DK0883405T3 - Aminoproteaseinhibitorer - Google Patents
AminoproteaseinhibitorerInfo
- Publication number
- DK0883405T3 DK0883405T3 DK96944847T DK96944847T DK0883405T3 DK 0883405 T3 DK0883405 T3 DK 0883405T3 DK 96944847 T DK96944847 T DK 96944847T DK 96944847 T DK96944847 T DK 96944847T DK 0883405 T3 DK0883405 T3 DK 0883405T3
- Authority
- DK
- Denmark
- Prior art keywords
- aminoprotease
- inhibitors
- compounds
- formula
- benzamidino
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US943195P | 1995-12-29 | 1995-12-29 | |
| PCT/US1996/020087 WO1997024135A1 (en) | 1995-12-29 | 1996-12-20 | Amidino protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0883405T3 true DK0883405T3 (da) | 2004-06-28 |
Family
ID=21737595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96944847T DK0883405T3 (da) | 1995-12-29 | 1996-12-20 | Aminoproteaseinhibitorer |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US6034127A (da) |
| EP (1) | EP0883405B1 (da) |
| JP (1) | JP2000503010A (da) |
| KR (1) | KR19990076817A (da) |
| AT (1) | ATE260112T1 (da) |
| BR (1) | BR9612360A (da) |
| CA (1) | CA2256309C (da) |
| CZ (1) | CZ206698A3 (da) |
| DE (1) | DE69631692T2 (da) |
| DK (1) | DK0883405T3 (da) |
| ES (1) | ES2213786T3 (da) |
| HU (1) | HUP9902256A3 (da) |
| IL (1) | IL124883A0 (da) |
| MX (1) | MX9805152A (da) |
| NO (1) | NO982987L (da) |
| NZ (1) | NZ326076A (da) |
| PL (1) | PL327986A1 (da) |
| PT (1) | PT883405E (da) |
| WO (1) | WO1997024135A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69631692T2 (de) | 1995-12-29 | 2004-12-02 | 3-Dimensional Pharmaceuticals, Inc. | Amidino proteaseinhibitoren |
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| TW499412B (en) * | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| EP1007037A4 (en) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | ANTITHROMBOTIC AGENTS |
| US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| DE69830410T2 (de) * | 1997-08-29 | 2006-01-26 | Tularik Ltd. | Meta-benzamidinderivate als serinprotease-inhibitoren |
| EP1142993B1 (en) | 1998-11-20 | 2009-08-05 | Fuso Pharmaceutical Industries Ltd. | Method for detecting pancreatitis |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| JP2001026506A (ja) * | 1999-04-28 | 2001-01-30 | Takeda Chem Ind Ltd | スルホンアミド誘導体 |
| US6586617B1 (en) * | 1999-04-28 | 2003-07-01 | Sumitomo Chemical Takeda Agro Company, Limited | Sulfonamide derivatives |
| AU2001277242A1 (en) * | 2000-08-04 | 2002-02-18 | 3-Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine protease inhibitors |
| AU2002239766B9 (en) * | 2000-11-03 | 2007-04-05 | The J. David Gladstone Institutes | Methods of treating disorders related to apoE |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| DK1383756T3 (da) * | 2001-04-24 | 2008-06-23 | Aryx Therapeutics | Cumarinderivater til anvendelse som antikoagulanter |
| DK1569912T3 (da) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazol-5-carboxamidin derivater som factor VIIa inhibitorer. |
| WO2005095326A2 (en) * | 2004-03-25 | 2005-10-13 | Elan Pharmaceuticals, Inc. | 2-amino- and 2-thio-substituted 1,3-diaminopropanes |
| GB0815781D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) * | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| US8894970B2 (en) | 2010-12-31 | 2014-11-25 | Corridor Pharmaceuticals, Inc. | Arginase inhibitors and methods of use thereof |
| US20160068486A1 (en) * | 2013-04-22 | 2016-03-10 | Reuter Chemische Apparatebau Kg | Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577432A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-phenoxypyrrolidines |
| CH526535A (de) | 1970-02-05 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung neuer Pyrrolidin-1-carboxamidinderivate |
| JPS537436B2 (da) * | 1974-04-16 | 1978-03-17 | ||
| JPS5175042A (ja) * | 1974-12-26 | 1976-06-29 | Ono Pharmaceutical Co | Guanijinoshibosanamidojudotaino seizohoho |
| HU177098B (en) * | 1979-01-04 | 1981-07-28 | Gyogyszerkutato Intezet | Process for producing new peptidyl-n-carboxy-l-arginin-a |
| US4316899A (en) | 1979-08-24 | 1982-02-23 | Beecham Group Limited | Chromanone derivatives, a process for their preparation and compositions containing them |
