DK1204649T3 - Arylmethylcarbonylaminothiazolderivater og deres anvendelse som antitumormidler - Google Patents
Arylmethylcarbonylaminothiazolderivater og deres anvendelse som antitumormidlerInfo
- Publication number
- DK1204649T3 DK1204649T3 DK00962760T DK00962760T DK1204649T3 DK 1204649 T3 DK1204649 T3 DK 1204649T3 DK 00962760 T DK00962760 T DK 00962760T DK 00962760 T DK00962760 T DK 00962760T DK 1204649 T3 DK1204649 T3 DK 1204649T3
- Authority
- DK
- Denmark
- Prior art keywords
- arylmethylcarbonylaminothiazole
- derivatives
- antitumor agents
- antitumor
- agents
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/372,832 US6114365A (en) | 1999-08-12 | 1999-08-12 | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| PCT/IB2000/001423 WO2001014353A1 (fr) | 1999-08-12 | 2000-08-11 | Derives d'arylmethyl-carbonylamino-thiazole utilisation de ceux-ci comme agents antitumoraux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1204649T3 true DK1204649T3 (da) | 2007-12-03 |
Family
ID=23469806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00962760T DK1204649T3 (da) | 1999-08-12 | 2000-08-11 | Arylmethylcarbonylaminothiazolderivater og deres anvendelse som antitumormidler |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US6114365A (fr) |
| EP (1) | EP1204649B1 (fr) |
| JP (1) | JP4864260B2 (fr) |
| KR (2) | KR100773709B1 (fr) |
| CN (1) | CN100410245C (fr) |
| AP (1) | AP1853A (fr) |
| AT (1) | ATE375987T1 (fr) |
| AU (1) | AU782882B2 (fr) |
| BG (1) | BG65484B1 (fr) |
| BR (1) | BR0013281A (fr) |
| CA (1) | CA2381097C (fr) |
| CY (1) | CY1107108T1 (fr) |
| CZ (1) | CZ303138B6 (fr) |
| DE (1) | DE60036803T2 (fr) |
| DK (1) | DK1204649T3 (fr) |
| EA (1) | EA005375B1 (fr) |
| EE (1) | EE04939B1 (fr) |
| ES (1) | ES2295056T3 (fr) |
| GE (1) | GEP20053475B (fr) |
| HK (1) | HK1054233B (fr) |
| HR (1) | HRP20020127B1 (fr) |
| HU (1) | HUP0202492A3 (fr) |
| IL (2) | IL147924A0 (fr) |
| IS (1) | IS2594B (fr) |
| MA (1) | MA25433A1 (fr) |
| MX (1) | MXPA02001508A (fr) |
| NO (1) | NO323576B1 (fr) |
| NZ (1) | NZ517236A (fr) |
| OA (1) | OA12047A (fr) |
| PT (1) | PT1204649E (fr) |
| RS (1) | RS50300B (fr) |
| SI (1) | SI1204649T1 (fr) |
| SK (1) | SK287373B6 (fr) |
| UA (1) | UA72538C2 (fr) |
| WO (1) | WO2001014353A1 (fr) |
| ZA (1) | ZA200201117B (fr) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020150921A1 (en) * | 1996-02-09 | 2002-10-17 | Francis Barany | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US6407103B2 (en) | 1998-04-21 | 2002-06-18 | Bristol-Myers Squibb Pharma Company | Indeno [1,2-c] pyrazol-4-ones and their uses |
| US6320050B1 (en) * | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
| US6610846B1 (en) * | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
| EP3222619A1 (fr) | 1999-04-15 | 2017-09-27 | Bristol-Myers Squibb Holdings Ireland | Inhibiteurs cycliques de la protéine tyrosine kinase |
| US7125875B2 (en) * | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US6114365A (en) | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6291504B1 (en) | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
| US20040048844A1 (en) * | 1999-10-20 | 2004-03-11 | Bristol-Myers Squibb Pharma Company | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents |
| WO2002048114A1 (fr) * | 2000-11-27 | 2002-06-20 | Pharmacia Italia S.P.A. | Derives phenylacetamido-pyrazole et leur utilisation comme agents antitumoraux |
| WO2002044174A2 (fr) * | 2000-12-01 | 2002-06-06 | Bristol-Myers Squibb Pharma Company | Derives de 3-(2,4-dimethylthiazol-5-yl)indeno[1,2-c]pyrazol-4-one et leur utilisation |
| AU2002228849A1 (en) | 2000-12-08 | 2002-06-18 | Bristol-Myers Squibb Pharma Company | Semicarbazides and their uses as cyclin dependent kinase inhibitors |
