DK1246809T3 - 5-aryl-1H-1,2,4-triazolforbindelser som inhibitor for cyclooxygenase-2 og farmaceutiske sammensætninger som indeholder dem - Google Patents

5-aryl-1H-1,2,4-triazolforbindelser som inhibitor for cyclooxygenase-2 og farmaceutiske sammensætninger som indeholder dem

Info

Publication number
DK1246809T3
DK1246809T3 DK00983110T DK00983110T DK1246809T3 DK 1246809 T3 DK1246809 T3 DK 1246809T3 DK 00983110 T DK00983110 T DK 00983110T DK 00983110 T DK00983110 T DK 00983110T DK 1246809 T3 DK1246809 T3 DK 1246809T3
Authority
DK
Denmark
Prior art keywords
aryl
pharmaceutical compositions
cyclooxygenase
inhibitor
compositions containing
Prior art date
Application number
DK00983110T
Other languages
Danish (da)
English (en)
Inventor
Jean-Claude Pascal
Denis Carniato
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Application granted granted Critical
Publication of DK1246809T3 publication Critical patent/DK1246809T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00983110T 1999-11-09 2000-11-06 5-aryl-1H-1,2,4-triazolforbindelser som inhibitor for cyclooxygenase-2 og farmaceutiske sammensætninger som indeholder dem DK1246809T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99402784A EP1099695A1 (en) 1999-11-09 1999-11-09 5-aryl-1H-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them
PCT/EP2000/010956 WO2001034577A1 (en) 1999-11-09 2000-11-06 5-aryl-1h-1,2,4-triazole compounds as inhibitors of cyclooxygenase-2 and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
DK1246809T3 true DK1246809T3 (da) 2003-10-20

Family

ID=8242172

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00983110T DK1246809T3 (da) 1999-11-09 2000-11-06 5-aryl-1H-1,2,4-triazolforbindelser som inhibitor for cyclooxygenase-2 og farmaceutiske sammensætninger som indeholder dem

Country Status (24)