| US4433152A (en) * | 1981-05-25 | 1984-02-21 | Nippon Chemiphar Co., Ltd. | Amidinopiperidine derivatives |
| JPS58194861A (ja) * | 1982-05-10 | 1983-11-12 | Nippon Chemiphar Co Ltd | 新規ピペリジン誘導体およびその製造法 |
| JPS62145060A (ja) | 1985-12-17 | 1987-06-29 | Tanabe Seiyaku Co Ltd | ピペラジン誘導体及びその製法 |
| US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
| DE3913597A1 (de) | 1989-04-25 | 1990-11-08 | Heumann Pharma Gmbh & Co | Diazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| TW201303B (da) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| DE4127404A1 (de) | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| CZ287209B6 (en) | 1992-02-05 | 2000-10-11 | Boehringer Ingelheim Kg | Amidine derivatives, process of their preparation and pharmaceutical preparations containing thereof |
| TW223629B (da) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| TW257757B (da) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| US5466811A (en) * | 1994-07-18 | 1995-11-14 | Merck & Co., Inc. | Dioxolenylmethyl carbamates pro moieties for amine drugs |
| DE4430757A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| DE4430755A1 (de) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| BR9610876A (pt) * | 1995-09-29 | 1999-07-13 | Dimensional Pharm Inc | Inibidores de protease de guanidino |
| DE69631692T2 (de) | 1995-12-29 | 2004-12-02 | 3-Dimensional Pharmaceuticals, Inc. | Amidino proteaseinhibitoren |
-
1996
- 1996-12-20 DE DE69631692T patent/DE69631692T2/de not_active Expired - Fee Related
- 1996-12-20 EP EP96944847A patent/EP0883405B1/en not_active Expired - Lifetime
- 1996-12-20 ES ES96944847T patent/ES2213786T3/es not_active Expired - Lifetime
- 1996-12-20 WO PCT/US1996/020087 patent/WO1997024135A1/en not_active Application Discontinuation
- 1996-12-20 BR BR9612360A patent/BR9612360A/pt unknown
- 1996-12-20 AT AT96944847T patent/ATE260112T1/de not_active IP Right Cessation
- 1996-12-20 JP JP09524371A patent/JP2000503010A/ja not_active Ceased
- 1996-12-20 IL IL12488396A patent/IL124883A0/xx unknown
- 1996-12-20 NZ NZ326076A patent/NZ326076A/en unknown
- 1996-12-20 PL PL96327986A patent/PL327986A1/xx unknown
- 1996-12-20 CZ CZ982066A patent/CZ206698A3/cs unknown
- 1996-12-20 KR KR1019980704943A patent/KR19990076817A/ko not_active Application Discontinuation
- 1996-12-20 PT PT96944847T patent/PT883405E/pt unknown
- 1996-12-20 CA CA002256309A patent/CA2256309C/en not_active Expired - Fee Related
- 1996-12-20 DK DK96944847T patent/DK0883405T3/da active
- 1996-12-20 HU HU9902256A patent/HUP9902256A3/hu unknown
- 1996-12-27 US US08/782,894 patent/US6034127A/en not_active Expired - Lifetime
-
1998
- 1998-06-24 MX MX9805152A patent/MX9805152A/es unknown
- 1998-06-26 NO NO982987A patent/NO982987L/no not_active Application Discontinuation
-
1999
- 1999-03-16 US US09/270,734 patent/US6133315A/en not_active Expired - Lifetime
-
2000
- 2000-02-11 US US09/502,005 patent/US6281206B1/en not_active Expired - Lifetime
- 2000-08-01 US US09/631,107 patent/US6225302B1/en not_active Expired - Lifetime
-
2001
- 2001-05-09 US US09/851,123 patent/US6414020B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997024135A1 (en) | 1997-07-10 |
| NO982987L (no) | 1998-08-28 |
| NZ326076A (en) | 1999-02-25 |
| CA2256309A1 (en) | 1997-07-10 |
| EP0883405A1 (en) | 1998-12-16 |
| HUP9902256A3 (en) | 2000-01-28 |
| US6034127A (en) | 2000-03-07 |
| US6414020B2 (en) | 2002-07-02 |
| US6225302B1 (en) | 2001-05-01 |
| US6133315A (en) | 2000-10-17 |
| JP2000503010A (ja) | 2000-03-14 |
| PT883405E (pt) | 2004-06-30 |
| ATE260112T1 (de) | 2004-03-15 |
| PL327986A1 (en) | 1999-01-04 |
| US20010025041A1 (en) | 2001-09-27 |
| US6281206B1 (en) | 2001-08-28 |
| NO982987D0 (no) | 1998-06-26 |
| EP0883405B1 (en) | 2004-02-25 |
| AU1432397A (en) | 1997-07-28 |
| DE69631692D1 (de) | 2004-04-01 |
| BR9612360A (pt) | 1999-07-13 |
| DE69631692T2 (de) | 2004-12-02 |
| ES2213786T3 (es) | 2004-09-01 |
| AU706145B2 (en) | 1999-06-10 |
| CZ206698A3 (cs) | 1998-11-11 |
| KR19990076817A (ko) | 1999-10-15 |
| EP0883405A4 (en) | 1999-04-28 |
| MX9805152A (es) | 1998-10-31 |
| HUP9902256A1 (hu) | 1999-10-28 |
| IL124883A0 (en) | 1999-01-26 |
| CA2256309C (en) | 2006-08-15 |
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