DK1263431T3 - Kondensationsderivater af thiocolchicin og baccatin som antitumormidler - Google Patents

Kondensationsderivater af thiocolchicin og baccatin som antitumormidler

Info

Publication number
DK1263431T3
DK1263431T3 DK01923660T DK01923660T DK1263431T3 DK 1263431 T3 DK1263431 T3 DK 1263431T3 DK 01923660 T DK01923660 T DK 01923660T DK 01923660 T DK01923660 T DK 01923660T DK 1263431 T3 DK1263431 T3 DK 1263431T3
Authority
DK
Denmark
Prior art keywords
thiocolchicine
baccatin
antitumor agents
condensation derivatives
condensation
Prior art date
Application number
DK01923660T
Other languages
Danish (da)
English (en)
Inventor
Ezio Bombardelli
Alessandro Pontiroli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK1263431T3 publication Critical patent/DK1263431T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK01923660T 2000-03-17 2001-03-12 Kondensationsderivater af thiocolchicin og baccatin som antitumormidler DK1263431T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000553A IT1319168B1 (it) 2000-03-17 2000-03-17 Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
PCT/EP2001/002740 WO2001068089A1 (en) 2000-03-17 2001-03-12 Condensation derivatives of thiocolchicine and baccatin as antitumor agents

Publications (1)

Publication Number Publication Date
DK1263431T3 true DK1263431T3 (da) 2008-09-29

Family

ID=11444500

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01923660T DK1263431T3 (da) 2000-03-17 2001-03-12 Kondensationsderivater af thiocolchicin og baccatin som antitumormidler

Country Status (21)

Country Link
US (1) US6683109B2 (no)
EP (1) EP1263431B1 (no)
JP (1) JP2003526665A (no)
KR (1) KR100766161B1 (no)
CN (1) CN1204886C (no)
AU (2) AU5037701A (no)
CA (1) CA2403168C (no)
CZ (1) CZ301626B6 (no)
DK (1) DK1263431T3 (no)
ES (1) ES2305067T3 (no)
HK (1) HK1051973A1 (no)
HU (1) HU229257B1 (no)
IL (1) IL151714A0 (no)
IT (1) IT1319168B1 (no)
NO (1) NO329422B1 (no)
PL (1) PL357376A1 (no)
PT (1) PT1263431E (no)
RU (1) RU2264393C2 (no)
SI (1) SI1263431T1 (no)
SK (1) SK286849B6 (no)
WO (1) WO2001068089A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
CA2354471A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 ester substituted taxanes
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
WO2005087222A1 (en) 2004-03-05 2005-09-22 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
EP2276755A4 (en) 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
AU2400692A (en) * 1991-07-19 1993-02-23 Hybritech Incorporated Trifunctional compounds having specificity for multi-drug resistant cells
CA2124329C (en) * 1991-11-27 2008-11-18 Gregory A. Kopia Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
US5426224A (en) * 1993-03-18 1995-06-20 The University Of North Carolina At Chapel Hill Mammalian DNA topoisomerase II inhibitor and method
WO1997024459A1 (en) * 1995-12-29 1997-07-10 Phanos Technologoes, Inc. Method for reducing unwanted cellular adhesions
PT1114815E (pt) * 1996-05-08 2005-01-31 Upjohn Co Processo para a preparacao de taxol

Also Published As

Publication number Publication date
RU2002124523A (ru) 2004-01-10
KR100766161B1 (ko) 2007-10-10
EP1263431B1 (en) 2008-05-28
HUP0300198A2 (hu) 2003-06-28
AU5037701A (en) 2001-09-24
JP2003526665A (ja) 2003-09-09
CN1416342A (zh) 2003-05-07
PT1263431E (pt) 2008-08-04
NO20024353L (no) 2002-09-12
EP1263431A1 (en) 2002-12-11
CA2403168C (en) 2010-06-15
HK1051973A1 (en) 2003-08-29
RU2264393C2 (ru) 2005-11-20
KR20020081432A (ko) 2002-10-26
SK13112002A3 (sk) 2003-02-04
CN1204886C (zh) 2005-06-08
ES2305067T3 (es) 2008-11-01
AU2001250377B2 (en) 2004-09-16
PL357376A1 (en) 2004-07-26
NO329422B1 (no) 2010-10-18
ITMI20000553A0 (it) 2000-03-17
CA2403168A1 (en) 2001-09-20
IL151714A0 (en) 2003-04-10
US20030073734A1 (en) 2003-04-17
SK286849B6 (sk) 2009-06-05
IT1319168B1 (it) 2003-09-26
HUP0300198A3 (en) 2005-02-28
WO2001068089A1 (en) 2001-09-20
HU229257B1 (en) 2013-10-28
CZ301626B6 (cs) 2010-05-05
SI1263431T1 (sl) 2008-08-31
ITMI20000553A1 (it) 2001-09-17
NO20024353D0 (no) 2002-09-12
US6683109B2 (en) 2004-01-27

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