DK1169337T3 - Steroidnitrater til behandlingen af oxidativ beskadigelse og endothel dysfunktion - Google Patents

Steroidnitrater til behandlingen af oxidativ beskadigelse og endothel dysfunktion

Info

Publication number
DK1169337T3
DK1169337T3 DK00917075T DK00917075T DK1169337T3 DK 1169337 T3 DK1169337 T3 DK 1169337T3 DK 00917075 T DK00917075 T DK 00917075T DK 00917075 T DK00917075 T DK 00917075T DK 1169337 T3 DK1169337 T3 DK 1169337T3
Authority
DK
Denmark
Prior art keywords
treatment
nitrates
steroid
oxidative damage
endothelial dysfunction
Prior art date
Application number
DK00917075T
Other languages
Danish (da)
English (en)
Inventor
Piero Del Soldato
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of DK1169337T3 publication Critical patent/DK1169337T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
DK00917075T 1999-04-13 2000-04-11 Steroidnitrater til behandlingen af oxidativ beskadigelse og endothel dysfunktion DK1169337T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI000751A IT1311922B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.
PCT/EP2000/003238 WO2000061604A2 (en) 1999-04-13 2000-04-11 Pharmaceutical compounds
EP00917075A EP1169337B1 (en) 1999-04-13 2000-04-11 Steroid nitrates for the treatment of oxidative injury and endothelial dysfunction

Publications (1)

Publication Number Publication Date
DK1169337T3 true DK1169337T3 (da) 2004-12-06

Family

ID=11382683

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00917075T DK1169337T3 (da) 1999-04-13 2000-04-11 Steroidnitrater til behandlingen af oxidativ beskadigelse og endothel dysfunktion

Country Status (25)

Country Link
US (3) US6909007B1 (https=)
EP (2) EP1475386A3 (https=)
JP (1) JP2002542162A (https=)
KR (2) KR100744701B1 (https=)
CN (2) CN1296380C (https=)
AT (1) ATE274521T1 (https=)
AU (2) AU766798B2 (https=)
BR (1) BR0009696A (https=)
CA (2) CA2370446C (https=)
DE (1) DE60013266T2 (https=)
DK (1) DK1169337T3 (https=)
ES (1) ES2226805T3 (https=)
HU (1) HUP0201872A3 (https=)
IL (2) IL145633A0 (https=)
IT (1) IT1311922B1 (https=)
MX (1) MXPA01010212A (https=)
NO (2) NO323374B1 (https=)
NZ (1) NZ514572A (https=)
PL (1) PL199579B1 (https=)
PT (1) PT1169337E (https=)
RU (1) RU2240325C2 (https=)
SI (1) SI1169337T1 (https=)
TR (2) TR200201899T2 (https=)
WO (1) WO2000061604A2 (https=)
ZA (1) ZA200108124B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2393724A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
JP4092203B2 (ja) 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
WO2003103602A2 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003279622A1 (en) 2002-06-28 2004-01-19 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
EP1940863B1 (en) 2005-09-02 2012-09-05 Nicox S.A. Nitrooxy derivatives of glucocorticoids
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7645749B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
US7645748B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
BRPI0807078A2 (pt) * 2007-02-05 2014-04-08 Nicox Sa Composto, e, formulação farmacêutica
US20090087425A1 (en) * 2007-08-10 2009-04-02 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) * 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
EP2214674A4 (en) * 2007-10-19 2011-03-30 Burnham Inst Medical Research INHIBITORS OF ANTI-APOPTOTIC PROTEINS
CN102186873A (zh) 2008-08-05 2011-09-14 尼科克斯公司 用于治疗视网膜和黄斑疾病的新型释放no的甾类化合物
EP2560634A1 (en) 2010-04-23 2013-02-27 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
CU20110244A7 (es) 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
KR101711513B1 (ko) * 2015-06-26 2017-03-02 주식회사 엘지생활건강 피부 개선용 조성물

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GB1458372A (en) 1973-03-05 1976-12-15 Leo Ab Steroid carbamates and allophanates
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FR2600653B1 (fr) * 1986-06-24 1988-12-16 Pasteur Strasbourg Universite Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du d-4 pregnene 3,20-dione ou avec des derives du d-1,4 pregnadiene 3,20-dione aux proprietes glucocorticoides et anti-inflammatoires, procedes d'obtention, compositions pharmaceutiques les contenant. proprietes pharmacologiques et applications
IT1204571B (it) * 1987-05-08 1989-03-10 Chiesi Farma Spa Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
DE3856512T2 (de) * 1987-06-29 2002-08-08 Massachusetts Institute Of Technology, Cambridge Nucleotidsequenz für Acetoacetyl-CoA Reduktase kodierend und Verfahren zur Herstellung von Polyester-Biopolymeren
DE4000397A1 (de) 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
JPH04273892A (ja) 1991-02-27 1992-09-30 Kao Corp 新規な２１−置換ステロイド化合物
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US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
DE19634793A1 (de) 1996-08-29 1998-03-05 Sanol Arznei Schwarz Gmbh S- und O-Nitratoacylverbindungen
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei

Also Published As

Publication number Publication date
US20070142342A1 (en) 2007-06-21
TR200201899T2 (tr) 2002-11-21
KR20060123788A (ko) 2006-12-04
PL199579B1 (pl) 2008-10-31
KR100744701B1 (ko) 2007-08-02
PL350775A1 (en) 2003-02-10
NZ514572A (en) 2004-03-26
CA2370446A1 (en) 2000-10-19
KR20010108489A (ko) 2001-12-07
ITMI990751A1 (it) 2000-10-13
BR0009696A (pt) 2002-01-08
WO2000061604A3 (en) 2001-03-15
PT1169337E (pt) 2004-11-30
IL175398A0 (en) 2006-09-05
HUP0201872A2 (en) 2002-10-28
CN1296380C (zh) 2007-01-24
US7186708B2 (en) 2007-03-06
WO2000061604A2 (en) 2000-10-19
ES2226805T3 (es) 2005-04-01
US20050176694A1 (en) 2005-08-11
NO323374B1 (no) 2007-04-16
KR100687821B1 (ko) 2007-02-28
CN1916013A (zh) 2007-02-21
NO20065784L (no) 2001-12-13
EP1475386A2 (en) 2004-11-10
AU3820100A (en) 2000-11-14
CA2370446C (en) 2008-03-25
CN1420891A (zh) 2003-05-28
DE60013266D1 (de) 2004-09-30
AU2004200263B2 (en) 2006-05-04
IT1311922B1 (it) 2002-03-20
TR200102929T2 (tr) 2002-04-22
MXPA01010212A (es) 2002-09-18
SI1169337T1 (en) 2005-04-30
AU2004200263A1 (en) 2004-02-19
EP1169337A2 (en) 2002-01-09
DE60013266T2 (de) 2005-01-20
ZA200108124B (en) 2003-03-26
IL145633A0 (en) 2002-06-30
ATE274521T1 (de) 2004-09-15
EP1169337B1 (en) 2004-08-25
US7524836B2 (en) 2009-04-28
JP2002542162A (ja) 2002-12-10
NO20014925L (no) 2001-12-13
EP1475386A3 (en) 2011-12-28
CA2586538C (en) 2010-06-22
AU766798B2 (en) 2003-10-23
CA2586538A1 (en) 2000-10-19
RU2240325C2 (ru) 2004-11-20
HUP0201872A3 (en) 2004-04-28
US6909007B1 (en) 2005-06-21
NO20014925D0 (no) 2001-10-10

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