ATE258165T1 - Verfahren und zwischenverbindungen zur herstellung von 1-(9h-carbazol-4-yloxy)-3-(2-(2- methoxy-phenoxy)-ethylamino)-propan-2-ol, carvediol, oder ein säureadditionssalz davon - Google Patents

Verfahren und zwischenverbindungen zur herstellung von 1-(9h-carbazol-4-yloxy)-3-(2-(2- methoxy-phenoxy)-ethylamino)-propan-2-ol, carvediol, oder ein säureadditionssalz davon

Info

Publication number
ATE258165T1
ATE258165T1 AT01929337T AT01929337T ATE258165T1 AT E258165 T1 ATE258165 T1 AT E258165T1 AT 01929337 T AT01929337 T AT 01929337T AT 01929337 T AT01929337 T AT 01929337T AT E258165 T1 ATE258165 T1 AT E258165T1
Authority
AT
Austria
Prior art keywords
carvediol
carbazol
yloxy
ethylamino
phenoxy
Prior art date
Application number
AT01929337T
Other languages
English (en)
Inventor
Thomas Pittelkow
Erik Fischer
Svend Peter Treppendahl
Original Assignee
Gea Farmaceutisk Fabrik As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Farmaceutisk Fabrik As filed Critical Gea Farmaceutisk Fabrik As
Application granted granted Critical
Publication of ATE258165T1 publication Critical patent/ATE258165T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT01929337T 2000-05-18 2001-05-03 Verfahren und zwischenverbindungen zur herstellung von 1-(9h-carbazol-4-yloxy)-3-(2-(2- methoxy-phenoxy)-ethylamino)-propan-2-ol, carvediol, oder ein säureadditionssalz davon ATE258165T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK200000801A DK174645B1 (da) 2000-05-18 2000-05-18 Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf
PCT/DK2001/000306 WO2001087837A1 (en) 2000-05-18 2001-05-03 Process and intermediates for the preparation of 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol or acid addition salts thereof

Publications (1)

Publication Number Publication Date
ATE258165T1 true ATE258165T1 (de) 2004-02-15

Family

ID=8159503

Family Applications (3)

Application Number Title Priority Date Filing Date
AT03077677T ATE322481T1 (de) 2000-05-18 2001-05-03 Zwischenverbindung zur herstellung von carvedilol
AT01929337T ATE258165T1 (de) 2000-05-18 2001-05-03 Verfahren und zwischenverbindungen zur herstellung von 1-(9h-carbazol-4-yloxy)-3-(2-(2- methoxy-phenoxy)-ethylamino)-propan-2-ol, carvediol, oder ein säureadditionssalz davon
AT03077684T ATE332892T1 (de) 2000-05-18 2001-05-03 Zwischenverbindung für die herstellung von carvedilol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03077677T ATE322481T1 (de) 2000-05-18 2001-05-03 Zwischenverbindung zur herstellung von carvedilol

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03077684T ATE332892T1 (de) 2000-05-18 2001-05-03 Zwischenverbindung für die herstellung von carvedilol

Country Status (8)

Country Link
EP (3) EP1367052B1 (de)
AT (3) ATE322481T1 (de)
CA (1) CA2407103A1 (de)
DK (4) DK174645B1 (de)
ES (3) ES2260575T3 (de)
NO (1) NO323828B1 (de)
PT (3) PT1367052E (de)
WO (1) WO2001087837A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268156B2 (en) 2002-06-27 2007-09-11 Sb Pharmco Puerto Rico Inc. Carvedilol phosphate salts and/or solvates thereof, corresponding compositions and/or methods of treatment
US20050261355A1 (en) 2002-06-27 2005-11-24 Sb Pharmco Puerto Rico Inc., Carvedilol hydobromide
US7468442B2 (en) 2003-04-21 2008-12-23 Matrix Laboratories Ltd. Process for the preparation of carvedilol form-II
EP1686986A4 (de) 2003-11-25 2009-05-27 Sb Pharmco Inc Carvedilol-salze, entsprechende zusammensetzungen, verfahren zur abgabe und/oder behandlung
KR100746455B1 (ko) 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3152168A (en) * 1961-09-05 1964-10-06 Monsanto Co Haloalkyl pentahalophenyl carbonates
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2506769A2 (fr) * 1978-06-09 1982-12-03 Delalande Sa Para-((cyano-5 n pentyl-1) phenyl)-3 methoxymethyl-5 oxazolidinone-2, son procede de preparation et ses applications en therapeutique
HU227441B1 (en) * 1997-11-24 2011-06-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing carvedilol, enantiomers and salts thereof

Also Published As

Publication number Publication date
EP1282601A1 (de) 2003-02-12
ES2268275T3 (es) 2007-03-16
EP1367052A3 (de) 2003-12-10
ATE332892T1 (de) 2006-08-15
EP1375474A2 (de) 2004-01-02
DK1367052T3 (da) 2006-09-25
ATE322481T1 (de) 2006-04-15
PT1375474E (pt) 2006-07-31
EP1375474B1 (de) 2006-04-05
NO20025476D0 (no) 2002-11-15
NO323828B1 (no) 2007-07-09
DK1375474T3 (da) 2006-08-07
PT1282601E (pt) 2004-06-30
EP1282601B1 (de) 2004-01-21
ES2260575T3 (es) 2006-11-01
ES2214414T3 (es) 2004-09-16
DK174645B1 (da) 2003-08-04
PT1367052E (pt) 2006-10-31
EP1375474A3 (de) 2004-10-06
NO20025476L (no) 2002-11-15
CA2407103A1 (en) 2001-11-22
EP1367052A2 (de) 2003-12-03
EP1367052B1 (de) 2006-07-12
WO2001087837A1 (en) 2001-11-22
DK200000801A (da) 2001-11-19
DK1282601T3 (da) 2004-05-24

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