| WO2002050071A1 (fr) * | 2000-12-21 | 2002-06-27 | Bristol-Myers Squibb Company | Inhibiteurs thiazolyl des tyrosine kinases de la famille tec |
| ES2254611T3 (es) * | 2001-05-11 | 2006-06-16 | Pfizer Products Inc. | Derivados de tiazol. |
| EP1724270A3 (fr) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Dérivés de phenylacetamido-thiazole, leur procédé de préparation et leur utilisation en tant qu'agents antitumoraux |
| DE60216097T2 (de) * | 2001-07-19 | 2007-06-28 | Pfizer Italia S.R.L. | Phenylacetamido-thiazole verbindungen, verfahren zu ihren herstellung und ihre anwendung als antitumor mittel |
| WO2003027104A1 (fr) * | 2001-09-27 | 2003-04-03 | Idrtech Inc. | Derives de fumagillol et procede permettant de les preparer |
| KR101018318B1 (ko) * | 2001-12-21 | 2011-03-04 | 노보 노르디스크 에이/에스 | Ｇｋ 활성제로서의 아미드 유도체 |
| MXPA05000130A (es) * | 2002-06-27 | 2005-02-17 | Novo Nordisk As | Derivados de aril-carbonilo como agentes terapeuticos. |
| JP2006517577A (ja) * | 2003-02-12 | 2006-07-27 | ファイザー・インク | 抗増殖性の２−（スルホ−フェニル）−アミノチアゾール誘導体 |
| EP1597256A1 (fr) * | 2003-02-21 | 2005-11-23 | Pfizer Inc. | Derives d'amino-thiazole substitues par n-heterocyclyle en tant qu'inhibiteurs de la proteine kinase |
| WO2004087138A1 (fr) * | 2003-03-31 | 2004-10-14 | Sucampo Ag | Procede de traitement de maladie vasculaire hyperpermeable |
| WO2005014591A1 (fr) * | 2003-07-15 | 2005-02-17 | L'oreal | 2-acylamino ou 2-sulfonylamino-1, 3-thiazoles en tant qu'agents de couplage pour la coloration d'oxydation de fibres keratiniques |
| FR2857664B1 (fr) * | 2003-07-15 | 2007-12-14 | Oreal | Nouveaux derives thiazoles et utilisation de ces derives pour la teinture des fibres keratiniques |
| US7351727B2 (en) * | 2003-09-02 | 2008-04-01 | Bristol-Myers Squibb Company | Inhibitors of 15-lipoxygenase |
| US20050074424A1 (en) * | 2003-10-03 | 2005-04-07 | Lev Salnikov | Using polyion polymers with glucose infusion for a cancer selective chemotherapy compound and method |
| US20070196395A1 (en) * | 2003-12-12 | 2007-08-23 | Mackerell Alexander | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain |
| CN102516240A (zh) * | 2004-01-06 | 2012-06-27 | 诺和诺德公司 | 杂芳基脲及其作为葡糖激酶活化剂的用途 |
| WO2006002119A2 (fr) | 2004-06-18 | 2006-01-05 | Gpc Biotech, Inc. | Utilisation d'inhibiteurs de kinase et leurs compositions |
| EP1621539A1 (fr) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Dérivées d'urée cyclique substitués par un heterocycle, leur prépration et leur utilisation pharmaceutique comee inhibiteurs de kinases |
| EP1621536A1 (fr) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Dérivés d'urées cycliques aminés, leur préparation et utilisation pharmaceutique en tant qu'inhibiteurs de Kinase |
| CA2575466A1 (fr) * | 2004-08-13 | 2006-02-23 | Genentech, Inc. | Composes a base de 2-amido-thiazole presentant une activite inhibitrice enzymatique utilisant de l'adenosine triphosphate (atp), et compositions, et leurs utilisations |
| EP2096107A1 (fr) | 2004-12-23 | 2009-09-02 | GPC Biotech AG | Dérivés d'acide squarique dotés d'une activité anti-proliférante |
| AU2006343359A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US7999114B2 (en) * | 2005-07-08 | 2011-08-16 | Novo Nordisk A/S | Dicycloalkylcarbamoyl ureas as glucokinase activators |
| CA2615938C (fr) | 2005-07-14 | 2014-04-29 | Novo-Nordisk A/S | Activateurs de l'uree glucokinase |
| EP1914234A1 (fr) * | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines et leur utilisation comme inhibiteurs de kinases |
| WO2008084043A1 (fr) * | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Activateurs de la glucokinase à base d'urée |
| WO2008084044A1 (fr) | 2007-01-11 | 2008-07-17 | Novo Nordisk A/S | Activateurs de l'urée glucokinase |
| US8153792B2 (en) * | 2007-02-13 | 2012-04-10 | Ab Science | Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors |
| US8450348B2 (en) * | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
| TWI437986B (zh) * | 2008-01-31 | 2014-05-21 | R Tech Ueno Ltd | 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途 |
| US8232402B2 (en) | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| EP2112152A1 (fr) | 2008-04-22 | 2009-10-28 | GPC Biotech AG | Dihydropteridinones comme inhibiteurs Plk |
| EP2112150B1 (fr) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Inhibiteurs Raf améliorés |
| JP2012508768A (ja) | 2008-11-13 | 2012-04-12 | リンク・メディスン・コーポレーション | アザキノリノン誘導体及びその使用 |
| UA103918C2 (en) * | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| AR075899A1 (es) * | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| EP2440556A1 (fr) * | 2009-06-10 | 2012-04-18 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la phosphatidylinositol 3-kinase |
| DE102009043260A1 (de) * | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
| EP2325185A1 (fr) | 2009-10-28 | 2011-05-25 | GPC Biotech AG | Inhibiteur de Plk |
| HU0900798D0 (en) | 2009-12-21 | 2010-03-01 | Vichem Chemie Kutato Kft | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
| WO2012092471A2 (fr) * | 2010-12-29 | 2012-07-05 | Development Center For Biotechnology | Nouveaux inhibiteurs de tubuline et procédés pour les utiliser |
| RU2011122942A (ru) | 2011-06-08 | 2012-12-20 | Общество С Ограниченной Ответственностью "Асинэкс Медхим" | Новые ингибиторы киназ |
| CN103387551B (zh) * | 2012-05-11 | 2015-05-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻唑类化合物及其用途 |
| SG10201701438QA (en) | 2012-08-23 | 2017-03-30 | Virostatics Srl | Novel 4,6-disubstituted aminopyrimidine derivatives |
| MX2018012287A (es) | 2016-04-11 | 2019-02-07 | Genfit | Metodos de tratamiento para enfermedades colestasicas y fibroticas. |
| KR20200104873A (ko) | 2017-12-06 | 2020-09-04 | 린 바이오사이언스, 피티와이 엘티디. | 튜불린 억제제 |
| CN111741944A (zh) * | 2018-02-01 | 2020-10-02 | 悉尼大学 | 抗癌化合物 |
| MX2020008905A (es) | 2018-06-12 | 2020-12-03 | Vtv Therapeutics Llc | Usos terapeuticos de activadores de glucoquinasa en combinacion con insulina o analogos de insulinas. |
| EP3712127A1 (fr) | 2019-03-22 | 2020-09-23 | Deutsches Krebsforschungszentrum | Nouveaux inhibiteurs de l'histone déacétylase 10 |
| WO2020193431A1 (fr) | 2019-03-22 | 2020-10-01 | Deutsches Krebsforschungszentrum | Nouveaux inhibiteurs de l'histone désacétylase 10 |
| EP4104835A4 (fr) * | 2020-02-10 | 2024-05-01 | Juntendo Educational Foundation | Inhibiteur de l'activité du récepteur de la ryanodine de type 2 |
| CN115322208B (zh) * | 2021-05-10 | 2023-04-11 | 中国药科大学 | 2-氨基噻唑类衍生物及其制备方法和医药用途 |
| WO2023182780A1 (fr) * | 2022-03-22 | 2023-09-28 | 오토텔릭바이오 주식회사 | Composé dérivé de thiazole et ses utilisations |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL125062C (fr) * | 1960-04-20 | |||
| TW513418B (en) * | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
| JPH1095777A (ja) * | 1996-07-31 | 1998-04-14 | Otsuka Pharmaceut Co Ltd | チアゾール誘導体 |
| US6794392B1 (en) * | 1996-09-30 | 2004-09-21 | Schering Aktiengesellschaft | Cell differentiation inducer |
| HUP0004512A3 (en) * | 1997-10-27 | 2003-01-28 | Agouron Pharmaceuticals Inc La | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
| US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| ATE288904T1 (de) * | 1998-06-18 | 2005-02-15 | Bristol Myers Squibb Co | Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| EP3222619A1 (fr) * | 1999-04-15 | 2017-09-27 | Bristol-Myers Squibb Holdings Ireland | Inhibiteurs cycliques de la protéine tyrosine kinase |
| US6114365A (en) | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| US6992081B2 (en) * | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| SE0102440D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compound |
| EP1321463B1 (fr) * | 2001-12-21 | 2007-08-08 | Virochem Pharma Inc. | Dérivés de thiazole et leur utilisation dans le traitement ou la prévention d'infections par des Flavivirus |
| KR101154163B1 (ko) * | 2003-01-27 | 2012-06-14 | 아스텔라스세이야쿠 가부시키가이샤 | 티아졸 유도체 및 ｖａｐ-1 저해제로서의 용도 |
-
1999
- 1999-08-12 US US09/372,832 patent/US6114365A/en not_active Expired - Lifetime
-
2000
- 2000-08-11 RS YUP-97/02A patent/RS50300B/sr unknown
- 2000-08-11 EA EA200200247A patent/EA005375B1/ru not_active IP Right Cessation
- 2000-08-11 CZ CZ20020486A patent/CZ303138B6/cs not_active IP Right Cessation
- 2000-08-11 AP APAP/P/2002/002441A patent/AP1853A/en active
- 2000-08-11 CA CA002381097A patent/CA2381097C/fr not_active Expired - Fee Related
- 2000-08-11 WO PCT/IB2000/001423 patent/WO2001014353A1/fr active IP Right Grant
- 2000-08-11 PT PT00962760T patent/PT1204649E/pt unknown
- 2000-08-11 IL IL14792400A patent/IL147924A0/xx active IP Right Grant
- 2000-08-11 ES ES00962760T patent/ES2295056T3/es not_active Expired - Lifetime
- 2000-08-11 EE EEP200200064A patent/EE04939B1/xx not_active IP Right Cessation
- 2000-08-11 MX MXPA02001508A patent/MXPA02001508A/es active IP Right Grant
- 2000-08-11 EP EP00962760A patent/EP1204649B1/fr not_active Expired - Lifetime
- 2000-08-11 SI SI200030974T patent/SI1204649T1/sl unknown
- 2000-08-11 KR KR1020027001844A patent/KR100773709B1/ko not_active IP Right Cessation
- 2000-08-11 DK DK00962760T patent/DK1204649T3/da active
- 2000-08-11 OA OA1200200052A patent/OA12047A/en unknown
- 2000-08-11 BR BR0013281-0A patent/BR0013281A/pt not_active IP Right Cessation
- 2000-08-11 GE GE4757A patent/GEP20053475B/en unknown
- 2000-08-11 NZ NZ517236A patent/NZ517236A/en not_active IP Right Cessation
- 2000-08-11 CN CNB008127336A patent/CN100410245C/zh not_active Expired - Fee Related
- 2000-08-11 JP JP2001518441A patent/JP4864260B2/ja not_active Expired - Fee Related
- 2000-08-11 HU HU0202492A patent/HUP0202492A3/hu unknown
- 2000-08-11 DE DE60036803T patent/DE60036803T2/de not_active Expired - Lifetime
- 2000-08-11 US US10/048,474 patent/US6784198B1/en not_active Expired - Fee Related
- 2000-08-11 SK SK180-2002A patent/SK287373B6/sk not_active IP Right Cessation
- 2000-08-11 KR KR1020077014635A patent/KR100827563B1/ko not_active IP Right Cessation
- 2000-08-11 AU AU74400/00A patent/AU782882B2/en not_active Ceased
- 2000-08-11 AT AT00962760T patent/ATE375987T1/de active
- 2000-11-08 UA UA2002031948A patent/UA72538C2/uk unknown
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2002
- 2002-01-31 IL IL147924A patent/IL147924A/en not_active IP Right Cessation
- 2002-02-08 ZA ZA200201117A patent/ZA200201117B/en unknown
- 2002-02-11 NO NO20020683A patent/NO323576B1/no not_active IP Right Cessation
- 2002-02-11 IS IS6264A patent/IS2594B/is unknown
- 2002-02-12 HR HR20020127A patent/HRP20020127B1/xx not_active IP Right Cessation
- 2002-03-05 BG BG106481A patent/BG65484B1/bg unknown
- 2002-03-11 MA MA26547A patent/MA25433A1/fr unknown
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2003
- 2003-09-11 HK HK03106484.7A patent/HK1054233B/zh not_active IP Right Cessation
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2004
- 2004-07-29 US US10/902,326 patent/US20050004120A1/en not_active Abandoned
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2007
- 2007-12-20 CY CY20071101629T patent/CY1107108T1/el unknown
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