ATE193526T1 - Alkylierte styrole als prodrugs zu cox-2- inhibitoren - Google Patents
Alkylierte styrole als prodrugs zu cox-2- inhibitorenInfo
- Publication number
- ATE193526T1 ATE193526T1 AT97900910T AT97900910T ATE193526T1 AT E193526 T1 ATE193526 T1 AT E193526T1 AT 97900910 T AT97900910 T AT 97900910T AT 97900910 T AT97900910 T AT 97900910T AT E193526 T1 ATE193526 T1 AT E193526T1
- Authority
- AT
- Austria
- Prior art keywords
- cox
- prodrugs
- inhibitors
- alkylated styrenes
- cyclooxygenase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1043296P | 1996-02-01 | 1996-02-01 | |
GBGB9605646.0A GB9605646D0 (en) | 1996-03-18 | 1996-03-18 | Alkylated styrenes as prodrugs to cox-2 inhibitors |
PCT/CA1997/000058 WO1997028121A1 (en) | 1996-02-01 | 1997-01-29 | Alkylated styrenes as prodrugs to cox-2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE193526T1 true ATE193526T1 (de) | 2000-06-15 |
Family
ID=26308948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97900910T ATE193526T1 (de) | 1996-02-01 | 1997-01-29 | Alkylierte styrole als prodrugs zu cox-2- inhibitoren |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0882016B1 (de) |
JP (1) | JP4004541B2 (de) |
AT (1) | ATE193526T1 (de) |
AU (1) | AU710675B2 (de) |
DE (1) | DE69702182T2 (de) |
ES (1) | ES2147973T3 (de) |
WO (1) | WO1997028121A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6071954A (en) * | 1997-03-14 | 2000-06-06 | Merk Frosst Canada, Inc. | (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors |
ATE244232T1 (de) * | 1997-03-14 | 2003-07-15 | Merck Frosst Canada Inc | (methylsulfonyl)phenyl-2-(5h)-furanone mit sauerstoff-bindung als cox-2-hemmer |
DE69940922D1 (de) * | 1999-10-08 | 2009-07-09 | Merial Sas | Polymorphe Form B von 3-(Cyclopropylmethoxy)-4-i4-(methylsulfonyl)phenyl -5,5-dimethyl-5H-furan-2-on |
RU2002119574A (ru) | 1999-12-23 | 2004-01-10 | Нитромед, Инк. (Us) | Нитрозированные и нитрозилированные ингибиторы циклооксигеназы-2, композиции на их основе и способы их применения |
KR100672628B1 (ko) | 2000-12-29 | 2007-01-23 | 엘지.필립스 엘시디 주식회사 | 액티브 매트릭스 유기 전계발광 디스플레이 장치 |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
US7211598B2 (en) | 2002-06-28 | 2007-05-01 | Nitromed, Inc. | Oxime and/or hydrozone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
DE102004027912A1 (de) * | 2004-06-09 | 2005-12-29 | Grünenthal GmbH | Substituierte Cyclopenten-Verbindungen |
WO2006055404A2 (en) * | 2004-11-16 | 2006-05-26 | Merck & Co., Inc. | Compounds for targeting mechanisms implicated in the progression of stroke |
WO2018138913A1 (ja) * | 2017-01-30 | 2018-08-02 | 株式会社テクノスルガ・ラボ | 保存溶液およびその保存溶液を用いた検体の保存方法、特に、検体のdnaおよび有機酸やポリアミン類などの化学物質の保存溶液およびその保存溶液を用いた保存方法 |
USD889219S1 (en) | 2017-08-04 | 2020-07-07 | Husqvarna Ab | Air outlet for a trimmer |
IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU625123B2 (en) * | 1989-04-24 | 1992-07-02 | Otsuka Pharmaceutical Factory, Inc. | 3-halogeno-2,3-diphenylacrylaldehyde derivative, method of production thereof and curing agent for hyperlipidemia |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
-
1997
- 1997-01-29 ES ES97900910T patent/ES2147973T3/es not_active Expired - Lifetime
- 1997-01-29 JP JP52719897A patent/JP4004541B2/ja not_active Expired - Fee Related
- 1997-01-29 AU AU14342/97A patent/AU710675B2/en not_active Ceased
- 1997-01-29 EP EP97900910A patent/EP0882016B1/de not_active Expired - Lifetime
- 1997-01-29 DE DE69702182T patent/DE69702182T2/de not_active Expired - Fee Related
- 1997-01-29 AT AT97900910T patent/ATE193526T1/de not_active IP Right Cessation
- 1997-01-29 WO PCT/CA1997/000058 patent/WO1997028121A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP4004541B2 (ja) | 2007-11-07 |
EP0882016B1 (de) | 2000-05-31 |
DE69702182T2 (de) | 2001-03-01 |
DE69702182D1 (de) | 2000-07-06 |
WO1997028121A1 (en) | 1997-08-07 |
JP2000505421A (ja) | 2000-05-09 |
AU710675B2 (en) | 1999-09-30 |
ES2147973T3 (es) | 2000-10-01 |
AU1434297A (en) | 1997-08-22 |
EP0882016A1 (de) | 1998-12-09 |
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Publication | Publication Date | Title |
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DE69410092T2 (de) | Phenyl heterocyclen als cyclooxygenase-2 inhibitoren | |
ATE212343T1 (de) | 3,4-diaryl-2-hydroxy-2,5-dihydrofurane als wirkstoffvorstufen von cox-2 inhibitoren | |
NL300175I1 (nl) | Methylsulfonylfenyl-2-(5H)-furanonen als remmers van COX-2. | |
ATE193526T1 (de) | Alkylierte styrole als prodrugs zu cox-2- inhibitoren | |
DE69703791D1 (de) | Diphenylstibene als prodrugs zu cox-2-inhibitoren | |
ATE223376T1 (de) | Bisarylcyclobutenderivate als cyclooxygenasehemmer | |
CA2244140A1 (en) | Alkylated styrenes as prodrugs to cox-2 inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |