DK1399138T3 - Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat - Google Patents
Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyratInfo
- Publication number
- DK1399138T3 DK1399138T3 DK02743039T DK02743039T DK1399138T3 DK 1399138 T3 DK1399138 T3 DK 1399138T3 DK 02743039 T DK02743039 T DK 02743039T DK 02743039 T DK02743039 T DK 02743039T DK 1399138 T3 DK1399138 T3 DK 1399138T3
- Authority
- DK
- Denmark
- Prior art keywords
- methylbutyrate
- hydroxy
- sodium
- solid formulations
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- CPRWZXWNQXUOOJ-UHFFFAOYSA-M sodium;3-hydroxy-3-methylbutanoate Chemical compound [Na+].CC(C)(O)CC([O-])=O CPRWZXWNQXUOOJ-UHFFFAOYSA-M 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- WHBGXDGQNOAWLX-UHFFFAOYSA-N 4,4-dimethyloxetan-2-one Chemical compound CC1(C)CC(=O)O1 WHBGXDGQNOAWLX-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Fats And Perfumes (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112236 | 2001-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1399138T3 true DK1399138T3 (da) | 2006-04-24 |
Family
ID=8177477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02743039T DK1399138T3 (da) | 2001-05-18 | 2002-05-17 | Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7026507B2 (cs) |
| EP (1) | EP1399138B1 (cs) |
| JP (1) | JP4166580B2 (cs) |
| CN (1) | CN100542525C (cs) |
| AT (1) | ATE317259T1 (cs) |
| AU (1) | AU2002338953B2 (cs) |
| BR (1) | BR0209820A (cs) |
| CA (1) | CA2447417C (cs) |
| CZ (1) | CZ302823B6 (cs) |
| DE (1) | DE50205794D1 (cs) |
| DK (1) | DK1399138T3 (cs) |
| ES (1) | ES2257559T3 (cs) |
| HU (1) | HUP0400080A3 (cs) |
| MX (1) | MXPA03010610A (cs) |
| PL (1) | PL367221A1 (cs) |
| WO (1) | WO2002094255A1 (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| US8022084B2 (en) | 2005-01-28 | 2011-09-20 | H. Lundbeck A/S | Polymorphic forms of a GABAA agonist |
| EP3006032A1 (en) | 2008-05-02 | 2016-04-13 | Gilead Sciences, Inc. | The use of solid carrier particles to improve the processability of a pharmaceutical agent |
| EP2295593A1 (en) | 2009-09-15 | 2011-03-16 | Philippe Marliere | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA |
| WO2012140276A2 (en) * | 2011-11-17 | 2012-10-18 | Lonza Ltd | Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts |
| WO2017086447A1 (ja) * | 2015-11-19 | 2017-05-26 | 協和発酵バイオ株式会社 | ３－ヒドロキシイソ吉草酸の一価カチオン塩の結晶および該結晶の製造方法 |
| EP3476825A4 (en) | 2016-06-24 | 2020-02-26 | Kyowa Hakko Bio Co., Ltd. | BETA-HYDROXY BETA-METHYLBUTYRIC ACID AMINO ACID SALT CRYSTAL AND METHOD FOR PRODUCING THE SAME |
| WO2019016883A1 (ja) * | 2017-07-19 | 2019-01-24 | 小林香料株式会社 | ３－ヒドロキシ－３－メチルブタン酸又はその塩の製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3148243B2 (ja) | 1992-09-16 | 2001-03-19 | アイオワ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 総コレステロールおよび低密度リポタンパク質コレステロールの血中レベルを減少させる方法 |
| US5348979A (en) | 1992-12-23 | 1994-09-20 | Iowa State University Research Foundation Inc. | Method of promoting nitrogen retention in humans |
| US6090978A (en) * | 1996-07-19 | 2000-07-18 | Met-Rx Usa, Inc. | Process for manufacturing 3-hydroxy-3-methylbutanoic acid |
| WO1998034897A1 (de) | 1997-02-10 | 1998-08-13 | Lonza Ag | Verfahren zur herstellung von 3-hydroxy-3-methylbuttersäure oder deren salze |
| WO2000014080A1 (en) * | 1998-09-03 | 2000-03-16 | Firmenich S.A. | Geranic acid derivatives |
-
2002
- 2002-05-17 ES ES02743039T patent/ES2257559T3/es not_active Expired - Lifetime
- 2002-05-17 WO PCT/EP2002/005435 patent/WO2002094255A1/de active IP Right Grant
- 2002-05-17 BR BR0209820-2A patent/BR0209820A/pt not_active IP Right Cessation
- 2002-05-17 HU HU0400080A patent/HUP0400080A3/hu unknown
- 2002-05-17 AT AT02743039T patent/ATE317259T1/de active
- 2002-05-17 DK DK02743039T patent/DK1399138T3/da active
- 2002-05-17 PL PL02367221A patent/PL367221A1/xx not_active Application Discontinuation
- 2002-05-17 MX MXPA03010610A patent/MXPA03010610A/es active IP Right Grant
- 2002-05-17 JP JP2002590973A patent/JP4166580B2/ja not_active Expired - Fee Related
- 2002-05-17 AU AU2002338953A patent/AU2002338953B2/en not_active Ceased
- 2002-05-17 CN CNB028135997A patent/CN100542525C/zh not_active Expired - Fee Related
- 2002-05-17 DE DE50205794T patent/DE50205794D1/de not_active Expired - Lifetime
- 2002-05-17 CZ CZ20032965A patent/CZ302823B6/cs not_active IP Right Cessation
- 2002-05-17 US US10/478,054 patent/US7026507B2/en not_active Expired - Fee Related
- 2002-05-17 CA CA2447417A patent/CA2447417C/en not_active Expired - Fee Related
- 2002-05-17 EP EP02743039A patent/EP1399138B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1068813A1 (en) | 2005-05-06 |
| HUP0400080A2 (hu) | 2004-05-28 |
| AU2002338953C1 (en) | 2002-12-03 |
| AU2002338953B2 (en) | 2006-06-29 |
| EP1399138B1 (de) | 2006-02-08 |
| JP2004536065A (ja) | 2004-12-02 |
| US7026507B2 (en) | 2006-04-11 |
| CA2447417C (en) | 2011-10-04 |
| CA2447417A1 (en) | 2002-11-28 |
| CZ302823B6 (cs) | 2011-11-30 |
| US20040143136A1 (en) | 2004-07-22 |
| WO2002094255A1 (de) | 2002-11-28 |
| PL367221A1 (en) | 2005-02-21 |
| MXPA03010610A (es) | 2004-04-02 |
| EP1399138A1 (de) | 2004-03-24 |
| HUP0400080A3 (en) | 2004-10-28 |
| ES2257559T3 (es) | 2006-08-01 |
| CN100542525C (zh) | 2009-09-23 |
| CZ20032965A3 (cs) | 2004-02-18 |
| JP4166580B2 (ja) | 2008-10-15 |
| ATE317259T1 (de) | 2006-02-15 |
| DE50205794D1 (de) | 2006-04-20 |
| CN1523983A (zh) | 2004-08-25 |
| BR0209820A (pt) | 2004-06-01 |
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