DK1385489T3 - Coatede granuler baseret på angiotensinomdannelsesenzymhæmmer - Google Patents

Coatede granuler baseret på angiotensinomdannelsesenzymhæmmer

Info

Publication number
DK1385489T3
DK1385489T3 DK02735534T DK02735534T DK1385489T3 DK 1385489 T3 DK1385489 T3 DK 1385489T3 DK 02735534 T DK02735534 T DK 02735534T DK 02735534 T DK02735534 T DK 02735534T DK 1385489 T3 DK1385489 T3 DK 1385489T3
Authority
DK
Denmark
Prior art keywords
group
converting enzyme
angiotensin converting
enzyme inhibitor
granules based
Prior art date
Application number
DK02735534T
Other languages
Danish (da)
English (en)
Inventor
Philippe Chenevier
Original Assignee
Ethypharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Sa filed Critical Ethypharm Sa
Application granted granted Critical
Publication of DK1385489T3 publication Critical patent/DK1385489T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
DK02735534T 2001-05-09 2002-05-03 Coatede granuler baseret på angiotensinomdannelsesenzymhæmmer DK1385489T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0106120A FR2824477B1 (fr) 2001-05-09 2001-05-09 Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes

Publications (1)

Publication Number Publication Date
DK1385489T3 true DK1385489T3 (da) 2006-05-22

Family

ID=8863079

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02735534T DK1385489T3 (da) 2001-05-09 2002-05-03 Coatede granuler baseret på angiotensinomdannelsesenzymhæmmer

Country Status (14)

Country Link
US (1) US20040171669A1 (de)
EP (1) EP1385489B1 (de)
JP (1) JP2004534024A (de)
CN (1) CN1327827C (de)
AT (1) ATE315385T1 (de)
CA (1) CA2446781C (de)
DE (1) DE60208673T2 (de)
DK (1) DK1385489T3 (de)
ES (1) ES2256485T3 (de)
FR (1) FR2824477B1 (de)
HK (1) HK1062642A1 (de)
MX (1) MXPA03009908A (de)
PT (1) PT1385489E (de)
WO (1) WO2002089775A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2857658B1 (fr) * 2003-07-16 2006-09-22 Rhodia Chimie Sa Nouveaux granules de phosphates de calcium de type hydroxyapatite, leur procede de preparation et leurs applications
EA011862B1 (ru) * 2004-03-24 2009-06-30 Актавис Груп Хф. Композиции рамиприла
CN101098679A (zh) * 2004-11-05 2008-01-02 国王医药研究与发展有限公司 稳定的雷米普利组合物及其制备方法
WO2006070845A1 (ja) * 2004-12-28 2006-07-06 Eisai R & D Management Co., Ltd. 速崩壊性錠剤及びその製造方法
EP1681049A1 (de) * 2005-01-12 2006-07-19 Physica Pharma In der Mundhöhle rasch zerfallende Arzneizusammensetzung und Dosierungsform, und Verfahren zu ihrer Herstellung
GB0518129D0 (en) * 2005-09-06 2005-10-12 Arrow Int Ltd Ramipril formulation
US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
GB2431579A (en) * 2005-10-28 2007-05-02 Arrow Int Ltd Ramipril formulations
WO2007074472A2 (en) * 2005-12-27 2007-07-05 Jubilant Organosys Limited Mouth dissolving pharmaceutical composition and process for preparing the same using a high amount of silicon dioxide
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
KR20080076382A (ko) * 2007-02-15 2008-08-20 (주)아모레퍼시픽 실로스타졸의 제어방출 제제 및 그 제조방법
PL382311A1 (pl) * 2007-04-27 2008-11-10 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Kompozycja farmaceutyczna o polepszonej stabilności zawierająca inhibitor acetylocholinoesterazy lub farmaceutycznie dopuszczalną jego sól oraz sposób jej wytwarzania
JP2010526811A (ja) * 2007-05-08 2010-08-05 ハーキュリーズ・インコーポレーテッド 堅牢な迅速崩壊錠剤の処方
US20100062062A1 (en) * 2008-09-11 2010-03-11 Aethos Pharmaceuticals, Inc. Stabilized Coating for Pharmaceutical Formulations
EP2612657B1 (de) * 2010-08-31 2023-08-09 Kyowa Kirin Co., Ltd. Schmelztablette
PL2801373T3 (pl) 2011-12-21 2017-07-31 Meiji Seika Pharma Co., Ltd. Lek do podawania miejscowego w leczeniu zaburzeń połykania
EP2814465B1 (de) * 2012-02-17 2019-07-03 Egis Gyógyszergyár Zrt. Pharmazeutische formulierung mit erhöhter stabilität
WO2013135853A1 (en) * 2012-03-15 2013-09-19 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical packaging product for the veterinary medical sector
CN102697749B (zh) * 2012-07-11 2018-01-16 上海上药新亚药业有限公司 盐酸贝那普利片的制备方法
US8568747B1 (en) 2012-10-05 2013-10-29 Silvergate Pharmaceuticals, Inc. Enalapril compositions
US9974768B2 (en) 2013-06-13 2018-05-22 Meiji Seika Pharma Co., Ltd. Pharmaceutical for improving dysphagia
US9463183B1 (en) 2015-10-30 2016-10-11 Silvergate Pharmaceuticals, Inc. Lisinopril formulations
US9669008B1 (en) 2016-03-18 2017-06-06 Silvergate Pharmaceuticals, Inc. Enalapril formulations
CN110623932A (zh) * 2019-10-29 2019-12-31 仁和堂药业有限公司 一种卡托普利片及其应用
CN110917181B (zh) * 2019-11-16 2021-01-26 浙江大学 一种甘草查尔酮b的分离方法及应用
WO2022076466A1 (en) 2020-10-05 2022-04-14 XWPharma Ltd. Modified release compositions of a gamma-hydroxybutyric acid derivative
TW202300139A (zh) 2021-03-19 2023-01-01 凱瑞康寧生技股份有限公司 γ-羟基丁酸衍生物的聯合釋放製劑的藥代動力學
CN115068434B (zh) * 2022-08-03 2023-05-09 昆山龙灯瑞迪制药有限公司 一种雷米普利片的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808413A (en) * 1987-04-28 1989-02-28 E. R. Squibb & Sons, Inc. Pharmaceutical compositions in the form of beadlets and method
CA1323833C (en) * 1987-04-28 1993-11-02 Yatindra M. Joshi Pharmaceutical compositions in the form of beadlets and method
DE3739690A1 (de) * 1987-11-24 1989-06-08 Hoechst Ag Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen
US5464632C1 (en) * 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
GB9324931D0 (en) * 1993-12-04 1994-01-26 Pfizer Ltd Glutaramide derivatives
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
US5683720A (en) * 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
FR2766089B1 (fr) * 1997-07-21 2000-06-02 Prographarm Lab Comprime multiparticulaire perfectionne a delitement rapide
US6086920A (en) * 1998-08-12 2000-07-11 Fuisz Technologies Ltd. Disintegratable microspheres
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
FR2785539B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Particules enrobees d'ibuprofene cristallin granule
FR2790387B1 (fr) * 1999-03-01 2001-05-18 Prographarm Laboratoires Comprime orodispersible presentant une faible friabilite et son procede de preparation
GB9904629D0 (en) * 1999-03-02 1999-04-21 Danbiosyst Uk Oral drug delivery system
AU7580000A (en) * 1999-09-17 2001-04-17 Mylan Pharmaceuticals, Inc. Stabilization of enalapril maleate with maleic acid
US6340471B1 (en) * 1999-12-30 2002-01-22 Alvin Kershman Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals
US6541025B1 (en) * 1999-12-30 2003-04-01 Shear/Kershman Laboratories, Inc. Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals

Also Published As

Publication number Publication date
ES2256485T3 (es) 2006-07-16
ATE315385T1 (de) 2006-02-15
EP1385489A1 (de) 2004-02-04
CN1507347A (zh) 2004-06-23
HK1062642A1 (en) 2004-11-19
DE60208673D1 (de) 2006-04-06
FR2824477A1 (fr) 2002-11-15
DE60208673T2 (de) 2006-09-07
CA2446781C (fr) 2012-10-16
MXPA03009908A (es) 2005-03-07
CN1327827C (zh) 2007-07-25
PT1385489E (pt) 2006-05-31
FR2824477B1 (fr) 2005-09-09
JP2004534024A (ja) 2004-11-11
WO2002089775A1 (fr) 2002-11-14
US20040171669A1 (en) 2004-09-02
EP1385489B1 (de) 2006-01-11
CA2446781A1 (fr) 2002-11-14

Similar Documents

Publication Publication Date Title
DK1385489T3 (da) Coatede granuler baseret på angiotensinomdannelsesenzymhæmmer
NO20045434L (no) En kombinasjon av en NMDA-antagonist og acetylkolinesteraseinhibitorer for behandlingen av Alzheimers sykdom
DE60218458D1 (de) Isochinolinon derivate als parp inhibitoren
WO2000059902A3 (en) Aryl sulfonyls as factor xa inhibitors
NO20032233D0 (no) Synergistiske foreninger som innbefatter en renininhibitor for kardiovaskul¶re sykdommer
CA2260337A1 (en) Therapeutic agents
NO20040211L (no) Kombinasjon av en aldosteronreseptor for antagonist og en HMB COA-reduktaseinhibitor
AU2001263399A1 (en) 1-(pyrrlolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indo linone derivatives
IT1289532B1 (it) Composti, di cloridrato di paroxetina e procedimenti per la loro preparazione
WO2005021557A3 (en) Poly-pegylated protease inhibitors
WO2003047520A3 (en) SUBSTITUTED AMINO METHYL FACTOR Xa INHIBITORS
NO20042932L (no) En ny polymorf form av sertralin-hydroklorid og preparater som inneholder denne, samt nye fremgangsmater for fremstilling av polymorfe former og en amorf form av sertralinhydroklorid
DK0883405T3 (da) Aminoproteaseinhibitorer
NO20001514L (no) Vitronectin-reseptor-antagonist
DE60027144D1 (de) Hydroxamsäure-derivate
YU47396A (sh) 2-acilaminopropanamini i formulacije koje ih sadrže
RS50089B (sr) Suspenzija ziprasidona
DK1007023T3 (da) 1-[1-(4-chlorphenyl)cyclobutyl]-3-methylbutylaminderivater til sænkning af urinniveauet hos mennesker
WO2001056555A3 (en) Use of cox-2 inhibitors for the treatment of constipation
DE69625505T2 (de) Guanidino proteiase inhibitoren
BR9813719A (pt) Agentes terapêuticos
IS6087A (is) N-(2-fenýl-4-amínó-bútýl)-1-naftamíð sem virka á móti taugakínín-1 viðtaka
AR038305A1 (es) Composicion farmaceutica dispersable oralmente de perindopril
AR038206A1 (es) Composicion farmaceutica dispersable oralmente de ivabradina
WO2003096874A3 (en) Coated sustained release tablets of a hygroscopic compound for once-a-day therapy