DK1181024T3 - Anvendelse af glycosaminoglycaner til behandling af senil demens - Google Patents

Anvendelse af glycosaminoglycaner til behandling af senil demens

Info

Publication number
DK1181024T3
DK1181024T3 DK00925281T DK00925281T DK1181024T3 DK 1181024 T3 DK1181024 T3 DK 1181024T3 DK 00925281 T DK00925281 T DK 00925281T DK 00925281 T DK00925281 T DK 00925281T DK 1181024 T3 DK1181024 T3 DK 1181024T3
Authority
DK
Denmark
Prior art keywords
treatment
senile dementia
glycosaminoglycans
alzheimer
ictus
Prior art date
Application number
DK00925281T
Other languages
Danish (da)
English (en)
Inventor
Umberto Cornelli
Ambrosi Luigi De
Israel Hanin
Jawed Fareed
John Lee
Stanley Lorens
Ronald F Mervis
Original Assignee
Umberto Cornelli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Umberto Cornelli filed Critical Umberto Cornelli
Application granted granted Critical
Publication of DK1181024T3 publication Critical patent/DK1181024T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
DK00925281T 1999-05-14 2000-05-12 Anvendelse af glycosaminoglycaner til behandling af senil demens DK1181024T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001066A IT1312107B1 (it) 1999-05-14 1999-05-14 Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile
PCT/EP2000/004311 WO2000069444A1 (fr) 1999-05-14 2000-05-12 Glycosaminoglycanes de poids moleculaire moyen egal a 2.400 d s'utilisant dans le traitement de la demence senile

Publications (1)

Publication Number Publication Date
DK1181024T3 true DK1181024T3 (da) 2005-06-13

Family

ID=11382970

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00925281T DK1181024T3 (da) 1999-05-14 2000-05-12 Anvendelse af glycosaminoglycaner til behandling af senil demens

Country Status (22)

Country Link
US (1) US6979680B1 (fr)
EP (1) EP1181024B1 (fr)
JP (1) JP2002544233A (fr)
KR (1) KR100711142B1 (fr)
CN (1) CN1178667C (fr)
AT (1) ATE288761T1 (fr)
AU (1) AU764743C (fr)
CA (1) CA2373975A1 (fr)
CZ (1) CZ20014092A3 (fr)
DE (1) DE60018061T2 (fr)
DK (1) DK1181024T3 (fr)
ES (1) ES2237425T3 (fr)
HK (1) HK1039903B (fr)
HU (1) HUP0201100A3 (fr)
IL (1) IL146458A0 (fr)
IT (1) IT1312107B1 (fr)
NO (1) NO328902B1 (fr)
PL (1) PL198016B1 (fr)
PT (1) PT1181024E (fr)
RU (1) RU2248800C2 (fr)
WO (1) WO2000069444A1 (fr)
ZA (1) ZA200109331B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1344781A1 (fr) * 2002-03-12 2003-09-17 Laboratori Derivati Organici S.P.A. Procédé de dépolymérisation de glycosaminoglycanes et les produits obtenus
ITMI20031023A1 (it) * 2003-05-21 2004-11-22 Umberto Cornelli Glicosaminoglicani aventi peso molecolare medio 2400 d atti al trattamento delle disfunzioni emozionali.
EP1524276A1 (fr) * 2003-10-16 2005-04-20 Laboratori Derivati Organici S.P.A. Procédé à étapes multiples pour la dépolymérisation de héparine et produits ainsi obtenus
US7939512B2 (en) 2004-10-13 2011-05-10 Laboratori Derivati Organici Spa Multistep process for the physical depolymerization of heparin and products obtained therefrom
DE602006016990D1 (de) 2005-12-22 2010-10-28 Bellus Health Int Ltd Behandlung von diabetischer nephropathie
WO2009007224A1 (fr) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Dérivés d'héparine de faible poids moléculaire ayant une activité neuroprotectrice
US8896239B2 (en) 2008-05-22 2014-11-25 Vladimir Yegorovich Balakin Charged particle beam injection method and apparatus used in conjunction with a charged particle cancer therapy system
WO2009142546A2 (fr) 2008-05-22 2009-11-26 Vladimir Yegorovich Balakin Procédé et dispositif de traitement anticancéreux par particules chargées à champs multiples
US9058910B2 (en) 2008-05-22 2015-06-16 Vladimir Yegorovich Balakin Charged particle beam acceleration method and apparatus as part of a charged particle cancer therapy system
EP2283713B1 (fr) 2008-05-22 2018-03-28 Vladimir Yegorovich Balakin Appareil de traitement du cancer par particules chargees a axes multiples
US8841866B2 (en) 2008-05-22 2014-09-23 Vladimir Yegorovich Balakin Charged particle beam extraction method and apparatus used in conjunction with a charged particle cancer therapy system
EP2403599A4 (fr) 2009-03-04 2017-11-22 Zakrytoe Aktsionernoe Obshchestvo Protom Procédé et appareil de thérapie contre le cancer par particules chargées à champs multiples
US8609097B2 (en) * 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
JP6336909B2 (ja) * 2011-10-14 2018-06-06 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィク 神経変性疾患の診断、予後予測又は治療の方法
CN112426434A (zh) * 2020-11-04 2021-03-02 山东大学 硫酸乙酰肝素在防治阿尔兹海默症中的应用
CN114478816A (zh) * 2022-02-11 2022-05-13 上海兴糖生物技术有限公司 一种白玉蜗牛多糖及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
US4847338A (en) * 1985-03-28 1989-07-11 University Of Iowa Research Foundation Low molecular weight heparin fragments as inhibitors of complement activation
DE3789159T2 (de) * 1986-05-01 1994-07-28 Toppan Printing Co Ltd Vorrichtung zur Simulation der Einstellung eines Abtasters.
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
IT1205042B (it) 1987-05-28 1989-03-10 Crinos Industria Farmaco Composizione farmaceutica ad attivita' terapeutica per il trattamento della demenza senile di tipo alzheimer
EP0337327A1 (fr) * 1988-04-09 1989-10-18 Bioiberica, S.A. Procédé de préparation de fractions oligosaccharides par une dépolymérisation chimique réglée d'héparine
IT1240615B (it) 1990-04-03 1993-12-17 Mediolanum Farmaceutici Spa Impiego del dermatan solfato nella prevenzione e terapia dell'invecchiamento cerebrale e degli stati di deficit funzionale del sistema nervoso centrale

Also Published As

Publication number Publication date
DE60018061D1 (de) 2005-03-17
EP1181024A1 (fr) 2002-02-27
WO2000069444A1 (fr) 2000-11-23
IL146458A0 (en) 2002-07-25
JP2002544233A (ja) 2002-12-24
CA2373975A1 (fr) 2000-11-23
KR100711142B1 (ko) 2007-04-24
HK1039903A1 (en) 2002-05-17
AU764743C (en) 2004-03-18
PL352070A1 (en) 2003-07-28
ZA200109331B (en) 2002-08-28
ES2237425T3 (es) 2005-08-01
AU4405200A (en) 2000-12-05
HUP0201100A3 (en) 2003-03-28
PL198016B1 (pl) 2008-05-30
ITMI991066A1 (it) 2000-11-14
AU764743B2 (en) 2003-08-28
CN1178667C (zh) 2004-12-08
NO20015544L (no) 2002-01-14
NO20015544D0 (no) 2001-11-13
KR20020005033A (ko) 2002-01-16
NO328902B1 (no) 2010-06-14
RU2248800C2 (ru) 2005-03-27
US6979680B1 (en) 2005-12-27
PT1181024E (pt) 2005-06-30
DE60018061T2 (de) 2006-04-13
HK1039903B (zh) 2005-08-26
IT1312107B1 (it) 2002-04-04
EP1181024B1 (fr) 2005-02-09
CZ20014092A3 (cs) 2002-04-17
CN1350459A (zh) 2002-05-22
HUP0201100A2 (hu) 2002-07-29
ATE288761T1 (de) 2005-02-15

Similar Documents

Publication Publication Date Title
DK1181024T3 (da) Anvendelse af glycosaminoglycaner til behandling af senil demens
CY1108514T1 (el) Παραγωγα 1-φαινυλαλκανεκαρβοξυλικου οξεος για τη θεραπεια νευρογενων ασθενειων
WO2003053330A3 (fr) Nouveaux composés
DK0721449T3 (da) Inhibitorer af beta-amyloidproteinproduktion
SI1427708T1 (sl) Derivati amino-ftalazinona kot zaviralci kinaze, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
MA25875A1 (fr) Nouveaux derives de l'acide aminodicarboxylique presentant des proprietes pharmaceutiques.
WO2000047568A3 (fr) Nouvelles benzothiazepines-1,2 presentant une activite d'inhibition de transport d'acide biliaire ileal et d'absorption de taurocholate
TR200001264T2 (tr) Alzheimer hastalığının antermotem teşhisi için bileşikler.
IL162214A (en) Pyridine derivatives and pharmaceutical compositions containing the same
CA2258548A1 (fr) Derives tricycliques substitues par phenylamino, destines au traitement des maladies hyperproliferatives
CY1110745T1 (el) Παραγωγα πυρρολιδονης ως αναστολεις μαοβ
AU2002314914A1 (en) Hydroxy alkyl amine derivatives as beta-secretase inhibitors and their use for the treatment of alzheimer's disease and similar diseases
WO2006040451A2 (fr) Nouveaux derives de 9h-pyrido (2, 3-b) indole en tant qu'inhibiteurs de cdk et gsk3 , leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes
AU2002359162A1 (en) Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3
PL346143A1 (en) Tan-1057 derivatives
WO2001083449A3 (fr) Modulateurs de pkc a base de pyrrolidone rigide
BRPI0410026A (pt) derivados de 3-amino-croman quinolina
HUP0203161A2 (hu) Benzamidinszármazékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
MXPA99003849A (es) Derivados 9a, 11b-deshidro de 9-oxima-3-ceto-6-0-metileritromicina.
CA2270026A1 (fr) Derives bicycliques substitues pour le traitement des troubles du systeme nerveux central
ES2127133A1 (es) Utilizacion de derivados 2,5-dihidroxibencenosulfonicos para la fabricacion de medicamentos destinados al tratamiento y a la prevencion de la enfermedad de alzheimer.