AU2001282058A1 - Peptide and peptide mimetic derivatives with integrin inhibitor properties II - Google Patents

Peptide and peptide mimetic derivatives with integrin inhibitor properties II

Info

Publication number
AU2001282058A1
AU2001282058A1 AU2001282058A AU8205801A AU2001282058A1 AU 2001282058 A1 AU2001282058 A1 AU 2001282058A1 AU 2001282058 A AU2001282058 A AU 2001282058A AU 8205801 A AU8205801 A AU 8205801A AU 2001282058 A1 AU2001282058 A1 AU 2001282058A1
Authority
AU
Australia
Prior art keywords
arg
lys
sup
gln
ile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001282058A
Inventor
Michel Dard
Christoph Gibson
Ulrich Hersel
Gunter Holzemann
Martin Kantlehner
Horst Kessler
Jorg Meyer
Berthold Nies
Gabor Sulyok
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2001282058A1 publication Critical patent/AU2001282058A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/10—Process efficiency

Abstract

The invention relates to compounds of formula (I) B-Q-X<SUB>1</SUB>, wherein B is a bioactive, cell adhesive mediating molecule, selected from the group (i) and Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 1) (ii), Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 2) (iii), Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 3) (iv), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (SEQ ID NO: 4) (v), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (SEQ ID NO: 5) (vi), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (SEQ ID NO: 6) (vii), wherein (i) X, Y, Z, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, A, Ar, Hal, Het, Het<SUP>1</SUP>, n, m, o, p, q, s, t have the meanings cited in claim 1 , Q is absent or is an organic spacer molecule, X<SUB>1 </SUB>is an anchor molecule selected from the group cited in claim 1 , and the salts thereof, which can be used as integrin inhibitors particularly for treatment of illness, deficiencies and inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.
AU2001282058A 2000-08-17 2001-08-02 Peptide and peptide mimetic derivatives with integrin inhibitor properties II Abandoned AU2001282058A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10040103 2000-08-17
DE10040103A DE10040103A1 (en) 2000-08-17 2000-08-17 Peptide and peptide mimetic derivatives with integrin inhibitor properties II
PCT/EP2001/008931 WO2002014350A2 (en) 2000-08-17 2001-08-02 Peptide and peptide mimetic derivatives with integrin inhibitor properties ii

Publications (1)

Publication Number Publication Date
AU2001282058A1 true AU2001282058A1 (en) 2002-02-25

Family

ID=7652667

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001282058A Abandoned AU2001282058A1 (en) 2000-08-17 2001-08-02 Peptide and peptide mimetic derivatives with integrin inhibitor properties II

Country Status (17)

Country Link
US (1) US7276482B2 (en)
EP (1) EP1309610B1 (en)
JP (1) JP4795620B2 (en)
KR (1) KR20030062318A (en)
CN (1) CN1446230A (en)
AT (1) ATE419269T1 (en)
AU (1) AU2001282058A1 (en)
CA (1) CA2419469C (en)
CY (1) CY1108945T1 (en)
CZ (1) CZ2003719A3 (en)
DE (2) DE10040103A1 (en)
DK (1) DK1309610T3 (en)
ES (1) ES2317926T3 (en)
MX (1) MXPA03001427A (en)
PL (1) PL366312A1 (en)
PT (1) PT1309610E (en)
WO (1) WO2002014350A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002040073A1 (en) 2000-11-20 2002-05-23 Université De Genève Endosseous implant
DE10325049A1 (en) * 2003-06-02 2004-12-23 Merck Patent Gmbh New peptide derivatives containing cell-adhesion molecule and phosphonate-containing anchor component, useful for treating disorders associated with implants, are inhibitors of integrins

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012727A1 (en) * 1991-01-25 1992-08-06 Regents Of The University Of Minnesota Laminin a chain domain vi polypeptides
PL337019A1 (en) * 1997-05-22 2000-07-31 Merck Patent Gmbh Peptide-coated implants and method of obtaining them
DE19755801A1 (en) * 1997-12-16 2000-06-21 Merck Patent Gmbh Implant with improved tissue integration
DE19755800A1 (en) * 1997-12-16 1999-06-17 Merck Patent Gmbh Cyclopeptide derivatives
DE19831710A1 (en) 1998-07-15 2000-01-20 Merck Patent Gmbh New diacyl-hydrazine derivatives, are integrin inhibitors useful for treating e.g. thrombosis, cardiac infarction, tumors, osteoporosis, inflammation or infection
DE19932796A1 (en) 1999-07-14 2001-01-18 Merck Patent Gmbh Diacylhydrazine derivatives

Also Published As

Publication number Publication date
CN1446230A (en) 2003-10-01
US20040043937A1 (en) 2004-03-04
JP2004506649A (en) 2004-03-04
WO2002014350A3 (en) 2002-09-19
JP4795620B2 (en) 2011-10-19
ATE419269T1 (en) 2009-01-15
CA2419469C (en) 2013-05-14
MXPA03001427A (en) 2003-06-06
CA2419469A1 (en) 2003-02-14
DE50114621D1 (en) 2009-02-12
CY1108945T1 (en) 2014-07-02
PL366312A1 (en) 2005-01-24
PT1309610E (en) 2009-03-16
US7276482B2 (en) 2007-10-02
DE10040103A1 (en) 2002-02-28
EP1309610A2 (en) 2003-05-14
DK1309610T3 (en) 2009-03-30
KR20030062318A (en) 2003-07-23
CZ2003719A3 (en) 2003-06-18
EP1309610B1 (en) 2008-12-31
ES2317926T3 (en) 2009-05-01
WO2002014350A2 (en) 2002-02-21

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