DK138663B - Fremgangsmåde til fremstilling af et antibiotisk stof, thienamycin. - Google Patents

Fremgangsmåde til fremstilling af et antibiotisk stof, thienamycin.

Info

Publication number
DK138663B
DK138663B DK528075AA DK528075A DK138663B DK 138663 B DK138663 B DK 138663B DK 528075A A DK528075A A DK 528075AA DK 528075 A DK528075 A DK 528075A DK 138663 B DK138663 B DK 138663B
Authority
DK
Denmark
Prior art keywords
thienamycin
preparation
antibiotic substance
antibiotic
substance
Prior art date
Application number
DK528075AA
Other languages
Danish (da)
English (en)
Other versions
DK138663C (sv
DK528075A (sv
Inventor
Jean Sawyer Kahan
Frederick Marvin Kahan
Edward Olley Stapley
Robert Thomas Goegelman
Sebastian Hernandez
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority to DK544975A priority Critical patent/DK140344C/da
Publication of DK528075A publication Critical patent/DK528075A/da
Publication of DK138663B publication Critical patent/DK138663B/da
Application granted granted Critical
Publication of DK138663C publication Critical patent/DK138663C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK528075AA 1974-11-25 1975-11-24 Fremgangsmåde til fremstilling af et antibiotisk stof, thienamycin. DK138663B (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK544975A DK140344C (da) 1974-12-19 1975-12-03 Fremgangsmaade til fremstilling af et antibiotisk stof thienamycin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/526,992 US3950357A (en) 1974-11-25 1974-11-25 Antibiotics

Publications (3)

Publication Number Publication Date
DK528075A DK528075A (sv) 1976-05-26
DK138663B true DK138663B (da) 1978-10-09
DK138663C DK138663C (sv) 1979-04-02

Family

ID=24099662

Family Applications (1)

Application Number Title Priority Date Filing Date
DK528075AA DK138663B (da) 1974-11-25 1975-11-24 Fremgangsmåde til fremstilling af et antibiotisk stof, thienamycin.

Country Status (35)

Country Link
US (1) US3950357A (sv)
JP (1) JPS5839519B2 (sv)
AR (1) AR211109A1 (sv)
AT (1) AT341664B (sv)
BE (1) BE835859A (sv)
BG (1) BG27916A3 (sv)
CA (1) CA1058104A (sv)
CH (1) CH622825A5 (sv)
CS (1) CS183829B2 (sv)
CY (1) CY1092A (sv)
DD (1) DD122103A5 (sv)
DE (1) DE2552638C3 (sv)
DK (1) DK138663B (sv)
EG (1) EG11963A (sv)
ES (1) ES442920A1 (sv)
FI (1) FI53718C (sv)
FR (1) FR2291748A1 (sv)
GB (1) GB1498087A (sv)
HK (1) HK60480A (sv)
HU (1) HU178052B (sv)
IE (1) IE42067B1 (sv)
IL (1) IL48521A (sv)
KE (1) KE3094A (sv)
LU (1) LU73860A1 (sv)
MY (1) MY8100228A (sv)
NL (1) NL182008C (sv)
NO (1) NO142227C (sv)
NZ (1) NZ179332A (sv)
PH (1) PH10809A (sv)
PL (1) PL96314B1 (sv)
RO (1) RO70072A (sv)
SE (1) SE431348B (sv)
SU (1) SU576967A3 (sv)
YU (1) YU36991B (sv)
ZA (1) ZA757366B (sv)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
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CH622825A5 (sv) 1981-04-30
FR2291748A1 (fr) 1976-06-18
IL48521A0 (en) 1976-01-30
FR2291748B1 (sv) 1980-06-20
LU73860A1 (sv) 1976-09-06
CA1058104A (en) 1979-07-10
DE2552638B2 (de) 1979-05-23
SE431348B (sv) 1984-01-30
DK138663C (sv) 1979-04-02
HU178052B (en) 1982-02-28
CY1092A (en) 1980-12-27
BE835859A (fr) 1976-05-24
PH10809A (en) 1977-09-07
IL48521A (en) 1979-01-31
DE2552638A1 (de) 1976-05-26
NO142227C (no) 1980-07-16
RO70072A (ro) 1980-10-30
NL182008C (nl) 1987-12-16
ZA757366B (en) 1977-07-27
US3950357A (en) 1976-04-13
FI53718B (sv) 1978-03-31
BG27916A3 (en) 1980-01-15
KE3094A (en) 1981-02-13
FI53718C (fi) 1978-07-10
SU576967A3 (ru) 1977-10-15
DD122103A5 (sv) 1976-09-12
IE42067L (en) 1976-05-25
FI753305A (sv) 1976-05-26
DE2552638C3 (de) 1980-01-31
NL7513686A (nl) 1976-05-28
HK60480A (en) 1980-11-07
NL182008B (nl) 1987-07-16
NO753944L (sv) 1976-05-26
GB1498087A (en) 1978-01-18
DK528075A (sv) 1976-05-26
YU36991B (en) 1984-08-31
CS183829B2 (en) 1978-07-31
EG11963A (en) 1978-06-30
YU297775A (en) 1982-02-25
PL96314B1 (pl) 1977-12-31
IE42067B1 (en) 1980-05-21
ES442920A1 (es) 1977-10-01
NO142227B (no) 1980-04-08
MY8100228A (en) 1981-12-31
AU8690675A (en) 1977-06-02
SE7513175L (sv) 1976-05-26
AT341664B (de) 1978-02-27
ATA891875A (de) 1977-06-15
JPS5173191A (sv) 1976-06-24
NZ179332A (en) 1981-04-24
JPS5839519B2 (ja) 1983-08-30
AR211109A1 (es) 1977-10-31

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