DK136890D0 - Retinsyrereceptormiddel og fremgangsmaade - Google Patents

Retinsyrereceptormiddel og fremgangsmaade

Info

Publication number
DK136890D0
DK136890D0 DK136890A DK136890A DK136890D0 DK 136890 D0 DK136890 D0 DK 136890D0 DK 136890 A DK136890 A DK 136890A DK 136890 A DK136890 A DK 136890A DK 136890 D0 DK136890 D0 DK 136890D0
Authority
DK
Denmark
Prior art keywords
receptor
novel
glucocorticoid
ligand
disclosed
Prior art date
Application number
DK136890A
Other languages
Danish (da)
English (en)
Other versions
DK136890A (da
Inventor
Ronald Mark Evans
Catherine Caroline Thompson
Vincent Giguere
Estelita Sebastian Ong
Prudimar Serrano Segui
Kazuhiko Umesono
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26826487&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK136890(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Publication of DK136890D0 publication Critical patent/DK136890D0/da
Publication of DK136890A publication Critical patent/DK136890A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/61Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/80Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK136890A 1987-12-02 1990-06-01 Retinsyrereceptormiddel og fremgangsmaade DK136890A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12833187A 1987-12-02 1987-12-02
US07/276,536 US4981784A (en) 1987-12-02 1988-11-30 Retinoic acid receptor method
PCT/US1988/004284 WO1989005355A1 (en) 1987-12-02 1988-12-01 Retinoic acid receptor composition and method

Publications (2)

Publication Number Publication Date
DK136890D0 true DK136890D0 (da) 1990-06-01
DK136890A DK136890A (da) 1990-06-01

Family

ID=26826487

Family Applications (1)

Application Number Title Priority Date Filing Date
DK136890A DK136890A (da) 1987-12-02 1990-06-01 Retinsyrereceptormiddel og fremgangsmaade

Country Status (11)

