DK1149094T3 - 4-(aminoalkoxy)-benzofuraner som N-myristoyltransferase-inhibitorer - Google Patents
4-(aminoalkoxy)-benzofuraner som N-myristoyltransferase-inhibitorerInfo
- Publication number
- DK1149094T3 DK1149094T3 DK99968791T DK99968791T DK1149094T3 DK 1149094 T3 DK1149094 T3 DK 1149094T3 DK 99968791 T DK99968791 T DK 99968791T DK 99968791 T DK99968791 T DK 99968791T DK 1149094 T3 DK1149094 T3 DK 1149094T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzofurans
- aminoalkoxy
- myristoyltransferase
- inhibitors
- myristoyltransferase inhibitors
- Prior art date
Links
- 108010016306 Glycylpeptide N-tetradecanoyltransferase Proteins 0.000 title 1
- 125000002431 aminoalkoxy group Chemical group 0.000 title 1
- 150000001907 coumarones Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98124120 | 1998-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1149094T3 true DK1149094T3 (da) | 2004-08-16 |
Family
ID=8233179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99968791T DK1149094T3 (da) | 1998-12-18 | 1999-12-10 | 4-(aminoalkoxy)-benzofuraner som N-myristoyltransferase-inhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6376491B1 (es) |
| EP (1) | EP1149094B1 (es) |
| JP (1) | JP3435404B2 (es) |
| KR (1) | KR20010081117A (es) |
| CN (1) | CN1333770A (es) |
| AR (1) | AR021714A1 (es) |
| AT (1) | ATE264855T1 (es) |
| AU (1) | AU754233B2 (es) |
| BR (1) | BR9916318A (es) |
| CA (1) | CA2355694A1 (es) |
| DE (1) | DE69916664T2 (es) |
| DK (1) | DK1149094T3 (es) |
| ES (1) | ES2217882T3 (es) |
| MX (1) | MXPA01006218A (es) |
| PE (1) | PE20001324A1 (es) |
| TR (1) | TR200101779T2 (es) |
| WO (1) | WO2000037464A2 (es) |
| ZA (1) | ZA200104410B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100882544B1 (ko) | 1999-05-24 | 2009-02-12 | 미쓰비시 타나베 파마 코퍼레이션 | 페녹시프로필아민 화합물 |
| SE9902987D0 (sv) * | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| AU2002224105A1 (en) * | 2000-11-27 | 2002-06-03 | Mitsubishi Pharma Corporation | Piperidine compounds and medicinal use thereof |
| US6653346B1 (en) * | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
| US7078541B2 (en) * | 2002-02-07 | 2006-07-18 | Galileo Pharmaceuticals, Inc. | Benzofuran derivatives |
| WO2006015279A1 (en) * | 2004-07-28 | 2006-02-09 | Neurogen Corporation | Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders |
| WO2007020936A1 (ja) * | 2005-08-17 | 2007-02-22 | Daiichi Sankyo Company, Limited | 抗真菌作用二環性複素環化合物 |
| US20090270496A1 (en) * | 2007-05-03 | 2009-10-29 | Courchesne William E | Antifungal compounds |
| GB0815947D0 (en) * | 2008-09-02 | 2008-10-08 | Univ Dundee | Compounds |
| CA2739901A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators |
| AU2009304598B2 (en) | 2008-10-17 | 2015-01-29 | Akaal Pharma Pty Ltd | S1P receptors modulators and their use thereof |
| GB201120993D0 (en) | 2011-12-06 | 2012-01-18 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| CN107540725B (zh) * | 2016-06-29 | 2020-04-07 | 孙青� | 一种水溶性丹参酮ⅱa衍生物及其制备与应用 |
| GB201820659D0 (en) | 2018-12-19 | 2019-01-30 | Imperial Innovations Ltd | Novel compostions and their use in therapy |
| GB201820660D0 (en) | 2018-12-19 | 2019-01-30 | Imperial Innovations Ltd | Cancer treatments |
| GB202014736D0 (en) | 2020-09-18 | 2020-11-04 | Imperial College Innovations Ltd | Novel compounds and their use in therapy |
| GB202017367D0 (en) | 2020-11-02 | 2020-12-16 | Imperial College Innovations Ltd | Novel use |
| WO2024052684A1 (en) | 2022-09-09 | 2024-03-14 | MyricX Pharma Limited | Antibody drug conjugate comprising nmt inhibitor and its use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1129072A (en) * | 1966-02-01 | 1968-10-02 | Ici Ltd | Benzofuran and indole derivatives |
| GB1256735A (es) * | 1969-03-06 | 1971-12-15 | ||
| US4056626A (en) | 1971-05-13 | 1977-11-01 | Kakenyaku Kako Co., Ltd. | Pharmaceutical composition containing benzofuran derivative |
| CA989411A (en) * | 1971-05-13 | 1976-05-18 | Kakenyaku Kako Co. | Benzofuran derivatives and preparation thereof |
| CA1089866A (en) * | 1975-10-20 | 1980-11-18 | Kiyoshi Ito | Benzofuran derivatives, preparation thereof and pharmaceutical compositions thereof |
| SU671256A1 (ru) * | 1977-06-08 | 1986-11-23 | Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе | Гидрохлорид 1-(2-карбэтокси-3-метилбензофуран-4-илокси-3-изопропиламино)-2-пропанола,обладающий антиаритмическим и @ -адреноблокирующим действием |
| JPS5740479A (en) * | 1980-08-21 | 1982-03-06 | Kaken Pharmaceut Co Ltd | Preparation of benzofuran derivative and its acid addition salt |
| EP0146243A1 (en) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase inhibitors |
| US5082967A (en) * | 1988-06-16 | 1992-01-21 | Washington University | Novel fatty acid analog enzyme substrates |
| FR2672598A1 (fr) * | 1991-02-11 | 1992-08-14 | Adir | Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH07215940A (ja) * | 1994-01-27 | 1995-08-15 | Torii Yakuhin Kk | 抗ウイルス活性を有する化合物 |
| JPH08198826A (ja) * | 1995-01-23 | 1996-08-06 | Torii Yakuhin Kk | 抗ウイルス活性を有する化合物 |
-
1999
- 1999-12-10 CA CA002355694A patent/CA2355694A1/en not_active Abandoned
- 1999-12-10 MX MXPA01006218A patent/MXPA01006218A/es unknown
- 1999-12-10 CN CN99815722A patent/CN1333770A/zh active Pending
- 1999-12-10 AT AT99968791T patent/ATE264855T1/de not_active IP Right Cessation
- 1999-12-10 BR BR9916318-7A patent/BR9916318A/pt not_active IP Right Cessation
- 1999-12-10 ES ES99968791T patent/ES2217882T3/es not_active Expired - Lifetime
- 1999-12-10 TR TR2001/01779T patent/TR200101779T2/xx unknown
- 1999-12-10 WO PCT/EP1999/009763 patent/WO2000037464A2/en active IP Right Grant
- 1999-12-10 EP EP99968791A patent/EP1149094B1/en not_active Expired - Lifetime
- 1999-12-10 DE DE69916664T patent/DE69916664T2/de not_active Expired - Fee Related
- 1999-12-10 KR KR1020017007661A patent/KR20010081117A/ko active IP Right Grant
- 1999-12-10 JP JP2000589535A patent/JP3435404B2/ja not_active Expired - Fee Related
- 1999-12-10 DK DK99968791T patent/DK1149094T3/da active
- 1999-12-10 AU AU26606/00A patent/AU754233B2/en not_active Ceased
- 1999-12-14 PE PE1999001249A patent/PE20001324A1/es not_active Application Discontinuation
- 1999-12-15 US US09/464,240 patent/US6376491B1/en not_active Expired - Fee Related
- 1999-12-16 AR ARP990106457A patent/AR021714A1/es not_active Application Discontinuation
-
2001
- 2001-05-29 ZA ZA200104410A patent/ZA200104410B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE264855T1 (de) | 2004-05-15 |
| US6376491B1 (en) | 2002-04-23 |
| BR9916318A (pt) | 2001-08-14 |
| WO2000037464A3 (en) | 2000-11-02 |
| KR20010081117A (ko) | 2001-08-27 |
| MXPA01006218A (es) | 2002-04-17 |
| EP1149094B1 (en) | 2004-04-21 |
| ZA200104410B (en) | 2002-08-29 |
| AR021714A1 (es) | 2002-07-31 |
| WO2000037464A2 (en) | 2000-06-29 |
| CN1333770A (zh) | 2002-01-30 |
| PE20001324A1 (es) | 2000-12-02 |
| JP2002533340A (ja) | 2002-10-08 |
| DE69916664T2 (de) | 2005-03-31 |
| CA2355694A1 (en) | 2000-06-29 |
| ES2217882T3 (es) | 2004-11-01 |
| AU754233B2 (en) | 2002-11-07 |
| JP3435404B2 (ja) | 2003-08-11 |
| AU2660600A (en) | 2000-07-12 |
| DE69916664D1 (de) | 2004-05-27 |
| TR200101779T2 (tr) | 2001-12-21 |
| EP1149094A2 (en) | 2001-10-31 |
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