DK1359222T3 - Hybrid human/porcin faktor VIII - Google Patents
Hybrid human/porcin faktor VIIIInfo
- Publication number
- DK1359222T3 DK1359222T3 DK03075987T DK03075987T DK1359222T3 DK 1359222 T3 DK1359222 T3 DK 1359222T3 DK 03075987 T DK03075987 T DK 03075987T DK 03075987 T DK03075987 T DK 03075987T DK 1359222 T3 DK1359222 T3 DK 1359222T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor viii
- porcine factor
- hybrid human
- domain
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/10—Factor VIII, AHF; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/864,004 US5364771A (en) | 1992-04-07 | 1992-04-07 | Hybrid human/porcine factor VIII |
EP93912141A EP0638088B1 (en) | 1992-04-07 | 1993-04-07 | Hybrid human/porcine factor viii |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1359222T3 true DK1359222T3 (da) | 2006-06-19 |
Family
ID=25342308
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93912141T DK0638088T3 (da) | 1992-04-07 | 1993-04-07 | Human/porcin faktor VIII-hybrid |
DK03075987T DK1359222T3 (da) | 1992-04-07 | 1993-04-07 | Hybrid human/porcin faktor VIII |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93912141T DK0638088T3 (da) | 1992-04-07 | 1993-04-07 | Human/porcin faktor VIII-hybrid |
Country Status (12)
Country | Link |
---|---|
US (2) | US5364771A (da) |
EP (2) | EP1359222B1 (da) |
JP (2) | JP3440097B2 (da) |
AT (2) | ATE322544T1 (da) |
AU (1) | AU682147B2 (da) |
CA (1) | CA2133203C (da) |
DE (2) | DE69334003T2 (da) |
DK (2) | DK0638088T3 (da) |
ES (2) | ES2235154T3 (da) |
HK (1) | HK1058946A1 (da) |
PT (1) | PT1359222E (da) |
WO (1) | WO1993020093A1 (da) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5663060A (en) * | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
US5859204A (en) * | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US5563045A (en) * | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
US5910481A (en) * | 1995-11-13 | 1999-06-08 | Immuno Ag | Hybrid proteins with modified activity |
US7560107B2 (en) | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
CA2343916A1 (en) | 1998-09-21 | 2000-03-30 | Genetics Institute, Inc. | Methods of downmodulating the immune response to therapeutic proteins |
WO2000028021A1 (de) | 1998-11-10 | 2000-05-18 | Baxter Aktiengesellschaft | Ein faktor viii-polypeptid mit faktor viii:c-aktivität |
AU2002248329B2 (en) * | 2001-01-12 | 2007-06-28 | The American National Red Cross | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII |
AU2002310438B2 (en) | 2001-06-14 | 2008-05-01 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
EP1572885A2 (en) * | 2001-08-08 | 2005-09-14 | Genzyme Corporation | Methods for treating diabetes and other blood sugar disorders |
US20040143104A1 (en) * | 2001-08-08 | 2004-07-22 | Wadsworth Samuel C. | Methods of treating diabetes and other blood sugar disorders |
ATE417618T1 (de) * | 2001-10-05 | 2009-01-15 | Expression Therapeutics Llc | Faktor-viii-polypeptide auf hohem expressionsniveau codierende nukleinsäure- und aminosäuresequenzen und verwendungsverfahren |
AU2002364509A1 (en) * | 2001-11-30 | 2003-06-17 | Emory University | Factor viii c2 domain variants |
EP1682106A4 (en) * | 2003-10-30 | 2008-06-11 | Univ Emory | MODIFIED FVIII FACTOR WITH REDUCED IMMUNOGENICITY THROUGH MUTAGENESIS OF A2 AND C2 EPITOPES |
US7211559B2 (en) | 2003-10-31 | 2007-05-01 | University Of Maryland, Baltimore | Factor VIII compositions and methods |
US20050107318A1 (en) * | 2003-11-17 | 2005-05-19 | Samuel Wadsworth | Methods of treating diabetes and other blood sugar disorders |
EP1750733B1 (en) | 2004-05-03 | 2013-12-11 | Emory University | METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII |
JP2008512098A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用 |
US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
WO2006029258A2 (en) | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
US20060080848A1 (en) * | 2004-10-19 | 2006-04-20 | Lace Charles R | Wheel blade sight |
US20100256062A1 (en) | 2004-12-06 | 2010-10-07 | Howard Tommy E | Allelic Variants of Human Factor VIII |
AU2006233638A1 (en) * | 2005-04-14 | 2006-10-19 | Csl Behring Gmbh | Modified coagulation Factor VIII with enhanced stability and its derivates |
EP1816201A1 (en) * | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
PL2007885T3 (pl) * | 2006-04-11 | 2010-12-31 | Csl Behring Gmbh | Sposób zwiększania odzysku peptydów terapeutycznych in vivo |
US7939632B2 (en) * | 2006-06-14 | 2011-05-10 | Csl Behring Gmbh | Proteolytically cleavable fusion proteins with high molar specific activity |
EP1935430A1 (en) * | 2006-12-22 | 2008-06-25 | CSL Behring GmbH | Modified coagulation factors with prolonged in vivo half-life |
US8754194B2 (en) * | 2006-12-22 | 2014-06-17 | Csl Behring Gmbh | Modified coagulation factors with prolonged in vivo half-life |
FR2913020B1 (fr) * | 2007-02-23 | 2012-11-23 | Biomethodes | Nouveaux facteurs viii pour le traitement des hemophiles de type a |
EP2291523B1 (en) | 2008-06-24 | 2014-12-17 | CSL Behring GmbH | Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
CA2780542C (en) | 2009-11-13 | 2020-03-24 | Grifols Therapeutics Inc. | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
HUE036233T2 (hu) | 2009-12-06 | 2018-06-28 | Bioverativ Therapeutics Inc | VIII-FC Faktor kimérás és hibrid polipeptidek, és ezek használati módszerei |
US20110177107A1 (en) * | 2010-01-14 | 2011-07-21 | Haplomics, Inc. | Predicting and reducing alloimmunogenicity of protein therapeutics |
EP2555793B1 (en) * | 2010-04-08 | 2015-07-08 | Baxter International Inc. | Methods for modeling protein stability |
EP3508573A1 (en) | 2010-07-09 | 2019-07-10 | Bioverativ Therapeutics Inc. | Systems for factor viii processing and methods thereof |
DK2635297T3 (da) | 2010-11-05 | 2019-05-06 | Baxalta GmbH | En ny variant af antihæmofil faktor viii, der har en øget specifik aktivitet |
EP3527218A1 (en) | 2011-06-10 | 2019-08-21 | Bioverativ Therapeutics Inc. | Pro-coagulant compounds and methods of use thereof |
EP4169525A1 (en) | 2011-07-08 | 2023-04-26 | Bioverativ Therapeutics Inc. | Factor viii chimeric and hybrid polypeptides, and methods of use thereof |
US10656167B2 (en) | 2011-07-25 | 2020-05-19 | Bioverativ Therapeutics Inc. | Assays to monitor bleeding disorders |
CN104271150A (zh) | 2012-01-12 | 2015-01-07 | 比奥根艾迪克Ma公司 | 嵌合因子viii多肽及其用途 |
EA029560B1 (ru) | 2012-01-12 | 2018-04-30 | Байоджен Эмэй Инк. | Применение химерного фактора свертывания крови для уменьшения ингибирующего иммунного ответа у субъекта |
EP2822577B1 (en) | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
LT2814840T (lt) | 2012-02-15 | 2020-02-25 | Bioverativ Therapeutics Inc. | Faktoriaus viii kompozicijos ir jų gavimo ir naudojimo būdai |
PT2882450T (pt) | 2012-07-11 | 2020-02-19 | Bioverativ Therapeutics Inc | Complexo de fator viii com xten e a proteína fator de von willebrand, e utilizações do mesmo |
US10001495B2 (en) | 2012-07-25 | 2018-06-19 | Bioverativ Therapeutics Inc. | Blood factor monitoring assay and uses thereof |
EP2908847B1 (en) | 2012-10-18 | 2022-03-30 | Bioverativ Therapeutics Inc. | Methods of using a fixed dose of a clotting factor |
EP2914293A4 (en) | 2012-10-30 | 2016-04-20 | Biogen Ma Inc | METHOD OF USE OF FVIII POLYPEPTIDE |
BR112015013311A2 (pt) | 2012-12-07 | 2017-11-14 | Haplomics Inc | indução de tolerancia e reparação de mutação do fator 8 |
JP6330026B2 (ja) | 2013-03-15 | 2018-05-23 | バイオベラティブ セラピューティクス インコーポレイテッド | 第viii因子ポリペプチド製剤 |
ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
SI3013855T1 (sl) | 2013-06-24 | 2021-06-30 | Xiao, Weidong | Mutantne sestave faktorja VIII in metode |
MX2015016567A (es) | 2013-06-28 | 2016-03-31 | Biogen Ma Inc | Enlazador escindible por trombina con xten y usos del mismo. |
EP3043813B1 (en) | 2013-08-08 | 2021-01-13 | Bioverativ Therapeutics Inc. | Purification of chimeric fviii molecules |
EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
WO2015070014A1 (en) | 2013-11-08 | 2015-05-14 | Biogen Idec Ma Inc. | Procoagulant fusion compound |
US10325687B2 (en) | 2013-12-06 | 2019-06-18 | Bioverativ Therapeutics Inc. | Population pharmacokinetics tools and uses thereof |
DK4176894T3 (da) | 2014-01-10 | 2024-05-27 | Bioverativ Therapeutics Inc | Kimære faktor viii-proteiner og anvendelser deraf |
AU2016301303B2 (en) | 2015-08-03 | 2021-10-07 | Bioverativ Therapeutics Inc. | Factor IX fusion proteins and methods of making and using same |
AU2019270184A1 (en) | 2018-05-18 | 2020-11-26 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia A |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE32011E (en) * | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
US4757006A (en) * | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4970300A (en) * | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
AU5772886A (en) * | 1985-04-12 | 1986-11-05 | Genetics Institute Inc. | Novel procoagulant proteins |
US4980456A (en) * | 1987-04-06 | 1990-12-25 | Scripps Clinic And Research Foundation | Recombinant factor VIIIC derived fragments |
US5004803A (en) * | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
US5246850A (en) * | 1990-07-31 | 1993-09-21 | Genentech, Inc. | DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells |
SE468050C (sv) * | 1991-03-15 | 1998-04-27 | Pharmacia & Upjohn Ab | Rekombinant derivat av human faktor VIII |
US5563045A (en) * | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
-
1992
- 1992-04-07 US US07/864,004 patent/US5364771A/en not_active Expired - Lifetime
-
1993
- 1993-04-07 ES ES93912141T patent/ES2235154T3/es not_active Expired - Lifetime
- 1993-04-07 ES ES03075987T patent/ES2261866T3/es not_active Expired - Lifetime
- 1993-04-07 DK DK93912141T patent/DK0638088T3/da active
- 1993-04-07 DE DE69334003T patent/DE69334003T2/de not_active Revoked
- 1993-04-07 PT PT03075987T patent/PT1359222E/pt unknown
- 1993-04-07 EP EP03075987A patent/EP1359222B1/en not_active Revoked
- 1993-04-07 AT AT03075987T patent/ATE322544T1/de not_active IP Right Cessation
- 1993-04-07 JP JP51778293A patent/JP3440097B2/ja not_active Expired - Fee Related
- 1993-04-07 WO PCT/US1993/003275 patent/WO1993020093A1/en active IP Right Grant
- 1993-04-07 AU AU42799/93A patent/AU682147B2/en not_active Ceased
- 1993-04-07 EP EP93912141A patent/EP0638088B1/en not_active Expired - Lifetime
- 1993-04-07 AT AT93912141T patent/ATE284963T1/de not_active IP Right Cessation
- 1993-04-07 DK DK03075987T patent/DK1359222T3/da active
- 1993-04-07 CA CA002133203A patent/CA2133203C/en not_active Expired - Fee Related
- 1993-04-07 DE DE69333724T patent/DE69333724T2/de not_active Expired - Fee Related
-
1994
- 1994-05-31 US US08/251,937 patent/US5583209A/en not_active Expired - Lifetime
-
2002
- 2002-10-23 JP JP2002308930A patent/JP3495365B2/ja not_active Expired - Fee Related
-
2004
- 2004-03-08 HK HK04101701A patent/HK1058946A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU4279993A (en) | 1993-11-08 |
DE69334003T2 (de) | 2007-01-25 |
EP1359222A2 (en) | 2003-11-05 |
US5364771A (en) | 1994-11-15 |
ATE322544T1 (de) | 2006-04-15 |
CA2133203C (en) | 2002-07-02 |
ATE284963T1 (de) | 2005-01-15 |
DK0638088T3 (da) | 2005-04-25 |
PT1359222E (pt) | 2006-07-31 |
JP2003174876A (ja) | 2003-06-24 |
EP0638088A4 (en) | 1996-06-26 |
ES2261866T3 (es) | 2006-11-16 |
CA2133203A1 (en) | 1993-10-14 |
JP3440097B2 (ja) | 2003-08-25 |
EP1359222B1 (en) | 2006-04-05 |
AU682147B2 (en) | 1997-09-25 |
WO1993020093A1 (en) | 1993-10-14 |
JP3495365B2 (ja) | 2004-02-09 |
DE69334003D1 (de) | 2006-05-18 |
EP0638088A1 (en) | 1995-02-15 |
HK1058946A1 (en) | 2004-06-11 |
ES2235154T3 (es) | 2005-07-01 |
EP0638088B1 (en) | 2004-12-15 |
DE69333724T2 (de) | 2005-11-10 |
EP1359222A3 (en) | 2003-11-19 |
JPH07508404A (ja) | 1995-09-21 |
DE69333724D1 (de) | 2005-01-20 |
US5583209A (en) | 1996-12-10 |
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