Country Link
US (2) US4981784A (de)
EP (2) EP0325849B1 (de)
JP (3) JP3006716B2 (de)
KR (1) KR970009951B1 (de)
AT (2) ATE124721T1 (de)
AU (1) AU628312B2 (de)
DE (2) DE3854120T2 (de)
DK (1) DK136890A (de)
ES (1) ES2073408T3 (de)
IE (1) IE68590B1 (de)
WO (1) WO1989005355A1 (de)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317090A (en) * 1987-12-16 1994-05-31 Institut Pasteur Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human hepatocellular carcinoma, and which is a retinoic acid receptor
EP0321362B1 (de) * 1987-12-16 1996-09-25 Institut Pasteur Retinoesäurerezeptor und Derivate davon, beide Substanzen codierende DNS und die Verwendung der Proteine und der DNS
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
AU633045B2 (en) * 1988-12-23 1993-01-21 Salk Institute For Biological Studies, The Receptor transcription-repression activity compositions and methods
WO1990011273A1 (en) * 1989-03-17 1990-10-04 The Salk Institute For Biological Studies Hormone response element compositions and assay
JPH04506073A (ja) * 1989-05-26 1992-10-22 ザ ソーク インスティテュート フォア バイオロジカル スタディーズ ステロイド/サイロイドスーパーファミリーのレセプターの優性の負のメンバー
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
US5776502A (en) * 1989-07-18 1998-07-07 Oncogene Science, Inc. Methods of transcriptionally modulating gene expression
US5665543A (en) * 1989-07-18 1997-09-09 Oncogene Science, Inc. Method of discovering chemicals capable of functioning as gene expression modulators
CA2067216A1 (en) * 1989-10-25 1991-04-26 Cary Alan Weinberger Receptor infection assay
CA2034220A1 (en) * 1990-01-16 1991-07-17 Donald P. Mcdonnell Expression vectors that produce steroid receptors, steroid receptor chimera, screening assays for steroid receptors and clinical assays using synthesized receptors and receptor vector
JPH05504479A (ja) 1990-02-09 1993-07-15 ザ ソーク インスティテュート フォア バイオロジカル スタディーズ レチノイドレセプター組成物および方法
US5688691A (en) * 1990-03-22 1997-11-18 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
US5861274A (en) * 1990-03-22 1999-01-19 The Salk Institute For Biological Studies Nucleic acids encoding peroxisome proliferator-activated receptor
EP0522054A4 (en) * 1990-03-22 1993-02-10 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods
US6440681B1 (en) 1990-04-03 2002-08-27 Merck & Co., Inc. Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US5599906A (en) * 1990-04-13 1997-02-04 Schering Corporation Protease assays
IL97996A0 (en) * 1990-04-30 1992-06-21 Novo Nordisk As Hybrid cellular receptor
DK106490D0 (da) * 1990-04-30 1990-04-30 Novo Nordisk As Celle
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
JPH06503713A (ja) * 1990-09-24 1994-04-28 ブレント,ロジャー スクリーニング・アッセイ
US5922596A (en) * 1990-12-10 1999-07-13 Bristol-Myers Squibb Co. Promoter of the retinoic acid receptor gene for directing gene expression
WO1992011365A1 (en) 1990-12-21 1992-07-09 The Rockefeller University Liver enriched transcription factor
WO1992016658A1 (en) * 1991-03-18 1992-10-01 The Salk Institute For Biological Studies Response element compositions and assays employing same
US5834213A (en) * 1991-05-02 1998-11-10 Baylor College Of Medicine Screening system and assay for identifying compounds that regulate steroid and orphan receptors mediation of DNA transcription
WO1992022667A1 (en) * 1991-06-14 1992-12-23 University Of Medicine And Dentistry Of New Jersey Analogs of glycoprotein hormone receptors which bind choriogonadotrophins, leutrophins, and follitrophins and methods for preparing and using same
DE69232188T2 (de) * 1991-08-23 2002-06-20 Ligand Pharmaceuticals, Inc. Verwendung von selektiven liganden zur behandlung von hormonansprechenden krankheitzuständen
US5871909A (en) * 1991-08-30 1999-02-16 The Regents Of The University Of Michigan Human cellular retinoic acid binding protein I and II DNA and methods of use
DE69232537T2 (de) * 1991-09-17 2002-10-24 The Salk Institute For Biological Studies, La Jolla Rezeptoren der steroid/thyroid superfamilie von rezeptoren
DE4138621A1 (de) * 1991-11-25 1993-06-17 Boehringer Ingelheim Int Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US5968989A (en) 1991-12-18 1999-10-19 The Salk Institute For Biological Studies Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
US7056954B2 (en) * 1991-12-18 2006-06-06 The Salk Institute For Biological Studies Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
US6506917B1 (en) 1991-12-18 2003-01-14 The Salk Institute For Biological Studies Compounds and compositions useful for modulation of processes mediated by RXR
EP0552612A3 (en) * 1992-01-22 1993-10-20 Hoffmann La Roche Methods for determining and isolating compounds which bind directly to nucleosolic proteins
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
US6989242B1 (en) 1992-02-26 2006-01-24 The General Hospital Coporation Car receptors and related molecules and methods
AU4117093A (en) * 1992-04-21 1993-11-18 Ligand Pharmaceuticals, Inc. Non-steroid progesterone receptor agonist and antagonist compounds and methods
US5808139A (en) * 1992-04-21 1998-09-15 Ligand Pharmaceuticals Incorporated Non-steroid progesterone receptor agonist and antagonist and compounds and methods
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5962731A (en) * 1992-04-22 1999-10-05 Ligand Pharmaceuticals Incorporated Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
JPH08500963A (ja) * 1992-04-28 1996-02-06 ザ・リージェンツ・オブ・ザ・ユニヴァーシティー・オブ・ミシガン ヒューマンcrabp−▲i▼及びcrabp−▲ii▼
EP0745121B1 (de) * 1992-05-14 2007-06-20 Baylor College Of Medicine Mutierte steroidhormonrezeptoren, methoden für ihre benutzung und molekularer schalter für gentherapie
US6416998B1 (en) * 1992-09-02 2002-07-09 Baylor College Of Medicine Plasmid encoding a modified steroid hormone
CA2144768A1 (en) * 1992-10-01 1994-04-14 Stephen H. Friend Functional assay for tumor supressor genes
AU5165193A (en) * 1992-10-07 1994-04-26 Merck & Co., Inc. Human steroid hormone receptor neri
ES2111289T5 (es) * 1993-01-21 2005-07-16 President And Fellows Of Harvard College Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto.
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
CA2155728C (en) * 1993-02-12 2000-04-25 Gerald R. Crabtree Regulated transcription of targeted genes and other biological events
GB2286397B (en) 1993-03-08 1997-09-10 Salk Inst Biotech Ind Human neuronal nicotinic acetylcholine receptor compositions and methods of employing same
SG54115A1 (en) * 1993-04-27 1998-11-16 Gerber Scient Products Inc Thermal printing apparatus with improved power supply
CA2140354A1 (en) * 1993-05-18 1994-11-24 Pierre Chambon Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins
US6031149A (en) * 1993-05-18 2000-02-29 Institut National De La Sante Et De La Recherche Medicale Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins
US5677336A (en) * 1993-10-21 1997-10-14 Ligand Pharmaceuticals Incorporated Non-steroid androgen receptor antagonist compounds and methods
US5506102A (en) * 1993-10-28 1996-04-09 Ligand Pharmaceuticals Incorporated Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription
WO1995013299A1 (en) * 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
US5523209A (en) * 1994-03-14 1996-06-04 The Scripps Research Institute Methods for identifying inhibitors of integrin activation
US5958683A (en) * 1994-03-30 1999-09-28 Novartis Corporation Screening method using the RZR receptor family
EP0769052A2 (de) * 1994-07-01 1997-04-23 The Salk Institute For Biological Studies Säugertier peroxisompoliferator-aktivierte rezeptoren und verwendungen davon
US6124439A (en) * 1994-08-17 2000-09-26 The Rockefeller University OB polypeptide antibodies and method of making
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US5679518A (en) * 1994-10-27 1997-10-21 Merck & Co., Inc. Method for finding transcription activators of the NER steroid hormone receptor
US5607967A (en) * 1994-10-27 1997-03-04 Merck & Co., Inc. Treatment of alzheimer's disease with 5-(tetradecyloxy)-2-furan carboxylic acid
US5702914A (en) * 1994-12-21 1997-12-30 The Salk Institute For Biological Studies Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements
US5932699A (en) 1995-01-13 1999-08-03 The General Hospital Corporation Retinoid X receptor-interacting polypeptides
AU711041B2 (en) * 1995-01-17 1999-10-07 Salk Institute For Biological Studies, The Methods, polypeptides, nucleotide sequence of XOR-6, a vitamin D-like receptor from xenopus
FR2732035B1 (fr) * 1995-03-23 1997-05-30 Agronomique Inst Nat Rech Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede
AU4745996A (en) * 1995-04-28 1996-11-18 Wisconsin Alumni Research Foundation Method for measuring hormones in biological samples
US6485967B1 (en) 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
US5726050A (en) * 1995-06-20 1998-03-10 Massachusetts Institute Of Technology Z-DNA binding protein and applications
US5777888A (en) * 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US6326140B1 (en) 1995-08-09 2001-12-04 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US6489441B1 (en) 1995-09-01 2002-12-03 The Salk Institute For Biological Studies Transcriptional co-repressor that interacts with nuclear hormone receptors
DK0792292T4 (da) * 1995-09-08 2009-07-20 Karobio Ab Orphan-receptor
WO1997010813A1 (en) * 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
AU726450B2 (en) * 1995-10-06 2000-11-09 Ligand Pharmaceuticals Incorporated Dimer-selective RXR modulators and methods for their use
CA2232712A1 (en) 1995-10-10 1997-04-17 Lyle Dean Crossland Juvenile hormone or one of its agonists as a chemical ligand to control gene expression in plants by receptor mediated transactivation
US20030044914A1 (en) * 1996-01-16 2003-03-06 The Salk Institute For Biological Studies Methods employing XOR-6, a vitamin D-like receptor from xenopus
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
US5919667A (en) * 1996-06-20 1999-07-06 The Salk Institute For Biological Studies Modular assembly retroviral vectors and uses thereof
US6017924A (en) 1996-06-27 2000-01-25 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
AU5729098A (en) * 1996-12-24 1998-07-17 Zymogenetics Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes
US6268165B1 (en) 1997-03-19 2001-07-31 The Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian cancer
AU744475B2 (en) 1997-04-24 2002-02-28 Bristol-Myers Squibb Company Methods and compositions for use in modulating expression of matrix metalloproteinase genes
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US6300488B1 (en) 1997-07-10 2001-10-09 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
US6222015B1 (en) 1997-09-08 2001-04-24 Merck & Co., Inc. Estrogen receptor
US6521814B1 (en) 1997-12-22 2003-02-18 Institut National De La Santa Et De La Recherche Medicale Use of ligands for treatment of diseases responsive to retinoids
US6348348B1 (en) * 1998-04-07 2002-02-19 The Carnegie Institution Of Washington Human hairless gene and protein
US6333318B1 (en) * 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
CA2334545A1 (en) 1998-06-12 1999-12-16 Ligand Pharmaceuticals Incorporated Treatment of anti-estrogen resistant breast cancer using rxr modulators
AR021484A1 (es) * 1998-09-10 2002-07-24 Pioneer Hi Bred Int Nuevos receptores de ecdisona y metodos de uso de los mismos
EP1114153A2 (de) * 1998-09-18 2001-07-11 The Rockefeller University Lynx, eine neue familie von rezeptorligande im zentralnervensystem, entsprechende nukleinsaüre und proteine und verwendungen davon
DE19855013C2 (de) 1998-11-20 2001-09-13 Schering Ag Androgen- und Progesteron-Rezeptor bindendes Hormon Response Element
US6773911B1 (en) * 1998-11-23 2004-08-10 Amgen Canada Inc. Apoptosis-inducing factor
US7056656B1 (en) 1999-01-25 2006-06-06 University Of Medicine And Dentistry Of New Jersey Tat-derived oligourea and its method of production and use in high affinity and specific binding HIV-1 TAR RNA
US20020132223A1 (en) * 1999-03-26 2002-09-19 City Of Hope Methods for modulating activity of the FXR nuclear receptor
US6586189B2 (en) 1999-06-18 2003-07-01 City Of Hope Screening method for PPAR-γ ligands
US6548739B2 (en) * 1999-06-18 2003-04-15 City Of Hope Method for activating peroxisome proliferator activated receptor-γ
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
JP2003508397A (ja) 1999-08-27 2003-03-04 リガンド・ファーマシューティカルズ・インコーポレイテッド アンドロゲンレセプターモジュレーターとしての8−置換−6−トリフルオロメチル−9−ピリド[3,2−g]キノリン化合物
JP2003508402A (ja) 1999-08-27 2003-03-04 リガンド・ファーマシューティカルズ・インコーポレイテッド アンドロゲン受容体モジュレーター化合物および方法
CA2385156A1 (en) * 1999-09-01 2001-03-08 Institut National De La Sante Et De La Recherche Medicale In vitro transcription systems and uses
CA2383565A1 (en) * 1999-09-14 2001-03-22 Ligand Pharmaceuticals Incorporated Rxr modulators with improved pharmacologic profile
JP2003509078A (ja) * 1999-09-22 2003-03-11 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 細胞に基づくアッセイ
