DK0638088T3 - Human/porcin faktor VIII-hybrid - Google Patents
Human/porcin faktor VIII-hybridInfo
- Publication number
- DK0638088T3 DK0638088T3 DK93912141T DK93912141T DK0638088T3 DK 0638088 T3 DK0638088 T3 DK 0638088T3 DK 93912141 T DK93912141 T DK 93912141T DK 93912141 T DK93912141 T DK 93912141T DK 0638088 T3 DK0638088 T3 DK 0638088T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor viii
- porcine factor
- human
- hybrid
- viii hybrid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/10—Factor VIII, AHF; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/864,004 US5364771A (en) | 1992-04-07 | 1992-04-07 | Hybrid human/porcine factor VIII |
PCT/US1993/003275 WO1993020093A1 (en) | 1992-04-07 | 1993-04-07 | Hybrid human/porcine factor viii |
EP93912141A EP0638088B1 (en) | 1992-04-07 | 1993-04-07 | Hybrid human/porcine factor viii |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0638088T3 true DK0638088T3 (da) | 2005-04-25 |
Family
ID=25342308
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93912141T DK0638088T3 (da) | 1992-04-07 | 1993-04-07 | Human/porcin faktor VIII-hybrid |
DK03075987T DK1359222T3 (da) | 1992-04-07 | 1993-04-07 | Hybrid human/porcin faktor VIII |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03075987T DK1359222T3 (da) | 1992-04-07 | 1993-04-07 | Hybrid human/porcin faktor VIII |
Country Status (12)
Country | Link |
---|---|
US (2) | US5364771A (da) |
EP (2) | EP0638088B1 (da) |
JP (2) | JP3440097B2 (da) |
AT (2) | ATE322544T1 (da) |
AU (1) | AU682147B2 (da) |
CA (1) | CA2133203C (da) |
DE (2) | DE69334003T2 (da) |
DK (2) | DK0638088T3 (da) |
ES (2) | ES2261866T3 (da) |
HK (1) | HK1058946A1 (da) |
PT (1) | PT1359222E (da) |
WO (1) | WO1993020093A1 (da) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5859204A (en) * | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US5663060A (en) * | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
US5563045A (en) * | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
US5910481A (en) * | 1995-11-13 | 1999-06-08 | Immuno Ag | Hybrid proteins with modified activity |
US7560107B2 (en) | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
US6458563B1 (en) * | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
NZ511034A (en) | 1998-09-21 | 2004-03-26 | American Nat Red Cross | Methods of downmodulating the immune response to therapeutic proteins |
EP1129186B2 (de) † | 1998-11-10 | 2016-11-30 | Stichting Sanquin Bloedvoorziening | Ein faktor viii-polypeptid mit faktor viii:c-aktivität |
CA2434097A1 (en) * | 2001-01-12 | 2002-08-08 | The American National Red Cross | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor viii |
DE60234193D1 (de) | 2001-06-14 | 2009-12-10 | Scripps Research Inst | Stabilisierte faktor viii mit gentechnisch konstruierten disulfidbindungen |
US20040143104A1 (en) * | 2001-08-08 | 2004-07-22 | Wadsworth Samuel C. | Methods of treating diabetes and other blood sugar disorders |
JP2005509409A (ja) * | 2001-08-08 | 2005-04-14 | ジェンザイム・コーポレーション | 糖尿病および他の血糖疾患の治療方法 |
JP4634036B2 (ja) * | 2001-10-05 | 2011-02-16 | エクスプレッション セラピューティクス, エルエルシー | 高レベルエキスプレッサー第viii因子ポリペプチドをコードする核酸配列およびアミノ酸配列および使用方法 |
AU2002364509A1 (en) * | 2001-11-30 | 2003-06-17 | Emory University | Factor viii c2 domain variants |
EP1682106A4 (en) * | 2003-10-30 | 2008-06-11 | Univ Emory | MODIFIED FVIII FACTOR WITH REDUCED IMMUNOGENICITY THROUGH MUTAGENESIS OF A2 AND C2 EPITOPES |
US7211559B2 (en) * | 2003-10-31 | 2007-05-01 | University Of Maryland, Baltimore | Factor VIII compositions and methods |
US20050107318A1 (en) * | 2003-11-17 | 2005-05-19 | Samuel Wadsworth | Methods of treating diabetes and other blood sugar disorders |
ES2449044T3 (es) | 2004-05-03 | 2014-03-18 | Emory University | Procedimiento de administración de fVIII sin dominio B porcino |
US20070066551A1 (en) | 2004-09-07 | 2007-03-22 | Keefe Anthony D | Aptamer medicinal chemistry |
US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
CA2579374A1 (en) | 2004-09-07 | 2006-03-30 | Archemix Corp. | Aptamers to von willebrand factor and their use as thrombotic disease therapeutics |
US20060080848A1 (en) * | 2004-10-19 | 2006-04-20 | Lace Charles R | Wheel blade sight |
US20100256062A1 (en) * | 2004-12-06 | 2010-10-07 | Howard Tommy E | Allelic Variants of Human Factor VIII |
AU2006233638A1 (en) * | 2005-04-14 | 2006-10-19 | Csl Behring Gmbh | Modified coagulation Factor VIII with enhanced stability and its derivates |
EP1816201A1 (en) * | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
KR101492422B1 (ko) * | 2006-04-11 | 2015-02-12 | 체에스엘 베링 게엠베하 | 치료용 폴리펩타이드의 생체내 회수율을 증가시키는 방법 |
US7939632B2 (en) * | 2006-06-14 | 2011-05-10 | Csl Behring Gmbh | Proteolytically cleavable fusion proteins with high molar specific activity |
EP1935430A1 (en) * | 2006-12-22 | 2008-06-25 | CSL Behring GmbH | Modified coagulation factors with prolonged in vivo half-life |
KR101542752B1 (ko) * | 2006-12-22 | 2015-08-10 | 체에스엘 베링 게엠베하 | 연장된 생체내 반감기를 갖는 변형된 응고 인자 |
FR2913020B1 (fr) * | 2007-02-23 | 2012-11-23 | Biomethodes | Nouveaux facteurs viii pour le traitement des hemophiles de type a |
CN103739712B (zh) | 2008-06-24 | 2016-10-05 | 德国杰特贝林生物制品有限公司 | 具有延长的体内半衰期的因子viii、冯·维勒布兰德因子或它们的复合物 |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
JP5876416B2 (ja) | 2009-11-13 | 2016-03-02 | グリフオルス・セラピユーテイクス・インコーポレーテツドGrifols Therapeutics,Inc. | フォンウィルブランド因子(vWF)含有調製品並びにこれに関連する方法、キット及び使用 |
LT2506868T (lt) | 2009-12-06 | 2018-02-26 | Bioverativ Therapeutics Inc. | Faktoriaus viii-fc chimeriniai ir hibridiniai polipeptidai ir jų panaudojimo būdai |
BR112012017483A2 (pt) * | 2010-01-14 | 2019-09-24 | Haplomics Inc | previsão e redução de aloimunogenicidade de terapêuticos de proteína |
WO2011127426A1 (en) * | 2010-04-08 | 2011-10-13 | Baxter International Inc. | Methods for modeling protein stability |
EP2591101B1 (en) | 2010-07-09 | 2018-11-07 | Bioverativ Therapeutics Inc. | Systems for factor viii processing and methods thereof |
SG190136A1 (en) | 2010-11-05 | 2013-07-31 | Baxter Int | A new variant of antihemophilic factor viii having increased specific activity |
EP2717898B1 (en) | 2011-06-10 | 2018-12-19 | Bioverativ Therapeutics Inc. | Pro-coagulant compounds and methods of use thereof |
CA2841066C (en) | 2011-07-08 | 2023-09-26 | Biogen Idec Hemophilia Inc. | Factor viii chimeric and hybrid polypeptides, and methods of use thereof |
US10656167B2 (en) | 2011-07-25 | 2020-05-19 | Bioverativ Therapeutics Inc. | Assays to monitor bleeding disorders |
ES2700583T3 (es) | 2012-01-12 | 2019-02-18 | Bioverativ Therapeutics Inc | Procedimientos para reducir la inmunogenicidad contra el Factor VIII en individuos sometidos a terapia con Factor VIII |
WO2013106787A1 (en) | 2012-01-12 | 2013-07-18 | Biogen Idec Ma Inc. | Chimeric factor viii polypeptides and uses thereof |
AU2013204636B2 (en) | 2012-02-15 | 2016-04-14 | Bioverativ Therapeutics Inc. | Recombinant Factor VIII proteins |
PL3564260T3 (pl) | 2012-02-15 | 2023-03-06 | Bioverativ Therapeutics Inc. | Kompozycje czynnika viii oraz sposoby ich wytwarzania i stosowania |
PL2882450T3 (pl) | 2012-07-11 | 2020-06-29 | Bioverativ Therapeutics Inc. | Kompleks czynnika viii z xten i białkiem czynnika von willebranda oraz jego zastosowania |
US10001495B2 (en) | 2012-07-25 | 2018-06-19 | Bioverativ Therapeutics Inc. | Blood factor monitoring assay and uses thereof |
US10391152B2 (en) | 2012-10-18 | 2019-08-27 | Bioverativ Therapeutics Inc. | Methods of using a fixed dose of a clotting factor |
EP3943102A1 (en) | 2012-10-30 | 2022-01-26 | Bioverativ Therapeutics Inc. | Methods of using fviii polypeptide |
EP2928303A4 (en) | 2012-12-07 | 2016-07-13 | Haplomics Inc | FACTOR VIII MUTATION REPAIR AND TOLERANCE INDUCTION |
EP4122487A1 (en) | 2013-03-15 | 2023-01-25 | Bioverativ Therapeutics Inc. | Factor viii polypeptide formulations |
EP2796145B1 (en) | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
WO2014209942A1 (en) | 2013-06-24 | 2014-12-31 | Weidong Xiao | Mutant factor viii compositions and methods |
CN113817069A (zh) | 2013-06-28 | 2021-12-21 | 比奥贝拉蒂治疗公司 | 具有xten的凝血酶可裂解连接子和其用途 |
