AU2001282058A1 - Peptide and peptide mimetic derivatives with integrin inhibitor properties II - Google Patents
Peptide and peptide mimetic derivatives with integrin inhibitor properties IIInfo
- Publication number
- AU2001282058A1 AU2001282058A1 AU2001282058A AU8205801A AU2001282058A1 AU 2001282058 A1 AU2001282058 A1 AU 2001282058A1 AU 2001282058 A AU2001282058 A AU 2001282058A AU 8205801 A AU8205801 A AU 8205801A AU 2001282058 A1 AU2001282058 A1 AU 2001282058A1
- Authority
- AU
- Australia
- Prior art keywords
- arg
- lys
- sup
- gln
- ile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title 2
- 229940125798 integrin inhibitor Drugs 0.000 title 1
- 239000007943 implant Substances 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000001133 acceleration Effects 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000004956 cell adhesive effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000010 osteolytic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Surgery (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to compounds of formula (I) B-Q-X<SUB>1</SUB>, wherein B is a bioactive, cell adhesive mediating molecule, selected from the group (i) and Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 1) (ii), Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 2) (iii), Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 3) (iv), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (SEQ ID NO: 4) (v), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (SEQ ID NO: 5) (vi), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (SEQ ID NO: 6) (vii), wherein (i) X, Y, Z, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, A, Ar, Hal, Het, Het<SUP>1</SUP>, n, m, o, p, q, s, t have the meanings cited in claim 1 , Q is absent or is an organic spacer molecule, X<SUB>1 </SUB>is an anchor molecule selected from the group cited in claim 1 , and the salts thereof, which can be used as integrin inhibitors particularly for treatment of illness, deficiencies and inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10040103 | 2000-08-17 | ||
DE10040103A DE10040103A1 (en) | 2000-08-17 | 2000-08-17 | Peptide and peptide mimetic derivatives with integrin inhibitor properties II |
PCT/EP2001/008931 WO2002014350A2 (en) | 2000-08-17 | 2001-08-02 | Peptide and peptide mimetic derivatives with integrin inhibitor properties ii |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001282058A1 true AU2001282058A1 (en) | 2002-02-25 |
Family
ID=7652667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001282058A Abandoned AU2001282058A1 (en) | 2000-08-17 | 2001-08-02 | Peptide and peptide mimetic derivatives with integrin inhibitor properties II |
Country Status (17)
Country | Link |
---|---|
US (1) | US7276482B2 (en) |
EP (1) | EP1309610B1 (en) |
JP (1) | JP4795620B2 (en) |
KR (1) | KR20030062318A (en) |
CN (1) | CN1446230A (en) |
AT (1) | ATE419269T1 (en) |
AU (1) | AU2001282058A1 (en) |
CA (1) | CA2419469C (en) |
CY (1) | CY1108945T1 (en) |
CZ (1) | CZ2003719A3 (en) |
DE (2) | DE10040103A1 (en) |
DK (1) | DK1309610T3 (en) |
ES (1) | ES2317926T3 (en) |
MX (1) | MXPA03001427A (en) |
PL (1) | PL366312A1 (en) |
PT (1) | PT1309610E (en) |
WO (1) | WO2002014350A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001221607A1 (en) | 2000-11-20 | 2002-05-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Endosseous implant |
DE10325049A1 (en) * | 2003-06-02 | 2004-12-23 | Merck Patent Gmbh | New peptide derivatives containing cell-adhesion molecule and phosphonate-containing anchor component, useful for treating disorders associated with implants, are inhibitors of integrins |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992012727A1 (en) * | 1991-01-25 | 1992-08-06 | Regents Of The University Of Minnesota | Laminin a chain domain vi polypeptides |
DE19755801A1 (en) * | 1997-12-16 | 2000-06-21 | Merck Patent Gmbh | Implant with improved tissue integration |
PL337019A1 (en) * | 1997-05-22 | 2000-07-31 | Merck Patent Gmbh | Peptide-coated implants and method of obtaining them |
DE19755800A1 (en) * | 1997-12-16 | 1999-06-17 | Merck Patent Gmbh | Cyclopeptide derivatives |
DE19831710A1 (en) | 1998-07-15 | 2000-01-20 | Merck Patent Gmbh | New diacyl-hydrazine derivatives, are integrin inhibitors useful for treating e.g. thrombosis, cardiac infarction, tumors, osteoporosis, inflammation or infection |
DE19932796A1 (en) | 1999-07-14 | 2001-01-18 | Merck Patent Gmbh | Diacylhydrazine derivatives |
-
2000
- 2000-08-17 DE DE10040103A patent/DE10040103A1/en not_active Withdrawn
-
2001
- 2001-08-02 CA CA2419469A patent/CA2419469C/en not_active Expired - Fee Related
- 2001-08-02 CZ CZ2003719A patent/CZ2003719A3/en unknown
- 2001-08-02 AT AT01960611T patent/ATE419269T1/en active
- 2001-08-02 AU AU2001282058A patent/AU2001282058A1/en not_active Abandoned
- 2001-08-02 DK DK01960611T patent/DK1309610T3/en active
- 2001-08-02 MX MXPA03001427A patent/MXPA03001427A/en unknown
- 2001-08-02 DE DE50114621T patent/DE50114621D1/en not_active Expired - Lifetime
- 2001-08-02 KR KR10-2003-7002263A patent/KR20030062318A/en not_active Application Discontinuation
- 2001-08-02 ES ES01960611T patent/ES2317926T3/en not_active Expired - Lifetime
- 2001-08-02 EP EP01960611A patent/EP1309610B1/en not_active Expired - Lifetime
- 2001-08-02 CN CN01814101A patent/CN1446230A/en active Pending
- 2001-08-02 PL PL01366312A patent/PL366312A1/en unknown
- 2001-08-02 US US10/344,668 patent/US7276482B2/en not_active Expired - Fee Related
- 2001-08-02 JP JP2002519487A patent/JP4795620B2/en not_active Expired - Fee Related
- 2001-08-02 PT PT01960611T patent/PT1309610E/en unknown
- 2001-08-02 WO PCT/EP2001/008931 patent/WO2002014350A2/en not_active Application Discontinuation
-
2009
- 2009-03-31 CY CY20091100374T patent/CY1108945T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
US7276482B2 (en) | 2007-10-02 |
MXPA03001427A (en) | 2003-06-06 |
DE50114621D1 (en) | 2009-02-12 |
JP2004506649A (en) | 2004-03-04 |
PT1309610E (en) | 2009-03-16 |
US20040043937A1 (en) | 2004-03-04 |
ATE419269T1 (en) | 2009-01-15 |
CZ2003719A3 (en) | 2003-06-18 |
DK1309610T3 (en) | 2009-03-30 |
CA2419469C (en) | 2013-05-14 |
WO2002014350A2 (en) | 2002-02-21 |
CN1446230A (en) | 2003-10-01 |
JP4795620B2 (en) | 2011-10-19 |
WO2002014350A3 (en) | 2002-09-19 |
CA2419469A1 (en) | 2003-02-14 |
KR20030062318A (en) | 2003-07-23 |
CY1108945T1 (en) | 2014-07-02 |
EP1309610A2 (en) | 2003-05-14 |
ES2317926T3 (en) | 2009-05-01 |
PL366312A1 (en) | 2005-01-24 |
EP1309610B1 (en) | 2008-12-31 |
DE10040103A1 (en) | 2002-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY129408A (en) | Disubstituted bicyclic, heterocycles, the preparation and the use thereof as pharmaceutical compositions | |
WO2002100812A1 (en) | Carboxylic acid derivative and salt thereof | |
IL157179A0 (en) | Fused heterocyclic compounds | |
UA70951C2 (en) | Benzimidazoles and medicament based thereon | |
YU9802A (en) | Cell adhesion inhibitors | |
BR0014651A (en) | Beta2-mediated cell adhesion inhibitors | |
WO2006027798A3 (en) | A process for preparation of an antidepressant compound | |
AU2001282059A1 (en) | Peptide and peptide mimetic conjugates with integrin-inhibitor properties | |
EP1077218A3 (en) | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors | |
NZ514576A (en) | Substituted 3-cyano-[1.7], [1.5], and [1.8]- naphthyridine inhibitors of tyrosine kinases | |
CA2395705A1 (en) | Substituted phenyl-piperazine derivatives, their preparation and use | |
WO2001036425A3 (en) | Imidazole compounds used as phosphodiesterase vii inhibitors | |
CY1108945T1 (en) | Derivatives and peptidomimetic derivatives of peptides with properties of INOPATIN II inhibitors | |
NZ515025A (en) | Solvates of pymetrozine | |
AU2003273728A1 (en) | A new crystalline form of the sodium salt of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid | |
WO2000039087A3 (en) | Substituted (aminoiminomethyl or aminomethyl)benzoheteroaryl compounds as factor xa inhibitors | |
US20200369734A1 (en) | Chimeric peptide for a biomimetic implant interface | |
WO1999023081A3 (en) | Trifluoromethylbiphenylyl-dihalophenylazolines as pesticides | |
HUP0104797A2 (en) | Method for preparing 4-(3-pyridinyl)-1h-imidazole and the intermediates used | |
HRP20020864A2 (en) | Cyclipostins, a method for their production and the use of the same | |
MX2008000497A (en) | Antiarrhythmic precursor compounds, methods of synthesis and methods of use. | |
PL322969A1 (en) | Substituted phenylamidines, pharmaceutic compositions containing theses compounds and method of obtaining them | |
NO20020886L (en) | Novel integrin <alfa> v <beta> 3 inhibitors | |
AU3043597A (en) | Anticoagulant peptide aldehyde derivatives | |
TW200504088A (en) | Avermectin B1 monosaccharide derivatives |