EP1832598A3 (de) 1999-09-30 2008-01-02 Hollis-Eden Pharmaceuticals Inc. Therapeutische Behandlung von androgenrezeptorbedingten Leiden
US7057015B1 (en) * 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
US7329728B1 (en) 1999-10-25 2008-02-12 The Scripps Research Institute Ligand activated transcriptional regulator proteins
CA2394229C (en) 1999-11-26 2010-04-13 Mcgill University Loci for idiopathic generalized epilepsy, mutations thereof and method using same to assess, diagnose, prognose or treat epilepsy
DK1741447T3 (da) 2000-01-21 2013-12-09 Novartis Ag Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
EP1259537A4 (de) * 2000-02-24 2004-05-12 Salk Inst For Biological Studi Genexpressionssystem basierend auf chimären rezeptoren
US20040033600A1 (en) * 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
AU2001252944A1 (en) * 2000-03-24 2001-10-08 City Of Hope Methods of modulating drug clearance mechanisms by altering SXR activity
WO2002000618A2 (en) * 2000-06-28 2002-01-03 University Technology Corporation Progesterone receptor-regulated gene expression and methods related thereto
US7011972B2 (en) 2000-07-18 2006-03-14 The Scripps Research Institute Fusion polypeptide comprising two ligand binding domains
JP2004504029A (ja) * 2000-07-18 2004-02-12 ノバルティス アクチエンゲゼルシャフト 単鎖、一量体、リガンド依存性ポリペプチドスイッチを用いる遺伝子発現の調節
US8105825B2 (en) * 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
JP2004533212A (ja) * 2000-10-24 2004-11-04 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 植物における遺伝子発現のコントロール
US20050136431A1 (en) * 2000-11-03 2005-06-23 Oakley Robert H. Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7018812B2 (en) * 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
US7163800B2 (en) * 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
AU2002218911A1 (en) * 2000-12-21 2002-07-01 Mcgill University Use of the prion protein (prp) for suppression of bax-mediated apoptosis
MXPA03007493A (es) 2001-02-20 2004-10-15 Rheogene Holdings Inc Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado.
US8715959B2 (en) 2001-02-20 2014-05-06 Intrexon Corporation Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
JP4955905B2 (ja) 2001-02-20 2012-06-20 イントレキソン コーポレーション キメラレチノイドx受容体および新規エクジソン受容体−ベースの誘導性遺伝子発現システムにおけるそれらの使用
ES2390070T3 (es) 2001-02-20 2012-11-06 Intrexon Corporation Nuevos receptores mutantes de sustitución y su uso en un sistema de expresión génica inducible basado en receptores nucleares
US7026484B2 (en) * 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
US7214690B2 (en) * 2001-02-23 2007-05-08 Ligand Pharmaceuticals Incorporated Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
US20040102367A1 (en) * 2001-02-23 2004-05-27 Gage Fred H Gene expression system based on chimeric receptors
WO2002072146A2 (en) * 2001-03-12 2002-09-19 Novartis Ag Combination of nateglinide or repaglinide with at least one further antidiabetic compound
US20040248919A1 (en) * 2001-03-14 2004-12-09 Bell Michael Gregory Fluorinated trienes and their use as rxr modulators
US20030003517A1 (en) * 2001-03-22 2003-01-02 Klein Elliott S. Methods of detecting dissociated nuclear hormone receptor ligands
EP1572866A4 (de) * 2001-03-23 2008-01-16 Syngenta Participations Ag Insekten-kernrezeptorgene und deren verwendungen
WO2002086064A2 (en) * 2001-04-20 2002-10-31 The Salk Institute For Biological Studies Inducible expression of transfected genes
JP4414142B2 (ja) 2001-05-11 2010-02-10 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 特異的結合タンパク質およびその使用
US20110313230A1 (en) 2001-05-11 2011-12-22 Terrance Grant Johns Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
WO2002095405A1 (en) * 2001-05-21 2002-11-28 The Regents Of The University Of California Membrane-resident steroid receptors and methods of use thereof
WO2003007950A1 (en) * 2001-07-20 2003-01-30 Eli Lilly And Company (pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid x receptor modulators
EP1288303A1 (de) * 2001-08-23 2003-03-05 Aventis Pharma S.A. Induzierbare Expressionssysteme unter Verwendung von PPAR Transkriptionsaktivatoren
AU2002333682A1 (en) * 2001-08-02 2003-02-17 Gencell S.A. Inducible expression systems employing ppar transcriptional activators
US7919269B2 (en) 2001-09-26 2011-04-05 Intrexon Corporation Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
WO2003027289A1 (en) 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
US20030077645A1 (en) * 2001-09-28 2003-04-24 Hager Gordon L. Superfamily receptor chimeras, translocation assay for superfamily receptor ligands, and methods and kits for detecting and characterizing receptor ligands
US20030212138A1 (en) * 2002-01-14 2003-11-13 Pharmacia Corporation Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
MXPA04011679A (es) * 2002-05-29 2005-03-07 Regeneron Pharma Sistema de expresion eucariotico inducible.
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
EP1388352A1 (de) 2002-08-08 2004-02-11 Laboratoires Fournier S.A. Verwendung eines ppar-alpha-Agonisten zur Behandlung von Patienten, die an mit ppar-gamma-Agonisten-Behandlung assozierter Fettleibigkeit leiden
EP1546331B2 (de) 2002-09-26 2016-01-13 K.U.Leuven Research & Development Integrase-assoziiertes protein
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) * 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
JP4391523B2 (ja) 2003-04-30 2009-12-24 オーロラ ディスカバリー インコーポレイティッド 高密度保存およびアッセイプラットフォームを提供するマルチウェルプレート
WO2005018573A2 (en) * 2003-08-22 2005-03-03 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
US7767792B2 (en) 2004-02-20 2010-08-03 Ludwig Institute For Cancer Research Ltd. Antibodies to EGF receptor epitope peptides
WO2005090282A1 (en) 2004-03-12 2005-09-29 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
US7935510B2 (en) * 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
WO2005115992A1 (en) 2004-05-23 2005-12-08 Housey Pharmaceuticals, Inc. Theramutein modulators
EP1771193A1 (de) * 2004-07-23 2007-04-11 Rheoscience A/S Gus3-neuropeptide zur regulierung der hypothalamusfunktion
US7544838B2 (en) * 2005-01-21 2009-06-09 City Of Hope Ligands for estrogen related receptors and methods for synthesis of said ligands
US8431110B2 (en) * 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
CA2598216C (en) 2005-06-17 2014-04-08 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
HRP20140091T4 (hr) 2005-09-14 2021-12-24 Takeda Pharmaceutical Company Limited Davanje inhibitora dipeptidil peptidaze
CN103789389B (zh) * 2005-11-23 2017-01-04 杰勒德·M·豪斯 鉴定、合成、优化和表征蛋白调节剂的化合物和方法
US20080107597A1 (en) * 2006-01-12 2008-05-08 Anaptys Biosciences, Inc. Isolation of antibodies that cross-react and neutralize rankl originating from multiple species
US8076517B2 (en) 2007-05-29 2011-12-13 Intrexon Corporation Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
EP2185730A4 (de) 2007-08-23 2010-10-27 Intrexon Corp Verfahren und zusammensetzungen zur krankheitsdiagnose
AU2008307643B9 (en) 2007-09-28 2014-04-17 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
AU2008311292B9 (en) 2007-10-08 2014-10-09 Intrexon Corporation Engineered dendritic cells and uses for the treatment of cancer
BRPI0821090B8 (pt) * 2007-12-21 2021-05-25 Ligand Pharm Inc moduladores seletivos de receptores de androgênio (sarms) e uso do mesmo
CA2718494C (en) 2008-03-14 2016-05-17 Intrexon Corporation Steroidal ligands and their use in gene switch modulation
US20110076232A1 (en) 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
WO2011041293A1 (en) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
CN102834393B (zh) 2010-02-03 2015-07-22 武田药品工业株式会社 细胞凋亡信号调节激酶1抑制剂
WO2011119773A1 (en) 2010-03-23 2011-09-29 Roeth Jeremiah F Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
EP3450568A3 (de) 2011-03-04 2019-04-24 Intrexon Corporation Vektoren für bedingte proteinexpression
CN105283439B (zh) 2013-03-15 2018-02-02 英特瑞克斯顿股份有限公司 含硼的二酰基肼类化合物
EP3094323A4 (de) 2014-01-17 2017-10-11 Ligand Pharmaceuticals Incorporated Verfahren und zusammensetzungen zur modulierung von hormonspiegeln
AU2015317862A1 (en) 2014-09-17 2017-04-06 Intrexon Corporation Boron-containing diacylhydrazine compounds
UY37343A (es) 2016-07-25 2018-02-28 Intrexon Corp Control del fenotipo en plantas
MX2019005235A (es) 2016-11-09 2019-12-05 Intrexon Corp Constructos de expresion de frataxina.
WO2018195339A1 (en) 2017-04-19 2018-10-25 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5171671A (en) * 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US5274077A (en) * 1987-12-02 1993-12-28 The Salk Institute For Biological Studies Retinoic acid receptor composition

Also Published As

Publication number Publication date
US4981784A (en) 1991-01-01
DE3856354D1 (de) 1999-09-02
IE883621L (en) 1989-06-02
ES2073408T3 (es) 1995-08-16
EP0540065B1 (de) 1999-07-28
ATE182685T1 (de) 1999-08-15
AU628312B2 (en) 1992-09-17
DE3854120D1 (de) 1995-08-10
ATE124721T1 (de) 1995-07-15
JPH10279599A (ja) 1998-10-20
JP3006716B2 (ja) 2000-02-07
AU2818889A (en) 1989-07-05
IE68590B1 (en) 1996-06-26
DE3854120T2 (de) 1996-01-11
KR900700601A (ko) 1990-08-16
EP0325849A2 (de) 1989-08-02
JPH10295385A (ja) 1998-11-10
EP0325849A3 (de) 1991-10-16
DE3856354T2 (de) 1999-12-16
EP0325849B1 (de) 1995-07-05
JPH03503597A (ja) 1991-08-15
US5599904A (en) 1997-02-04
EP0540065A1 (de) 1993-05-05
KR970009951B1 (ko) 1997-06-19
DK136890A (da) 1990-06-01
WO1989005355A1 (en) 1989-06-15

Similar Documents

Publication Publication Date Title
DK136890D0 (da) Retinsyrereceptormiddel og fremgangsmaade
Simon et al. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t (17; 22)(q22; q13. 1) in dermatofibrosarcoma protuberans (DP)
Lee et al. Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis
Kent et al. A male-specific role for SOX9 in vertebrate sex determination
Dabauvalle et al. Monoclonal antibodies to a Mr 68000 pore complex glycoprotein interfere with nuclear protein uptake in Xenopus oocytes
Fujimori et al. Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos
Corps et al. Receptors for epidermal growth factor and insulin-like growth factor-I on preimplantation trophoderm of the pig
ATE145406T1 (de) Gamma-retinoinsäure-rezeptor
DE69531302D1 (de) Zellsystem mit einer spezifischen wechselwirkung von peptid-bindenden paaren
DE69323765D1 (de) Säugetier-rezeptoren für interleukin 10 (il-10)
DE69030579D1 (de) Verfahren zur herstellung von fusionsproteinen
KR950700328A (ko) 레티노산 응답요소의 구성 활성화인자 수용체 및 관련 분자와 방법(carreceptors and related molecules and methods)
WO2000001817A3 (en) Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods
Brown et al. Binding of zona pellucida proteins to a boar sperm polypeptide of M r53000 and identification of zona moieties involved
ole-MoiYoi et al. Identification of human glandular kallikrein in the beta cell of the pancreas
EP0938679B1 (de) Rezeptorbindungsassay, für den rezeptorbindungsassay geeigneter rekombinanter fusionsrezeptor, vektor zu dessen herstellung sowie reagenziensatz für die durchführung des rezeptorbindungsassays
KR930701620A (ko) 재조합 dna 백터를 이용하여 인체 t-세포 리셉터 성분에 대한 단일 클론성 항체의 제조방법
Hasebe et al. Rapid and selective removal of larval erythrocytes from systemic circulation during metamorphosis of the bullfrog, Rana catesbeiana
AR018045A1 (es) Proteina placentaria 13 y polipetido, molecula de adn que los codifica, anticuerpos capaces de enlazarse a ellos, metodo para la deteccion decomplicaciones relacionadas con el embarazo, metodo recombinante para la produccion de dicha proteina y un equipo para el diagnostico de complicacionesrelacion
Momoi et al. Evidence for structural dissimilarity in the neurotransmitter binding region of purified acetylcholine receptors from human muscle and Torpedo electric organ
DeFeudis et al. Comparison of the “specific” binding of [3H] GABA and [3H] muscimol to a particulate fraction of rat brain
Evans et al. Chimeric steroid hormone superfamily receptor proteins
DE19645729C1 (de) Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
WO2000034335A3 (en) 'death domain' containing receptors
Fry et al. Adenoviral‐mediated expression of functional na+ channel β1 subunits tagged with a yellow fluorescent protein

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment