DK1282601T3 - Fremgangsmåde og mellemprodukter til fremstilling af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf - Google Patents
Fremgangsmåde og mellemprodukter til fremstilling af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte derafInfo
- Publication number
- DK1282601T3 DK1282601T3 DK01929337T DK01929337T DK1282601T3 DK 1282601 T3 DK1282601 T3 DK 1282601T3 DK 01929337 T DK01929337 T DK 01929337T DK 01929337 T DK01929337 T DK 01929337T DK 1282601 T3 DK1282601 T3 DK 1282601T3
- Authority
- DK
- Denmark
- Prior art keywords
- carvedilol
- preparation
- carbazol
- yloxy
- propan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK200000801A DK174645B1 (da) | 2000-05-18 | 2000-05-18 | Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
| PCT/DK2001/000306 WO2001087837A1 (en) | 2000-05-18 | 2001-05-03 | Process and intermediates for the preparation of 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol or acid addition salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1282601T3 true DK1282601T3 (da) | 2004-05-24 |
Family
ID=8159503
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK200000801A DK174645B1 (da) | 2000-05-18 | 2000-05-18 | Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
| DK03077677T DK1375474T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
| DK01929337T DK1282601T3 (da) | 2000-05-18 | 2001-05-03 | Fremgangsmåde og mellemprodukter til fremstilling af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
| DK03077684T DK1367052T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK200000801A DK174645B1 (da) | 2000-05-18 | 2000-05-18 | Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf |
| DK03077677T DK1375474T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03077684T DK1367052T3 (da) | 2000-05-18 | 2001-05-03 | Mellemprodukt til fremstillingen af carvedilol |
Country Status (8)
| Country | Link |
|---|---|
| EP (3) | EP1375474B1 (da) |
| AT (3) | ATE258165T1 (da) |
| CA (1) | CA2407103A1 (da) |
| DK (4) | DK174645B1 (da) |
| ES (3) | ES2260575T3 (da) |
| NO (1) | NO323828B1 (da) |
| PT (3) | PT1375474E (da) |
| WO (1) | WO2001087837A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04012923A (es) * | 2002-06-27 | 2005-03-31 | Sb Pharmco Inc | Sales de fosfato de carvedilol y/o solvatos de las mismas, composiciones correspondientes y/o metodos de tratamiento. |
| US20050261355A1 (en) | 2002-06-27 | 2005-11-24 | Sb Pharmco Puerto Rico Inc., | Carvedilol hydobromide |
| EP1615888A1 (en) | 2003-04-21 | 2006-01-18 | Matrix Laboratories Ltd | Process for the preparation of carvedilol form-ii |
| JP2007512372A (ja) * | 2003-11-25 | 2007-05-17 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール塩、対応する組成物、送達および／または治療方法 |
| KR100746455B1 (ko) * | 2006-02-23 | 2007-08-03 | 안국약품 주식회사 | 고광학순도의 키랄 카베딜롤의 제조방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3152168A (en) * | 1961-09-05 | 1964-10-06 | Monsanto Co | Haloalkyl pentahalophenyl carbonates |
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2506769A2 (fr) * | 1978-06-09 | 1982-12-03 | Delalande Sa | Para-((cyano-5 n pentyl-1) phenyl)-3 methoxymethyl-5 oxazolidinone-2, son procede de preparation et ses applications en therapeutique |
| HU227441B1 (en) * | 1997-11-24 | 2011-06-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing carvedilol, enantiomers and salts thereof |
-
2000
- 2000-05-18 DK DK200000801A patent/DK174645B1/da not_active IP Right Cessation
-
2001
- 2001-05-03 ES ES03077677T patent/ES2260575T3/es not_active Expired - Lifetime
- 2001-05-03 ES ES03077684T patent/ES2268275T3/es not_active Expired - Lifetime
- 2001-05-03 ES ES01929337T patent/ES2214414T3/es not_active Expired - Lifetime
- 2001-05-03 EP EP03077677A patent/EP1375474B1/en not_active Expired - Lifetime
- 2001-05-03 AT AT01929337T patent/ATE258165T1/de not_active IP Right Cessation
- 2001-05-03 PT PT03077677T patent/PT1375474E/pt unknown
- 2001-05-03 EP EP01929337A patent/EP1282601B1/en not_active Expired - Lifetime
- 2001-05-03 DK DK03077677T patent/DK1375474T3/da active
- 2001-05-03 EP EP03077684A patent/EP1367052B1/en not_active Expired - Lifetime
- 2001-05-03 PT PT01929337T patent/PT1282601E/pt unknown
- 2001-05-03 DK DK01929337T patent/DK1282601T3/da active
- 2001-05-03 AT AT03077677T patent/ATE322481T1/de not_active IP Right Cessation
- 2001-05-03 DK DK03077684T patent/DK1367052T3/da active
- 2001-05-03 PT PT03077684T patent/PT1367052E/pt unknown
- 2001-05-03 CA CA002407103A patent/CA2407103A1/en not_active Abandoned
- 2001-05-03 WO PCT/DK2001/000306 patent/WO2001087837A1/en active IP Right Grant
- 2001-05-03 AT AT03077684T patent/ATE332892T1/de not_active IP Right Cessation
-
2002
- 2002-11-15 NO NO20025476A patent/NO323828B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1282601A1 (en) | 2003-02-12 |
| NO20025476D0 (no) | 2002-11-15 |
| PT1282601E (pt) | 2004-06-30 |
| EP1367052A2 (en) | 2003-12-03 |
| NO323828B1 (no) | 2007-07-09 |
| ES2214414T3 (es) | 2004-09-16 |
| ATE322481T1 (de) | 2006-04-15 |
| DK1375474T3 (da) | 2006-08-07 |
| WO2001087837A1 (en) | 2001-11-22 |
| PT1375474E (pt) | 2006-07-31 |
| ATE258165T1 (de) | 2004-02-15 |
| EP1367052B1 (en) | 2006-07-12 |
| EP1367052A3 (en) | 2003-12-10 |
| DK200000801A (da) | 2001-11-19 |
| EP1375474B1 (en) | 2006-04-05 |
| EP1375474A2 (en) | 2004-01-02 |
| CA2407103A1 (en) | 2001-11-22 |
| EP1375474A3 (en) | 2004-10-06 |
| DK1367052T3 (da) | 2006-09-25 |
| EP1282601B1 (en) | 2004-01-21 |
| DK174645B1 (da) | 2003-08-04 |
| ES2260575T3 (es) | 2006-11-01 |
| NO20025476L (no) | 2002-11-15 |
| PT1367052E (pt) | 2006-10-31 |
| ES2268275T3 (es) | 2007-03-16 |
| ATE332892T1 (de) | 2006-08-15 |
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