DE60105746D1 - 2-(4-Pyridinyl)-Benzofurane zur Verwendung als Metalloprotease-Inhibitoren - Google Patents

2-(4-Pyridinyl)-Benzofurane zur Verwendung als Metalloprotease-Inhibitoren

Info

Publication number
DE60105746D1
DE60105746D1 DE60105746T DE60105746T DE60105746D1 DE 60105746 D1 DE60105746 D1 DE 60105746D1 DE 60105746 T DE60105746 T DE 60105746T DE 60105746 T DE60105746 T DE 60105746T DE 60105746 D1 DE60105746 D1 DE 60105746D1
Authority
DE
Germany
Prior art keywords
benzofurans
pyridinyl
metalloprotease inhibitors
metalloprotease
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60105746T
Other languages
English (en)
Other versions
DE60105746T2 (de
Inventor
Nanteuil Guillaume De
Alain Benoist
Philippe Pastoureau
Massimo Sabatini
John Hickman
Alain Pierre
Gordon Tucker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of DE60105746D1 publication Critical patent/DE60105746D1/de
Application granted granted Critical
Publication of DE60105746T2 publication Critical patent/DE60105746T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60105746T 2000-12-22 2001-12-21 2-(4-Pyridinyl)-Benzofurane zur Verwendung als Metalloprotease-Inhibitoren Expired - Fee Related DE60105746T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0016826 2000-12-22
FR0016826A FR2818643B1 (fr) 2000-12-22 2000-12-22 Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques que les contiennent

Publications (2)

Publication Number Publication Date
DE60105746D1 true DE60105746D1 (de) 2004-10-28
DE60105746T2 DE60105746T2 (de) 2005-10-06

Family

ID=8858043

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60105746T Expired - Fee Related DE60105746T2 (de) 2000-12-22 2001-12-21 2-(4-Pyridinyl)-Benzofurane zur Verwendung als Metalloprotease-Inhibitoren

Country Status (25)

Country Link
US (1) US6686348B2 (de)
EP (1) EP1217002B1 (de)
JP (1) JP2002226479A (de)
KR (1) KR100445388B1 (de)
CN (1) CN1159318C (de)
AR (1) AR035409A1 (de)
AT (1) ATE277053T1 (de)
AU (1) AU783908B2 (de)
BR (1) BR0106248A (de)
CA (1) CA2364864C (de)
DE (1) DE60105746T2 (de)
DK (1) DK1217002T3 (de)
EA (1) EA004254B1 (de)
ES (1) ES2227096T3 (de)
FR (1) FR2818643B1 (de)
HK (1) HK1047100B (de)
HU (1) HUP0105410A3 (de)
MX (1) MXPA01012896A (de)
NO (1) NO321490B1 (de)
NZ (1) NZ516338A (de)
PL (1) PL351301A1 (de)
PT (1) PT1217002E (de)
SI (1) SI1217002T1 (de)
TR (1) TR200402720T4 (de)
ZA (1) ZA200110517B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
ES2537514T3 (es) 2003-04-04 2015-06-09 Incyte Corporation Composiciones, métodos y kits relacionados con la escisión de HER-2
DE102005002500A1 (de) * 2005-01-19 2006-07-27 Sanofi-Aventis Deutschland Gmbh Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen
EP1848333B1 (de) 2005-01-28 2013-10-23 The Regents of The University of California Hochfrequenzspektroskopie einsetzende systeme und verfahren zur beurteilung von schmerz und degenerativen gewebeeigenschaften
US8761860B2 (en) 2009-10-14 2014-06-24 Nocimed, Llc MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
US8825131B2 (en) 2009-10-14 2014-09-02 Nocimed, Llc MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs
WO2011162364A1 (ja) * 2010-06-23 2011-12-29 住友化学株式会社 有害節足動物防除組成物および複素環化合物
US9280718B2 (en) 2010-11-24 2016-03-08 Nocimed, Llc Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy
US8965094B2 (en) 2012-04-14 2015-02-24 Nocimed, Llc Magnetic resonance spectroscopy pulse sequence, acquisition, and processing system and method
EP4289347A3 (de) 2016-06-19 2024-03-06 Aclarion, Inc. Magnetresonanz-spektroskopiesystem und verfahren zur diagnose von schmerz oder infektionen im zusammenhang mit propionsäure

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5880154A (ja) * 1981-11-06 1983-05-14 Matsushita Electric Ind Co Ltd テ−プ移送装置
JPH08157463A (ja) * 1994-11-30 1996-06-18 Canon Inc 液晶性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、液晶装置
FR2748026B1 (fr) * 1996-04-26 1998-06-05 Adir Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SK284041B6 (sk) * 1996-08-28 2004-08-03 The Procter And Gamble Company Spirocyklická metaloproteázová inhibítorová zlúčenina a jej použitie

Also Published As

Publication number Publication date
CN1159318C (zh) 2004-07-28
HK1047100B (zh) 2005-01-07
BR0106248A (pt) 2002-08-20
ES2227096T3 (es) 2005-04-01
EA200101230A1 (ru) 2002-06-27
CA2364864A1 (fr) 2002-06-22
SI1217002T1 (en) 2004-12-31
US6686348B2 (en) 2004-02-03
NO321490B1 (no) 2006-05-15
HUP0105410A2 (en) 2002-08-28
EA004254B1 (ru) 2004-02-26
AR035409A1 (es) 2004-05-26
NZ516338A (en) 2003-05-30
NO20016177D0 (no) 2001-12-18
EP1217002B1 (de) 2004-09-22
AU9744201A (en) 2002-06-27
HK1047100A1 (en) 2003-02-07
JP2002226479A (ja) 2002-08-14
PT1217002E (pt) 2004-11-30
ZA200110517B (en) 2002-07-11
DK1217002T3 (da) 2005-01-24
EP1217002A1 (de) 2002-06-26
CA2364864C (fr) 2006-07-18
US20020137744A1 (en) 2002-09-26
ATE277053T1 (de) 2004-10-15
HUP0105410A3 (en) 2004-01-28
PL351301A1 (en) 2002-07-01
KR100445388B1 (ko) 2004-08-25
TR200402720T4 (tr) 2004-11-22
HU0105410D0 (en) 2002-02-28
MXPA01012896A (es) 2003-07-21
NO20016177L (no) 2002-06-24
CN1359900A (zh) 2002-07-24
KR20020051886A (ko) 2002-06-29
DE60105746T2 (de) 2005-10-06
FR2818643A1 (fr) 2002-06-28
FR2818643B1 (fr) 2003-02-07
AU783908B2 (en) 2005-12-22

Similar Documents

Publication Publication Date Title
DE60106022D1 (de) Thiophenverbindungen zur verwendung als antikrebsmittel
DE60140366D1 (de) Piperidinverbindungen zur verwendung als ccr-3-inhibitoren
ATE437862T1 (de) Pyrimidin-5-onderivate als ldl-pla2 inhibitoren
DE60115937D1 (de) Piperidinverbindungen zur verwendung als antiallergika
ATE237329T1 (de) Metalloprotease inhibitoren
DK1255752T3 (da) Pyrrolsubstituerede 2-indolinonproteinkinaseinhibitorer
DE60143301D1 (de) Polyarylcarboxamide zur verwendung als lipidsenker
DE60211317D1 (de) Rho-kinase inhibitoren
DE60218138D1 (de) Rho-kinase inhibitoren
ATE256127T1 (de) Betacarbolinderivate als phosphodiesterase- inhibitoren
ATE380806T1 (de) 2-amino-3-(alkyl)-pyrimidonderivate als gsk3.beta.-hemmer
NO20041293L (no) Alkyn-aryl-fosfodiesterase-4-inhibitorer
ATE278690T1 (de) Substituierte pyprolopyridinonderivate als phosphodiesterase-inhibitoren
ATE297897T1 (de) Ortho-substituierte stickstoffhaltige bisarylverbindungen zur verwendung als kalium- kanal-inhibitoren
NO20024521D0 (no) Heterocyklisk sidekjede-inneholdende metalloproteaseinhibitorer
DE50107316D1 (de) Neue substituierte imidazotriazinone als pde ii-inhibitoren
PT1401828E (pt) Compostos de n-formil-hidroxilamina como inibidores de pdf
DK1272488T3 (da) Tri-aryl-substitueret ethan-PDE4-inhibitorer
NO20014243L (no) Dihetero-substituerte metalloproteaseinhibitorer
ATE428420T1 (de) Substituierte 8-arylchinoline als phosphodiesterase-4-hemmer
DE60105746D1 (de) 2-(4-Pyridinyl)-Benzofurane zur Verwendung als Metalloprotease-Inhibitoren
NO20014875D0 (no) Promedikamenter for trombin inhibitorer
ATE302781T1 (de) Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer
ATE553097T1 (de) Piperidin- und piperazin-substituierte n- hydroxyformamiden zur verwendung als metalloproteinaseinhibitoren
NO20024481D0 (no) Difluorbutyrsyre metalloproteaseinhibitorer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee