KR100687821B1 - 산화적 손상 및 내피세포 기능부전의 치료를 위한 스테로이드 질산염 - Google Patents

산화적 손상 및 내피세포 기능부전의 치료를 위한 스테로이드 질산염 Download PDF

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Publication number
KR100687821B1
KR100687821B1 KR1020017012940A KR20017012940A KR100687821B1 KR 100687821 B1 KR100687821 B1 KR 100687821B1 KR 1020017012940 A KR1020017012940 A KR 1020017012940A KR 20017012940 A KR20017012940 A KR 20017012940A KR 100687821 B1 KR100687821 B1 KR 100687821B1
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acid
compound
steroid
formula
group
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KR20010108489A (ko
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델솔다토피에로
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니콕스 에스. 에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
KR1020017012940A 1999-04-13 2000-04-11 산화적 손상 및 내피세포 기능부전의 치료를 위한 스테로이드 질산염 Expired - Fee Related KR100687821B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI99A000751 1999-04-13
IT1999MI000751A IT1311922B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.
PCT/EP2000/003238 WO2000061604A2 (en) 1999-04-13 2000-04-11 Pharmaceutical compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020067024049A Division KR100744701B1 (ko) 1999-04-13 2000-04-11 산화적 손상 및 내피세포 기능부전의 치료를 위한스테로이드 질산염

Publications (2)

Publication Number Publication Date
KR20010108489A KR20010108489A (ko) 2001-12-07
KR100687821B1 true KR100687821B1 (ko) 2007-02-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020017012940A Expired - Fee Related KR100687821B1 (ko) 1999-04-13 2000-04-11 산화적 손상 및 내피세포 기능부전의 치료를 위한 스테로이드 질산염
KR1020067024049A Expired - Fee Related KR100744701B1 (ko) 1999-04-13 2000-04-11 산화적 손상 및 내피세포 기능부전의 치료를 위한스테로이드 질산염

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020067024049A Expired - Fee Related KR100744701B1 (ko) 1999-04-13 2000-04-11 산화적 손상 및 내피세포 기능부전의 치료를 위한스테로이드 질산염

Country Status (25)

Country Link
US (3) US6909007B1 (https=)
EP (2) EP1169337B1 (https=)
JP (1) JP2002542162A (https=)
KR (2) KR100687821B1 (https=)
CN (2) CN1296380C (https=)
AT (1) ATE274521T1 (https=)
AU (2) AU766798B2 (https=)
BR (1) BR0009696A (https=)
CA (2) CA2586538C (https=)
DE (1) DE60013266T2 (https=)
DK (1) DK1169337T3 (https=)
ES (1) ES2226805T3 (https=)
HU (1) HUP0201872A3 (https=)
IL (2) IL145633A0 (https=)
IT (1) IT1311922B1 (https=)
MX (1) MXPA01010212A (https=)
NO (2) NO323374B1 (https=)
NZ (1) NZ514572A (https=)
PL (1) PL199579B1 (https=)
PT (1) PT1169337E (https=)
RU (1) RU2240325C2 (https=)
SI (1) SI1169337T1 (https=)
TR (2) TR200102929T2 (https=)
WO (1) WO2000061604A2 (https=)
ZA (1) ZA200108124B (https=)

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AP2002002582A0 (en) 1999-12-23 2002-09-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) * 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005535642A (ja) 2002-06-28 2005-11-24 ニトロメッド インコーポレーティッド オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
CN102134269A (zh) 2005-09-02 2011-07-27 尼科克斯公司 糖皮质激素硝酰氧基衍生物
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7645749B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
US7645748B2 (en) * 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
EP2109617A1 (en) * 2007-02-05 2009-10-21 Nicox S.A. Nitric oxide releasing steroids
US20090087425A1 (en) * 2007-08-10 2009-04-02 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) * 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
CA2703723A1 (en) * 2007-10-19 2009-04-23 Burnham Institute Of Medical Research Inhibitors of anti-apoptotic proteins
JP2011529933A (ja) 2008-08-05 2011-12-15 ニコックス エス エイ 網膜および黄斑の疾患の治療のための新規なｎｏ放出性ステロイド
EP2560634A1 (en) 2010-04-23 2013-02-27 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
CU20110244A7 (es) 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
KR101711513B1 (ko) * 2015-06-26 2017-03-02 주식회사 엘지생활건강 피부 개선용 조성물

