08
JPS5088076A (de) 1975-07-15
SE415100B (sv) 1980-09-08
IL46181A0 (en) 1975-03-13

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