US10947269B2 (en) | 2013-08-08 | 2021-03-16 | Bioverativ Therapeutics Inc. | Purification of chimeric FVIII molecules |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
US10584147B2 (en) | 2013-11-08 | 2020-03-10 | Biovertiv Therapeutics Inc. | Procoagulant fusion compound |
ES2967617T3 (es) | 2013-12-06 | 2024-05-03 | Bioverativ Therapeutics Inc | Herramientas de farmacocinética poblacional y sus usos |
IL282168B2 (en) | 2014-01-10 | 2023-03-01 | Bioverativ Therapeutics Inc | Factor viii chimeric proteins and their uses |
CN108472337B (zh) | 2015-08-03 | 2022-11-25 | 比奥贝拉蒂治疗公司 | 因子ix融合蛋白以及其制备和使用方法 |
SG11202010767SA (en) | 2018-05-18 | 2020-11-27 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE32011E (en) * | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
US4757006A (en) * | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4970300A (en) * | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
JPH0788399B2 (ja) * | 1985-04-12 | 1995-09-27 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | 新規プロコアギュラント蛋白質 |
US4980456A (en) * | 1987-04-06 | 1990-12-25 | Scripps Clinic And Research Foundation | Recombinant factor VIIIC derived fragments |
US5004803A (en) * | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
US5246850A (en) * | 1990-07-31 | 1993-09-21 | Genentech, Inc. | DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells |
SE468050C (sv) * | 1991-03-15 | 1998-04-27 | Pharmacia & Upjohn Ab | Rekombinant derivat av human faktor VIII |
US5563045A (en) * | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
-
1992
- 1992-04-07 US US07/864,004 patent/US5364771A/en not_active Expired - Lifetime
-
1993
- 1993-04-07 JP JP51778293A patent/JP3440097B2/ja not_active Expired - Fee Related
- 1993-04-07 AU AU42799/93A patent/AU682147B2/en not_active Ceased
- 1993-04-07 DK DK93912141T patent/DK0638088T3/da active
- 1993-04-07 CA CA002133203A patent/CA2133203C/en not_active Expired - Fee Related
- 1993-04-07 AT AT03075987T patent/ATE322544T1/de not_active IP Right Cessation
- 1993-04-07 AT AT93912141T patent/ATE284963T1/de not_active IP Right Cessation
- 1993-04-07 EP EP93912141A patent/EP0638088B1/en not_active Expired - Lifetime
- 1993-04-07 ES ES03075987T patent/ES2261866T3/es not_active Expired - Lifetime
- 1993-04-07 WO PCT/US1993/003275 patent/WO1993020093A1/en active IP Right Grant
- 1993-04-07 DK DK03075987T patent/DK1359222T3/da active
- 1993-04-07 PT PT03075987T patent/PT1359222E/pt unknown
- 1993-04-07 EP EP03075987A patent/EP1359222B1/en not_active Revoked
- 1993-04-07 DE DE69334003T patent/DE69334003T2/de not_active Revoked
- 1993-04-07 ES ES93912141T patent/ES2235154T3/es not_active Expired - Lifetime
- 1993-04-07 DE DE69333724T patent/DE69333724T2/de not_active Expired - Fee Related
-
1994
- 1994-05-31 US US08/251,937 patent/US5583209A/en not_active Expired - Lifetime
-
2002
- 2002-10-23 JP JP2002308930A patent/JP3495365B2/ja not_active Expired - Fee Related
-
2004
- 2004-03-08 HK HK04101701A patent/HK1058946A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2133203C (en) | 2002-07-02 |
DE69334003T2 (de) | 2007-01-25 |
HK1058946A1 (en) | 2004-06-11 |
AU682147B2 (en) | 1997-09-25 |
JPH07508404A (ja) | 1995-09-21 |
JP3440097B2 (ja) | 2003-08-25 |
ES2261866T3 (es) | 2006-11-16 |
US5364771A (en) | 1994-11-15 |
EP1359222B1 (en) | 2006-04-05 |
ATE284963T1 (de) | 2005-01-15 |
ES2235154T3 (es) | 2005-07-01 |
DE69334003D1 (de) | 2006-05-18 |
EP0638088B1 (en) | 2004-12-15 |
PT1359222E (pt) | 2006-07-31 |
DE69333724T2 (de) | 2005-11-10 |
EP1359222A3 (en) | 2003-11-19 |
CA2133203A1 (en) | 1993-10-14 |
DK1359222T3 (da) | 2006-06-19 |
EP0638088A4 (en) | 1996-06-26 |
ATE322544T1 (de) | 2006-04-15 |
DE69333724D1 (de) | 2005-01-20 |
US5583209A (en) | 1996-12-10 |
JP3495365B2 (ja) | 2004-02-09 |
AU4279993A (en) | 1993-11-08 |
JP2003174876A (ja) | 2003-06-24 |
WO1993020093A1 (en) | 1993-10-14 |
EP1359222A2 (en) | 2003-11-05 |
EP0638088A1 (en) | 1995-02-15 |
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