DK1007023T3 - 1-[1-(4-chlorphenyl)cyclobutyl]-3-methylbutylaminderivater til sænkning af urinniveauet hos mennesker - Google Patents
1-[1-(4-chlorphenyl)cyclobutyl]-3-methylbutylaminderivater til sænkning af urinniveauet hos menneskerInfo
- Publication number
- DK1007023T3 DK1007023T3 DK97942030T DK97942030T DK1007023T3 DK 1007023 T3 DK1007023 T3 DK 1007023T3 DK 97942030 T DK97942030 T DK 97942030T DK 97942030 T DK97942030 T DK 97942030T DK 1007023 T3 DK1007023 T3 DK 1007023T3
- Authority
- DK
- Denmark
- Prior art keywords
- humans
- pct
- cyclobutyl
- chlorophenyl
- methylbutylamine
- Prior art date
Links
- WQSACWZKKZPCHN-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine Chemical class C=1C=C(Cl)C=CC=1C1(C(N)CC(C)C)CCC1 WQSACWZKKZPCHN-UHFFFAOYSA-N 0.000 title 1
- 210000002700 urine Anatomy 0.000 title 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 201000001431 Hyperuricemia Diseases 0.000 abstract 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 1
- UWAOJIWUVCMBAZ-UHFFFAOYSA-N [1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-dimethylazanium;chloride Chemical compound Cl.C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UWAOJIWUVCMBAZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940116269 uric acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9619962.5A GB9619962D0 (en) | 1996-09-25 | 1996-09-25 | Medical treatment |
| PCT/EP1997/005034 WO1998013033A1 (en) | 1996-09-25 | 1997-09-15 | Medical treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1007023T3 true DK1007023T3 (da) | 2003-08-25 |
Family
ID=10800448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97942030T DK1007023T3 (da) | 1996-09-25 | 1997-09-15 | 1-[1-(4-chlorphenyl)cyclobutyl]-3-methylbutylaminderivater til sænkning af urinniveauet hos mennesker |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6162831A (da) |
| EP (1) | EP1007023B1 (da) |
| JP (1) | JP2001501608A (da) |
| KR (1) | KR20000048568A (da) |
| CN (1) | CN1231604A (da) |
| AT (1) | ATE239460T1 (da) |
| AU (1) | AU722129B2 (da) |
| BG (1) | BG103278A (da) |
| BR (1) | BR9711414A (da) |
| CA (1) | CA2266438A1 (da) |
| DE (1) | DE69721838T2 (da) |
| DK (1) | DK1007023T3 (da) |
| ES (1) | ES2199374T3 (da) |
| GB (1) | GB9619962D0 (da) |
| HR (1) | HRP970519A2 (da) |
| HU (1) | HUP9904545A3 (da) |
| IL (1) | IL128851A (da) |
| NO (1) | NO991425L (da) |
| NZ (1) | NZ334668A (da) |
| PL (1) | PL332423A1 (da) |
| PT (1) | PT1007023E (da) |
| SK (1) | SK32199A3 (da) |
| TR (1) | TR199900649T2 (da) |
| TW (1) | TW415842B (da) |
| WO (1) | WO1998013033A1 (da) |
| ZA (1) | ZA978573B (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339106B1 (en) | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
| US6476078B2 (en) | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| US6331571B1 (en) | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
| US6974838B2 (en) | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
| US6552087B1 (en) | 1999-03-19 | 2003-04-22 | Abbott Gmbh & Co. Kg | Therapeutic agent comprising (+)-sibutramine |
| CZ20013284A3 (cs) * | 1999-03-19 | 2002-10-16 | Knoll Gmbh | Farmaceutická kompozice pro léčbu osteoartritidy nebo dny |
| US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
| WO2002083631A1 (en) | 2001-04-13 | 2002-10-24 | Sepracor Inc. | Methods of preparing didesmethylsibutramine and other sibutramine derivatives |
| US9655932B2 (en) * | 2002-03-13 | 2017-05-23 | Kibow Biotech, Inc. | Composition and method for preventing or treating gout or hyperuricemia |
| US11103542B2 (en) | 2002-03-13 | 2021-08-31 | Kibow Biotech, Inc. | Composition and method for maintaining healthy kidney function |
| EP1545484A4 (en) * | 2002-10-05 | 2010-01-13 | Hanmi Pharm Ind Co Ltd | PHARMACEUTICAL COMPOSITION COMPRISING CRYSTALLINE SIBUTRAMINE METHANESULFONATE HEMIHYDRATE |
| US20050131074A1 (en) * | 2003-08-04 | 2005-06-16 | Beckman Kristen M. | Methods for treating metabolic syndrome |
| EP1778261A4 (en) * | 2004-07-21 | 2010-08-11 | Univ Florida | COMPOSITIONS AND METHODS FOR TREATMENT AND DIAGNOSIS OF INSULIN RESISTANCE |
| KR100627687B1 (ko) * | 2005-04-20 | 2006-09-25 | 주식회사 씨티씨바이오 | 시부트라민 유리염기 함유 조성물 및 이의 제조방법 |
| US20100099773A1 (en) * | 2006-11-22 | 2010-04-22 | Jae-Sun Kim | Inclusion complex of sibutramine and beta-cyclodextrin |
| WO2018125735A1 (en) | 2016-12-29 | 2018-07-05 | Kibow Biotech, Inc. | Composition and method for maintaining healthy kidney function |
| EP3906059A4 (en) * | 2018-11-02 | 2022-06-22 | Ampersand Biopharmaceuticals, Inc. | MANAGING THE RISK OF CATION OVERLOAD AND ELECTROLYTE BALANCE WITH TOPICALLY APPLIED BUFFER |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52768B1 (en) * | 1981-04-06 | 1988-02-17 | Boots Co Ltd | 1-arylcyclobutylalkylamine compounds useful as therapeutic agents |
| GB8531071D0 (en) * | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
| GB8704777D0 (en) * | 1987-02-28 | 1987-04-01 | Boots Co Plc | Medical treatment |
| JP2675573B2 (ja) * | 1988-03-31 | 1997-11-12 | 科研製薬株式会社 | 脳機能改善剤 |
| IE61928B1 (en) * | 1988-11-29 | 1994-11-30 | Boots Co Plc | Treatment of obesity |
| AU4542893A (en) * | 1992-06-23 | 1994-01-24 | Sepracor, Inc. | Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine |
| JPH07508281A (ja) * | 1992-06-23 | 1995-09-14 | セプラコア インコーポレーテッド | 光学的に純粋な（＋）シブトラミンを用いるうつ病およびその他の障害を治療する方法ならびに組成物 |
| US5459164A (en) * | 1994-02-03 | 1995-10-17 | Boots Pharmaceuticals, Inc. | Medical treatment |
-
1996
- 1996-09-25 GB GBGB9619962.5A patent/GB9619962D0/en active Pending
-
1997
- 1997-09-15 AU AU43851/97A patent/AU722129B2/en not_active Ceased
- 1997-09-15 US US09/269,339 patent/US6162831A/en not_active Expired - Fee Related
- 1997-09-15 PL PL97332423A patent/PL332423A1/xx unknown
- 1997-09-15 SK SK321-99A patent/SK32199A3/sk unknown
- 1997-09-15 WO PCT/EP1997/005034 patent/WO1998013033A1/en not_active Application Discontinuation
- 1997-09-15 HU HU9904545A patent/HUP9904545A3/hu unknown
- 1997-09-15 NZ NZ334668A patent/NZ334668A/xx unknown
- 1997-09-15 PT PT97942030T patent/PT1007023E/pt unknown
- 1997-09-15 IL IL12885197A patent/IL128851A/xx not_active IP Right Cessation
- 1997-09-15 TR TR1999/00649T patent/TR199900649T2/xx unknown
- 1997-09-15 ES ES97942030T patent/ES2199374T3/es not_active Expired - Lifetime
- 1997-09-15 DE DE69721838T patent/DE69721838T2/de not_active Expired - Fee Related
- 1997-09-15 CN CN97198232A patent/CN1231604A/zh active Pending
- 1997-09-15 BR BR9711414-6A patent/BR9711414A/pt not_active Application Discontinuation
- 1997-09-15 KR KR1019990702491A patent/KR20000048568A/ko not_active Application Discontinuation
- 1997-09-15 CA CA002266438A patent/CA2266438A1/en not_active Abandoned
- 1997-09-15 JP JP10515217A patent/JP2001501608A/ja active Pending
- 1997-09-15 AT AT97942030T patent/ATE239460T1/de not_active IP Right Cessation
- 1997-09-15 EP EP97942030A patent/EP1007023B1/en not_active Expired - Lifetime
- 1997-09-15 DK DK97942030T patent/DK1007023T3/da active
- 1997-09-25 HR HR9619962.5A patent/HRP970519A2/hr not_active Application Discontinuation
- 1997-09-25 TW TW086113992A patent/TW415842B/zh not_active IP Right Cessation
- 1997-09-25 ZA ZA978573A patent/ZA978573B/xx unknown
-
1999
- 1999-03-24 NO NO991425A patent/NO991425L/no unknown
- 1999-03-24 BG BG103278A patent/BG103278A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE239460T1 (de) | 2003-05-15 |
| NZ334668A (en) | 2000-07-28 |
| ES2199374T3 (es) | 2004-02-16 |
| JP2001501608A (ja) | 2001-02-06 |
| IL128851A0 (en) | 2000-01-31 |
| HUP9904545A3 (en) | 2000-12-28 |
| US6162831A (en) | 2000-12-19 |
| BG103278A (en) | 2000-01-31 |
| DE69721838D1 (de) | 2003-06-12 |
| PL332423A1 (en) | 1999-09-13 |
| GB9619962D0 (en) | 1996-11-13 |
| PT1007023E (pt) | 2003-08-29 |
| KR20000048568A (ko) | 2000-07-25 |
| BR9711414A (pt) | 2000-04-25 |
| AU4385197A (en) | 1998-04-17 |
| EP1007023B1 (en) | 2003-05-07 |
| AU722129B2 (en) | 2000-07-20 |
| ZA978573B (en) | 1999-03-25 |
| TR199900649T2 (xx) | 1999-07-21 |
| HUP9904545A2 (hu) | 2000-11-28 |
| DE69721838T2 (de) | 2004-01-22 |
| SK32199A3 (en) | 1999-12-10 |
| EP1007023A1 (en) | 2000-06-14 |
| IL128851A (en) | 2001-08-26 |
| NO991425D0 (no) | 1999-03-24 |
| NO991425L (no) | 1999-03-24 |
| CN1231604A (zh) | 1999-10-13 |
| TW415842B (en) | 2000-12-21 |
| HRP970519A2 (en) | 1998-08-31 |
| CA2266438A1 (en) | 1998-04-02 |
| WO1998013033A1 (en) | 1998-04-02 |
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