DK1217002T3 - 2-(4-pyridinyl)benzofuraner som metalloproteaseinhibitorer - Google Patents

2-(4-pyridinyl)benzofuraner som metalloproteaseinhibitorer

Info

Publication number
DK1217002T3
DK1217002T3 DK01403333T DK01403333T DK1217002T3 DK 1217002 T3 DK1217002 T3 DK 1217002T3 DK 01403333 T DK01403333 T DK 01403333T DK 01403333 T DK01403333 T DK 01403333T DK 1217002 T3 DK1217002 T3 DK 1217002T3
Authority
DK
Denmark
Prior art keywords
benzofurans
pyridinyl
metalloprotease inhibitors
metalloprotease
inhibitors
Prior art date
Application number
DK01403333T
Other languages
English (en)
Inventor
Nanteuil Guillaume De
John Hickman
Alain Pierre
Alain Benoist
Philippe Pastoureau
Massimo Sabatini
Gordon Tucker
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1217002T3 publication Critical patent/DK1217002T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
DK01403333T 2000-12-22 2001-12-21 2-(4-pyridinyl)benzofuraner som metalloproteaseinhibitorer DK1217002T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0016826A FR2818643B1 (fr) 2000-12-22 2000-12-22 Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques que les contiennent

Publications (1)

Publication Number Publication Date
DK1217002T3 true DK1217002T3 (da) 2005-01-24

Family

ID=8858043

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01403333T DK1217002T3 (da) 2000-12-22 2001-12-21 2-(4-pyridinyl)benzofuraner som metalloproteaseinhibitorer

Country Status (25)

Country Link
US (1) US6686348B2 (da)
EP (1) EP1217002B1 (da)
JP (1) JP2002226479A (da)
KR (1) KR100445388B1 (da)
CN (1) CN1159318C (da)
AR (1) AR035409A1 (da)
AT (1) ATE277053T1 (da)
AU (1) AU783908B2 (da)
BR (1) BR0106248A (da)
CA (1) CA2364864C (da)
DE (1) DE60105746T2 (da)
DK (1) DK1217002T3 (da)
EA (1) EA004254B1 (da)
ES (1) ES2227096T3 (da)
FR (1) FR2818643B1 (da)
HK (1) HK1047100B (da)
HU (1) HUP0105410A3 (da)
MX (1) MXPA01012896A (da)
NO (1) NO321490B1 (da)
NZ (1) NZ516338A (da)
PL (1) PL351301A1 (da)
PT (1) PT1217002E (da)
SI (1) SI1217002T1 (da)
TR (1) TR200402720T4 (da)
ZA (1) ZA200110517B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US8088737B2 (en) 2003-04-04 2012-01-03 Incyte Corporation Compositions, methods and kits relating to Her-2 cleavage
DE102005002500A1 (de) 2005-01-19 2006-07-27 Sanofi-Aventis Deutschland Gmbh Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen
JP5537775B2 (ja) * 2005-01-28 2014-07-02 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 細胞組織の痛み及び変性特性を評価するために核磁気共鳴（ｎｍｒ）分光を用いるシステム及び方法
US8825131B2 (en) 2009-10-14 2014-09-02 Nocimed, Llc MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
US8761860B2 (en) 2009-10-14 2014-06-24 Nocimed, Llc MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
WO2011162364A1 (ja) * 2010-06-23 2011-12-29 住友化学株式会社 有害節足動物防除組成物および複素環化合物
US9280718B2 (en) 2010-11-24 2016-03-08 Nocimed, Llc Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy
US8965094B2 (en) 2012-04-14 2015-02-24 Nocimed, Llc Magnetic resonance spectroscopy pulse sequence, acquisition, and processing system and method
WO2017222945A1 (en) 2016-06-19 2017-12-28 Nocimed, Inc. Magnetic resonance spectroscopy system and method for diagnosing pain or infection associated with propionic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5880154A (ja) * 1981-11-06 1983-05-14 Matsushita Electric Ind Co Ltd テ−プ移送装置
JPH08157463A (ja) * 1994-11-30 1996-06-18 Canon Inc 液晶性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、液晶装置
FR2748026B1 (fr) * 1996-04-26 1998-06-05 Adir Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE272062T1 (de) * 1996-08-28 2004-08-15 Procter & Gamble Spirocyclisch metalloprotease inhibitoren

