CY1108945T1 - Παραγωγα πεπτιδιων και πεπτιδομιμητικων ενωσεων με ιδιοτητες αναστολεα ενσωματινης ιι - Google Patents
Παραγωγα πεπτιδιων και πεπτιδομιμητικων ενωσεων με ιδιοτητες αναστολεα ενσωματινης ιιInfo
- Publication number
- CY1108945T1 CY1108945T1 CY20091100374T CY091100374T CY1108945T1 CY 1108945 T1 CY1108945 T1 CY 1108945T1 CY 20091100374 T CY20091100374 T CY 20091100374T CY 091100374 T CY091100374 T CY 091100374T CY 1108945 T1 CY1108945 T1 CY 1108945T1
- Authority
- CY
- Cyprus
- Prior art keywords
- arg
- lys
- sup
- gln
- ile
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Abstract
Ενώσεις του τύπου (I): B-Q-X1, όπου Β σημαίνει βιοενεργό μόριο που μεσολαβεί στην κυτταρική προσκόλληση, επιλεγόμενο από την ομάδα (i) και Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (ii), Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (iii), Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (iv), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (v), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (vi), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (vii), όπου για (i) Χ, Υ, Ζ, R2, R3, R4, A, Ar, Hal, Het, Het1, n, m, o, p, q, s, t έχουν τις σημασίες που δίδονται στην αξίωση 1, Q είναι απούσα ή είναι οργανικό διαχωριστικό μόριο, Χ1 είναι μόριο αγκίστρωσης, επιλεγόμενο από την ομάδα που δίδεται στην αξίωση 1, καθώς και άλατα αυτών, μπορούν να χρησιμοποιηθούν ως αναστολείς ενσωματίνης, ιδίως για την αγωγή παθήσεων, ατελειών, φλεγμονών προκαλούμενων από εμφυτεύματα και οστεολυτικών παθήσεων όπως οστεοπόρωσης, θρόμβωσης, καρδιακού εμφράγματος και αρτηριοσκλήρυνσης, καθώς και για την επιτάχυνση και ενίσχυση της διεργασίας ολοκλήρωσης του εμφυτεύματος ή της βιοσυμβατικής επιφάνειας στον ιστό.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10040103A DE10040103A1 (de) | 2000-08-17 | 2000-08-17 | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften II |
EP01960611A EP1309610B1 (de) | 2000-08-17 | 2001-08-02 | Peptid- und peptidmimetika-derivate mit integrin-inhibitor-eigenschaften ii |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108945T1 true CY1108945T1 (el) | 2014-07-02 |
Family
ID=7652667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100374T CY1108945T1 (el) | 2000-08-17 | 2009-03-31 | Παραγωγα πεπτιδιων και πεπτιδομιμητικων ενωσεων με ιδιοτητες αναστολεα ενσωματινης ιι |
Country Status (17)
Country | Link |
---|---|
US (1) | US7276482B2 (el) |
EP (1) | EP1309610B1 (el) |
JP (1) | JP4795620B2 (el) |
KR (1) | KR20030062318A (el) |
CN (1) | CN1446230A (el) |
AT (1) | ATE419269T1 (el) |
AU (1) | AU2001282058A1 (el) |
CA (1) | CA2419469C (el) |
CY (1) | CY1108945T1 (el) |
CZ (1) | CZ2003719A3 (el) |
DE (2) | DE10040103A1 (el) |
DK (1) | DK1309610T3 (el) |
ES (1) | ES2317926T3 (el) |
MX (1) | MXPA03001427A (el) |
PL (1) | PL366312A1 (el) |
PT (1) | PT1309610E (el) |
WO (1) | WO2002014350A2 (el) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001221607A1 (en) | 2000-11-20 | 2002-05-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Endosseous implant |
DE10325049A1 (de) * | 2003-06-02 | 2004-12-23 | Merck Patent Gmbh | Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften III |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992012727A1 (en) * | 1991-01-25 | 1992-08-06 | Regents Of The University Of Minnesota | Laminin a chain domain vi polypeptides |
DE19755801A1 (de) * | 1997-12-16 | 2000-06-21 | Merck Patent Gmbh | Mit die Zelladhäsion vermittelnden Peptiden beschichtete Implantate und Verfahren zu ihrer Herstellung |
US6280760B1 (en) * | 1997-05-22 | 2001-08-28 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Peptide-coated implants and methods for producing same |
DE19755800A1 (de) * | 1997-12-16 | 1999-06-17 | Merck Patent Gmbh | Cyclopeptidderivate |
DE19831710A1 (de) | 1998-07-15 | 2000-01-20 | Merck Patent Gmbh | Diacylhydrazinderivate |
DE19932796A1 (de) | 1999-07-14 | 2001-01-18 | Merck Patent Gmbh | Diacylhydrazinderivate |
-
2000
- 2000-08-17 DE DE10040103A patent/DE10040103A1/de not_active Withdrawn
-
2001
- 2001-08-02 PL PL01366312A patent/PL366312A1/xx unknown
- 2001-08-02 CN CN01814101A patent/CN1446230A/zh active Pending
- 2001-08-02 AU AU2001282058A patent/AU2001282058A1/en not_active Abandoned
- 2001-08-02 WO PCT/EP2001/008931 patent/WO2002014350A2/de not_active Application Discontinuation
- 2001-08-02 CA CA2419469A patent/CA2419469C/en not_active Expired - Fee Related
- 2001-08-02 AT AT01960611T patent/ATE419269T1/de active
- 2001-08-02 PT PT01960611T patent/PT1309610E/pt unknown
- 2001-08-02 US US10/344,668 patent/US7276482B2/en not_active Expired - Fee Related
- 2001-08-02 DE DE50114621T patent/DE50114621D1/de not_active Expired - Lifetime
- 2001-08-02 MX MXPA03001427A patent/MXPA03001427A/es unknown
- 2001-08-02 CZ CZ2003719A patent/CZ2003719A3/cs unknown
- 2001-08-02 ES ES01960611T patent/ES2317926T3/es not_active Expired - Lifetime
- 2001-08-02 EP EP01960611A patent/EP1309610B1/de not_active Expired - Lifetime
- 2001-08-02 DK DK01960611T patent/DK1309610T3/da active
- 2001-08-02 KR KR10-2003-7002263A patent/KR20030062318A/ko not_active Application Discontinuation
- 2001-08-02 JP JP2002519487A patent/JP4795620B2/ja not_active Expired - Fee Related
-
2009
- 2009-03-31 CY CY20091100374T patent/CY1108945T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL366312A1 (en) | 2005-01-24 |
WO2002014350A2 (de) | 2002-02-21 |
DK1309610T3 (da) | 2009-03-30 |
MXPA03001427A (es) | 2003-06-06 |
AU2001282058A1 (en) | 2002-02-25 |
JP2004506649A (ja) | 2004-03-04 |
CZ2003719A3 (cs) | 2003-06-18 |
WO2002014350A3 (de) | 2002-09-19 |
PT1309610E (pt) | 2009-03-16 |
JP4795620B2 (ja) | 2011-10-19 |
CA2419469A1 (en) | 2003-02-14 |
US7276482B2 (en) | 2007-10-02 |
CN1446230A (zh) | 2003-10-01 |
DE10040103A1 (de) | 2002-02-28 |
EP1309610B1 (de) | 2008-12-31 |
DE50114621D1 (de) | 2009-02-12 |
EP1309610A2 (de) | 2003-05-14 |
ATE419269T1 (de) | 2009-01-15 |
KR20030062318A (ko) | 2003-07-23 |
ES2317926T3 (es) | 2009-05-01 |
CA2419469C (en) | 2013-05-14 |
US20040043937A1 (en) | 2004-03-04 |
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