Country Link
US (1) US6803380B1 (cs)
EP (2) EP1099695A1 (cs)
JP (1) JP4786846B2 (cs)
CN (1) CN1198807C (cs)
AT (1) ATE245148T1 (cs)
AU (1) AU778819B2 (cs)
BR (1) BR0015440A (cs)
CA (1) CA2390649C (cs)
CZ (1) CZ20021591A3 (cs)
DE (1) DE60003949T2 (cs)
DK (1) DK1246809T3 (cs)
ES (1) ES2203538T3 (cs)
HU (1) HUP0203376A3 (cs)
IL (2) IL149370A0 (cs)
MX (1) MXPA01012903A (cs)
NO (1) NO328008B1 (cs)
NZ (1) NZ518682A (cs)
PL (1) PL204230B1 (cs)
PT (1) PT1246809E (cs)
RU (1) RU2249588C2 (cs)
SI (1) SI1246809T1 (cs)
TW (1) TWI268925B (cs)
WO (1) WO2001034577A1 (cs)
ZA (1) ZA200203165B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2240661T3 (es) 2001-07-05 2005-10-16 Pfizer Products Inc. Sulfonil-heteroaril-triazoles como agentes antiinflamatorios y analgesicos.
EP1273582B1 (en) 2001-07-05 2005-06-29 Pfizer Products Inc. Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents
CA2390181A1 (en) * 2001-07-05 2003-01-05 Andrei Shavnya Sulfonyl aryl triazoles as anti-inflammatory/analgesic agents
KR100824233B1 (ko) * 2001-10-10 2008-04-24 씨제이제일제당 (주) 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난3,4-디하이드로-1ｈ-나프탈렌 유도체
WO2003037336A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer
AUPR878201A0 (en) 2001-11-09 2001-12-06 Fujisawa Pharmaceutical Co., Ltd. New compounds
KR100686537B1 (ko) 2001-12-28 2007-02-27 씨제이 주식회사 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
US6797722B2 (en) * 2002-05-03 2004-09-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
KR100467668B1 (ko) * 2002-08-07 2005-01-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470075B1 (ko) * 2002-11-21 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100491317B1 (ko) * 2002-11-26 2005-05-24 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
KR100470076B1 (ko) * 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2004060367A1 (en) * 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Imidazole and triazole derivatives useful as selective cox-1 inhibitors
WO2006114377A1 (en) * 2005-04-28 2006-11-02 Ciba Specialty Chemicals Holding Inc. Electroluminescent device
EP2051966A2 (en) * 2006-08-09 2009-04-29 Pfizer Products Inc. Heterocycles useful as inhibitors of carbonic anhydrase
KR101893624B1 (ko) * 2010-11-26 2018-08-30 가부시키가이샤 한도오따이 에네루기 켄큐쇼 유기금속 착물, 발광 엘리먼트, 발광 디바이스, 전자 디바이스 및 조명 디바이스
WO2012170839A2 (en) * 2011-06-09 2012-12-13 Cardeus Pharmaceuticals, Inc. Treatment of neuroinflammatory disease with selective cox1 inhibitors
US8853248B2 (en) * 2012-04-05 2014-10-07 Hubert Maehr (1,2,3-triazolyl)sulfonyl derivatives
CN104693133A (zh) * 2015-02-16 2015-06-10 广州市盈宇医药科技有限公司 一种环氧化酶-2选择性抑制剂及其制备方法和应用
AU2019229521A1 (en) 2018-03-08 2020-09-03 Bayer Aktiengesellschaft Use of heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides in plant protection
SG11202008739TA (en) 2018-04-12 2020-10-29 Bayer Ag N-(cyclopropylmethyl)-5-(methylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as pesticides
IL310857A (en) 2018-04-25 2024-04-01 Bayer Ag Heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
BR112022000915A2 (pt) 2019-07-23 2022-05-17 Bayer Ag Compostos de heteroaril-triazol como pesticidas
UY38796A (es) 2019-07-23 2021-02-26 Bayer Ag Novedosos compuestos de heteroaril-triazol como plaguicidas
UY38911A (es) 2019-10-09 2021-05-31 Bayer Ag Compuestos de heteroarilo-triazol como pesticidas, formulaciones, usos y métodos de uso de los mismos
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
BR112022016400A2 (pt) 2020-02-18 2022-10-25 Bayer Ag Compostos inovadores de heteroaril-triazol como pesticidas
TWI754474B (zh) * 2020-11-30 2022-02-01 翁豐富 具選擇性第二型環氧合酶抑制活性之1,2,4-三氮唑衍生物及其用途
CN112480073B (zh) * 2020-12-02 2022-03-22 武汉药明康德新药开发有限公司 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW226993B (cs) * 1992-05-29 1994-07-21 Kumiai Chemical Industry Co
JP3682075B2 (ja) * 1993-04-16 2005-08-10 クミアイ化学工業株式会社 トリアゾール誘導体及び殺虫、殺ダニ剤
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
JPH0776577A (ja) * 1993-07-14 1995-03-20 Kumiai Chem Ind Co Ltd ジフェニルトリアゾール誘導体及び殺虫、殺ダニ剤
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation

Also Published As

Publication number Publication date
HUP0203376A3 (en) 2004-12-28
CZ20021591A3 (cs) 2002-07-17
CA2390649C (en) 2008-05-06
EP1246809A1 (en) 2002-10-09
ES2203538T3 (es) 2004-04-16
WO2001034577A1 (en) 2001-05-17
HUP0203376A2 (hu) 2003-01-28
CN1198807C (zh) 2005-04-27
IL149370A (en) 2007-06-17
PT1246809E (pt) 2003-11-28
MXPA01012903A (es) 2002-11-07
PL204230B1 (pl) 2009-12-31
DE60003949T2 (de) 2004-05-27
EP1099695A1 (en) 2001-05-16
CN1387517A (zh) 2002-12-25
NZ518682A (en) 2003-07-25
JP2003513961A (ja) 2003-04-15
PL356120A1 (en) 2004-06-14
JP4786846B2 (ja) 2011-10-05
AU778819B2 (en) 2004-12-23
AU1998501A (en) 2001-06-06
US6803380B1 (en) 2004-10-12
NO20022202L (no) 2002-05-08
NO328008B1 (no) 2009-11-09
BR0015440A (pt) 2002-07-02
SI1246809T1 (en) 2004-02-29
EP1246809B1 (en) 2003-07-16
NO20022202D0 (no) 2002-05-08
DE60003949D1 (de) 2003-08-21
IL149370A0 (en) 2002-11-10
CA2390649A1 (en) 2001-05-17
RU2249588C2 (ru) 2005-04-10
ATE245148T1 (de) 2003-08-15
TWI268925B (en) 2006-12-21
ZA200203165B (en) 2003-06-25

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