Also Published As

Publication number Publication date
NO321490B1 (no) 2006-05-15
NO20016177L (no) 2002-06-24
EP1217002B1 (fr) 2004-09-22
KR100445388B1 (ko) 2004-08-25
KR20020051886A (ko) 2002-06-29
HUP0105410A2 (en) 2002-08-28
HK1047100A1 (en) 2003-02-07
PL351301A1 (en) 2002-07-01
CN1159318C (zh) 2004-07-28
EP1217002A1 (fr) 2002-06-26
PT1217002E (pt) 2004-11-30
DE60105746T2 (de) 2005-10-06
JP2002226479A (ja) 2002-08-14
ES2227096T3 (es) 2005-04-01
BR0106248A (pt) 2002-08-20
MXPA01012896A (es) 2003-07-21
ZA200110517B (en) 2002-07-11
ATE277053T1 (de) 2004-10-15
HK1047100B (zh) 2005-01-07
TR200402720T4 (tr) 2004-11-22
US20020137744A1 (en) 2002-09-26
EA004254B1 (ru) 2004-02-26
AU9744201A (en) 2002-06-27
AU783908B2 (en) 2005-12-22
AR035409A1 (es) 2004-05-26
SI1217002T1 (en) 2004-12-31
EA200101230A1 (ru) 2002-06-27
FR2818643A1 (fr) 2002-06-28
DE60105746D1 (de) 2004-10-28
CN1359900A (zh) 2002-07-24
NZ516338A (en) 2003-05-30
CA2364864C (fr) 2006-07-18
HU0105410D0 (en) 2002-02-28
NO20016177D0 (no) 2001-12-18
US6686348B2 (en) 2004-02-03
FR2818643B1 (fr) 2003-02-07
HUP0105410A3 (en) 2004-01-28
CA2364864A1 (fr) 2002-06-22

Similar Documents

Publication Publication Date Title
CY2012007I2 (el) Πεπτιδομιμητικοι αναστολεις πρωτεασης
ATE237329T1 (de) Metalloprotease inhibitoren
NO20030055L (no) Colchinolderivater som angiogenese inhibitorer
DK1383731T3 (da) Biarylforbindelser som serinproteaseinhibitorer
ATE437862T1 (de) Pyrimidin-5-onderivate als ldl-pla2 inhibitoren
ATE524441T1 (de) Vla-4-inhibitoren
DE60211317D1 (de) Rho-kinase inhibitoren
DE60218138D1 (de) Rho-kinase inhibitoren
NO20034042L (no) Metallproteinase-inhibitorer
NO20031853D0 (no) Spiro-pyrimidin-2,4,6-trion metalloproteinase inhibitorer
NO20024521D0 (no) Heterocyklisk sidekjede-inneholdende metalloproteaseinhibitorer
NO20024997D0 (no) 2-guanidino-4-arylkinazoliner som NHE-3-inhibitorer
NO20034032L (no) Metallproteinase-inhibitorer
NO20025811D0 (no) Forbindelser som er effektive som beta-2-adrenoreseptor- anonister så vel som PDE4-inhibitorer
DK1272488T3 (da) Tri-aryl-substitueret ethan-PDE4-inhibitorer
NO20014243D0 (no) Dihetero-substituerte metalloprotease inhibitorer
NO20032807D0 (no) Substituerte 8-arylkinolin-fosfodiesterase-4-inhibitorer
DK1217002T3 (da) 2-(4-pyridinyl)benzofuraner som metalloproteaseinhibitorer
NO20025786L (no) Protaseinhibitorer
NO20024481D0 (no) Difluorbutyrsyre metalloproteaseinhibitorer
NO20025005L (no) Proteaseinhibitorer
NO20032328D0 (no) Proteaseinhibitorer
NO20032290L (no) Nye forbindelser for anvendelse som HIV-protease-inhibitorer