DK1309610T3 - Peptid- og peptidmimetika-derivater med integrininhibitor-egenskaber II - Google Patents
Peptid- og peptidmimetika-derivater med integrininhibitor-egenskaber IIInfo
- Publication number
- DK1309610T3 DK1309610T3 DK01960611T DK01960611T DK1309610T3 DK 1309610 T3 DK1309610 T3 DK 1309610T3 DK 01960611 T DK01960611 T DK 01960611T DK 01960611 T DK01960611 T DK 01960611T DK 1309610 T3 DK1309610 T3 DK 1309610T3
- Authority
- DK
- Denmark
- Prior art keywords
- arg
- lys
- sup
- gln
- ile
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title 2
- 229940125798 integrin inhibitor Drugs 0.000 title 1
- 239000007943 implant Substances 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000001133 acceleration Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000004956 cell adhesive effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000010 osteolytic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Surgery (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10040103A DE10040103A1 (de) | 2000-08-17 | 2000-08-17 | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften II |
| PCT/EP2001/008931 WO2002014350A2 (fr) | 2000-08-17 | 2001-08-02 | Derives peptidiques et derives de mimetiques peptidiques ayant des proprietes ii d'inhibition de l'integrine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1309610T3 true DK1309610T3 (da) | 2009-03-30 |
Family
ID=7652667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01960611T DK1309610T3 (da) | 2000-08-17 | 2001-08-02 | Peptid- og peptidmimetika-derivater med integrininhibitor-egenskaber II |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7276482B2 (fr) |
| EP (1) | EP1309610B1 (fr) |
| JP (1) | JP4795620B2 (fr) |
| KR (1) | KR20030062318A (fr) |
| CN (1) | CN1446230A (fr) |
| AT (1) | ATE419269T1 (fr) |
| AU (1) | AU2001282058A1 (fr) |
| CA (1) | CA2419469C (fr) |
| CY (1) | CY1108945T1 (fr) |
| CZ (1) | CZ2003719A3 (fr) |
| DE (2) | DE10040103A1 (fr) |
| DK (1) | DK1309610T3 (fr) |
| ES (1) | ES2317926T3 (fr) |
| MX (1) | MXPA03001427A (fr) |
| PL (1) | PL366312A1 (fr) |
| PT (1) | PT1309610E (fr) |
| WO (1) | WO2002014350A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001221607A1 (en) | 2000-11-20 | 2002-05-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Endosseous implant |
| DE10325049A1 (de) * | 2003-06-02 | 2004-12-23 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften III |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992012727A1 (fr) * | 1991-01-25 | 1992-08-06 | Regents Of The University Of Minnesota | Polypeptides du domaine vi de la chaine a de laminine |
| DE19755801A1 (de) * | 1997-12-16 | 2000-06-21 | Merck Patent Gmbh | Mit die Zelladhäsion vermittelnden Peptiden beschichtete Implantate und Verfahren zu ihrer Herstellung |
| PL337019A1 (en) * | 1997-05-22 | 2000-07-31 | Merck Patent Gmbh | Peptide-coated implants and method of obtaining them |
| DE19755800A1 (de) * | 1997-12-16 | 1999-06-17 | Merck Patent Gmbh | Cyclopeptidderivate |
| DE19831710A1 (de) | 1998-07-15 | 2000-01-20 | Merck Patent Gmbh | Diacylhydrazinderivate |
| DE19932796A1 (de) | 1999-07-14 | 2001-01-18 | Merck Patent Gmbh | Diacylhydrazinderivate |
-
2000
- 2000-08-17 DE DE10040103A patent/DE10040103A1/de not_active Withdrawn
-
2001
- 2001-08-02 CA CA2419469A patent/CA2419469C/fr not_active Expired - Fee Related
- 2001-08-02 CZ CZ2003719A patent/CZ2003719A3/cs unknown
- 2001-08-02 AT AT01960611T patent/ATE419269T1/de active
- 2001-08-02 AU AU2001282058A patent/AU2001282058A1/en not_active Abandoned
- 2001-08-02 DK DK01960611T patent/DK1309610T3/da active
- 2001-08-02 MX MXPA03001427A patent/MXPA03001427A/es unknown
- 2001-08-02 DE DE50114621T patent/DE50114621D1/de not_active Expired - Lifetime
- 2001-08-02 KR KR10-2003-7002263A patent/KR20030062318A/ko not_active Application Discontinuation
- 2001-08-02 ES ES01960611T patent/ES2317926T3/es not_active Expired - Lifetime
- 2001-08-02 EP EP01960611A patent/EP1309610B1/fr not_active Expired - Lifetime
- 2001-08-02 CN CN01814101A patent/CN1446230A/zh active Pending
- 2001-08-02 PL PL01366312A patent/PL366312A1/xx unknown
- 2001-08-02 US US10/344,668 patent/US7276482B2/en not_active Expired - Fee Related
- 2001-08-02 JP JP2002519487A patent/JP4795620B2/ja not_active Expired - Fee Related
- 2001-08-02 PT PT01960611T patent/PT1309610E/pt unknown
- 2001-08-02 WO PCT/EP2001/008931 patent/WO2002014350A2/fr not_active Application Discontinuation
-
2009
- 2009-03-31 CY CY20091100374T patent/CY1108945T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7276482B2 (en) | 2007-10-02 |
| MXPA03001427A (es) | 2003-06-06 |
| DE50114621D1 (de) | 2009-02-12 |
| JP2004506649A (ja) | 2004-03-04 |
| PT1309610E (pt) | 2009-03-16 |
| US20040043937A1 (en) | 2004-03-04 |
| ATE419269T1 (de) | 2009-01-15 |
| CZ2003719A3 (cs) | 2003-06-18 |
| CA2419469C (fr) | 2013-05-14 |
| WO2002014350A2 (fr) | 2002-02-21 |
| CN1446230A (zh) | 2003-10-01 |
| JP4795620B2 (ja) | 2011-10-19 |
| WO2002014350A3 (fr) | 2002-09-19 |
| CA2419469A1 (fr) | 2003-02-14 |
| KR20030062318A (ko) | 2003-07-23 |
| AU2001282058A1 (en) | 2002-02-25 |
| CY1108945T1 (el) | 2014-07-02 |
| EP1309610A2 (fr) | 2003-05-14 |
| ES2317926T3 (es) | 2009-05-01 |
| PL366312A1 (en) | 2005-01-24 |
| EP1309610B1 (fr) | 2008-12-31 |
| DE10040103A1 (de) | 2002-02-28 |
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