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EP0436936A2 (de) * 1990-01-09 1991-07-17 Hoechst Aktiengesellschaft Lipidselektive Antioxidantien sowie deren Herstellung und Verwendung
WO1997041144A1 (en) * 1996-05-02 1997-11-06 G.D. Searle & Co. Novel steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
WO1998015568A2 (en) * 1996-10-04 1998-04-16 Nicox S.A. Nitrate esters of corticoid compounds and pharmaceutical applications thereof

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ATE144250T1 (de) 1991-12-26 1996-11-15 Wisconsin Alumni Res Found 26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung
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Publication number Priority date Publication date Assignee Title
EP0436936A2 (de) * 1990-01-09 1991-07-17 Hoechst Aktiengesellschaft Lipidselektive Antioxidantien sowie deren Herstellung und Verwendung
WO1997041144A1 (en) * 1996-05-02 1997-11-06 G.D. Searle & Co. Novel steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
WO1998015568A2 (en) * 1996-10-04 1998-04-16 Nicox S.A. Nitrate esters of corticoid compounds and pharmaceutical applications thereof

Also Published As

Publication number Publication date
KR20010108489A (ko) 2001-12-07
NO20014925L (no) 2001-12-13
CA2370446C (en) 2008-03-25
AU2004200263B2 (en) 2006-05-04
WO2000061604A3 (en) 2001-03-15
ITMI990751A1 (it) 2000-10-13
PT1169337E (pt) 2004-11-30
CA2586538C (en) 2010-06-22
EP1475386A3 (en) 2011-12-28
US7524836B2 (en) 2009-04-28
NO20014925D0 (no) 2001-10-10
IL145633A0 (en) 2002-06-30
PL350775A1 (en) 2003-02-10
ZA200108124B (en) 2003-03-26
DE60013266D1 (de) 2004-09-30
NZ514572A (en) 2004-03-26
AU3820100A (en) 2000-11-14
US20070142342A1 (en) 2007-06-21
CA2370446A1 (en) 2000-10-19
RU2240325C2 (ru) 2004-11-20
IT1311922B1 (it) 2002-03-20
ATE274521T1 (de) 2004-09-15
TR200201899T2 (tr) 2002-11-21
NO20065784L (no) 2001-12-13
JP2002542162A (ja) 2002-12-10
MXPA01010212A (es) 2002-09-18
SI1169337T1 (en) 2005-04-30
KR100744701B1 (ko) 2007-08-02
KR20060123788A (ko) 2006-12-04
PL199579B1 (pl) 2008-10-31
US7186708B2 (en) 2007-03-06
CN1296380C (zh) 2007-01-24
EP1169337B1 (en) 2004-08-25
CN1420891A (zh) 2003-05-28
EP1475386A2 (en) 2004-11-10
TR200102929T2 (tr) 2002-04-22
CA2586538A1 (en) 2000-10-19
IL175398A0 (en) 2006-09-05
HUP0201872A2 (en) 2002-10-28
NO323374B1 (no) 2007-04-16
AU766798B2 (en) 2003-10-23
ES2226805T3 (es) 2005-04-01
CN1916013A (zh) 2007-02-21
WO2000061604A2 (en) 2000-10-19
DK1169337T3 (da) 2004-12-06
AU2004200263A1 (en) 2004-02-19
HUP0201872A3 (en) 2004-04-28
US6909007B1 (en) 2005-06-21
US20050176694A1 (en) 2005-08-11
BR0009696A (pt) 2002-01-08
DE60013266T2 (de) 2005-01-20
EP1169337A2 (en) 2002-01-09

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